LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 255

Search options

  1. Article: Tandem Exon Duplications Expanding the Alternative Splicing Repertoire.

    Ivanov, T M / Pervouchine, D D

    Acta naturae

    2022  Volume 14, Issue 1, Page(s) 73–81

    Abstract: Tandem exon duplications play an important role in the evolution of eukaryotic genes, providing a generic mechanism for adaptive regulation of protein function. In recent studies, tandem exon duplications have been linked to mutually exclusive exon ... ...

    Abstract Tandem exon duplications play an important role in the evolution of eukaryotic genes, providing a generic mechanism for adaptive regulation of protein function. In recent studies, tandem exon duplications have been linked to mutually exclusive exon choice, a pattern of alternative splicing in which one and only one exon from a group of tandemly arranged exons is included in the mature transcript. Here, we revisit the problem of identifying tandem exon duplications in eukaryotic genomes using bioinformatic methods and show that tandemly duplicated exons are abundant not only in the coding parts, but also in the untranslated regions. We present a number of remarkable examples of tandem exon duplications, identify unannotated duplicated exons, and provide statistical support for their expression using large panels of RNA-seq experiments.
    Language English
    Publishing date 2022-04-19
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 2075-8251
    ISSN 2075-8251
    DOI 10.32607/actanaturae.11583
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Motor Decision-Making as a Common Denominator in Motor Pathology and a Possible Rehabilitation Target.

    Germanova, K / Panidi, K / Ivanov, T / Novikov, P / Ivanova, G E / Villringer, A / Nikulin, V V / Nazarova, M

    Neurorehabilitation and neural repair

    2023  Volume 37, Issue 8, Page(s) 577–586

    Abstract: Despite the substantial progress in motor rehabilitation, patient involvement and motivation remain major challenges. They are typically addressed with communicational and environmental strategies, as well as with improved goal-setting procedures. Here ... ...

    Abstract Despite the substantial progress in motor rehabilitation, patient involvement and motivation remain major challenges. They are typically addressed with communicational and environmental strategies, as well as with improved goal-setting procedures. Here we suggest a new research direction and framework involving Neuroeconomics principles to investigate the role of Motor Decision-Making (MDM) parameters in motivational component and motor performance in rehabilitation. We argue that investigating NE principles could bring new approaches aimed at increasing active patient engagement in the rehabilitation process by introducing more movement choice, and adapting existing goal-setting procedures. We discuss possible MDM implementation strategies and illustrate possible research directions using examples of stroke and psychiatric disorders.
    MeSH term(s) Humans ; Stroke Rehabilitation ; Stroke/psychology ; Motivation ; Movement
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/15459683231186986
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Author Correction: Multilayer redox-based HfO

    Park, Seongae / Spetzler, Benjamin / Ivanov, Tzvetan / Ziegler, Martin

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21013

    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25502-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Multilayer redox-based HfO

    Park, Seongae / Spetzler, Benjamin / Ivanov, Tzvetan / Ziegler, Martin

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18266

    Abstract: Redox-based memristive devices have shown great potential for application in neuromorphic computing systems. However, the demands on the device characteristics depend on the implemented computational scheme and unifying the desired properties in one ... ...

    Abstract Redox-based memristive devices have shown great potential for application in neuromorphic computing systems. However, the demands on the device characteristics depend on the implemented computational scheme and unifying the desired properties in one stable device is still challenging. Understanding how and to what extend the device characteristics can be tuned and stabilized is crucial for developing application specific designs. Here, we present memristive devices with a functional trilayer of HfO
    MeSH term(s) Neural Networks, Computer ; Oxidation-Reduction
    Chemical Substances titanium dioxide (15FIX9V2JP)
    Language English
    Publishing date 2022-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-22907-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: A supraclavicular cystic lymphangioma in adult: a rare entity.

    Rasmont, Céline / Deleuze, Catherine / Ivanov, Todor / Ferdin, Fabian / Lemaitre, Jean

    Journal of surgical case reports

    2022  Volume 2022, Issue 3, Page(s) rjac141

    Abstract: Cystic lymphangioma is a benign congenital disease that is more seen in head and neck regions. We report a case of a 54-year-old man with a growing supraclavicular mass. The ultrasonography and magnetic resonance imaging suggested a cystic lymphangioma. ... ...

    Abstract Cystic lymphangioma is a benign congenital disease that is more seen in head and neck regions. We report a case of a 54-year-old man with a growing supraclavicular mass. The ultrasonography and magnetic resonance imaging suggested a cystic lymphangioma. The mass was surgically totally removed without any recurrence. Histology examination confirmed the diagnosis. Cystic lymphangioma in adults is a rare entity and the literature on the subject is poor with no global recommendations.
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac141
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Controlled Membrane Transport in Polymeric Biomimetic Nanoreactors.

    Cao, Shoupeng / Ivanov, Tsvetomir / de Souza Melchiors, Marina / Landfester, Katharina / Caire da Silva, Lucas

    Chembiochem : a European journal of chemical biology

    2023  Volume 24, Issue 7, Page(s) e202200718

    Abstract: Polymersome-based biomimetic nanoreactors (PBNs) have generated great interest in nanomedicine and cell mimicry due to their robustness, tuneable chemistry, and broad applicability in biologically relevant fields. In this concept review, we mainly ... ...

    Abstract Polymersome-based biomimetic nanoreactors (PBNs) have generated great interest in nanomedicine and cell mimicry due to their robustness, tuneable chemistry, and broad applicability in biologically relevant fields. In this concept review, we mainly discuss the state of the art in functional polymersomes as biomimetic nanoreactors with membrane-controlled transport. PBNs that use environmental changes or external stimuli to adjust membrane permeability while maintaining structural integrity are highlighted. By encapsulating catalytic species, PBNs are able to convert inactive substrates into functional products in a controlled manner. In addition, special attention is paid to the use of PBNs as tailored artificial organelles with biomedical applications in vitro and in vivo, facilitating the fabrication of next-generation artificial organelles as therapeutic nanocompartments.
    MeSH term(s) Biomimetics ; Nanomedicine ; Biological Transport ; Polymers/chemistry ; Artificial Cells
    Chemical Substances Polymers
    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202200718
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Competitive state of movements during planning predicts sequence performance.

    Mantziara, Myrto / Ivanov, Tsvetoslav / Houghton, George / Kornysheva, Katja

    Journal of neurophysiology

    2021  Volume 125, Issue 4, Page(s) 1251–1268

    Abstract: Humans can learn and produce skilled movement sequences from memory, yet the nature of sequence planning is not well understood. Previous computational and neurophysiological work suggests that movements in a sequence are planned as parallel graded ... ...

    Abstract Humans can learn and produce skilled movement sequences from memory, yet the nature of sequence planning is not well understood. Previous computational and neurophysiological work suggests that movements in a sequence are planned as parallel graded activations and selected for output through competition. However, the relevance of this planning pattern to sequence production fluency and accuracy, as opposed to the temporal structure of sequences, is unclear. To resolve this question, we assessed the relative availability of constituent movements behaviorally during the preparation of motor sequences from memory. In three separate multisession experiments, healthy participants were trained to retrieve and produce four-element finger press sequences with particular timing according to an abstract sequence cue. We evaluated reaction time (RT) and error rate as markers of movement availability to constituent movement probes. Our results demonstrate that longer preparation time produces more pronounced differences in availability between adjacent sequence elements, whereas no effect was found for sequence speed or temporal grouping. Further, participants with larger position-dependent differences in movement availability tended to initiate correct sequences faster and with a higher temporal accuracy. Our results suggest that competitive preactivation is established gradually during sequence planning and predicts sequence skill, rather than the temporal structure of the motor sequence.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Motor Activity/physiology ; Motor Skills/physiology ; Reaction Time/physiology ; Serial Learning/physiology ; Time Factors ; Young Adult
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00645.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.224: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Yoga vs Physical Therapy in Multiple Sclerosis: Results of Randomized Controlled Trial and the Training Protocol.

    Lysogorskaia, Elena / Ivanov, Timur / Mendalieva, Ainagul / Ulmasbaeva, Elena / Youshko, Maxim / Brylev, Lev

    Annals of neurosciences

    2023  Volume 30, Issue 4, Page(s) 242–250

    Abstract: Background: Yoga originated in the territory of modern India more than 3,000 years ago uses techniques for working with the musculoskeletal system, cardiorespiratory system, and attention. Currently, the effectiveness and safety of yoga in patients with ...

    Abstract Background: Yoga originated in the territory of modern India more than 3,000 years ago uses techniques for working with the musculoskeletal system, cardiorespiratory system, and attention. Currently, the effectiveness and safety of yoga in patients with various neurological disorders, including multiple sclerosis (MS), is of interest to many scientists and clinicians.
    Purpose: The main aim of this study is to examine the effect of yoga on symptoms and quality of life in patients with MS vs physical therapy (exercise therapy) and no exercise.
    Methods: The patients were randomly assigned to three groups (yoga, physical therapy (PT), or waiting list). After 12 weeks of regular exercises (or the absence of them), the effect of yoga and PT on the functional status and quality of life of patients were evaluated. The data were collected during the patients' two visits to the study center - before the start of the study and at the end of the 12-week period. The in-person examination included a doctor's assessment of the Expanded Disability Status Scale (EDSS), the SF-36 quality of life questionnaire, the fatigue scale, the Berg balance scale, and the 6-min walking test.
    Results: A total of 36 patients finished the clinical study: thirty women and six men. There was no statistically significant difference between the groups in terms of improvement in MS symptoms as measured by the balance, walking test, and fatigue scales. However, in the analysis of eight criteria of SF-36 quality-of-life questionnaire by the covariation analysis, statistically significant differences were found in favor of the yoga group in terms of physical functioning (PF) (
    Conclusion: Thus, regular yoga classes under the guidance of qualified staff are a promising method of non-drug rehabilitation of patients with MS with motor disorders.
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1177/09727531231161994
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis.

    Cao, Shoupeng / Ivanov, Tsvetomir / Heuer, Julian / Ferguson, Calum T J / Landfester, Katharina / Caire da Silva, Lucas

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 39

    Abstract: Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless cellular organelles. Their biomimetic properties, such as molecular crowding and ...

    Abstract Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless cellular organelles. Their biomimetic properties, such as molecular crowding and selective partitioning, make them promising components for designing cell-like materials. However, their use as artificial organelles has been limited by their complex molecular structure, limited control over internal microenvironment properties, and inherent colloidal instability. Here we report the design of dipeptide coacervates that exhibit enhanced stability, biocompatibility, and a hydrophobic microenvironment. The hydrophobic character facilitates the encapsulation of hydrophobic species, including transition metal-based catalysts, enhancing their efficiency in aqueous environments. Dipeptide coacervates carrying a metal-based catalyst are incorporated as active artificial organelles in cells and trigger an internal non-biological chemical reaction. The development of coacervates with a hydrophobic microenvironment opens an alternative avenue in the field of biomimetic materials with applications in catalysis and synthetic biology.
    MeSH term(s) Dipeptides ; Artificial Cells/chemistry ; Biomolecular Condensates ; Transition Elements/chemistry ; Catalysis ; Organelles/chemistry
    Chemical Substances Dipeptides ; Transition Elements
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44278-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Synthetic Cells: From Simple Bio-Inspired Modules to Sophisticated Integrated Systems.

    Guindani, Camila / da Silva, Lucas Caire / Cao, Shoupeng / Ivanov, Tsvetomir / Landfester, Katharina

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 16, Page(s) e202110855

    Abstract: Bottom-up synthetic biology is the science of building systems that mimic the structure and function of living cells from scratch. To do this, researchers combine tools from chemistry, materials science, and biochemistry to develop functional and ... ...

    Abstract Bottom-up synthetic biology is the science of building systems that mimic the structure and function of living cells from scratch. To do this, researchers combine tools from chemistry, materials science, and biochemistry to develop functional and structural building blocks to construct synthetic cell-like systems. The many strategies and materials that have been developed in recent decades have enabled scientists to engineer synthetic cells and organelles that mimic the essential functions and behaviors of natural cells. Examples include synthetic cells that can synthesize their own ATP using light, maintain metabolic reactions through enzymatic networks, perform gene replication, and even grow and divide. In this Review, we discuss recent developments in the design and construction of synthetic cells and organelles using the bottom-up approach. Our goal is to present representative synthetic cells of increasing complexity as well as strategies for solving distinct challenges in bottom-up synthetic biology.
    MeSH term(s) Artificial Cells/chemistry ; Organelles/chemistry ; Synthetic Biology
    Language English
    Publishing date 2022-03-30
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202110855
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top