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  1. AU="Iyappan, Petchi"
  2. AU="Naomi Nakagata"
  3. AU="Marianne A. van der Sande"
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  1. Article ; Online: Immunomodulatory effect of Myrtenol on benzo (a) pyrene-induced lung cancer in Swiss albino mice via modulation of tumor markers, cytokines and inhibition of PCNA expression.

    Zhang, Haoliang / Ramamoorthy, Anuradha / Rengarajan, Thamaraiselvan / Iyappan, Petchi / Alahmadi, Tahani A / Wainwright, Milton / Hussein-Al-Ali, Samer Hasan

    Journal of biochemical and molecular toxicology

    2023  Volume 38, Issue 1, Page(s) e23578

    Abstract: Lung cancer is one of the most common cancers in men. Although many diagnostic and treatment regimens have been followed in the treatment for lung cancer, increasing mortality rate due to lung cancer is depressing and hence requires alternative plant ... ...

    Abstract Lung cancer is one of the most common cancers in men. Although many diagnostic and treatment regimens have been followed in the treatment for lung cancer, increasing mortality rate due to lung cancer is depressing and hence requires alternative plant based therapeutics with with less side-effects. Myrtenol exhibits anti-inflammatory and antioxidant properties. Hence we intended to study the effect of Myrtenol on B(a)P-induced lung cancer. Our study showed that B(a)P lowered hematological count, decreased phagocyte and avidity indices, nitroblue tetrazolium (NBT) reduction, levels of immunoglubulins, antioxidant levels, whereas Myrtenol treatment restored them back to normal levels. On the other hand, xenobiotic and liver dysfunction marker enzymes and pro-inflammatory cytokines were elevated on B(a)P exposure, which retuned back to normal by Myrtenol. This study thus describes the immunomodulatory and antioxidant effects of Myrtenol on B[a]P-induced immune destruction.
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Lung Neoplasms/chemically induced ; Lung Neoplasms/drug therapy ; Cytokines/metabolism ; Benzo(a)pyrene/toxicity ; Antioxidants/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Biomarkers, Tumor/metabolism ; Lung/metabolism ; Bicyclic Monoterpenes
    Chemical Substances Cytokines ; Benzo(a)pyrene (3417WMA06D) ; myrtenol (S1B8392IQY) ; Antioxidants ; Proliferating Cell Nuclear Antigen ; Biomarkers, Tumor ; Bicyclic Monoterpenes
    Language English
    Publishing date 2023-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Logistic regression analysis of risk factors for pediatric burns: a case-control study in underdeveloped minority areas in China.

    Lin, Ziren / Iyappan, Petchi / Huang, Zhiqun / Sooranna, Suren Rao / Wu, Yongfang / Lan, Liuting / Huang, Cheng / Liang, Feiteng / Zhao, Daji / Huang, Dingjin

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1365492

    Abstract: Background: Pediatric burns are common, especially in underdeveloped countries, and these can physically affect the children involved and have an impact on their mental health. The aim of the present study was to assess the effect of pediatric burns in ... ...

    Abstract Background: Pediatric burns are common, especially in underdeveloped countries, and these can physically affect the children involved and have an impact on their mental health. The aim of the present study was to assess the effect of pediatric burns in underdeveloped minority areas of China.
    Methods: Case information from 192 children was collected from outpatient and inpatient clinics using a survey questionnaire. These included 90 pediatric burn cases and 102 controls who were children without burns. A stepwise logistic regression analysis was used to determine the risk factors for pediatric burns in order to establish a model. The goodness-of-fit for the model was assessed using the Hosmer and Lemeshow test as well as receiver operating characteristic and internal calibration curves. A nomogram was then used to analyze the contribution of each influencing factor to the pediatric burns model.
    Results: Seven variables, including gender, age, ethnic minority, the household register, mother's employment status, mother's education and number of children, were analyzed for both groups of children. Of these, age, ethnic minority, mother's employment status and number of children in a household were found to be related to the occurrence of pediatric burns using univariate logistic regression analysis (
    Conclusions: This study showed that there are several risk factors strongly correlated to pediatric burns, including age, ethnic minority, the number of children in a household and mother's employment status. Government officials should direct their preventive approach to tackling the problem of pediatric burns by promoting awareness of these findings.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1365492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fucoxanthin induced apoptotic cell death in oral squamous carcinoma (KB) cells.

    Iyappan, Petchi / Bala, M Devi / Sureshkumar, M / Veeraraghavan, Vishnu Priya / Palanisamy, Arulselvan

    Bioinformation

    2021  Volume 17, Issue 1, Page(s) 181–191

    Abstract: Fucoxanthin (Fx) is an active compound commonly found in the many types of seaweed with numerous biological activities. The main goal of this investigation is to explore the effect of Fx against the cell proliferation, apoptotic induction and oxidative ... ...

    Abstract Fucoxanthin (Fx) is an active compound commonly found in the many types of seaweed with numerous biological activities. The main goal of this investigation is to explore the effect of Fx against the cell proliferation, apoptotic induction and oxidative stress in the oral squamous (KB) cell line. Cytotoxicity of Fx was determined by MTT assay. The intracellular ROS production, mitochondrial membrane potential (MMP) and apoptosis induction in KB cells were examined through DCFH-DA, Rhodamine-123 and DAPI, and dual staining techniques. Effect of Fx on the antioxidant enzymes and lipid peroxidation in the KB cells was studied through the standard procedures. Fx treated KB cells showed morphological changes and reduced cell survival, which is exhibited by the cytotoxic activity of 50 µM/ml (IC50) Fx against the KB cells. The Fx treatment considerably induced the apoptotosis cells (EB/AO) and decreased the MMP (Rh-123) in KB cells. Further, it was pointed out that there was an increased lipid peroxidation (LPO) with decreased antioxidants (CAT, SOD and GSH). These results concluded that Fx has the cytotoxic effect against KB cells and has the potential to induce the apoptosis via increased oxidative stress. Hence, the Fx can be a promising agent for the treatment of oral cancer and it may lead to the development of cancer therapeutics.
    Language English
    Publishing date 2021-01-31
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/97320630017181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4).

    Iyappan, Petchi / Bala, M Devi / Sureshkumar, M / Veeraraghavan, Vishnu Priya / Palanisamy, Arulselvan

    Bioinformation

    2021  Volume 17, Issue 1, Page(s) 171–180

    Abstract: The immature lymphoid cells with chromosomal structural and numerical abnormalities cause the acute lymphoblastic leukemia (ALL). This hematologic disorder constitutes about 25% of cancer prognosis among children and adolescents. D-Carvone, a monocyclic ... ...

    Abstract The immature lymphoid cells with chromosomal structural and numerical abnormalities cause the acute lymphoblastic leukemia (ALL). This hematologic disorder constitutes about 25% of cancer prognosis among children and adolescents. D-Carvone, a monocyclic monoterpene obtained from the essential oils extracted from plants is reported to possess the various biological activities. The present study was aimed to investigate the anticancer potential of D-Carvone against the human leukemic Molt-4 cells. The cytotoxicity of DCarvone was analyzed by MTT assay. The level of lipid peroxidation and antioxidants were determined. The intracellular ROS, MMP and apoptosis were demonstrated by fluorescent staining techniques. The MTT assay revealed that the D-Carvone treatment suppressed the viability of Molt-4 cells and the IC
    Language English
    Publishing date 2021-01-31
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/97320630017171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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