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  1. Article ; Online: CORR Insights®: Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing.

    Iwata, Shintaro

    Clinical orthopaedics and related research

    2024  Volume 482, Issue 3, Page(s) 564–565

    MeSH term(s) Humans ; Protein-Tyrosine Kinases ; Sarcoma/therapy ; Sarcoma/drug therapy ; Bone and Bones ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/therapy ; DNA/therapeutic use ; RNA/therapeutic use
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; DNA (9007-49-2) ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002998
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  2. Article: [Ⅲ. Early Phase Drug Development and Precision Medicine for Osteosarcoma].

    Iwata, Shintaro

    Gan to kagaku ryoho. Cancer & chemotherapy

    2021  Volume 48, Issue 3, Page(s) 351–355

    MeSH term(s) Bone Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Development ; Humans ; Osteosarcoma/drug therapy ; Precision Medicine
    Language Japanese
    Publishing date 2021-04-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  3. Article ; Online: Cerebral regional oxygen saturation as a predictive parameter for preoperative heart failure and delayed hemodynamic recovery in transcutaneous aortic valve implantation: a retrospective cohort study.

    Iwata, Shihoko / Ozaki, Makoto

    Journal of clinical monitoring and computing

    2024  

    Abstract: This study aimed to investigate the relationship of perioperative cerebral regional oxygen saturation ( ... ...

    Abstract This study aimed to investigate the relationship of perioperative cerebral regional oxygen saturation (rSO
    Language English
    Publishing date 2024-02-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-024-01129-2
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  4. Article ; Online: ASO Author Reflections: Venous Thromboembolism in a Patient with Musculoskeletal Tumor: Fact or Fiction?

    Iwata, Shintaro

    Annals of surgical oncology

    2020  Volume 28, Issue 7, Page(s) 3928–3929

    MeSH term(s) Humans ; Neoplasms ; Syndrome ; Venous Thromboembolism/etiology
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09359-9
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  5. Article ; Online: Recent progress in membrane protein dynamics revealed by X-ray free electron lasers: Molecular movies of microbial rhodopsins.

    Nango, Eriko / Iwata, So

    Current opinion in structural biology

    2023  Volume 81, Page(s) 102629

    Abstract: Microbial rhodopsin is a membrane protein with a domain of seven-transmembrane helices and a retinal chromophore. The main function of this protein is to perform light-induced ion transport, either actively or passively, by acting as pumps, channels, and ...

    Abstract Microbial rhodopsin is a membrane protein with a domain of seven-transmembrane helices and a retinal chromophore. The main function of this protein is to perform light-induced ion transport, either actively or passively, by acting as pumps, channels, and light sensors. It is widely used for optogenetic application to control the activity of specific cells in living tissues by light. Time-resolved serial femtosecond crystallography (TR-SFX) with the use of X-ray free electron lasers is an effective technique for capturing dynamic ion transport and efflux structures across membranes with high spatial and temporal resolutions. Here, we outline recent TR-SFX studies of microbial rhodopsins, including a pump and a channel. We also discuss differences and similarities observed in the structural dynamics derived from the TR-SFX structures.
    MeSH term(s) Rhodopsins, Microbial/chemistry ; Membrane Proteins ; Electrons ; Motion Pictures ; Lasers ; Crystallography, X-Ray
    Chemical Substances Rhodopsins, Microbial ; Membrane Proteins
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2023.102629
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  6. Article ; Online: A Recql5 mutant facilitates complex CRISPR/Cas9-mediated-chromosomal engineering in mouse zygotes.

    Iwata, Satoru / Nagahara, Miki / Ido, Risako / Iwamoto, Takashi

    Genetics

    2024  

    Abstract: Complex chromosomal rearrangements (CCRs) are often observed in clinical samples from patients with cancer and congenital diseases but are difficult to induce experimentally. Here, we report the first success in establishing animal models for CCRs. ... ...

    Abstract Complex chromosomal rearrangements (CCRs) are often observed in clinical samples from patients with cancer and congenital diseases but are difficult to induce experimentally. Here, we report the first success in establishing animal models for CCRs. Mutation in Recql5, a crucial member of the DNA helicase RecQ family involved in DNA replication, transcription, and repair, enabled CRISPR/Cas9-mediated CCRs, establishing a mouse model containing triple fusion genes and megabase-sized inversions. Some of these structural features of individual chromosomal rearrangements use template switching and microhomology-mediated break-induced replication mechanisms and are reminiscent of the newly described phenomenon "chromoanasynthesis." These data show that Recql5-mutant mice could be a powerful tool to analyze the pathogenesis of CCRs (particularly chromoanasynthesis) whose underlying mechanisms are poorly understood. The Recql5 mutants generated in this study are to be deposited at key animal research facilities, thereby making them accessible for future research on CCRs.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyae054
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  7. Article ; Online: Roles of the Default Mode Network in Different Aspects of Self-representation When Remembering Social Autobiographical Memories.

    Katsumi, Azusa / Iwata, Saeko / Tsukiura, Takashi

    Journal of cognitive neuroscience

    2024  , Page(s) 1–16

    Abstract: Autobiographical memory (AM) is episodic memory for personally experienced events, in which self-representation is more important than that in laboratory-based memory. Theoretically, self-representation in a social context is categorized as the ... ...

    Abstract Autobiographical memory (AM) is episodic memory for personally experienced events, in which self-representation is more important than that in laboratory-based memory. Theoretically, self-representation in a social context is categorized as the interpersonal self (IS) referred to in a social interaction with a person or the social-valued self (SS) based on the reputation of the self in the surrounding society. Although functional neuroimaging studies have demonstrated the involvement of the default mode network (DMN) in self-representation, little is known about how the DMN subsystems contribute differentially to IS-related and SS-related AMs. To elucidate this issue, we used fMRI to scan healthy young adults during the recollection of AMs. We performed multivariate pattern analysis (MVPA) and assessed functional connectivity in the DMN subsystems: the midline core, medial temporal lobe (MTL), and dorsomedial pFC (dmPFC) subsystems. The study yielded two main sets of findings. First, MVPA revealed that all DMN subsystems showed significant classification accuracy between IS-related and nonsocial-self-related AMs, and IS-related functional connectivity of the midline core regions with the retrosplenial cortex of the MTL subsystem and the dmPFC of the dmPFC subsystem was significant. Second, MVPA significantly distinguished between SS-related and nonsocial-self-related AMs in the midline core and dmPFC subsystems but not in the MTL subsystem, and SS-related functional connectivity with the midline core regions was significant in the temporal pole and TPJ of the dmPFC subsystem. Thus, dissociable neural mechanisms in the DMN could contribute to different aspects of self-representation in social AMs.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_02143
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    Zs.A 2623: Show issues Location:
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  8. Article: Association of Viral Infection With the Development and Pathogenesis of Systemic Lupus Erythematosus.

    Iwata, Shigeru / Tanaka, Yoshiya

    Frontiers in medicine

    2022  Volume 9, Page(s) 849120

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage in women of childbearing age and has a relapsing-remitting course. SLE is caused by the interaction between genetic and environmental factors, however, its ... ...

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage in women of childbearing age and has a relapsing-remitting course. SLE is caused by the interaction between genetic and environmental factors, however, its underlying triggers remain unknown. Among the environmental factors, the involvement of infections as a trigger for SLE, especially those of viral etiology, has been widely reported. Human endogenous retroviruses (HERVs) may put patients at a genetic predisposition to SLE, while the Epstein-Barr virus (EBV) may play a role as an environmental factor that triggers the development of SLE. It has been suggested that EBV-infected B-cells may become resistant to apoptosis, resulting in the activation, proliferation, and antibody production of autoreactive B-cells, which cause tissue damage in SLE. However, the interaction between the virus and immune cells, as well as the impact of the virus on the differentiation and dysfunction of immune cells, remain unclear. In this review, we focus on the relationship between the development and pathogenesis of SLE and viral infections, as well as the mechanism of SLE exacerbation via activation of immune cells, such as B-cells, based on the latest findings.
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.849120
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  9. Article ; Online: Physiological and Metabolic Responses to Low-Volume Sprint Interval Exercises: Influence of Sprint Duration and Repetitions.

    Yamagishi, Takaki / Iwata, Soya / Otsuka, Shun / Ichinose, Hoshizora / Kawakami, Yasuo

    Medicine and science in sports and exercise

    2024  

    Abstract: Purpose: This study aimed to determine physiological and metabolic responses to two different sprint interval exercises (SIE) matched for total sprint duration and sprint-to-rest ratio.: Methods: After having measured peak oxygen uptake (V̇O 2peak ), ...

    Abstract Purpose: This study aimed to determine physiological and metabolic responses to two different sprint interval exercises (SIE) matched for total sprint duration and sprint-to-rest ratio.
    Methods: After having measured peak oxygen uptake (V̇O 2peak ), fourteen healthy males (27.1 ± 4.8 years, 169.6 ± 6.0 cm, 64.5 ± 8.4 kg, V̇O 2peak : 47.2 ± 7.7 ml·kg -1 ·min -1 ) performed four 10-s sprints with 80-s recovery (SIE10) and two 20-s sprints with 160-s recovery (SIE20) on different occasions in a counterbalanced crossover manner. Pulmonary V̇O 2 and changes in tissue oxygenation index (∆TOI) at vastus lateralis (VL) and rectus femoris (RF) were measured during the SIEs. Furthermore, T2-weighted MRI was taken immediately before and after the SIEs to determine the activation levels of VL, RF, vastus medialis, vastus intermedius, adductor magnus, biceps femoris long head, semitendinosus and semimembranosus at 50% of right thigh length.
    Results: In SIE10, increases in V̇O 2 and ∆TOI at VL and RF plateaued after the second sprint, whereas session-averaged ∆TOI was greater in SIE20 than SIE10 in both muscles (VL: 20.9 ± 7.4 vs. 14.2 ± 5.9%, RF: 22.8 ± 9.3 vs. 12.9 ± 6.6%, p = 0.00). While both SIEs significantly increased T2 values in all eight muscles, those magnitudes were similar between the conditions (SIE10 vs. SIE20: 5-16 vs. 8-16%).
    Conclusions: This study showed blunted responses of whole-body (V̇O 2 ) and peripheral (∆TOI) oxidative responses with successive sprints (sprint 1 < sprint 2-4) in SIE10, suggesting that increasing sprint repetitions does not necessarily induce greater oxidative metabolism or stimulus. Moreover, greater peripheral oxygen extraction (∆TOI) was achieved with SIE20, whereas %changes of T2 indicates that the thigh muscles were similarly activated between the SIE conditions.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003420
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    Zs.A 869: Show issues Location:
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  10. Article ; Online: Glomangiopericytoma with

    Iwata, Shinji / Kitazawa, Riko / Kitazawa, Sohei / Hato, Naohito

    BMJ case reports

    2023  Volume 16, Issue 9

    Abstract: Glomangiopericytoma (GPC) is a rare tumour, accounting <0.5% of all nasal cavity tumours. It is classified as borderline malignant to indolent and is associated with perivascular myeloid cells. We report a case of GPC in a woman in her 80s who presented ... ...

    Abstract Glomangiopericytoma (GPC) is a rare tumour, accounting <0.5% of all nasal cavity tumours. It is classified as borderline malignant to indolent and is associated with perivascular myeloid cells. We report a case of GPC in a woman in her 80s who presented with nasal obstruction. The tumour originated from the nasal septum and was resected via endoscopic sinus surgery. Histopathological examination revealed dense spindle-shaped to oval-shaped mesenchymal cells forming tumour nodules with staghorn-like vessel formation. Immunohistochemical analysis revealed that the tumour cells were positive for α-smooth muscle actin, CD34, β-catenin and cyclin D1, whereas they were negative for STAT6. The percentage of Ki-67-positive cells was approximately 2%. Recent studies have demonstrated a high frequency of β-catenin (
    MeSH term(s) Female ; Humans ; beta Catenin/genetics ; Precancerous Conditions ; Nose Neoplasms ; Antigens, CD34 ; Mutation
    Chemical Substances beta Catenin ; Antigens, CD34 ; CTNNB1 protein, human
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256787
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