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  1. Article ; Online: Acute worsening of glycemic control in a patient with type 2 diabetes and non‐small cell lung cancer after administration of lorlatinib

    Yoshio Nakano / Mai Miyasato‐Isoda / Iwao Gohma / Tomomi Fujisawa

    Clinical Case Reports, Vol 10, Iss 1, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract A patient with non‐small cell lung cancer (NSCLC) exhibited extreme hyperglycemia after lorlatinib treatment. The present case highlights the importance of glucose monitoring during lorlatinib administration and intensifying hyperglycemia ... ...

    Abstract Abstract A patient with non‐small cell lung cancer (NSCLC) exhibited extreme hyperglycemia after lorlatinib treatment. The present case highlights the importance of glucose monitoring during lorlatinib administration and intensifying hyperglycemia treatment.
    Keywords adverse event ; hyperglycemia ; lorlatinib ; non‐small cell lung cancer ; type 2 diabetes ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Assessing the effects of exposure to a SARS-CoV-2 re-positive patient in healthcare personnel

    Yoshihiko Ogawa / Koji Nishida / Iwao Gohma / Kei Kasahara / Hisakazu Yano

    BMC Research Notes, Vol 13, Iss 1, Pp 1-

    2020  Volume 4

    Abstract: Abstract Objective To evaluate whether patients with COVID-19 who have tested re-positive with the PCR test for the SARS-CoV-2 virus are infectious is a challenge in the current circumstances. A follow-up survey was conducted with healthcare personnel ( ... ...

    Abstract Abstract Objective To evaluate whether patients with COVID-19 who have tested re-positive with the PCR test for the SARS-CoV-2 virus are infectious is a challenge in the current circumstances. A follow-up survey was conducted with healthcare personnel (HCP) who were exposed to a patient whose PCR test results for SARS-CoV-2 were re-positive 18 days after the initial confirmation of negative PCR results. Results We studied a total of 15 HCP who had contact exposures (15/15) and aerosol exposures (7/15). None of them tested positive for IgG against SARS-CoV-2 on blood examination. None of them had any symptoms during 10 days of active isolation. All PCR tests conducted using the nasopharyngeal swabs collected from the HCP on day 10 were negative. No apparent infection was found in any of the HCP who had contact exposure with and/or aerosol exposure to the patient whose PCR test results for SARS-CoV-2 were re-positive 18 days after the initial confirmation of negative results of PCR tests for SARS-CoV-2. Clinical trial: Trial Registration: No. 170, approved June 10th, 2020 by the ethics committee of Sakai City Medical Center.
    Keywords SARS-CoV-2 ; COVID-19 ; Healthcare personnel ; PCR re-positive ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Analysis of the predictive factors for a critical illness of COVID-19 during treatment － relationship between serum zinc level and critical illness of COVID-19 −

    Yukako Yasui / Hiroyuki Yasui / Kumiko Suzuki / Takako Saitou / Yoshiki Yamamoto / Toshihiko Ishizaka / Kouji Nishida / Shingo Yoshihara / Iwao Gohma / Yoshihiko Ogawa

    International Journal of Infectious Diseases, Vol 100, Iss , Pp 230-

    2020  Volume 236

    Abstract: Objectives: Because most severely ill patients with COVID-19 in our hospital showed zinc deficiency, we aimed to examine the relationship between the patient’s serum zinc level and severe cases of COVID-19. Methods: Serum zinc <70 μg/dL was defined as ... ...

    Abstract Objectives: Because most severely ill patients with COVID-19 in our hospital showed zinc deficiency, we aimed to examine the relationship between the patient’s serum zinc level and severe cases of COVID-19. Methods: Serum zinc <70 μg/dL was defined as the criterion for hypozincemia, and patients continuously with serum zinc <70 μg/dL were classified in the hypozincemia cohort. To evaluate whether hypozincemia could be a predictive factor for a critical illness of COVID-19, we performed a multivariate analysis by employing logistic regression analysis. Results: Prolonged hypozincemia was found to be a risk factor for a severe case of COVID-19. In evaluating the relationship between the serum zinc level and severity of patients with COVID-19 by multivariate logistic regression analysis, critical illness can be predicted through the sensitivity and false specificity of a ROC curve with an error rate of 10.3% and AUC of 94.2% by only two factors: serum zinc value (P = 0.020) and LDH value (P = 0.026). Conclusions: Proper management of the prediction results in this study can contribute to establishing and maintaining a safe medical system, taking the arrival of the second wave, and the spread of COVID-19 in the future into consideration.
    Keywords COVID-19 ; Serum zinc ; Predictive factors ; Logistic regression analysis ; Critical illness ; Japan ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Subject code 630
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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