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  1. Article ; Online: COVID-19 en Chile: análisis de su impacto por olas y regiones.

    Ayala, Andrés / Dintrans, Pablo Villalobos / Elorrieta, Felipe / Maddaleno, Matilde / Vargas, Claudio / Iturriaga, Andrés

    Revista medica de Chile

    2024  Volume 151, Issue 3, Page(s) 269–279

    Abstract: Background: The effects of COVID-19 in Chile changed over time and among regions.: Aim: To identify patterns in the impact and evolution of COVID-19 for each wave generated between 2020 and 2022 at the 16 regions of the country.: Material and ... ...

    Title translation The impact of the different waves of COVID-19 pandemic in Chile across regions.
    Abstract Background: The effects of COVID-19 in Chile changed over time and among regions.
    Aim: To identify patterns in the impact and evolution of COVID-19 for each wave generated between 2020 and 2022 at the 16 regions of the country.
    Material and methods: Several indicators related to the pandemic, their evolution and their consequences for the health system and the health of the population were calculated.
    Results: There are differences in the evolution of the infection across the regions of the country, as well as heterogeneity between waves. Specifically, the second wave in Chile was identified as the one with the greatest impact, with a national death rate of 123.5 deaths per 100,000 inhabitants and 66.4% intensive care unit occupancy rate due to COVID-19. Performing a geographic analysis, it was possible to find systematic patterns, for example, between regions with higher immunization rates and lower rates of lethality, such as the cases of Ñuble and Atacama regions.
    Conclusions: These results emphasize the need to consider regional differences and the temporal context for the elaboration of strategies to the efficient management of a pandemic.
    MeSH term(s) Humans ; COVID-19 ; Chile/epidemiology ; Pandemics ; Intensive Care Units ; Research Design
    Language Spanish
    Publishing date 2024-01-31
    Publishing country Chile
    Document type English Abstract ; Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872023000300269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Relevant features for Gender Classification in NIR Periocular Images

    Viedma, Ignacio / Tapia, Juan / Iturriaga, Andres / Busch, Christoph

    2019  

    Abstract: Most gender classifications methods from NIR images have used iris information. Recent work has explored the use of the whole periocular iris region which has surprisingly achieve better results. This suggests the most relevant information for gender ... ...

    Abstract Most gender classifications methods from NIR images have used iris information. Recent work has explored the use of the whole periocular iris region which has surprisingly achieve better results. This suggests the most relevant information for gender classification is not located in the iris as expected. In this work, we analyze and demonstrate the location of the most relevant features that describe gender in periocular NIR images and evaluate its influence its classification. Experiments show that the periocular region contains more gender information than the iris region. We extracted several features (intensity, texture, and shape) and classified them according to its relevance using the XgBoost algorithm. Support Vector Machine and nine ensemble classifiers were used for testing gender accuracy when using the most relevant features. The best classification results were obtained when 4,000 features located on the periocular region were used (89.22\%). Additional experiments with the full periocular iris images versus the iris-Occluded images were performed. The gender classification rates obtained were 84.35\% and 85.75\% respectively. We also contribute to the state of the art with a new database (UNAB-Gender). From results, we suggest focussing only on the surrounding area of the iris. This allows us to realize a faster classification of gender from NIR periocular images.

    Comment: 12 pages, Paper accepted by IET Biometrics
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2019-04-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases.

    Osorio, Luis A / Lozano, Mauricio / Soto, Paola / Moreno-Hidalgo, Viviana / Arévalo-Gil, Angely / Ramírez-Balaguera, Angie / Hevia, Daniel / Cifuentes, Jorge / Hidalgo, Yessia / Alcayaga-Miranda, Francisca / Pasten, Consuelo / Morales, Danna / Varela, Diego / Urquidi, Cinthya / Iturriaga, Andrés / Rivera-Palma, Alejandra / Larrea-Gómez, Ricardo / Irarrázabal, Carlos E

    International journal of molecular sciences

    2024  Volume 25, Issue 9

    Abstract: The diagnosis of cardiovascular disease (CVD) is still limited. Therefore, this study demonstrates the presence of human ether-a-go-go-related gene 1 (hERG1) and heat shock protein 47 (Hsp47) on the surface of small extracellular vesicles (sEVs) in human ...

    Abstract The diagnosis of cardiovascular disease (CVD) is still limited. Therefore, this study demonstrates the presence of human ether-a-go-go-related gene 1 (hERG1) and heat shock protein 47 (Hsp47) on the surface of small extracellular vesicles (sEVs) in human peripheral blood and their association with CVD. In this research, 20 individuals with heart failure and 26 participants subjected to cardiac stress tests were enrolled. The associations between hERG1 and/or Hsp47 in sEVs and CVD were established using Western blot, flow cytometry, electron microscopy, ELISA, and nanoparticle tracking analysis. The results show that hERG1 and Hsp47 were present in sEV membranes, extravesicularly exposing the sequences
    MeSH term(s) Humans ; Extracellular Vesicles/metabolism ; Biomarkers/blood ; Male ; Cardiovascular Diseases/metabolism ; Female ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Middle Aged ; Animals ; HSP47 Heat-Shock Proteins/metabolism ; Rats ; ERG1 Potassium Channel/metabolism ; Aged ; Adult ; Ether-A-Go-Go Potassium Channels/metabolism ; Heart Failure/metabolism ; Heart Failure/pathology ; Heart Failure/blood
    Chemical Substances Biomarkers ; HSP47 Heat-Shock Proteins ; ERG1 Potassium Channel ; KCNH1 protein, human ; Ether-A-Go-Go Potassium Channels
    Language English
    Publishing date 2024-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission.

    Lafourcade, Carlos Andrés / Fernández, Anllely / Ramírez, Juan Pablo / Corvalán, Katherine / Carrasco, Miguel Ángel / Iturriaga, Andrés / Bátiz, Luis Federico / Luarte, Alejandro / Wyneken, Ursula

    Cells

    2020  Volume 9, Issue 6

    Abstract: Stress is a widespread problem in today's societies, having important consequences on brain function. Among the plethora of mechanisms involved in the stress response at the molecular level, the role of microRNAs (miRNAs) is beginning to be recognized. ... ...

    Abstract Stress is a widespread problem in today's societies, having important consequences on brain function. Among the plethora of mechanisms involved in the stress response at the molecular level, the role of microRNAs (miRNAs) is beginning to be recognized. The control of gene expression by these noncoding RNAs makes them essential regulators of neuronal and synaptic physiology, and alterations in their levels have been associated with pathological conditions and mental disorders. In particular, the excitatory (i.e., glutamate-mediated) neurotransmission is importantly affected by stress. Here, we found that loss of miR-26a-5p (miR-26a henceforth) function in primary hippocampal neurons increased the frequency and amplitude of miniature excitatory currents, as well as the expression levels of the excitatory postsynaptic scaffolding protein PSD95. Incubation of primary hippocampal neurons with corticosterone downregulated miR-26a, an effect that mirrored our in vivo results, as miR-26a was downregulated in the hippocampus as well as in blood serum-derived small extracellular vesicles (sEVs) of rats exposed to two different stress paradigms by movement restriction (i.e., stress by restraint in cages or by complete immobilization in bags). Overall, these results suggest that miR-26a may be involved in the generalized stress response and that a stress-induced downregulation of miR-26a could have long-term effects on glutamate neurotransmission.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Disease Models, Animal ; Disks Large Homolog 4 Protein ; Down-Regulation/genetics ; Extracellular Vesicles/metabolism ; MicroRNAs/blood ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Miniature Postsynaptic Potentials ; Rats, Sprague-Dawley ; Stress, Psychological/genetics ; Synapses/metabolism ; Synaptic Transmission/genetics
    Chemical Substances Biomarkers ; Disks Large Homolog 4 Protein ; MIRN26 microRNA, rat ; MicroRNAs
    Language English
    Publishing date 2020-06-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9061364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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