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  1. Article ; Online: Thoracoscopic repair for late-presenting congenital diaphragmatic hernia with thoracic kidney in a child.

    Fukuhara, Masahiro / Kaisyakuji, Yushi / Sato, Tomoe / Izaki, Tomoko

    Asian journal of endoscopic surgery

    2023  Volume 16, Issue 3, Page(s) 640–643

    Abstract: Congenital diaphragmatic hernia (CDH) with a hernia sac and thoracic kidney is a very rare congenital anomaly. Recently, the usefulness of endoscopic surgery for CDH has been reported. We herein report a patient who underwent thoracoscopic repair of CDH ... ...

    Abstract Congenital diaphragmatic hernia (CDH) with a hernia sac and thoracic kidney is a very rare congenital anomaly. Recently, the usefulness of endoscopic surgery for CDH has been reported. We herein report a patient who underwent thoracoscopic repair of CDH with a hernia sac and thoracic kidney. A 7-year-old boy was referred to our hospital due to a diagnosis of CDH without clinical symptoms. Computed tomography showed herniation of the intestine into the left thorax and left-sided thoracic kidney. The key points of operation are resection of the hernia sac and identification of the suturable diaphragm under the presence of the thoracic kidney. In the present case, after repositioning the kidney to the subdiaphragmatic area completely, the border of the diaphragmatic rim was clearly visualized. Good visibility allowed resection of the hernia sac without damaging the phrenic nerve and closure of the diaphragmatic defect.
    MeSH term(s) Male ; Humans ; Child ; Hernias, Diaphragmatic, Congenital/complications ; Hernias, Diaphragmatic, Congenital/diagnostic imaging ; Hernias, Diaphragmatic, Congenital/surgery ; Thoracoscopy/methods ; Diaphragm/surgery ; Thorax ; Kidney/surgery
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2503256-2
    ISSN 1758-5910 ; 1758-5902
    ISSN (online) 1758-5910
    ISSN 1758-5902
    DOI 10.1111/ases.13214
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  2. Article ; Online: An infected urachal cyst presenting as repeated cystitis in a child.

    Fukuhara, Masahiro / Uchida, Yasuyuki / Yamaguchi, Yoshiki / Sato, Tomoe / Izaki, Tomoko

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15086

    MeSH term(s) Child ; Cystitis/diagnosis ; Humans ; Urachal Cyst/complications ; Urachal Cyst/diagnosis
    Language English
    Publishing date 2022-03-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15086
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  3. Article ; Online: TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development.

    Kamakura, Sachiko / Hayase, Junya / Kohda, Akira / Iwakiri, Yuko / Chishiki, Kanako / Izaki, Tomoko / Sumimoto, Hideki

    EMBO reports

    2023  Volume 25, Issue 1, Page(s) 144–167

    Abstract: The tight junction (TJ) in epithelial cells is formed by integral membrane proteins and cytoplasmic scaffolding proteins. The former contains the claudin family proteins with four transmembrane segments, while the latter includes Par3, a PDZ domain- ... ...

    Abstract The tight junction (TJ) in epithelial cells is formed by integral membrane proteins and cytoplasmic scaffolding proteins. The former contains the claudin family proteins with four transmembrane segments, while the latter includes Par3, a PDZ domain-containing adaptor that organizes TJ formation. Here we show the single membrane-spanning protein TMEM25 localizes to TJs in epithelial cells and binds to Par3 via a PDZ-mediated interaction with its C-terminal cytoplasmic tail. TJ development during epithelial cell polarization is accelerated by depletion of TMEM25, and delayed by overexpression of TMEM25 but not by that of a C-terminally deleted protein, indicating a regulatory role of TMEM25. TMEM25 associates via its N-terminal extracellular domain with claudin-1 and claudin-2 to suppress their cis- and trans-oligomerizations, both of which participate in TJ strand formation. Furthermore, Par3 attenuates TMEM25-claudin association via binding to TMEM25, implying its ability to affect claudin oligomerization. Thus, the TJ protein TMEM25 appears to negatively regulate claudin assembly in TJ formation, which regulation is modulated by its interaction with Par3.
    MeSH term(s) Tight Junctions/metabolism ; Claudins/genetics ; Claudins/metabolism ; Carrier Proteins/metabolism ; Epithelial Cells ; Claudin-1/genetics ; Claudin-1/metabolism
    Chemical Substances Claudins ; Carrier Proteins ; Claudin-1
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-023-00018-0
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  4. Article ; Online: Long-term cosmetic outcomes of the slit-slide procedure for umbilical hernia repair in children.

    Onishi, Shun / Esumi, Genshiro / Fukuhara, Masahiro / Sato, Tomoe / Izaki, Tomoko / Ieiri, Satoshi / Handa, Noritoshi

    Surgery today

    2023  

    Abstract: Purpose: To assess the long-term cosmetic outcomes of the "slit-slide procedure", designed to provide a more natural appearance for umbilical hernia repair, as perceived by the patients and their parents.: Methods: A total of 149 patients with ... ...

    Abstract Purpose: To assess the long-term cosmetic outcomes of the "slit-slide procedure", designed to provide a more natural appearance for umbilical hernia repair, as perceived by the patients and their parents.
    Methods: A total of 149 patients with umbilical hernia underwent the slit-slide procedure at our hospital. The slit-slide procedure allows for the creation of an umbilicus with a more natural and integrated appearance. The patient satisfaction survey questionnaire was mailed to the families (n = 139), and there were 74 (53.2%) respondents. A questionnaire survey on postoperative appearance was also distributed to pediatric surgeons.
    Results: The median age at the time of operation was 2.5 years (range, 2 months to 14 years) and the average median age at the time of answering the questionnaire was 6.25 years old (range, 2.5-14.8 years). The average median period of observation was 3.2 years (range, 4 months to 8.97 years). Most patients (89.2%) and parents (93.2%) were satisfied with the appearance of the umbilicus. Twenty-seven patients reported improved satisfaction after surgery (36.2%). Surgeons tended to score the elongated-oval shape highly; however, there was no difference in satisfaction among the shapes.
    Conclusion: The slit-slide procedure is not only effective and safe, but it achieves a satisfactory aesthetic outcome.
    Language English
    Publishing date 2023-11-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-023-02760-3
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  5. Article ; Online: Successful management of pyriform sinus cyst and fistula using endoscopic electrocauterization.

    Kawakubo, Naonori / Obata, Satoshi / Yoshimaru, Koichiro / Miyoshi, Kina / Izaki, Tomoko / Tajiri, Tatsuro

    DEN open

    2022  Volume 3, Issue 1, Page(s) e128

    Abstract: Objectives: Pyriform sinus cyst (PSC) and pyriform sinus fistula (PSF) is a rare congenital malformation that arises from the third or fourth branchial structure. In our study, we describe the safety and the utility of endoscopic electrocauterization ... ...

    Abstract Objectives: Pyriform sinus cyst (PSC) and pyriform sinus fistula (PSF) is a rare congenital malformation that arises from the third or fourth branchial structure. In our study, we describe the safety and the utility of endoscopic electrocauterization against PSC/PSF.
    Methods: We retrospectively reviewed the records of patients who underwent endoscopic electrocauterization for PSC/PSF at our hospital. The internal opening of the fistula was identified under general anesthesia using a flexible endoscope (XQ-260 or H-290; Olympus, Tokyo, Japan), and the DualKnifeJ (KD-655L; Olympus) was used to ablate the internal opening.
    Results: We experienced three PSF and three PSC patients. The postoperative course was uneventful in all cases. The patients declared no pain in the neck, and there were no cases showing recurrent nerve paralysis. Five in six cases (83%), the closure of fistula was archived in the first cauterization. One case (16.6%) required repeated cauterization. No recurrence was found during the follow-up period ( median: 1 year) in any cases.
    Conclusions: Owing to its rarity in neonates, the diagnosis and treatment of PSC remains complicated and not clearly described. Complete removal of the fistula and the cyst with or without affected thyroid tissue was previously the most commonly used treatment. From our experience, we believe that endoscopic electrocauterization can be the first choice not only for PSF but also for neonatal PSC. In conclusion, endoscopic electrocauterization is feasible even for neonatal PSC. Further investigations including multicenter analyses are needed.
    Language English
    Publishing date 2022-05-15
    Publishing country Australia
    Document type Journal Article
    ISSN 2692-4609
    ISSN (online) 2692-4609
    DOI 10.1002/deo2.128
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  6. Article: [“FULFILLING LIFE”FOR BOTH FEMALE AND MALE SURGEONS IN THE FUTURE SOCIETY FOR SURGEONS].

    Izaki, Tomoko / Miyata, Junko / Taguchi, Tomoaki

    Nihon Geka Gakkai zasshi

    2018  Volume 117, Issue 6, Page(s) 478–479

    MeSH term(s) Female ; Humans ; Male ; Physicians, Women ; Societies, Medical ; Surgeons ; Workload
    Language Japanese
    Publishing date 2018-09-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 412544-7
    ISSN 1880-1129 ; 0301-4894
    ISSN (online) 1880-1129
    ISSN 0301-4894
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  7. Article ; Online: The experiences of interval appendectomy for inflammatory appendiceal mass.

    Takahashi, Yoshiaki / Obata, Satoshi / Matsuura, Toshiharu / Kawano, Yuki / Yanagi, Yusuke / Yoshimaru, Koichiro / Izaki, Tomoko / Taguchi, Tomoaki

    Pediatrics international : official journal of the Japan Pediatric Society

    2021  Volume 63, Issue 1, Page(s) 88–93

    Abstract: Background: Interval appendectomy (IA) is a common treatment of acute appendicitis (AA) with inflammatory appendiceal mass (IAM). However, the management of patients with IAM is still controversial. The aim of this study was to assess the outcomes in ... ...

    Abstract Background: Interval appendectomy (IA) is a common treatment of acute appendicitis (AA) with inflammatory appendiceal mass (IAM). However, the management of patients with IAM is still controversial. The aim of this study was to assess the outcomes in patients with this condition.
    Methods: We retrospectively evaluated 244 patients with AA for their clinical characteristics and outcomes.
    Results: Forty-three patients had IAM at the first medical examination. The mean age was significantly younger and the C-reactive protein level significantly higher (12.6 vs 3.1 mg/dL) in patients with IAM. Thirty-four patients received IA, and nine received emergency appendectomy (EA). In the IA group, the diameter of the abscess was larger than in the EA group (31.4 vs 16.1 mm). The total length of hospitalization was longer in the IA group than the EA group (20.6 vs 7.0 days), although the operative time was longer in the EA group because of adhesion (101.1 vs 192.1 min). Furthermore, most IA patients received a reduced-port appendectomy (74% vs 11%). Recurrence occurred in approximately 15% of patients awaiting IA. There were no complications in either group.
    Conclusions: Although each treatment approach has its advantages and disadvantages, both IA and EA can be the first option for the treatment of AA with IAM.
    MeSH term(s) Abscess ; Acute Disease ; Appendectomy ; Appendicitis/pathology ; Appendicitis/surgery ; Emergency Treatment ; Humans ; Retrospective Studies
    Language English
    Publishing date 2021-01-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.14358
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  8. Article ; Online: Testicular ascent after laparoscopic percutaneous extraperitoneal closure for inguinal hernias.

    Shono, Takeshi / Izaki, Tomoko / Nakahori, Ryouichi / Yoshimaru, Koichirou

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

    2015  Volume 25, Issue 1, Page(s) 105–108

    Abstract: Aim: Laparoscopic percutaneous extraperitoneal closure (LPEC) has been widely performed for the repair of pediatric inguinal hernias in Japan. This study aimed to evaluate the testicular ascent and orchiopexy after LPEC in males with inguinal hernias.!## ...

    Abstract Aim: Laparoscopic percutaneous extraperitoneal closure (LPEC) has been widely performed for the repair of pediatric inguinal hernias in Japan. This study aimed to evaluate the testicular ascent and orchiopexy after LPEC in males with inguinal hernias.
    Methods: The medical records of male patients who underwent LPEC procedures for the repair of an inguinal hernia from January 2010 to December 2013 at our institution were reviewed. The patients who underwent orchiopexy after the LPEC procedure were investigated, the characteristics studied were the birth weight of the patients, the age when they underwent LPEC, the mean time from LPEC to orchiopexy, and the location of the affected testes. The LPEC procedure was performed by extraperitoneal circuit suturing around the internal inguinal ring with a long straight special needle (Lapaherclosure; Hakko Medical Co., Tokyo, Japan).
    Results: During the 4-year period of this study, 438 LPECs were performed on 367 male patients. Orchiopexy was performed on 14 testes (3.2%) in 10 patients who had previously undergone LPEC. Five of the 10 patients were extremely low-birth-weight infants. The mean time from LPEC to orchiopexy was 13.2 months. In 7 of these 10 patients, both testes were initially identified in the scrotum at 3 months after LPECs, but they later showed ascending or retractile testes. In another three patients, the ipsilateral testes were elevated early after LPECs, and they were thought to be missed congenital undescended testes. At orchiopexy, 10 of the 14 testes were located in the inguinal region, and the other four testes were retractile. During the orchiopexy, the remaining processus vaginalis was found to adhere to the spermatic cord in all of the patients with ascending testes.
    Conclusion: The postoperative testicular ascent should be carefully examined after the LPEC procedure in patients with pediatric inguinal hernias, especially in extremely low-birth-weight infants.
    MeSH term(s) Child ; Child, Preschool ; Follow-Up Studies ; Hernia, Inguinal/surgery ; Herniorrhaphy/methods ; Humans ; Infant ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Laparoscopy/methods ; Male ; Orchiopexy ; Peritoneum/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Testicular Diseases/etiology ; Testicular Diseases/surgery ; Treatment Outcome
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 1065043-x
    ISSN 1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
    ISSN (online) 1439-359X
    ISSN 0939-7248 ; 0939-6764 ; 0930-7249
    DOI 10.1055/s-0034-1387938
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    Zs.A 3140: Show issues Location:
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  9. Article ; Online: The outcome of real-time evaluation of biliary flow using near-infrared fluorescence cholangiography with Indocyanine green in biliary atresia surgery.

    Yanagi, Yusuke / Yoshimaru, Koichiro / Matsuura, Toshiharu / Shibui, Yuichi / Kohashi, Kenichi / Takahashi, Yoshiaki / Obata, Satoshi / Sozaki, Ryota / Izaki, Tomoko / Taguchi, Tomoaki

    Journal of pediatric surgery

    2019  Volume 54, Issue 12, Page(s) 2574–2578

    Abstract: Background: Indocyanine green (ICG) fluorescence imaging is a promising tool for intraoperative decision-making. The aim of this study was to evaluate the utility of near-infrared fluorescence cholangiography (NIR-FCG) with ICG in primary surgery for ... ...

    Abstract Background: Indocyanine green (ICG) fluorescence imaging is a promising tool for intraoperative decision-making. The aim of this study was to evaluate the utility of near-infrared fluorescence cholangiography (NIR-FCG) with ICG in primary surgery for biliary atresia (BA).
    Methods: We performed NIR-FCG with ICG in 10 BA patients and observed the fluorescence of their hilar micro-bile ducts and hilar exudate in order to assess the appropriate level at which to dissect the hilar fibrous corn. We compared the jaundice outcome of 10 patients using NIR-FCG (Group A) to that of 35 historical patients in whom NIR-FCG had not been used (Group B).
    Results: The mean age of patients was 74.8 days. The classification of BA was type I in two cases and type-III in eight cases. NIR-FCG visualized the hilar micro-bile ducts, and the incidence of positive fluorescence was 80%. The ratio of postoperative normalization of hyperbilirubinemia in Group A was significantly higher than that in Group B (1.0 vs. 0.65, p < 0.05).
    Conclusion: NIR-FCG provided important objectifiable information about the biliary structures in surgery of BA. Although the number of cases was small, our results suggest that NIR-FCG may be useful for improving the outcome of primary surgery for BA.
    Type of study: Study of Diagnostic Test.
    Level of evidence: Level III.
    MeSH term(s) Bile Ducts/diagnostic imaging ; Bile Ducts/surgery ; Biliary Atresia/diagnostic imaging ; Biliary Atresia/surgery ; Cholangiography/methods ; Female ; Humans ; Indocyanine Green/therapeutic use ; Infant ; Male ; Optical Imaging/methods ; Retrospective Studies ; Spectroscopy, Near-Infrared/methods ; Surgery, Computer-Assisted/methods
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2019-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2019.08.029
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  10. Article ; Online: Feasibility of Laparoscopic Fundoplication Without Removing the Preceding Gastrostomy in Severely Neurologically Impaired Patients: A Multicenter Evaluation of the Traction Technique.

    Muto, Mitsuru / Murakami, Masakazu / Masuya, Ryuta / Fukuhara, Masahiro / Shibui, Yuichi / Nishida, Nanako / Kedoin, Chihiro / Nagano, Ayaka / Sugita, Koshiro / Yano, Keisuke / Onishi, Shun / Harumatsu, Toshio / Yamada, Koji / Yamada, Waka / Kawano, Takafumi / Matsukubo, Makoto / Izaki, Tomoko / Nakame, Kazuhiko / Kaj, Tatsuru /
    Hirose, Ryuichiro / Nanashima, Atsushi / Ieiri, Satoshi

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 33, Issue 5, Page(s) 518–521

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Female ; Humans ; Gastrostomy/methods ; Fundoplication/methods ; Gastroesophageal Reflux/surgery ; Retrospective Studies ; Feasibility Studies ; Traction ; Stomach/surgery ; Laparoscopy/methods
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2022.0576
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