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Article ; Online: Large-scale resurgence of herpangina in Japan, following the easing of COVID-19 measures.

Ujiie, Mugen / Nakamoto, Takato / Iwamoto, Noriko / Tsuzuki, Shinya

IJID regions

2023 Volume 10, Page(s) 15–17

Abstract: Objectives: This study examined the rise in herpangina cases and its demographic trends in Japan post-easing of COVID-19 restrictions in the summer of 2023, assessing its potential strain on pediatric healthcare.: Methods: Weekly herpangina cases ... ...

Abstract	Objectives: This study examined the rise in herpangina cases and its demographic trends in Japan post-easing of COVID-19 restrictions in the summer of 2023, assessing its potential strain on pediatric healthcare. Methods: Weekly herpangina cases data from the National Institute of Infectious Diseases from 2017 to 2023 were analyzed using difference-in-differences methodology and Poisson regression models, incorporating variables such as time, the COVID-19 pandemic, and the easing of measures. Statistical significance was set at a two-sided Results: A significant increase in herpangina cases was observed from the 19th to the 27th week of 2023, with a notable shift in age distribution compared to that of pre-pandemic years. Poisson regression analysis revealed a positive correlation between the number of herpangina cases and the easing of infection control measures. There was an increase in other respiratory illnesses, including respiratory syncytial virus, particularly in children aged 3 and above. Conclusion: We found a surge in herpangina cases in Japan after the easing of the COVID-19 restrictions during the summer of 2023, along with a noticeable increase in other respiratory illnesses, emphasizing the potential strain on pediatric healthcare and reinforcing the ongoing significance of implementing general infection prevention strategies.
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2023.11.008
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Article ; Online: Structure-Indicated LC-MS/MS Bioanalysis of Therapeutic Antibodies.

Iwamoto, Noriko / Shimada, Takashi

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2313, Page(s) 187–205

Abstract: Monoclonal antibodies bind to Protein A/G resin with 100 nm-diameter pores, which orients the Fab toward the reaction solution. Then, they can be proteolyzed using trypsin immobilized on the surface of 200 nm-diameter nanoparticles. The difference ... ...

Abstract	Monoclonal antibodies bind to Protein A/G resin with 100 nm-diameter pores, which orients the Fab toward the reaction solution. Then, they can be proteolyzed using trypsin immobilized on the surface of 200 nm-diameter nanoparticles. The difference between the two particle diameters allows Fab-selective proteolysis by limiting trypsin access to the antibody substrate. The specific signature peptide of monoclonal antibody is collected, which comprises the complementarity-determining regions (CDRs). Excess trypsin protease and peptide fragments from common sequences in Fc that inhibit the analysis can then be separated and removed. The resulting peptide samples are separated through high performance liquid chromatography on a 20 nm-diameter pore-size reversed-phase C18 column. These are then sequentially ionized with an electrospray interface and subjected to mass spectrometry (MS). In MS, peptide ions are trapped and fragment ions are generated by the collision-induced dissociation with argon gas. These are detected with multiple reaction monitoring measurements to perform a highly sensitive and accurate quantitative analysis.By focusing on various physicochemical features at each analytical scene, such as characteristic structure and orientation of antibody, control of trypsin reaction field, carry-over on HPLC column, ionization suppression effect from endogenous proteins, and detection of amino acid sequence specificity of antibody, we optimized the overall conditions from the sample processing up to MS detection and developed analytical validation and clinical application of many therapeutic antibodies using our Fab-selective proteolysis technology that is based on the structure-indicated approach.
MeSH term(s)	Antibodies, Monoclonal ; Chromatography, High Pressure Liquid ; Peptides ; Tandem Mass Spectrometry ; Trypsin
Chemical Substances	Antibodies, Monoclonal ; Peptides ; Trypsin (EC 3.4.21.4)
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1450-1_11
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Article ; Online: Resurgence of Respiratory Syncytial Virus Infections during COVID-19 Pandemic, Tokyo, Japan.

Ujiie, Mugen / Tsuzuki, Shinya / Nakamoto, Takato / Iwamoto, Noriko

Emerging infectious diseases

2021 Volume 27, Issue 11, Page(s) 2969–2970

Abstract: More than a year into the coronavirus-19 pandemic, intensified infection control measures have controlled most viral respiratory infections in Tokyo, Japan. As of July 2021, however, an unusually high number of respiratory syncytial virus infections were ...

Abstract	More than a year into the coronavirus-19 pandemic, intensified infection control measures have controlled most viral respiratory infections in Tokyo, Japan. As of July 2021, however, an unusually high number of respiratory syncytial virus infections were reported in Tokyo. This resurgence may have resulted from restarting social activities for children.
MeSH term(s)	COVID-19 ; Child ; Humans ; Japan/epidemiology ; Pandemics ; Respiratory Syncytial Virus Infections/epidemiology ; SARS-CoV-2 ; Tokyo/epidemiology
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2711.211565
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Zs.A 4778: Show issues

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Article ; Online: Regulated LC-MS/MS bioanalysis technology for therapeutic antibodies and Fc-fusion proteins using structure-indicated approach.

Iwamoto, Noriko / Shimada, Takashi

Drug metabolism and pharmacokinetics

2018 Volume 34, Issue 1, Page(s) 19–24

Abstract: In recent studies, the development of bioanalysis technologies using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has attracted attention. Our developed nano-surface and molecular-orientation limited (nSMOL) proteolysis enables Fab-specific ... ...

Abstract	In recent studies, the development of bioanalysis technologies using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has attracted attention. Our developed nano-surface and molecular-orientation limited (nSMOL) proteolysis enables Fab-specific proteolysis and is optimal for LC-MS/MS analysis of antibody drugs and Fc-fusion proteins in biological samples. In this nSMOL method, antibodies and Fc-fusion proteins are held in pores of the particle and the subsequent proteolysis is carried out with protease-immobilized nanoparticles. The Fab of antibodies or fused region of Fc-fusion protein can be held to orient toward the reaction solution. The access of the immobilized protease is limited to a part in the structure of protein substrate on the particle surface. Thus, nSMOL proteolysis reacts selectively at the Fab complementarity-determining region of antibodies or N-terminal specific domain of Fc-fusion proteins and can be applied to both types of drugs. We have already evaluated drug concentrations in biological samples pretreated with nSMOL proteolysis using LC-MS/MS for more than twenty drugs, of which ten drugs have been fully validated and published. In this review, we discuss the development and application of LC-MS/MS bioanalysis, which enables the bioanalysis of therapeutic antibodies and Fc-fusion proteins by focusing on a structure-based approach.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/analysis ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/genetics ; Chromatography, Liquid/methods ; Chromatography, Liquid/standards ; Humans ; Proto-Oncogene Proteins/analysis ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/genetics ; Receptors, Fc/analysis ; Receptors, Fc/chemistry ; Receptors, Fc/genetics ; Structure-Activity Relationship ; Tandem Mass Spectrometry/methods ; Tandem Mass Spectrometry/standards
Chemical Substances	Antibodies, Monoclonal ; Proto-Oncogene Proteins ; Receptors, Fc
Language	English
Publishing date	2018-10-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2095748-8
ISSN	1880-0920 ; 1347-4367 ; 0916-1139
ISSN (online)	1880-0920
ISSN	1347-4367 ; 0916-1139
DOI	10.1016/j.dmpk.2018.10.002
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Zs.A 3734: Show issues

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Article ; Online: The First Case of a Child Infected with SARS-CoV-2 Omicron Variant in Japan, December 2021.

Horigome, Akihisa / Yamanaka, Junko / Takasago, Satoshi / Iwamoto, Noriko / Saito, Tomoya / Shichino, Hiroyuki

Japanese journal of infectious diseases

2022 Volume 76, Issue 1, Page(s) 69–71

Abstract: We report the first pediatric patient infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japan. The patient was a one-year-old boy who resided in Japan. He went abroad with his parents from November 12, ... ...

Abstract	We report the first pediatric patient infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japan. The patient was a one-year-old boy who resided in Japan. He went abroad with his parents from November 12, 2021 to November 28, 2021 and had no known contact with coronavirus disease (COVID-19) patients there. Upon arrival at the Narita International Airport on November 28, 2021, his father tested positive for SARS-CoV-2 via a quantitative antigen test. Because the boy and his mother tested negative for SARS-CoV-2, they quarantined together at a hotel separately from his father. On December 4, 2021, the boy tested positive by reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, without symptoms, and was hospitalized with his mother; he and his father were both found to be infected with the SARS-CoV-2 Omicron variant. The boy was not vaccinated against COVID-19. RT-PCR results were negative starting on December 20, 2021. The incubation period and required period for negative conversion of SARS-CoV-2 RNA of the Omicron variant case were similar to those of the cases of conventional strains. We should carefully consider the potential of the SARS-CoV-2 Omicron variant to spread widely among unvaccinated children.
MeSH term(s)	Male ; Humans ; Child ; Infant ; Japan ; SARS-CoV-2/genetics ; RNA, Viral ; COVID-19/diagnosis
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-08-31
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2021.896
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Ua VI Zs.409: Show issues

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Article ; Online: Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature.

Toyodome, Soichiro / Wakasa, Tomoko / Hirose, Katsutoshi / Iwamoto, Noriko / Suzuki, Seiya / Nemoto, Naoto / Toyosawa, Satoru / Nagata, Tetsuji

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 114

Abstract: Background: Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local ... ...

Abstract	Background: Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear. Case presentation: This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor. Conclusion: It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.
MeSH term(s)	Humans ; Male ; Middle Aged ; Odontogenic Tumors/diagnostic imaging ; Odontogenic Tumors/surgery ; Maxilla ; Biopsy ; Ameloblastoma/diagnostic imaging ; Ameloblastoma/surgery ; Diagnosis, Differential
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-03861-w
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Article ; Online: Clinical efficacy of remdesivir for COVID-19 in children: A propensity-score-matched analysis.

Shoji, Kensuke / Asai, Yusuke / Akiyama, Takayuki / Tsuzuki, Shinya / Matsunaga, Nobuaki / Suzuki, Setsuko / Iwamoto, Noriko / Funaki, Takanori / Miyairi, Isao / Ohmagari, Norio

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 29, Issue 9, Page(s) 930–933

Abstract: Clinical efficacy of remdesivir in children with COVID-19 is unclear. This propensity-score-matched retrospective cohort study of children with COVID-19 showed that the rate of patients achieving defervescence on Day 4 was higher in the remdesivir group ... ...

Abstract	Clinical efficacy of remdesivir in children with COVID-19 is unclear. This propensity-score-matched retrospective cohort study of children with COVID-19 showed that the rate of patients achieving defervescence on Day 4 was higher in the remdesivir group than in the non-remdesivir group, but was not statistically different (86.7% vs 73.3%, P = 0.333).
MeSH term(s)	Humans ; Child ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; Antiviral Agents/therapeutic use ; COVID-19 Drug Treatment ; Treatment Outcome ; Alanine/therapeutic use
Chemical Substances	Antiviral Agents ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2023-06-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.06.006
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Zs.A 5236: Show issues

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Article ; Online: Recent advances in mass spectrometry-based approaches for proteomics and biologics: Great contribution for developing therapeutic antibodies.

Iwamoto, Noriko / Shimada, Takashi

Pharmacology & therapeutics

2017 Volume 185, Page(s) 147–154

Abstract: Since the turn of the century, mass spectrometry (MS) technologies have continued to improve dramatically, and advanced strategies that were impossible a decade ago are increasingly becoming available. The basic characteristics behind these advancements ... ...

Abstract	Since the turn of the century, mass spectrometry (MS) technologies have continued to improve dramatically, and advanced strategies that were impossible a decade ago are increasingly becoming available. The basic characteristics behind these advancements are MS resolution, quantitative accuracy, and information science for appropriate data processing. The spectral data from MS contain various types of information. The benefits of improving the resolution of MS data include accurate molecular structural-derived information, and as a result, we can obtain a refined biomolecular structure determination in a sequential and large-scale manner. Moreover, in MS data, not only accurate structural information but also the generated ion amount plays an important rule. This progress has greatly contributed a research field that captures biological events as a system by comprehensively tracing the various changes in biomolecular dynamics. The sequential changes of proteome expression in biological pathways are very essential, and the amounts of the changes often directly become the targets of drug discovery or indicators of clinical efficacy. To take this proteomic approach, it is necessary to separate the individual MS spectra derived from each biomolecule in the complexed biological samples. MS itself is not so infinite to perform the all peak separation, and we should consider improving the methods for sample processing and purification to make them suitable for injection into MS. The above-described characteristics can only be achieved using MS with any analytical instrument. Moreover, MS is expected to be applied and expand into many fields, not only basic life sciences but also forensic medicine, plant sciences, materials, and natural products. In this review, we focus on the technical fundamentals and future aspects of the strategies for accurate structural identification, structure-indicated quantitation, and on the challenges for pharmacokinetics of high-molecular-weight protein biopharmaceuticals.
MeSH term(s)	Biological Products/chemistry ; Biological Products/therapeutic use ; Humans ; Mass Spectrometry ; Proteins/chemistry ; Proteins/therapeutic use ; Proteomics
Chemical Substances	Biological Products ; Proteins
Language	English
Publishing date	2017-12-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2017.12.007
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Zs.A 1183: Show issues

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Article: High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with

Iwamoto, Noriko / Takamatsu, Yuki / Asai, Yusuke / Tsuchiya, Kiyoto / Matsuda, Kouki / Oshiro, Yusuke / Inamura, Natsumi / Terada, Mari / Nemoto, Takashi / Kimura, Moto / Saito, Sho / Morioka, Shinichiro / Kenji, Maeda / Mitsuya, Hiroaki / Ohmagari, Norio

Heliyon

2024 Volume 10, Issue 2, Page(s) e24513

Abstract: Background: Antibody testing can easily evaluate the clinical status of patients, aid in the diagnosis of multisystem inflammatory syndrome, and monitor the immunity level in the population. However, the applicability of serological tests in detecting ... ...

Abstract	Background: Antibody testing can easily evaluate the clinical status of patients, aid in the diagnosis of multisystem inflammatory syndrome, and monitor the immunity level in the population. However, the applicability of serological tests in detecting antibodies against the severe acute respiratory syndrome 2 (SARS-CoV-2) spike-binding protein remains limited. This study aimed to quantify both serum-derived neutralizing immunoglobulin-G (IgG) antibody activity and the amount of anti-SARS-CoV-2 Spike-IgG (S-IgG) in convalescent sera/plasmas and evaluate the direct correlation between the Methods: We evaluated the neutralizing activity of purified IgG (IgG-EC Results: A high correlation was observed between S-IgG and IgG-EC Conclusions: Quantitative S-IgG tests are a useful and convenient tool for estimating
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24513
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Article ; Online: Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an immunocompromised host who had received CD20 depleting therapy for follicular lymphoma.

Maruki, Taketomo / Nomoto, Hidetoshi / Iwamoto, Noriko / Yamamoto, Kei / Kurokawa, Masami / Iwatsuki-Horimoto, Kiyoko / Yamayoshi, Seiya / Suzuki, Yutaka / Kawaoka, Yoshihiro / Ohmagari, Norio

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2024

Abstract: The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination ... ...

Abstract	The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination with intravenous immunoglobulin (IVIg) in a patient who had received CD20 depleting therapy for follicular lymphoma and experienced recurrent COVID-19 relapses. After the patient received IVIg treatment, the viral load decreased without recurrence. Subsequently, it was found that the anti-spike antibody titer in the administered immunoglobulin was high at 9528.0 binding antibody units/mL. Our case highlights the potential of combination therapy with selective IVIg and antiviral drugs for relapsed immunocompromised COVID-19 patients who have received CD20 depleting therapy.
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2024.01.008
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