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  1. Article ; Online: Pathologic Findings in Severe Coal Workers' Pneumoconiosis in Contemporary US Coal Miners.

    Cool, Carlyne D / Murray, Jill / Vorajee, Naseema I / Rose, Cecile S / Zell-Baran, Lauren M / Sanyal, Soma / Franko, Angela D / Almberg, Kirsten S / Iwaniuk, Cayla / Go, Leonard H T / Green, Francis H Y / Cohen, Robert A

    Archives of pathology & laboratory medicine

    2023  

    Abstract: Context.—: The pathology of coal workers' pneumoconiosis (CWP) and its most severe form-progressive massive fibrosis (PMF)-in US coal miners has changed in recent years. Severe disease is occurring in younger miners and has been linked to an increase in ...

    Abstract Context.—: The pathology of coal workers' pneumoconiosis (CWP) and its most severe form-progressive massive fibrosis (PMF)-in US coal miners has changed in recent years. Severe disease is occurring in younger miners and has been linked to an increase in silica dust exposure.
    Objective.—: To update the description of the pathologic features of CWP in contemporary miners compared to historical miners.
    Design.—: This study is a retrospective expert classification of lung tissue from 85 historical and contemporary coal miners with PMF. Significant pathologic features were scored by using a standardized instrument with consensus achieved for major findings, including newly defined categories of PMF as coal-type, mixed-type, and silica-type.
    Results.—: Pathologic features associated with silica dust exposure, including silica-type PMF, mineral dust alveolar proteinosis (MDAP), and immature (early stage) silicotic nodules were increased in contemporary miners. Detailed descriptions of the pathology of contemporary CWP with illustrative figures are provided.
    Conclusions.—: Silica-related pathologies are more common in contemporary miners. Severe forms of CWP can be detected by subtyping PMF lesions (if present) or by identification of mature and immature silicotic nodules, coal mine dust-related alveolar proteinosis, and severe inflammation in coal miners' lungs. Silica-type PMF cases showed significantly higher levels of MDAP than either mixed- or coal-type PMF (P < .001). High profusion of birefringent silica/silicate particles was observed more frequently in cases with immature (early stage) silicotic nodules (P = .04). Severe inflammation was also significantly increased in contemporary miners (P = .03). Our findings underscore the urgent need to revise current exposure limits and monitoring of respirable crystalline silica in US coal mines.
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2022-0491-OA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Historical shift in pathological type of progressive massive fibrosis among coal miners in the USA.

    Go, Leonard H T / Rose, Cecile S / Zell-Baran, Lauren M / Almberg, Kirsten S / Iwaniuk, Cayla / Clingerman, Sidney / Richardson, Diana L / Abraham, Jerrold L / Cool, Carlyne D / Franko, Angela D / Green, Francis H Y / Hubbs, Ann F / Murray, Jill / Orandle, Marlene S / Sanyal, Soma / Vorajee, Naseema I / Sarver, Emily A / Petsonk, Edward L / Cohen, Robert A

    Occupational and environmental medicine

    2023  Volume 80, Issue 8, Page(s) 425–430

    Abstract: Background: Pneumoconiosis among coal miners in the USA has been resurgent over the past two decades, despite modern dust controls and regulatory standards. Previously published studies have suggested that respirable crystalline silica (RCS) is a ... ...

    Abstract Background: Pneumoconiosis among coal miners in the USA has been resurgent over the past two decades, despite modern dust controls and regulatory standards. Previously published studies have suggested that respirable crystalline silica (RCS) is a contributor to this disease resurgence. However, evidence has been primarily indirect, in the form of radiographic features.
    Methods: We obtained lung tissue specimens and data from the National Coal Workers' Autopsy Study. We evaluated specimens for the presence of progressive massive fibrosis (PMF) and used histopathological classifications to type these specimens into coal-type, mixed-type and silica-type PMF. Rates of each were compared by birth cohort. Logistic regression was used to assess demographic and mining characteristics associated with silica-type PMF.
    Results: Of 322 cases found to have PMF, study pathologists characterised 138 (43%) as coal-type, 129 (40%) as mixed-type and 55 (17%) as silica-type PMF. Among earlier birth cohorts, coal-type and mixed-type PMF were more common than silica-type PMF, but their rates declined in later birth cohorts. In contrast, the rate of silica-type PMF did not decline in cases from more recent birth cohorts. More recent year of birth was significantly associated with silica-type PMF.
    Conclusions: Our findings demonstrate a shift in PMF types among US coal miners, from a predominance of coal- and mixed-type PMF to a more commonly encountered silica-type PMF. These results are further evidence of the prominent role of RCS in the pathogenesis of pneumoconiosis among contemporary US coal miners.
    MeSH term(s) Humans ; United States/epidemiology ; Coal Mining ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/pathology ; Pneumoconiosis ; Silicon Dioxide/adverse effects ; Dust ; Coal/adverse effects ; Fibrosis
    Chemical Substances Silicon Dioxide (7631-86-9) ; Dust ; Coal
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2022-108643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Un I Zs.461: Show issues Location:
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  3. Article ; Online: Mining Tenure and Job Duties Differ Among Contemporary and Historic Underground Coal Miners With Progressive Massive Fibrosis.

    Zell-Baran, Lauren M / Go, Leonard H T / Sarver, Emily / Almberg, Kirsten S / Iwaniuk, Cayla / Green, Francis H Y / Abraham, Jerrold L / Cool, Carlyne / Franko, Angela / Hubbs, Ann F / Murray, Jill / Orandle, Marlene S / Sanyal, Soma / Vorajee, Naseema / Cohen, Robert A / Rose, Cecile S

    Journal of occupational and environmental medicine

    2022  Volume 65, Issue 4, Page(s) 315–320

    Abstract: Objective: To characterize differences in mining jobs and tenure between contemporary (born 1930+, working primarily with modern mining technologies) and historic coal miners with progressive massive fibrosis (PMF).: Methods: We classified jobs as ... ...

    Abstract Objective: To characterize differences in mining jobs and tenure between contemporary (born 1930+, working primarily with modern mining technologies) and historic coal miners with progressive massive fibrosis (PMF).
    Methods: We classified jobs as designated occupations (DOs) and non-DOs based on regulatory sampling requirements. Demographic, occupational characteristics, and histopathological PMF type were compared between groups.
    Results: Contemporary miners ( n = 33) had significantly shorter mean total (30.4 years vs 37.1 years, P = 0.0006) and underground (28.8 years vs 35.8 years, P = 0.001) mining tenure compared with historic miners ( n = 289). Silica-type PMF was significantly more common among miners in non-DOs (30.1% vs 15.8%, P = 0.03) and contemporary miners (58.1% vs 15.2%, P < 0.0001).
    Conclusions: Primary jobs changed over time with the introduction of modern mining technologies and likely changed exposures for workers. Elevated crystalline silica exposures are likely in non-DOs and require attention.
    MeSH term(s) Humans ; Coal Mining ; Pneumoconiosis ; Occupations ; Silicon Dioxide ; Fibrosis ; Coal ; Occupational Exposure/adverse effects
    Chemical Substances Silicon Dioxide (7631-86-9) ; Coal
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pathology and Mineralogy Demonstrate Respirable Crystalline Silica Is a Major Cause of Severe Pneumoconiosis in U.S. Coal Miners.

    Cohen, Robert A / Rose, Cecile S / Go, Leonard H T / Zell-Baran, Lauren M / Almberg, Kirsten S / Sarver, Emily A / Lowers, Heather A / Iwaniuk, Cayla / Clingerman, Sidney M / Richardson, Diana L / Abraham, Jerrold L / Cool, Carlyne D / Franko, Angela D / Hubbs, Ann F / Murray, Jill / Orandle, Marlene S / Sanyal, Soma / Vorajee, Naseema I / Petsonk, Edward L /
    Zulfikar, Rafia / Green, Francis H Y

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 9, Page(s) 1469–1478

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Anthracosis/epidemiology ; Coal ; Coal Mining ; Dust ; Humans ; Occupational Exposure/adverse effects ; Pneumoconiosis/epidemiology ; Prevalence ; Pulmonary Alveolar Proteinosis ; Silicon Dioxide/adverse effects ; United States/epidemiology
    Chemical Substances Coal ; Dust ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202109-1064OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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