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  1. Article: [Economic and logistical problems of radiation oncology].

    Solodkiĭ, V A / Pan'shin, G A / Sotnikov, V M / Ivashin, A V

    Voprosy onkologii

    2014  Volume 60, Issue 2, Page(s) 6–14

    Abstract: An analysis of economic and logistical problems of radiation oncology is presented based on domestic and foreign literature. Despite the high efficacy of radiotherapy this branch of oncology is not financed enough in most countries. As a consequence, it ... ...

    Abstract An analysis of economic and logistical problems of radiation oncology is presented based on domestic and foreign literature. Despite the high efficacy of radiotherapy this branch of oncology is not financed enough in most countries. As a consequence, it is ubiquitously marked radiotherapy capacity deficit that does not allow to fully realize its therapeutic potential. Medical electron accelerators and related equipment have become increasingly complex and expensive and radiotherapy techniques more consuming. Even in developed countries growing waiting times for radiotherapy, not using the most modern and efficient radiotherapy technologies (image guiding, etc.) has become a daily reality. Based on these data, we assessed the prospects and possibilities of upgrading the technical base of radiation oncology in Russia including the development of hadron therapy.
    MeSH term(s) Developed Countries ; Humans ; Proton Therapy/economics ; Proton Therapy/trends ; Radiation Oncology/economics ; Radiation Oncology/methods ; Radiation Oncology/standards ; Radiation Oncology/trends ; Radiotherapy/economics ; Radiotherapy/methods ; Radiotherapy/standards ; Radiotherapy/trends ; Russia
    Language Russian
    Publishing date 2014
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [The optimal radiation volume after first-line chemotherapy in Hodgkin lymphoma].

    Ivashin, A V / Datsenko, P V / Pan'shin, G A / Sotnikov, V M / Gombolevskiĭ, V A / Golub, S V / Evstikheev, É V

    Voprosy onkologii

    2012  Volume 58, Issue 1, Page(s) 61–65

    Abstract: Radiation therapy has evolved from extended-field radiation therapy (EFRT) to involved-field radiation therapy (IFRT), reducing toxicity while maintaining high cure rates. Recent publications recommend a further reduction to involved-nodal radiation ... ...

    Abstract Radiation therapy has evolved from extended-field radiation therapy (EFRT) to involved-field radiation therapy (IFRT), reducing toxicity while maintaining high cure rates. Recent publications recommend a further reduction to involved-nodal radiation therapy (INRT); however, this has not been clinically validated. The need for irradiation or optimal radiation volume after chemotherapy are not defined. The treatment results of 296 Hodgkin's disease patients receiving ABVD or BEACOPP-21 chemotherapy with consequent EFRT demonstrate CR/PR > or = 80% and 99% local disease control rate. Beam therapy with EFRT is possible to use if dose levels don't exceed 30 Gy. Higher doses demands reduction of volume of radiating target. In our opinion the optimum program of beam therapy involves 2 stages with maximal possible dose level EFRT followed by additional INRT. Those approaches offer perspectives for Hodgkin's disease treatment.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/administration & dosage ; Cyclophosphamide/administration & dosage ; Dacarbazine/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Hodgkin Disease/drug therapy ; Hodgkin Disease/mortality ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; Procarbazine/administration & dosage ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/methods ; Treatment Outcome ; Vinblastine/administration & dosage ; Vincristine/administration & dosage
    Chemical Substances Bleomycin (11056-06-7) ; Procarbazine (35S93Y190K) ; Vincristine (5J49Q6B70F) ; Vinblastine (5V9KLZ54CY) ; Etoposide (6PLQ3CP4P3) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language Russian
    Publishing date 2012
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [The optimal total focal radiotherapy dosage after first-line chemotherapy in patients with Hodgkin lymphoma].

    Datsenko, P V / Pan'shin, G A / Sotnikov, V M / Ivashin, A V / Evstikheev, É V / Golub, S V / Gombolevskiĭ, V A

    Voprosy onkologii

    2012  Volume 58, Issue 4, Page(s) 527–531

    Abstract: Based on the treatment results of 300 Hodgkin lymphoma patients the authors formulated the basic approaches for radiation treatment in ABVD and BEACOPP-21 chemotherapy regimens recipients. In patients with complete response to chemotherapy any dose ... ...

    Abstract Based on the treatment results of 300 Hodgkin lymphoma patients the authors formulated the basic approaches for radiation treatment in ABVD and BEACOPP-21 chemotherapy regimens recipients. In patients with complete response to chemotherapy any dose regimen (26 to 44 Gr) leads to 100% local disease control. In patients with major response to chemotherapy (PR> or =80%) the 36 Gr total focal dose allows an adequate local control, more intensive local control doesn't yield better results. In patients with PR 0-79% the implication of total focal doses less than 40 Gr leads to statistically significant increase of nodal relapse rate. These treatment approaches may be implied by specialists conducting chemotherapy and radiation therapy in Hodgkin lymphoma patients.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/administration & dosage ; Cyclophosphamide/administration & dosage ; Dacarbazine/administration & dosage ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Hodgkin Disease/drug therapy ; Hodgkin Disease/mortality ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Middle Aged ; Neoplasm, Residual/radiotherapy ; Prednisone/administration & dosage ; Procarbazine/administration & dosage ; Radiotherapy Dosage ; Radiotherapy, Adjuvant ; Treatment Outcome ; Vinblastine/administration & dosage ; Vincristine/administration & dosage
    Chemical Substances Bleomycin (11056-06-7) ; Procarbazine (35S93Y190K) ; Vincristine (5J49Q6B70F) ; Vinblastine (5V9KLZ54CY) ; Etoposide (6PLQ3CP4P3) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language Russian
    Publishing date 2012
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

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  4. Article: [Role of response to first-line chemotherapy and of the primary lesion in Hodgkin lymphoma].

    Datsenko, P V / Pan'shin, G A / Sotnikov, V M / Ivashin, A V / Gombolevskiĭ, V A / Golub, S V / Evstikheev, É V

    Voprosy onkologii

    2012  Volume 58, Issue 1, Page(s) 66–70

    Abstract: Based on the results of combined treatment with inclusion of ABVD and BEACOPP-21 chemotherapy regimens the basic principles of therapy depending on the nodal relaps criterium were developed. The most rational approach to treatment results evaluation ... ...

    Abstract Based on the results of combined treatment with inclusion of ABVD and BEACOPP-21 chemotherapy regimens the basic principles of therapy depending on the nodal relaps criterium were developed. The most rational approach to treatment results evaluation concerns the lesions with the least response to chemotherapy. The groups of "adequate" and "inadequate" response to chemotherapy should be formed. The initial lesion localisation doesn't play an important part in the modern chemotherapy settings and should not be concerned while choosing tactics of radiation therapy. The method described should interest oncologists and radiologists involved in the treatment of Hodgkin lymphoma.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/administration & dosage ; Cyclophosphamide/administration & dosage ; Dacarbazine/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Hodgkin Disease/drug therapy ; Hodgkin Disease/mortality ; Hodgkin Disease/pathology ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; Procarbazine/administration & dosage ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/methods ; Treatment Outcome ; Vinblastine/administration & dosage ; Vincristine/administration & dosage
    Chemical Substances Bleomycin (11056-06-7) ; Procarbazine (35S93Y190K) ; Vincristine (5J49Q6B70F) ; Vinblastine (5V9KLZ54CY) ; Etoposide (6PLQ3CP4P3) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language Russian
    Publishing date 2012
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Recent results with upgraded VES setup

    Polyakov B. / Plekhanov A. / Nikolaenko V. / Mikhasenko M. / Matveev V. / Konstantinov V. / Karavaeva M. / Kachaev I. / Ivashin A. / Ekimov A. / Dorofeev V. / Khokhlov Yu. / Ryabchikov D. / Volkov E. / Zaitsev A.

    EPJ Web of Conferences, Vol 37, p

    π−3π0 and other systems

    2012  Volume 01029

    Abstract: Status of the VES setup upgrade is shortly reviewed. A number of one-prong multi-photon final states not (or badly) accessible with the VES before, such as the π−3π0, π−ηπ0 in background favorable mode π−4γ and others, becomes promising for the study. An ...

    Abstract Status of the VES setup upgrade is shortly reviewed. A number of one-prong multi-photon final states not (or badly) accessible with the VES before, such as the π−3π0, π−ηπ0 in background favorable mode π−4γ and others, becomes promising for the study. An overview of new data set is presented. The preliminary results of PWA of the π−2π0, system show a clear signal of the f0(980) in the π(1800) decay.
    Keywords Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
    Language English
    Publishing date 2012-12-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: The PWA of π−π0 system in the presence of a significant irremovable background

    Mikhasenko M. / Dorofeev V. / Ekimov A. / Gotman V. / Ivashin A. / Kachaev I. / Kalendarev V. / Khokhlov Yu. / Kholodenko M. / Konstantinov V. / Kravchenko S. / Matveev V. / Nikolaenko V. / Plekhanov A. / Ryabchikov D. / Salomatin Yu. / Sugonyaev V. / Zaitsev A.

    EPJ Web of Conferences, Vol 81, p

    2014  Volume 02012

    Abstract: 7 × 106 events of the reaction π−N → π−π0N′ were collected at the VES experiment. Mass independent angular analysis is performed to study production mechanism of ρ-meson. t-channel ω-exchange and π-exchange are isolated. The analysis is done for 8 bins ... ...

    Abstract 7 × 106 events of the reaction π−N → π−π0N′ were collected at the VES experiment. Mass independent angular analysis is performed to study production mechanism of ρ-meson. t-channel ω-exchange and π-exchange are isolated. The analysis is done for 8 bins of a four momentum transfer squared to extract cross-section dependence of t′. Novel method of waves extraction is applied to deal with a significant irremovable background.
    Keywords Physics ; QC1-999 ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The PWA of π−π0 system in the presence of a significant irremovable background

    Mikhasenko M. / Dorofeev V. / Ekimov A. / Gotman V. / Ivashin A. / Kachaev I. / Kalendarev V. / Khokhlov Yu. / Kholodenko M. / Konstantinov V. / Kravchenko S. / Matveev V. / Nikolaenko V. / Plekhanov A. / Ryabchikov D. / Salomatin Yu. / Sugonyaev V. / Zaitsev A.

    EPJ Web of Conferences, Vol 81, p

    2014  Volume 02012

    Abstract: 7 × 106 events of the reaction π−N → π−π0N′ were collected at the VES experiment. Mass independent angular analysis is performed to study production mechanism of ρ-meson. t-channel ω-exchange and π-exchange are isolated. The analysis is done for 8 bins ... ...

    Abstract 7 × 106 events of the reaction π−N → π−π0N′ were collected at the VES experiment. Mass independent angular analysis is performed to study production mechanism of ρ-meson. t-channel ω-exchange and π-exchange are isolated. The analysis is done for 8 bins of a four momentum transfer squared to extract cross-section dependence of t′. Novel method of waves extraction is applied to deal with a significant irremovable background.
    Keywords Physics ; QC1-999 ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: [The role of adjuvant radiotherapy in the complex treatment of stage III-IV aggressive non-Hodgkin's lymphoma].

    Sotnikov, V M / Pan'shin, G A / Datsenko, P V / Ivashin, A V / Smol'tsova, N N

    Voprosy onkologii

    2009  Volume 55, Issue 4, Page(s) 443–446

    Abstract: Immediate and end results of chemoradiotherapy of 225 patients (average age--43 years) with primary aggressive non-Hodgkin's lymphomas stage III-IV were evaluated. Stage 1 of treatment included 4-8 cycles of chemotherapy (ACOP and other standard ... ...

    Abstract Immediate and end results of chemoradiotherapy of 225 patients (average age--43 years) with primary aggressive non-Hodgkin's lymphomas stage III-IV were evaluated. Stage 1 of treatment included 4-8 cycles of chemotherapy (ACOP and other standard protocols); stage 2--irradiation of residual foci with 20-50 Gy, or 20-36 Gy for originally extensive and extralymphatic foci when in full remission. The latter's rate rose from 24 to 65% (p < or = 0.05) following adjuvant radiotherapy although that of failures remained unchanged. The disease is specific, so relapse-free survival in cases of generalized primary aggressive lymphoma in full remission remained unchanged too whatever the stage at which full remission emerged.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/pathology ; Lymphoma, Non-Hodgkin/radiotherapy ; Male ; Middle Aged ; Neoplasm Staging ; Radiotherapy Dosage ; Radiotherapy, Adjuvant ; Remission Induction ; Retrospective Studies ; Treatment Outcome
    Language Russian
    Publishing date 2009
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article: [Multivariate analysis of risk of cardiac complications in Hodgkin's lymphoma].

    Podol'skiĭ, P N / Datsenko, P V / Pan'shin, G A / Sotnikov, V M / Mel'nik, Iu D / Ivashin, A V / Bozhenko, V K

    Voprosy onkologii

    2009  Volume 55, Issue 4, Page(s) 447–450

    Abstract: A computer database was created to take care of a wide range of protocols for combined treatment of Hodgkin's disease stage I-IV (n=1,573). Early-onset radiation-related injuries (pneumonitis) and exposure of lung tissues to radiation were identified as ... ...

    Abstract A computer database was created to take care of a wide range of protocols for combined treatment of Hodgkin's disease stage I-IV (n=1,573). Early-onset radiation-related injuries (pneumonitis) and exposure of lung tissues to radiation were identified as the main risk factors for cardiopathology development. It is suggested that total focal dosage used after chemotherapy be reviewed since total dosage for the entire lymph collector in excess of 30 Gy might contribute to hazards of cardiopathology. However, a locally administered TTD ranging 36-44 Gy to deal with residual tumor offers best advantage in preventing local relapse. Nor does it increase the risk of future complications. Our approach might promote individualization of prognosis as far as cardiac complications involved in Hodgkin's lymphoma are concerned.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Female ; Heart/radiation effects ; Heart Diseases/etiology ; Heart Diseases/mortality ; Heart Neoplasms/secondary ; Hodgkin Disease/drug therapy ; Hodgkin Disease/pathology ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Mechlorethamine/administration & dosage ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Pneumonia/etiology ; Prednisone/administration & dosage ; Procarbazine/administration & dosage ; Prognosis ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/adverse effects ; Risk Assessment ; Risk Factors ; Survival Analysis ; Vincristine/administration & dosage
    Chemical Substances Procarbazine (35S93Y190K) ; Mechlorethamine (50D9XSG0VR) ; Vincristine (5J49Q6B70F) ; Prednisone (VB0R961HZT)
    Language Russian
    Publishing date 2009
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

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  10. Article: Planirovanie avtomatizirovannoĭ luchevoĭ terapii mestnorasprostranennogo raka mochevogo puzyria.

    Kaprin, A D / Pan'shin, G A / Titova, V A / Ivashin, A V / Shafir, I I / Belle, T S

    Urologiia (Moscow, Russia : 1999)

    1999  , Issue 6, Page(s) 20–26

    Abstract: How to apply information obtained with modern methods of visualization of urinary bladder (UB) primary cancer and regional metastatic zones (ultrasound investigation, computer tomography, NMR-tomography, urography, cystoscopy) in design of radiotherapy ... ...

    Title translation Design of automatic radiotherapy of locally spread cancer of the urinary bladder.
    Abstract How to apply information obtained with modern methods of visualization of urinary bladder (UB) primary cancer and regional metastatic zones (ultrasound investigation, computer tomography, NMR-tomography, urography, cystoscopy) in design of radiotherapy is demonstrated as well as contribution of each of these methods to design of individual regimens of computer gamma-therapy. This advanced method of radiotherapy makes use of computer design and programs of multicenter and multiposition static and dynamic techniques of calculation of total dose distributions which comply with topographic anatomy of the tumor and radiobiological programs of radiotherapy of UB cancer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Dose-Response Relationship, Radiation ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Radiation Dosage ; Radiotherapy Planning, Computer-Assisted ; Ultrasonography ; Urinary Bladder/diagnostic imaging ; Urinary Bladder/radiation effects ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/radiotherapy ; Urography
    Language Russian
    Publishing date 1999-11
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 43204-0
    ISSN 1728-2985 ; 0042-1154
    ISSN 1728-2985 ; 0042-1154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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