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  1. Article ; Online: Phylogeny of Alisma (Alismataceae) revisited: implications for polyploid evolution and species delimitation.

    Ito, Yu / Tanaka, Norio

    Journal of plant research

    2023  Volume 136, Issue 5, Page(s) 613–629

    Abstract: Alisma L. is a genus of aquatic and wetland plants belonging to family Alismataceae. At present, it is thought to contain ten species. Variation in ploidy level is known in the genus, with diploids, tetraploids and hexaploids recorded. Previous molecular ...

    Abstract Alisma L. is a genus of aquatic and wetland plants belonging to family Alismataceae. At present, it is thought to contain ten species. Variation in ploidy level is known in the genus, with diploids, tetraploids and hexaploids recorded. Previous molecular phylogenetic studies of Alisma have generated a robust backbone that reveals important aspects of the evolutionary history of this cosmopolitan genus, yet questions remain unresolved about the formation of the polyploid taxa and the taxonomy of one particularly challenging, widely distributed species complex. Here we directly sequenced, or cloned and sequenced, nuclear DNA (nrITS and phyA) and chloroplast DNA (matK, ndhF, psbA-trnH and rbcL) of multiple samples of six putative species and two varieties, and conducted molecular phylogenetic analyses. Alisma canaliculatum and its two varieties known in East Asia and A. rariflorum endemic to Japan possess closely related but heterogeneous genomes, strongly indicating that the two species were generated from two diploid progenitors, and are possibly siblings of one another. This evolutionary event may have occurred in Japan. Alisma canaliculatum var. canaliculatum is segregated into two types, each of which are geographically slightly differentiated in Japan. We reconstructed a single phylogeny based on the multi-locus data using Homologizer and then applied species delimitation analysis (STACEY). This allowed us to discern A. orientale as apparently endemic to the Southeast Asian Massif and distinct from the widespread A. plantago-aquatica. The former species was most likely formed through parapatric speciation at the southern edge of the distribution of the latter.
    MeSH term(s) Phylogeny ; Alisma/genetics ; Alismataceae/genetics ; DNA, Plant/genetics ; Sequence Analysis, DNA ; Polyploidy ; Evolution, Molecular
    Chemical Substances DNA, Plant
    Language English
    Publishing date 2023-07-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-023-01477-1
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  2. Article ; Online: Impact of preoperative haemoglobin, albumin, lymphocyte, and platelet score on oral cancer prognosis.

    Ito, Yu / Abe, Atsushi / Hayashi, Hiroki

    Oral diseases

    2024  

    Abstract: Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.: Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) ...

    Abstract Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.
    Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) who underwent radical surgery between 2012 and 2022 were included. Factors affecting overall survival and disease-free survival according to the haemoglobin, albumin, lymphocyte, and platelet score were examined. Patients were categorised into low- and high-score groups using optimal cut-off values obtained from receiver operating characteristic curve analysis.
    Results: The low-score group had poorer overall and disease-free survival (p < 0.001 each). Multivariate analysis identified alcohol consumption (hazard ratio [HR], 3.83; 95% confidence interval [CI]: 1.56-9.41, p = 0.003); vascular invasion (HR, 3.97; 95% CI: 1.60-9.85, p = 0.003); and the haemoglobin, albumin, lymphocyte, and platelet score (HR, 0.39; 95% CI: 0.20-0.78, p = 0.007) as independent prognostic factors for overall survival and vascular (HR, 3.66; 95% CI: 1.79-7.50, p < 0.001) and lymphovascular (HR, 2.44; 95% CI: 1.36-4.41, p = 0.003) invasion as independent prognostic factors for disease-free survival.
    Conclusion: The preoperative haemoglobin, albumin, lymphocyte, and platelet score may be a significant prognostic factor for patients with oral squamous cell carcinoma undergoing radical surgery.
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14950
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    Zs.A 4427: Show issues Location:
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  3. Article: Thickening of aqueous nanoparticle suspension using DC electric field

    Mori, Takamasa / Iseki, Natsumi / Ito, Yu / Kitamura, Kenta

    Colloids and surfaces. 2022 Sept. 05, v. 648

    2022  

    Abstract: It is challenging to thicken a well-dispersed nanoparticle suspension without changing the particle dispersion state. In our previous report, we demonstrated that several kinds of particles can be quickly settled from solutions by applying a DC electric ... ...

    Abstract It is challenging to thicken a well-dispersed nanoparticle suspension without changing the particle dispersion state. In our previous report, we demonstrated that several kinds of particles can be quickly settled from solutions by applying a DC electric field. Thus, we attempted to gravitationally thicken a well-dispersed aqueous nanoparticle suspension using a DC electric field instead of a flocculant. To increase the recovery ratio of nanoparticles, it is necessary to prevent particle deposition on the electrodes. Therefore, in this study, we investigated the effect of switching the direction of the DC electric field after certain intervals, and clarified the effect of the switching time on the concentration and particle size of the concentrated suspension. The concentration of an alumina nanoparticle suspension quickly increased by a factor of at least three by applying the DC electric field. In addition, the particle size measured by dynamic light scattering after the application of the DC electric field was almost the same as the nominal average particle size, suggesting that the particles in the aggregates did not overcome the potential barrier and redisperse when the field was removed. Therefore, the use of the DC electric field successfully thickened the aqueous nanoparticle suspension and the particles in the thickened suspension were well dispersed. The findings show that the proposed method has the potential to change material fabrication processes, enabling a dilute nanoparticle suspension prepared by synthesis to be easily and rapidly concentrated.
    Keywords aluminum oxide ; electric field ; flocculants ; gravity ; particle size
    Language English
    Dates of publication 2022-0905
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2022.129387
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  4. Article ; Online: Sick sinus syndrome diagnosed after a sinus arrest during treatment for zygomatic fracture: a case report.

    Hayashi, Hiroki / Abe, Atsushi / Oguma, Tetsushi / Ito, Yu / Nakayama, Atsushi

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 676

    Abstract: Background: Intraoperative sinus arrest is rarely seen during zygomatic fracture treatment. The patient was diagnosed with sick sinus syndrome based on repeated postoperative sinus arrest, which could have resulted in death if diagnosed late, making ... ...

    Abstract Background: Intraoperative sinus arrest is rarely seen during zygomatic fracture treatment. The patient was diagnosed with sick sinus syndrome based on repeated postoperative sinus arrest, which could have resulted in death if diagnosed late, making this case very significant to report.
    Case presentation: Sick sinus syndrome is an arrhythmia associated with reduced automaticity of the sinoatrial node or impaired sinoatrial node conduction. We report the case of a 67-year-old man diagnosed with the syndrome after a sinus arrest that occurred during a zygomatic fracture treatment. The patient had cheek pain and mouth opening disorder, dizziness after fainting and sustaining a facial injury. Preoperative examination determined that the syncope was due to drug-induced arrhythmia, and surgery was authorized after drug withdrawal. During the operation, sinus arrest was observed due to trigeminal vagal reflex, and heart rate was restarted by stopping the operation and chest compressions. After the surgery, the patient showed symptoms of dizziness and palpitations, and sinus arrest following atrial fibrillation and supraventricular tachycardia, which was diagnosed as sick sinus syndrome, and a pacemaker was implanted. Currently, 8 years have passed since the surgery, and there are no symptoms of mouth opening disorder, dizziness, or palpitations.
    Conclusions: In the case of maxillofacial injuries due to syncope, cardiogenic syncope is a possibility, and repeated syncope is a risk for death due to delayed diagnosis. There are no reports of maxillofacial trauma leading to a diagnosis of sick sinus syndrome. The purpose of this case report is to disseminate the importance of diagnosing the cause of syncope as well as injury treatment.
    MeSH term(s) Male ; Humans ; Aged ; Zygomatic Fractures ; Sick Sinus Syndrome/therapy ; Dizziness ; Syncope/etiology ; Atrial Fibrillation
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03413-0
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  5. Article ; Online: Electromyographic activities of glenohumeral joint muscles during shoulder forward flexion with isometric horizontal abduction loading.

    Ito, Yu / Matsumoto, Hisashi / Ishida, Tomoya / Suenaga, Naoki / Oizumi, Naomi

    Journal of shoulder and elbow surgery

    2023  Volume 32, Issue 8, Page(s) 1718–1727

    Abstract: Background: Isometric horizontal abduction loading has been applied to improve imbalanced scapular muscle activities during shoulder exercises; however, the effect on glenohumeral joint muscle activity remains unclear. The purpose of this study was to ... ...

    Abstract Background: Isometric horizontal abduction loading has been applied to improve imbalanced scapular muscle activities during shoulder exercises; however, the effect on glenohumeral joint muscle activity remains unclear. The purpose of this study was to investigate the changes in electromyographic activity of shoulder muscles during forward flexion with isometric horizontal abduction loading in healthy participants.
    Methods: Thirteen healthy men were recruited for this study. Participants performed shoulder forward flexion with isometric horizontal abduction loading using an elastic band (Flex-band condition) and forward flexion without shoulder loading (Normal-flex condition). Muscle activities were evaluated while maintaining shoulder flexion at 60°, 90°, 120°, and 150° (static task) and during active shoulder flexion from 0° to maximum elevation (dynamic task). Surface electrodes were placed on the deltoid, pectoralis major, infraspinatus, and teres minor muscles to measure the activities of the shoulder muscles during each task. The muscle activities during the static task were compared using a 2-way analysis of variance with repeated measures of the 2 factors, loading condition and flexion position, and a paired t test was used for comparisons between the 2 conditions during the dynamic task (significance level set at P < .05).
    Results: For the static task, the Flex-band condition significantly increased the deltoid middle and posterior activities by 2-15 times and the infraspinatus and teres minor activities by 2-3 times compared with the Normal-flex condition at all positions. In contrast, the Flex-band condition significantly decreased (by about half) the activities of the deltoid anterior (at 120° and 150°) and pectoralis major (at all positions) compared with the Normal-flex condition. For the dynamic task, the Flex-band condition significantly increased the deltoid middle, deltoid posterior, infraspinatus, and teres minor activities by 2-7 times and decreased the deltoid anterior activity by approximately two-thirds.
    Conclusions: Applying isometric horizontal abduction loading during shoulder forward flexion may be useful in improving the imbalanced muscle activities of the glenohumeral joint, such as excessive activity of the deltoid anterior and pectoralis major and dysfunction of the deltoid middle, deltoid posterior, and shoulder external rotator muscles. Shoulder forward flexion with horizontal abduction loading could be available for exercise in patients who have massive rotator cuff tears or who have undergone rotator cuff repair and shoulder arthroplasty.
    MeSH term(s) Male ; Humans ; Shoulder/physiology ; Shoulder Joint/physiology ; Electromyography ; Rotator Cuff ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2023.01.006
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    Zs.A 3973: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Association between tumor response to systemic therapy and patient-reported disease symptoms.

    Ito, Yu / Awano, Nobuyasu / Takahashi, Naoko / Izumo, Takehiro / Kunitoh, Hideo

    Japanese journal of clinical oncology

    2022  Volume 52, Issue 12, Page(s) 1423–1429

    Abstract: Background: The association of treatment-induced tumor shrinkage with symptom palliation for patients with lung cancer remains unknown. We investigated this correlation using the Edmonton Symptom Assessment System-Revised.: Methods: Using the in- ... ...

    Abstract Background: The association of treatment-induced tumor shrinkage with symptom palliation for patients with lung cancer remains unknown. We investigated this correlation using the Edmonton Symptom Assessment System-Revised.
    Methods: Using the in-hospital cancer registry, we identified patients receiving chemotherapy and/or immunotherapy for newly diagnosed advanced or metastatic lung cancer. Tumor response and post-treatment Edmonton Symptom Assessment System-Revised were obtained after 2-3 treatment cycles. Patients were divided into groups with or without >30% unidirectional tumor shrinkage (objective response [OR] or non-OR [N-OR] groups, respectively). They were further classified as good-objective response (>50% unidirectional tumor shrinkage), moderate-objective response (30-50% shrinkage), progressive disease (>20% tumor growth or new lesion) or stable disease (SD; N-objective response and non-progressive disease). The primary endpoint was change in the total Edmonton Symptom Assessment System-Revised score from baseline. The Mann-Whitney U test was used for analysis.
    Results: In total, 113 patients were enrolled. The total Edmonton Symptom Assessment System-Revised score was significantly more improved in the OR group versus the N-OR group (median: 5 vs. 2, respectively; P = 0.013). This association was more prominent in patients with small-cell lung cancer and large-cell neuroendocrine tumor than those with other histology. Sensitivity analyses showed that the total Edmonton Symptom Assessment System-Revised score was more improved in the OR group versus the SD group (median: 5 vs. 3, respectively; P = 0.029) and in the 'good-OR' group versus the 'moderate-OR and SD' group (median: 7.5 vs. 2, respectively; P = 0.003), suggesting that greater tumor shrinkage led to more symptom amelioration.
    Conclusions: Tumor shrinkage was associated with Edmonton Symptom Assessment System-Revised score improvement in patients with lung cancer receiving systemic therapy.
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyac142
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    Zs.A 1298: Show issues Location:
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  7. Article ; Online: Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma.

    Ito, Yu / Abe, Atsushi / Hayashi, Hiroki / Momokita, Moeko / Furuta, Hiroshi

    Oral diseases

    2022  Volume 29, Issue 5, Page(s) 2076–2085

    Abstract: Objectives: To investigate the prognostic impact of preoperative Geriatric Nutritional Risk Index (GNRI) values in older adults undergoing radical surgery for oral squamous cell carcinoma (OSCC).: Subjects and methods: This retrospective study ... ...

    Abstract Objectives: To investigate the prognostic impact of preoperative Geriatric Nutritional Risk Index (GNRI) values in older adults undergoing radical surgery for oral squamous cell carcinoma (OSCC).
    Subjects and methods: This retrospective study included 61 patients ≥65 years old with OSCC (43 men, 18 women; age: 72.1 ± 5.4 years) who underwent radical surgery between 2013 and 2020. Factors influencing overall survival (OS) and disease-free survival (DFS) were examined.
    Results: Receiver operating characteristic curve analysis indicated that the optimal GNRI value for classifying patients into low-GNRI (<93.7; OS: n = 19 [31.1%], DFS: n = 42 [68.9%]) and high-GNRI groups (≥93.7; OS, n = 19 [31.1%]; DFS, n = 42 [68.9%]) was 93.7. OS and DFS rates were significantly lower in the low-GNRI group than in the high-GNRI group. Univariate analysis indicated that alcohol use, preoperative serum C-reactive protein level, lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with OS, while lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with DFS. In multivariate analysis, only GNRI was significantly correlated with OS. DFS and postoperative treatment were independent predictors of DFS.
    Conclusions: Preoperative GNRI may be a significant prognostic factor in older adults with OSCC. GNRI assessment and nutritional intervention may improve prognosis in patients at high nutritional risk.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Carcinoma, Squamous Cell/surgery ; Prognosis ; Nutritional Status ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck ; Nutrition Assessment ; Risk Factors ; Mouth Neoplasms/surgery ; Head and Neck Neoplasms
    Language English
    Publishing date 2022-05-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14255
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    Zs.A 4427: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Change in Shear Elastic Modulus of Thigh Muscle by Changing Muscle Length Using Ultrasound Shear Wave Elastography in Beagle Dogs.

    Shimizu, Miki / Ito, Yu

    Veterinary and comparative orthopaedics and traumatology : V.C.O.T

    2019  Volume 32, Issue 6, Page(s) 454–459

    Abstract: Objectives:  This study investigated the relationship between the change in the shear elastic modulus and the change in muscle length using ultrasound shear wave elastography.: Study design:  Four thigh muscles, cranial part of the sartorius, vastus ... ...

    Abstract Objectives:  This study investigated the relationship between the change in the shear elastic modulus and the change in muscle length using ultrasound shear wave elastography.
    Study design:  Four thigh muscles, cranial part of the sartorius, vastus lateralis, biceps femoris and semitendinosus muscles, of 21 pelvic limbs in 12 clinically healthy Beagle dogs were used. The muscle length was estimated using a radiograph and the flexed and extended positions of the coxofemoral and stifle joints, respectively. The shear elastic modulus (kPa) was measured in two joint positions using ultrasound shear wave elastography. Shear elastic modulus was expressed as median of 10 consecutive measurements. The percentage change of elastic modulus was calculated from the shear elastic modulus in elongated condition and pre-elongated condition of muscle.
    Results:  The elastic modulus of all muscles increased when the muscle was elongated. The shear elastic modulus for both joint positions and the percentage change of the shear elastic modulus (%) in cranial part of the sartorius were highest in all muscles. Intra-observer correlation coefficient (1.2) was 0.75 to 0.96 and intra-observer correlation coefficients (2.2) was 0.46 to 0.96.
    Conclusion:  This study revealed that the shear elastic modulus of muscle was changed by the change in muscle length and increased when the muscle was elongated. Ultrasound shear wave elastography can be used to assess the elastic properties of canine muscle.
    MeSH term(s) Animals ; Dogs/physiology ; Elasticity Imaging Techniques/methods ; Elasticity Imaging Techniques/veterinary ; Female ; Male ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiology ; Thigh ; Ultrasonography/veterinary
    Language English
    Publishing date 2019-06-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0039-1692449
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    Zs.A 2352: Show issues Location:
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  9. Article ; Online: Evaluation of Scoring Systems for Airway Management After Oral Cancer Surgery: A Retrospective Study.

    Abe, Atsushi / Umemura, Eri / Hayashi, Hiroki / Ito, Yu / Adachi, Moriyasu

    The Annals of otology, rhinology, and laryngology

    2021  Volume 130, Issue 8, Page(s) 873–880

    Abstract: Objective: Postoperative airway obstruction following oral cancer surgery is difficult to predict. Scoring systems used to assess the need for tracheotomy use risk factors as criteria. We aimed to examine whether these clinical scoring systems can ... ...

    Abstract Objective: Postoperative airway obstruction following oral cancer surgery is difficult to predict. Scoring systems used to assess the need for tracheotomy use risk factors as criteria. We aimed to examine whether these clinical scoring systems can predict airway obstruction following oral cancer surgery.
    Methods: We assessed 95 patients who underwent oral cancer surgery without tracheotomy under general anesthesia between January 2007 and April 2019. We reviewed multiple factors from the patients' medical records, including age, sex, tumor site, body mass index, tumor stage, type of surgery, airway management method, Cameron and Gupta scores, and postoperative airway complications.
    Results: Tumors were located in the maxilla (
    Conclusions: Screening based on the Gupta score appears to be effective in predicting postoperative airway obstruction. We propose that this screening tool can be used to better plan tracheotomy and other airway management strategies during preoperative patient assessment.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Airway Management ; Airway Obstruction/etiology ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Oral Surgical Procedures/adverse effects ; Postoperative Complications/etiology ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Tracheotomy
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/0003489420984353
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  10. Article ; Online: Rate of Torque Development in the Quadriceps after Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autografts in Young Female Athletes.

    Suzuki, Makoto / Ishida, Tomoya / Samukawa, Mina / Matsumoto, Hisashi / Ito, Yu / Aoki, Yoshimitsu / Tohyama, Harukazu

    International journal of environmental research and public health

    2022  Volume 19, Issue 18

    Abstract: This study aims to compare the limb symmetry index (LSI) of the rate of torque development (RTD) of the quadriceps with that of the peak torque after anterior cruciate ligament reconstruction (ACLR) using semitendinosus and gracilis tendon (STG) ... ...

    Abstract This study aims to compare the limb symmetry index (LSI) of the rate of torque development (RTD) of the quadriceps with that of the peak torque after anterior cruciate ligament reconstruction (ACLR) using semitendinosus and gracilis tendon (STG) autografts and to investigate the associations of the LSI of torque parameters with patient-reported knee function. The participants included 23 female athletes after ACLR with STG grafts. Isometric quadriceps tests were performed using an isokinetic dynamometer. The peak torque, RTD
    MeSH term(s) Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction ; Athletes ; Autografts/surgery ; Female ; Hamstring Tendons/surgery ; Humans ; Infant ; Muscle Strength ; Torque
    Language English
    Publishing date 2022-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191811761
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