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  1. Article ; Online: Is Extra Virgin Olive Oil the Critical Ingredient Driving the Health Benefits of a Mediterranean Diet? A Narrative Review.

    Flynn, Mary M / Tierney, Audrey / Itsiopoulos, Catherine

    Nutrients

    2023  Volume 15, Issue 13

    Abstract: Most chronic diseases are preventable with a healthy diet, although there is debate about the optimal dietary approach. Increasingly more countries are focusing on food-based guidelines rather than the traditional nutrient-based approach. Although there ... ...

    Abstract Most chronic diseases are preventable with a healthy diet, although there is debate about the optimal dietary approach. Increasingly more countries are focusing on food-based guidelines rather than the traditional nutrient-based approach. Although there is good agreement on plant foods, controversy remains about the types and amounts of fats and oils. This narrative review aims to systematically summarize and evaluate the latest evidence on the protective effects of extra virgin olive oil (EVOO) on disease risk factors. A systematic search of the relevant literature using PubMed, Cochrane Library, and Embase databases was conducted for the years 2000 through December 2022. A narrative synthesis was then undertaken. Of 281 retrieved articles, 34 articles fulfilled our inclusion criteria and were included. Compared with other dietary fats and low-fat diets, EVOO is superior in the management of clinical biomarkers including lowering blood pressure and LDL-c, increasing protective HDL-c, improving glycemic control, and weight management. The protective effects of EVOO are likely due to its polyphenol content rather than the monounsaturated fat content. It is therefore important to promote the regular use of EVOO in the context of healthy dietary patterns such as the Mediterranean diet for maximal health benefit.
    MeSH term(s) Olive Oil ; Diet, Mediterranean ; Dietary Fats ; Diet, Fat-Restricted ; Diet, Healthy
    Chemical Substances Olive Oil ; Dietary Fats
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15132916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The anti-inflammatory effects of a Mediterranean diet: a review.

    Itsiopoulos, Catherine / Mayr, Hannah L / Thomas, Colleen J

    Current opinion in clinical nutrition and metabolic care

    2022  Volume 25, Issue 6, Page(s) 415–422

    Abstract: Purpose of review: Chronic noncommunicable diseases remain the leading cause of morbidity and mortality worldwide and the majority are preventable with a healthy diet and lifestyle, but controversy remains as to the best approach. Greater adherence to a ...

    Abstract Purpose of review: Chronic noncommunicable diseases remain the leading cause of morbidity and mortality worldwide and the majority are preventable with a healthy diet and lifestyle, but controversy remains as to the best approach. Greater adherence to a traditional Mediterranean diet has consistently been associated with lower morbidity and mortality from cardiovascular disease, diabetes and many cancers, and lower all-cause mortality. Despite the well known benefits on chronic disease risk there remains some scepticism as to the effects of this dietary pattern across populations outside the Mediterranean and the mechanisms of action of this traditional plant-based dietary pattern.This narrative review aims to summarize the latest evidence on the health protective effects of a traditional Mediterranean diet on chronic noncommunicable diseases, specifically focussing on the anti-inflammatory effects of this highly published dietary pattern.
    Recent findings: Recent high-quality evidence now supports a Mediterranean diet in secondary prevention of cardiovascular disease with impacts on atherosclerosis progression, likely through reduction of systemic inflammation and irrespective of changes in cholesterol or weight. The Mediterranean diet has a low Dietary Inflammatory Index illustrating its anti-inflammatory potential. This dietary pattern beneficially modulates the gut microbiota and immune system, including emerging evidence for efficacy against severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019). Emerging evidence shows clinicians are not routinely recommending a Mediterranean diet despite well known evidence due to barriers such as lack of training, patient materials and concerns about potential patient adherence.
    Summary: The physiological mechanisms of action of this healthy diet pattern are becoming better understood to be multisystem and involving the gut. Larger controlled trials investigating mechanistic effects in broader non-Mediterranean populations are warranted. Although reflected in therapeutic guidelines for chronic disease management worldwide there are individual, clinical practice and health system barriers to its implementation that need a multisectoral approach to address.
    MeSH term(s) COVID-19/prevention & control ; Cardiovascular Diseases/prevention & control ; Cholesterol ; Diet, Mediterranean ; Humans ; Noncommunicable Diseases
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The assessment of dietary carotenoid intake of the Cardio-Med FFQ using food records and biomarkers in an Australian cardiology cohort: a pilot validation.

    Kucianski, Teagan / Mayr, Hannah L / Tierney, Audrey / Vally, Hassan / Thomas, Colleen J / Karimi, Leila / Wood, Lisa G / Itsiopoulos, Catherine

    Journal of nutritional science

    2024  Volume 13, Page(s) e20

    Abstract: Dietary carotenoids are associated with lower risk of CHD. Assessment of dietary carotenoid intake using questionnaires can be susceptible to measurement error. Consequently, there is a need to validate data collected from FFQs which measure carotenoid ... ...

    Abstract Dietary carotenoids are associated with lower risk of CHD. Assessment of dietary carotenoid intake using questionnaires can be susceptible to measurement error. Consequently, there is a need to validate data collected from FFQs which measure carotenoid intake. This study aimed to assess the performance of the Cardio-Med Survey Tool (CMST)-FFQ-version 2 (v2) as a measure of dietary carotenoid intake over 12-months against plasma carotenoids biomarkers and 7-Day Food Records (7DFR) in an Australian cardiology cohort. Dietary carotenoid intakes (β- and α-carotene, lycopene, β-cryptoxanthin and lutein/zeaxanthin) were assessed using the 105-item CMST-FFQ-v2 and compared to intakes measured by 7DFR and plasma carotenoid concentrations. Correlation coefficients were calculated between each dietary method, and validity coefficients (VCs) were calculated between each dietary method and theoretical true intake using the 'methods of triads'. Thirty-nine participants aged 37-77 years with CHD participated in the cross-sectional study. The correlation between FFQ and plasma carotenoids were largest and significant for β-carotene (0.39,
    MeSH term(s) Humans ; Lycopene ; beta Carotene ; Beta-Cryptoxanthin ; Cross-Sectional Studies ; Australia ; Carotenoids ; Cardiology ; Biomarkers
    Chemical Substances alpha-carotene (45XWE1Z69V) ; Lycopene (SB0N2N0WV6) ; beta Carotene (01YAE03M7J) ; Beta-Cryptoxanthin ; Carotenoids (36-88-4) ; Biomarkers
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2656288-1
    ISSN 2048-6790 ; 2048-6790
    ISSN (online) 2048-6790
    ISSN 2048-6790
    DOI 10.1017/jns.2024.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Method validation for a greener approach to the quantification of 25-hydroxy vitamin D3 in patient serum using supported liquid extraction and liquid chromatography-tandem mass spectrometry.

    Turrell, Gavin / Thrimawithana, Thilini / Itsiopoulos, Catherine / Greaves, Ronda F / Zakaria, Rosita

    Clinical chemistry and laboratory medicine

    2023  Volume 61, Issue 12, Page(s) e255–e258

    MeSH term(s) Humans ; Cholecalciferol ; Tandem Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Chromatography, High Pressure Liquid/methods ; Vitamin D
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-06-09
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does BMI Modify the Association between Vitamin D and Pulmonary Function in Children of the Mild Asthma Phenotype?

    Papamichael, Maria Michelle / Itsiopoulos, Catherine / Katsardis, Charis / Tsoukalas, Dimitris / Erbas, Bircan

    International journal of environmental research and public health

    2022  Volume 19, Issue 24

    Abstract: Vitamin D deficiency and obesity are global health problems that are associated with increased asthma risk in children. The purpose of this study was to investigate whether BMI modifies pulmonary function across vitamin D tertiles in pediatric asthma ... ...

    Abstract Vitamin D deficiency and obesity are global health problems that are associated with increased asthma risk in children. The purpose of this study was to investigate whether BMI modifies pulmonary function across vitamin D tertiles in pediatric asthma patients of the mild asthma phenotype. This cross-sectional study conducted from November 2016-September 2017 compared lung function variability as assessed by spirometry and nitric oxide in exhaled breath (FeNO) among 35 normal-weight and 26 overweight/obese Greek schoolchildren (5-12 years old) with mild asthma. Serum 25 (OH)D levels ≥ 30 ng/mL were defined as 'sufficient', 20-30 ng/mL 'insufficient', and <20 ng/mL 'deficient'. Stratification by BMI category, linear regression showed positive associations between D, % FVC (β = 0.49, 95%CI: 0.05, 0.94), and % FEV
    MeSH term(s) Humans ; Vitamin D ; Overweight/complications ; Body Mass Index ; Cross-Sectional Studies ; Asthma/drug therapy ; Lung ; Obesity/complications ; Phenotype ; Nitric Oxide
    Chemical Substances Vitamin D (1406-16-2) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192416768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Journey mapping long COVID: Agency and social support for long-hauling.

    Figueiredo, Bernardo / Sheahan, Jacob / Luo, Shiqi / Bird, Stephen / Wong Lit Wan, Dawn / Xenos, Sophia / Itsiopoulos, Catherine / Jessup, Rebecca / Zheng, Zhen

    Social science & medicine (1982)

    2023  Volume 340, Page(s) 116485

    Abstract: Long COVID, also known as Post COVID-19 condition, is defined by the WHO as the continuation or development of new symptoms three months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least two months with no other explanation. ...

    Abstract Long COVID, also known as Post COVID-19 condition, is defined by the WHO as the continuation or development of new symptoms three months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least two months with no other explanation. Despite many studies examining the causes and mechanisms of this disease, fewer studies have sought to understand the experience of those suffering from long COVID, or "long-haulers," This study contributes to the understanding of long-haulers (N = 14) by examining the role of agency and social support in shaping their journeys with long COVID. Drawing on a combination of interviews, questionnaires, and video diaries over a three-month period, journey mapping was used to document the participants' experiences, including symptoms, coping strategies, and lifestyle changes. Analysis of these journey maps resulted in a framework with four clusters demonstrating the importance of social support and patient agency shaping participants' Long COVID trajectory; the study contributes valuable insights into the daily lives and challenges individuals face with long COVID, informing the development of targeted support programs.
    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; SARS-CoV-2 ; Social Support ; Coping Skills
    Language English
    Publishing date 2023-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.116485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The rationale and design of a Mediterranean diet accompanied by time restricted feeding to optimise the management of type 2 diabetes: The MedDietFast randomised controlled trial

    Papamichou, Dimitra / Panagiotakos, Demosthenes B. / Holmes, Elaine / Koutsakis, Polychronis / Katsoulotos, Hariklia / Loo, Ruey L. / Itsiopoulos, Catherine

    The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2022 Jan., v. 32, no. 1

    2022  

    Abstract: Substantial scientific evidence supports the effectiveness of a Mediterranean diet (MedDiet) in managing type 2 diabetes mellitus (T2DM). Potential benefits of time restricted feeding (TRF) in T2DM are unknown. The MedDietFast trial aims to investigate ... ...

    Abstract Substantial scientific evidence supports the effectiveness of a Mediterranean diet (MedDiet) in managing type 2 diabetes mellitus (T2DM). Potential benefits of time restricted feeding (TRF) in T2DM are unknown. The MedDietFast trial aims to investigate the efficacy of a MedDiet with or without TRF compared to standard care diet in managing T2DM.120 adults aged 20–75 with a body mass index (BMI) of 20–35 kg/m² and T2DM will be randomised in a 3-arm parallel design to follow an ad libitum MedDiet with or without 12-h TRF or the standard Australian Dietary Guidelines (ADG) for 24 weeks. All groups will receive dietary counselling fortnightly for 12 weeks and monthly thereafter. The primary outcome is changes in HbA1c from baseline to 12 and 24 weeks. Secondary outcomes include fasting blood glucose, insulin, blood lipids, weight loss, insulin resistance index (HOMA), Glucagon-like peptide 1 (GLP-1) and high-sensitivity C- reactive protein (hs-CRP). Data on medical history, anthropometry, wellbeing, MedDiet adherence and satiety will be measured at a private clinic via self-report questionnaires at baseline, 6, 12 and 24 weeks. Additionally, specimens (blood, urine and stool) will be collected at all time points for future omics analysis.The MedDietFast trial will examine the feasibility and effectiveness of a MedDiet with/without TRF in T2DM patients. Potential synergistic effects of a MedDiet with TRF will be evaluated. Future studies will generate microbiomic and metabolomic data for translation of findings into simple and effective management plans for T2DM patients.Australia and New Zealand Clinical Trials Register, ACTRN12619000246189;
    Keywords Mediterranean diet ; blood ; blood glucose ; body mass index ; glucagon-like peptide 1 ; insulin ; insulin resistance ; medical history ; metabolism ; metabolomics ; noninsulin-dependent diabetes mellitus ; satiety ; urine ; weight loss ; New Zealand
    Language English
    Dates of publication 2022-01
    Size p. 220-230.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2021.09.031
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Poor adherence to the Mediterranean diet is associated with increased likelihood of metabolic syndrome components in children: the Healthy Growth Study

    George, Elena S / Gavrili, Stavroula / Itsiopoulos, Catherine / Manios, Yannis / Moschonis, George

    Public health nutrition. 2021 July, v. 24, no. 10

    2021  

    Abstract: To examine the associations between the level of adherence to the Mediterranean diet (MedDiet) with obesity, insulin resistance (IR), metabolic syndrome (MetS) and its components in schoolchildren. The Healthy Growth Study was a large epidemiological ... ...

    Abstract To examine the associations between the level of adherence to the Mediterranean diet (MedDiet) with obesity, insulin resistance (IR), metabolic syndrome (MetS) and its components in schoolchildren. The Healthy Growth Study was a large epidemiological cross-sectional study. School children who were enrolled in primary schools in four counties covering the northern, southern, western and central part of Greece were invited to participate. The study was conducted with a representative sample of 9–13-year-old schoolchildren (n 1972) with complete data. This study applied the KIDMed score to determine ‘poor’ (≤3), ‘medium’ (4-7) and ‘high’ (≥8) adherence of children to the MedDiet. The research hypothesis was examined using multivariate logistic regression models, controlling for potential confounders. The percentage of children with ‘poor’, ‘medium’ and ‘high’ adherence to the MedDiet was 64·8 %, 34·2 % and 1 %, respectively. Furthermore, the prevalence of obesity, IR and MetS was 11·6 %, 28·8 % and 3·4 %, respectively. Logistic regression analyses revealed that ‘poor’ adherence to the MedDiet was associated with an increased likelihood for central obesity (OR 1·31; 95 % CI 1·01, 1·73), hypertriglyceridaemia (OR 2·80; 95 % CI 1·05, 7·46) and IR (OR 1·31; 95 % CI 1·05, 1·64), even after adjusting for several potential confounders. The present study showed that approximately two-thirds of the examined sample of schoolchildren in Greece have ‘poor’ adherence to the MedDiet, which also increases the likelihood for central obesity, hypertriglyceridaemia and IR. Prospective studies are needed to confirm whether these are cause–effect associations.
    Keywords Mediterranean diet ; cross-sectional studies ; hypertriglyceridemia ; insulin resistance ; metabolic syndrome ; obesity ; public health ; regression analysis ; Greece
    Language English
    Dates of publication 2021-07
    Size p. 2823-2833.
    Publishing place Cambridge University Press
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980021001701
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: A Mediterranean and low‐fat dietary intervention in non‐alcoholic fatty liver disease patients: Exploring participant experience and perceptions about dietary change

    George, Elena S. / Forsyth, Adrienne K. / Reddy, Anjana / Itsiopoulos, Catherine / Roberts, Stuart K. / Nicoll, Amanda J. / Ryan, Marno C. / Tierney, Audrey C.

    Journal of Human Nutrition and Dietetics. 2023 June, v. 36, no. 3 p.592-602

    2023  

    Abstract: BACKGROUND: A Mediterranean diet (MD) appears to be beneficial in non‐alcoholic fatty liver disease (NAFLD) patients in Mediterranean countries; however, the acceptability of a MD in non‐Mediterranean populations has not been thoroughly explored. The ... ...

    Abstract BACKGROUND: A Mediterranean diet (MD) appears to be beneficial in non‐alcoholic fatty liver disease (NAFLD) patients in Mediterranean countries; however, the acceptability of a MD in non‐Mediterranean populations has not been thoroughly explored. The present study aimed to explore the acceptability through understanding the barriers and enablers of the MD and low‐fat diet (LFD) interventions as perceived by participating Australian adults from multicultural backgrounds with NAFLD. METHODS: Semi‐structured telephone interviews were performed with 23 NAFLD trial participants at the end of a 12‐week dietary intervention in a multicentre, parallel, randomised clinical trial. Data were analysed using thematic analysis. RESULTS: Participants reported that they enjoyed taking part in the MD and LFD interventions and perceived that they had positive health benefits from their participation. Compared with the LFD, the MD group placed greater emphasis on enjoyment and intention to maintain dietary changes. Novelty, convenience and the ability to swap food/meals were key enablers for the successful implementation for both of the dietary interventions. Flavour and enjoyment of food, expressed more prominently by MD intervention participants, were fundamental components of the diets with regard to reported adherence and intention to maintain dietary change. CONCLUSIONS: Participants randomised to the MD reported greater acceptability of the diet than those randomised to the LFD, predominantly related to perceived novelty and palatability of the diet.
    Keywords Mediterranean diet ; clinical trials ; dietetics ; fatty liver ; flavor ; low fat diet ; nutritional intervention ; palatability ; telephones
    Language English
    Dates of publication 2023-06
    Size p. 592-602.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13069
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Adherence to the Mediterranean Diet and Successful aging in Greeks living in Greece and abroad: the epidemiological Mediterranean Islands Study (MEDIS)

    Papadimitriou, Anastasia / Foscolou, Alexandra / Itsiopoulos, Catherine / Thodis, Antonia / Kouris-Blazos, Antigone / Brazionis, Laima / Sidossis, Amalia C. / Polychronopoulos, Evangelos / Kokkinos, Peter / Panagiotakos, Demosthenes / Sidossis, Labros S.

    Nutrition and Health. 2023 June, v. 29, no. 2 p.287-295

    2023  

    Abstract: Background: Whether older immigrant populations from the Mediterranean region, continue to follow the MD long after they immigrated is not known. Aim: Compare adherence to the MD and successful aging levels between Greeks living in Greece (GG) and Greeks ...

    Abstract Background: Whether older immigrant populations from the Mediterranean region, continue to follow the MD long after they immigrated is not known. Aim: Compare adherence to the MD and successful aging levels between Greeks living in Greece (GG) and Greeks living abroad (GA). Methods: Anthropometrical, clinical, psychological, sociodemographic, dietary and lifestyle parameters were assessed in a cross-sectional manner in a sample of 252 GG and 252 GA. Mediterranean Diet Score (MedDietScore range 0-55) was used to assess adherence to the MD. Successful aging was evaluated with the validated successful aging index (SAI range 0-10). Results: GA presented higher adherence to MD (p < 0.001); they were consuming significantly more cereals, legumes, vegetables, and fruits compared to GG. GG consumed significantly more dairy (3.8 ± 2.9 vs. 1.9 ± 2.2, p < 0.001) and potatoes (2.4 ± 1.6 vs. 1.9 ± 1.5, p < 0.001) compared to GA. Meat (p = 0.27), poultry (p = 0.72), fish (p = 0.68), olive oil (p = 0.16) and alcohol consumption (p = 0.05) were comparable between the two groups (all p’s > 0.05). MedDietScore was positively associated with SAI among both groups after adjusting for possible confounders (0.041 ± 0.014, p = 0.003 GG and 0.153 ± 0.035, p < 0.001 GA). Also, legumes, cereals, fruits and vegetables were found to be beneficial for successful aging. Conclusion: Adherence to the MD is associated with higher levels of successful aging among people of the same genetic background living in different environments. However, traditional dietary habits are gradually abandoned in their native countries, when, at the same time, are considered cultural heritage and preserved accordingly among immigrants.
    Keywords Mediterranean diet ; alcohol drinking ; cultural heritage ; fish ; genetic background ; lifestyle ; meat ; olive oil ; people ; poultry ; Greece ; Mediterranean region ; Successful aging ; healthy aging ; immigrant population ; acculturation ; nutrition transition
    Language English
    Dates of publication 2023-06
    Size p. 287-295.
    Publishing place SAGE Publications
    Document type Article ; Online
    ZDB-ID 603215-1
    ISSN 2047-945X ; 0260-1060
    ISSN (online) 2047-945X
    ISSN 0260-1060
    DOI 10.1177/02601060211072363
    Database NAL-Catalogue (AGRICOLA)

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