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  1. Article ; Online: Transfusion-dependent anemia secondary to vitamin C deficiency.

    Angeli, Allison M / Megna, Bryant / Mazepa, Marshall / Ivy, Zalaya K / Sultan, Shahnaz / Sloan, Joshua A

    American journal of hematology

    2022  Volume 97, Issue 5, Page(s) E166–E167

    MeSH term(s) Anemia/etiology ; Anemia, Iron-Deficiency ; Ascorbic Acid Deficiency/complications ; Humans ; Scurvy ; Vitamin B 12 ; Vitamin B 12 Deficiency/complications
    Chemical Substances Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease.

    Belcher, John D / Nguyen, Julia / Chen, Chunsheng / Abdulla, Fuad / Conglin, Ruan / Ivy, Zalaya K / Cummings, Jason / Dudler, Thomas / Vercellotti, Gregory M

    Translational research : the journal of laboratory and clinical medicine

    2022  Volume 249, Page(s) 1–12

    Abstract: Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion pathophysiology, and pain. Complement activation markers are increased in SCD in ... ...

    Abstract Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion pathophysiology, and pain. Complement activation markers are increased in SCD in steady-state and further increased during vaso-occlusive crisis (VOC). However, the mechanisms driving complement activation in SCD have not been completely elucidated. Ischemia-reperfusion and heme released from hemoglobin during hemolysis, events that characterize SCD pathophysiology, can activate the lectin pathway (LP) and alternative pathway (AP), respectively. Here we evaluated the role of LP and AP in Townes sickle (SS) mice using inhibitory monoclonal antibodies (mAb) to mannose binding lectin (MBL)-associated serine protease (MASP)-2 or MASP-3, respectively. Townes SS mice were pretreated with MASP-2 mAb, MASP-3 mAb, isotype control mAb, or PBS before they were challenged with hypoxia-reoxygenation or hemoglobin. Pretreatment of SS mice with MASP-2 or MASP-3 mAb, markedly reduced Bb fragments, C4d and C5a in plasma and complement deposition in the liver, kidneys, and lungs collected 4 hours after challenge compared to control mAb-treated mice. Consistent with complement inhibition, hepatic inflammation markers NF-ĸB phospho-p65, VCAM-1, ICAM-1, and E-selectin were significantly reduced in SS mice pretreated with MASP-2 or MASP-3 mAb. Importantly, MASP-2 or MASP-3 mAb pretreatment significantly inhibited microvascular stasis (vaso-occlusion) induced by hypoxia-reoxygenation or hemoglobin. These studies suggest that the LP and the AP are both playing a role in promoting inflammation and vaso-occlusion in SCD. Inhibiting complement activation via the LP or the AP might inhibit inflammation and prevent VOC in SCD patients.
    MeSH term(s) Anemia, Sickle Cell/complications ; Animals ; Antibodies, Monoclonal/pharmacology ; Complement Activation ; Disease Models, Animal ; E-Selectin ; Heme ; Hemoglobins ; Hemolysis ; Hypoxia ; Inflammation ; Intercellular Adhesion Molecule-1 ; Mannose-Binding Lectins ; Mannose-Binding Protein-Associated Serine Proteases/metabolism ; Mice ; NF-kappa B ; Vascular Cell Adhesion Molecule-1/metabolism ; Volatile Organic Compounds
    Chemical Substances Antibodies, Monoclonal ; E-Selectin ; Hemoglobins ; Mannose-Binding Lectins ; NF-kappa B ; Vascular Cell Adhesion Molecule-1 ; Volatile Organic Compounds ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Heme (42VZT0U6YR) ; MASP-2 protein, mouse (EC 3.4.21.-) ; MASP-3 protein, mouse (EC 3.4.21.-) ; Mannose-Binding Protein-Associated Serine Proteases (EC 3.4.21.-)
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2246684-8
    ISSN 1878-1810 ; 1532-6543 ; 1931-5244
    ISSN (online) 1878-1810 ; 1532-6543
    ISSN 1931-5244
    DOI 10.1016/j.trsl.2022.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs 42: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation.

    Ivy, Zalaya K / Belcher, John D / Khasabova, Iryna A / Chen, Chunsheng / Juliette, Joseph P / Abdulla, Fuad / Ruan, Conglin / Allen, Kaje / Nguyen, Julia / Rogness, Victoria M / Beckman, Joan D / Khasabov, Sergey G / Gupta, Kalpna / Taylor, Ronald P / Simone, Donald A / Vercellotti, Gregory M

    Blood

    2023  Volume 142, Issue 22, Page(s) 1918–1927

    Abstract: Vaso-occlusive pain episodes (VOE) cause severe pain in patients with sickle cell disease (SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates complement. We hypothesized that complement activation is linked to VOE. We ... ...

    Abstract Vaso-occlusive pain episodes (VOE) cause severe pain in patients with sickle cell disease (SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates complement. We hypothesized that complement activation is linked to VOE. We used cold to induce VOE in the Townes sickle homozygous for hemoglobin S (HbSS) mouse model and complement inhibitors to determine whether anaphylatoxin C5a mediates VOE. We used a dorsal skinfold chamber to measure microvascular stasis (vaso-occlusion) and von Frey filaments applied to the plantar surface of the hind paw to assess mechanical hyperalgesia in HbSS and control Townes mice homozygous for hemoglobin A (HbAA) mice after cold exposure at 10°C/50°F for 1 hour. Cold exposure induced more vaso-occlusion in nonhyperalgesic HbSS mice (33%) than in HbAA mice (11%) or HbSS mice left at room temperature (1%). Cold exposure also produced mechanical hyperalgesia as measured by paw withdrawal threshold in HbSS mice compared with that in HbAA mice or HbSS mice left at room temperature. Vaso-occlusion and hyperalgesia were associated with an increase in complement activation fragments Bb and C5a in plasma of HbSS mice after cold exposure. This was accompanied by an increase in proinflammatory NF-κB activation and VCAM-1 and ICAM-1 expression in the liver. Pretreatment of nonhyperalgesic HbSS mice before cold exposure with anti-C5 or anti-C5aR monoclonal antibodies (mAbs) decreased vaso-occlusion, mechanical hyperalgesia, complement activation, and liver inflammatory markers compared with pretreatment with control mAb. Anti-C5 or -C5aR mAb infusion also abrogated mechanical hyperalgesia in HbSS mice with ongoing hyperalgesia at baseline. These findings suggest that C5a promotes vaso-occlusion, pain, and inflammation during VOE and may play a role in chronic pain.
    MeSH term(s) Mice ; Humans ; Animals ; Hyperalgesia/etiology ; Hyperalgesia/metabolism ; Mice, Transgenic ; Pain ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/metabolism ; Sickle Cell Trait/complications ; Complement Activation
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022019282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  4. Article ; Online: Improved Guideline Adherence With Integrated Sickle Cell Disease and Asthma Care.

    McClain, Brandi L / Ivy, Zalaya K / Bryant, Valencia / Rodeghier, Mark / DeBaun, Michael R

    American journal of preventive medicine

    2016  Volume 51, Issue 1 Suppl 1, Page(s) S62–8

    Abstract: Introduction: In children with sickle cell disease (SCD), concomitant asthma is associated with increased morbidity and mortality when compared with children with SCD without asthma. Despite the well-established burden of asthma in children with SCD, no ...

    Abstract Introduction: In children with sickle cell disease (SCD), concomitant asthma is associated with increased morbidity and mortality when compared with children with SCD without asthma. Despite the well-established burden of asthma in children with SCD, no paradigm of care exists for the co-management of these two diseases.
    Methods: To address this gap, an integrated SCD and asthma clinic was created in a community health center that included (1) a dual respiratory therapist/asthma case manager; (2) an SCD nurse practitioner with asthma educator certification; (3) an onsite pulmonary function test laboratory; (4) a pediatric hematologist with expertise in managing SCD and asthma; and (5) application of the National Asthma Education and Prevention Program guidelines. A before (2010-2012) and after (2013-2014) study design was used to assess for improved quality of care with implementation of an integrative care model among 61 children with SCD and asthma followed from 2010 to 2014.
    Results: Asthma action plan utilization after initial diagnosis increased with the integrative care model (n=16, 56% before, 100% after, p=0.003), as did the use of spirometry in children aged ≥5 years (n=41, 65% before, 95% after, p<0.001) and correction of lower airway obstruction (n=10, 30% before, 80% after, p=0.03).
    Conclusions: Although the use of an integrative care model for SCD and asthma improved evidence-based asthma care, longer follow-up and evaluation will be needed to determine the impact on SCD-related morbidity.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/mortality ; Asthma/complications ; Asthma/therapy ; Child ; Delivery of Health Care, Integrated ; Female ; Guideline Adherence ; Humans ; Male ; Patient Care Team/statistics & numerical data ; Prospective Studies ; Respiratory Function Tests ; Respiratory Therapy ; Spirometry
    Language English
    Publishing date 2016-06-06
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2016.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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