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Book: Living marine resources

Iversen, Edwin Severin

their utilization and management

1996

Author's details	Edwin S. Iversen
Keywords	Meeresressourcen ; Ressourcenpolitik ; Fischerei ; Management ; Meerestiere ; Fischereibiologie ; Meeresfische ; Fischbestand ; Seefischerei ; Nachhaltigkeit
Subject	Meer ; Marine Ressourcen ; Nachhaltige Entwicklung ; Langfristige Entwicklung ; Sustainable Development ; Dauerhafte Entwicklung ; Zukunftsfähige Entwicklung ; Meeresfischerei ; Seefische ; Salzwasserfische ; Marine Tiere ; Unternehmen ; Unternehmensmanagement ; Unternehmensführung ; Leitung ; Berufsfischerei ; Fischereiwesen ; Natürliche Ressourcen
Size	XVI, 403 S. : Ill., graph. Darst., Kt.
Publisher	Chapman & Hall
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007103069
ISBN	0-412-98741-4 ; 978-0-412-98741-0
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
968/781	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Association of time-temperature curves with outcomes in temperature management for cardiac arrest.

Luedke, Matthew William / Graffagnino, Carmelo / McKinney, B Grace / Piper, Jill / Iversen, Edwin / Kolls, Brad

BMJ neurology open

2022 Volume 4, Issue 1, Page(s) e000273

Abstract: Background/purpose: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the ... ...

Abstract	Background/purpose: Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target duration, the concept of temperature dose-the duration spent at a given depth of hypothermia-is not as well explored. Methods: In this retrospective study, we examined 66 patients 18 years of age or older undergoing therapeutic hypothermia for cardiac arrest between 2007 and 2010 to assess the relationship of temperature dose with outcomes. Demographic, clinical, outcome and temperature data were collected. Demographic and clinical data underwent bivariate regression analysis for association with outcome. Time-temperature curves were divided into pre-determined temperature thresholds and assessed by logistic regression analysis for association with outcome. A second, multivariate regression analysis was performed controlling for factors associated with poor outcomes. Results: Old age was significantly associated with poor outcome and a shockable arrest rhythm was significantly associated with positive outcome. Subjects spent an average of 2.82 hours below 35°C, 7.31 hours ≥35°C to ≤36.5°C, 24.75 hours >36.5 to <38.0°C and 7.06 hours ≥38°C. Logistic regression analysis revealed borderline significant positive association between good outcome and time at a cooling depth (35°C-36.5°C, p=0.05); adjusted for old age, the association became significant (p=0.04). Conclusion: Controlling for old age, longer durations between >35°C, ≤36.5°C during therapeutic hypothermia for cardiac arrest were significantly associated with good clinical outcomes. Time spent within a given temperature range may be useful for measuring the effect of temperature management.
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ISSN	2632-6140
ISSN (online)	2632-6140
DOI	10.1136/bmjno-2022-000273
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Article ; Online: Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program.

Kolls, Brad J / Ehrlich, Matthew E / Monk, Lisa / Shah, Shreyansh / Roettig, Mayme / Iversen, Edwin / Jollis, James G / Granger, Christopher B / Graffagnino, Carmelo

American heart journal

2023 Volume 269, Page(s) 72–83

Abstract: Background: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate ... ...

Abstract	Background: Despite guidelines and strong evidence supporting intravenous thrombolysis and endovascular thrombectomy for acute stroke, access to these interventions remains a challenge. The objective of the IMPROVE stroke care program was to accelerate acute stroke care delivery by implementing best practices and improving the regional systems of care within comprehensive stroke networks. Methods: The IMPROVE Stroke Care program was a prospective quality improvement program based on established models used in acute coronary care. Nine hub hospitals (comprehensive stroke centers), 52 regional/community referral hospitals (spokes), and over 100 emergency medical service agencies participated. Through 6 regional meetings, 49 best practices were chosen for improvement by the participating sites. Over 2 years, progress was tracked and discussed weekly and performance reviews were disseminated quarterly. Results: Data were collected on 21,647 stroke code activations of which 8,502 (39.3%) activations had a final diagnosis of stroke. There were 7,226 (85.0%) ischemic strokes, and thrombolytic therapy was administered 2,814 times (38.9%). There was significant overall improvement in the proportion that received lytic therapy within 45 minutes (baseline of 44.6%-60.4%). The hubs were more frequently achieving this at baseline, but both site types improved. A total of 1,455 (17.1%) thrombectomies were included in the data of which 401 (27.6%) were transferred from a spoke. There was no clinically significant change in door-to-groin times for hub-presenting thrombectomy patients, however, significant improvement occurred for transferred cases, 46 minutes (interquartile range [IQR] 36, 115.5) at baseline to 27 minutes (IQR 10, 59). Conclusions: The IMPROVE program approach was successful at improving the delivery of thrombolytic intervention across the consortium at both spoke and hub sites through collaborative efforts to operationalize guideline-based care through iterative sharing of performance and best practices for implementation. Our approach allowed identification of both opportunities for improvement and operational best practices providing guidance on how best to create a regional stroke care network and operationalize the published acute stroke care guidelines.
MeSH term(s)	Humans ; Quality Improvement ; Prospective Studies ; Stroke/diagnosis ; Fibrinolytic Agents/therapeutic use ; Thrombolytic Therapy ; Treatment Outcome ; Time-to-Treatment
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2023.11.020
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Article ; Online: Assessment of

Nepomuceno, Thales C / Lyra, Paulo / Zhu, Jianbin / Yi, Fanchao / Martin, Rachael H / Lupu, Daniel / Peterson, Luke / Peres, Lauren C / Berry, Anna / Iversen, Edwin S / Couch, Fergus J / Mo, Qianxing / Monteiro, Alvaro N

JCO clinical cancer informatics

2024 Volume 8, Page(s) e2300251

Abstract: Purpose: The emergence of large real-world clinical databases and tools to mine electronic medical records has allowed for an unprecedented look at large data sets with clinical and epidemiologic correlates. In clinical cancer genetics, real-world ... ...

Abstract	Purpose: The emergence of large real-world clinical databases and tools to mine electronic medical records has allowed for an unprecedented look at large data sets with clinical and epidemiologic correlates. In clinical cancer genetics, real-world databases allow for the investigation of prevalence and effectiveness of prevention strategies and targeted treatments and for the identification of barriers to better outcomes. However, real-world data sets have inherent biases and problems (eg, selection bias, incomplete data, measurement error) that may hamper adequate analysis and affect statistical power. Methods: Here, we leverage a real-world clinical data set from a large health network for patients with breast cancer tested for variants in Results: In the cohort, White and Black patients were over-represented, whereas non-White Hispanic and Asian patients were under-represented. Incorrect or missing variant designations were the most significant contributor to data loss. While manual curation corrected many incorrect designations, a sizable fraction of patient carriers remained with incorrect or missing variant designations. Despite the large number of patients with clinical significance not reported, original reported clinical significance assessments were accurate. Reassessment of variants in which clinical significance was not reported led to a marked improvement in data quality. Conclusion: We identify the most common issues with
MeSH term(s)	Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/epidemiology ; Female ; Germ-Line Mutation ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Registries ; Middle Aged ; Genetic Predisposition to Disease ; Adult ; Electronic Health Records ; Aged
Chemical Substances	BRCA1 Protein ; BRCA2 Protein ; BRCA1 protein, human ; BRCA2 protein, human
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2473-4276
ISSN (online)	2473-4276
DOI	10.1200/CCI.23.00251
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Aquaculture sourcebook

Iversen, Edwin Severin / Hale, Kay K.

a guide to North American species

(An AVI book)

1992

Author's details	Edwin S. Iversen and Kay K. Hale
Series title	An AVI book
Keywords	Nordamerika ; Fischzucht ; Aquakultur
Subject	Fischhaltung ; Fische
Size	X, 308 S. : Ill., graph. Darst.
Publisher	Van Nostrand Reinhold u.a.
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT006877186
ISBN	0-442-00992-5 ; 978-0-442-00992-2
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
968/439	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Characterization of dependencies between growth and division in budding yeast.

Mayhew, Michael B / Iversen, Edwin S / Hartemink, Alexander J

Journal of the Royal Society, Interface

2017 Volume 14, Issue 127

Abstract: Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding ... ...

Abstract	Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding yeast
MeSH term(s)	Cell Cycle/physiology ; Models, Biological ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/physiology
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2016.0993
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Article ; Online: TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.

Sosa-Pagán, Jason O / Iversen, Edwin S / Grandl, Jörg

Scientific reports

2017 Volume 7, Issue 1, Page(s) 549

Abstract: Several transient receptor potential (TRP) ion channels can be directly activated by hot or cold temperature with high sensitivity. However, the structures and molecular mechanism giving rise to their high temperature sensitivity are not fully understood. ...

Abstract	Several transient receptor potential (TRP) ion channels can be directly activated by hot or cold temperature with high sensitivity. However, the structures and molecular mechanism giving rise to their high temperature sensitivity are not fully understood. One hypothesized mechanism assumes that temperature activation is driven by the exposure of hydrophobic residues to solvent. This mechanism further predicts that residues are exposed to solvent in a coordinated fashion, but without necessarily being located in close proximity to each other. However, there is little experimental evidence supporting this mechanism in TRP channels. Here, we combined high-throughput mutagenesis, functional screening, and deep sequencing to identify mutations from a total of ~7,300 TRPV1 random mutant clones. We found that strong decreases in hydrophobicity of amino acids are better tolerated for activation by capsaicin than for activation by hot temperature, suggesting that strong hydrophobicity might be specifically required for temperature activation. Altogether, our work provides initial correlative support for a previously hypothesized temperature mechanism in TRP ion channels.
MeSH term(s)	Amino Acids/chemistry ; Amino Acids/genetics ; Animals ; Cell Line ; DNA Mutational Analysis ; High-Throughput Nucleotide Sequencing ; Humans ; Hydrophobic and Hydrophilic Interactions ; Ion Channel Gating ; Models, Molecular ; Mutation ; Protein Conformation ; Rats ; Structure-Activity Relationship ; TRPV Cation Channels/agonists ; TRPV Cation Channels/chemistry ; TRPV Cation Channels/genetics ; Temperature
Chemical Substances	Amino Acids ; TRPV Cation Channels ; Trpv1 protein, rat
Language	English
Publishing date	2017-04-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-00636-4
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Article ; Online: A diverse portfolio of marine protected areas can better advance global conservation and equity.

Gill, David A / Lester, Sarah E / Free, Christopher M / Pfaff, Alexander / Iversen, Edwin / Reich, Brian J / Yang, Shu / Ahmadia, Gabby / Andradi-Brown, Dominic A / Darling, Emily S / Edgar, Graham J / Fox, Helen E / Geldmann, Jonas / Trung Le, Duong / Mascia, Michael B / Mesa-Gutiérrez, Roosevelt / Mumby, Peter J / Veverka, Laura / Warmuth, Laura M

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 10, Page(s) e2313205121

Abstract: Marine protected areas (MPAs) are widely used for ocean conservation, yet the relative impacts of various types of MPAs are poorly understood. We estimated impacts on fish biomass from no-take and multiple-use (fished) MPAs, employing a rigorous matched ... ...

Abstract	Marine protected areas (MPAs) are widely used for ocean conservation, yet the relative impacts of various types of MPAs are poorly understood. We estimated impacts on fish biomass from no-take and multiple-use (fished) MPAs, employing a rigorous matched counterfactual design with a global dataset of >14,000 surveys in and around 216 MPAs. Both no-take and multiple-use MPAs generated positive conservation outcomes relative to no protection (58.2% and 12.6% fish biomass increases, respectively), with smaller estimated differences between the two MPA types when controlling for additional confounding factors (8.3% increase). Relative performance depended on context and management: no-take MPAs performed better in areas of high human pressure but similar to multiple-use in remote locations. Multiple-use MPA performance was low in high-pressure areas but improved significantly with better management, producing similar outcomes to no-take MPAs when adequately staffed and appropriate use regulations were applied. For priority conservation areas where no-take restrictions are not possible or ethical, our findings show that a portfolio of well-designed and well-managed multiple-use MPAs represents a viable and potentially equitable pathway to advance local and global conservation.
MeSH term(s)	Animals ; Humans ; Conservation of Natural Resources ; Fisheries ; Biomass ; Fishes ; Ecosystem
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2313205121
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Article ; Online: BRCA1 frameshift variants leading to extended incorrect protein C termini.

Nepomuceno, Thales C / Foo, Tzeh Keong / Richardson, Marcy E / Ranola, John Michael O / Weyandt, Jamie / Varga, Matthew J / Alarcon, Amaya / Gutierrez, Diana / von Wachenfeldt, Anna / Eriksson, Daniel / Kim, Raymond / Armel, Susan / Iversen, Edwin / Couch, Fergus J / Borg, Åke / Xia, Bing / Carvalho, Marcelo A / Monteiro, Alvaro N A

HGG advances

2024 Volume 5, Issue 3, Page(s) 100296

Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Published Erratum
ISSN	2666-2477
ISSN (online)	2666-2477
DOI	10.1016/j.xhgg.2024.100296
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Article ; Online: Assessment of small in-frame indels and C-terminal nonsense variants of BRCA1 using a validated functional assay.

Nepomuceno, Thales C / Dos Santos, Ana P P / Fernandes, Vanessa C / Elias, Anna B R / Gomes, Thiago T / Suarez-Kurtz, Guilherme / Iversen, Edwin S / Couch, Fergus J / Monteiro, Alvaro N A / Carvalho, Marcelo A

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16203

Abstract: BRCA1 (Breast Cancer 1, early onset) is linked to breast and ovarian cancer predisposition. Still, the risks conferred by a significant portion of BRCA1 variants identified in the population remains unknown. Most of these variants of uncertain ... ...

Abstract	BRCA1 (Breast Cancer 1, early onset) is linked to breast and ovarian cancer predisposition. Still, the risks conferred by a significant portion of BRCA1 variants identified in the population remains unknown. Most of these variants of uncertain significance are missense alterations. However, the functional implications of small in-frame deletions and/or insertions (indels) are also difficult to predict. Our group has previously evaluated the functional impact of 347 missense variants using an extensively validated transcriptional activity assay. Here we show a systematic assessment of 30 naturally occurring in-frame indels located at the C-terminal region of BRCA1. We identified positions sensitive and tolerant to alterations, expanding the knowledge of structural determinants of BRCA1 function. We further designed and assessed the impact of four single codon deletions in the tBRCT linker region and six nonsense variants at the C-terminus end of BRCA1. Amino acid substitutions, deletions or insertions in the disordered region do not significantly impact activity and are not likely to constitute pathogenic alleles. On the other hand, a sizeable fraction of in-frame indels at the BRCT domain significantly impact function. We then use a Bayesian integrative statistical model to derive the probability of pathogenicity for each variant. Our data highlights the importance of assessing the impact of small in-frame indels in BRCA1 to improve risk assessment and clinical decisions for carriers.
MeSH term(s)	Alleles ; Amino Acid Substitution ; BRCA1 Protein/metabolism ; Bayes Theorem ; Breast Neoplasms ; Female ; Genes, BRCA1 ; Genetic Predisposition to Disease ; Humans ; Mutation, Missense ; Ovarian Neoplasms/genetics
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20500-4
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