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Article: Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey.

Ogasawara, Naotaka / Funaki, Yasushi / Kasugai, Kunio / Ebi, Masahide / Tamura, Yasuhiro / Izawa, Shinya / Sasaki, Makoto

Journal of neurogastroenterology and motility

2021 Volume 28, Issue 2, Page(s) 291–302

Abstract: Background/aims: Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan.: Methods: This internet-based survey ...

Abstract	Background/aims: Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. Methods: This internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment were also evaluated. Results: Among 10 000 survey responses received, functional constipation (Rome IV diagnostic criteria) was reported by 439 participants; chronic constipation (Japanese guidelines) by 3804 participants; and subjective constipation symptoms by 2563 participants. The number of participants with constipation/GERD overlap ranged from 73 to 1533 depending on the criteria used. Regardless of the definition used, all GERD groups had significantly higher odds of being constipated than non-GERD participants: the OR (95% CI) for all 9 combinations of definitions ranged between 1.56 (1.21, 2.01) and 2.67 (2.44, 2.92) (all Conclusion: Individuals with constipation/GERD overlap tend to have worsened symptoms and quality of life.
Language	English
Publishing date	2021-11-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2573719-3
ISSN	2093-0887 ; 2093-0879
ISSN (online)	2093-0887
ISSN	2093-0879
DOI	10.5056/jnm21065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Small-Intestinal Metastasis from Lung Carcinoma.

Ogasawara, Naotaka / Ono, Satoshi / Sugiyama, Tomoya / Adachi, Kazunori / Yamaguchi, Yoshiharu / Izawa, Shinya / Ebi, Masahide / Funaki, Yasushi / Sasaki, Makoto / Kasugai, Kunio

Case reports in gastroenterology

2022 Volume 16, Issue 1, Page(s) 195–200

Abstract: A 62-year-old man was referred to our hospital because of abdominal pain. Computed tomography revealed an approximately 7-cm-diameter tumor in the left abdomen with metastatic lymph nodes, an approximately 1-cm-diameter round tumor in contact with the ... ...

Abstract	A 62-year-old man was referred to our hospital because of abdominal pain. Computed tomography revealed an approximately 7-cm-diameter tumor in the left abdomen with metastatic lymph nodes, an approximately 1-cm-diameter round tumor in contact with the subclavian artery in the apical lobe of the right lung, and mediastinal lymph node enlargement in contact with the superior vena cava. Esophagogastroduodenoscopy and colonoscopy revealed no abnormalities. Double-balloon endoscopy revealed a whole circumferential ulcer in the jejunum approximately 20 cm from the ligament of Treitz. Biopsy analysis of an ulcer specimen revealed a poorly differentiated carcinoma. Immunohistochemical staining of the specimen showed that it was positive for thyroid transcription factor 1 and cytokeratin 7 and negative for cytokeratin 20, GATA-binding protein 3, caudal-type homeobox protein 2, and paired box 8. Positron emission tomography revealed positive findings in the small-intestinal tumor, nearby mesenteric lymph nodes, lymph nodes around the abdominal aorta, lung tumor, and mediastinal lymph node in the apical lobe of the right lung. Accordingly, the patient was diagnosed as having a lung carcinoma with small-intestinal metastasis (T1b, N3, M1c; cStage IVB). Pathological examination helped distinguish the primary small-intestinal tumor from the metastatic small-intestinal tumor and detect the tumor origin.
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000523663
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Article ; Online: A case of ulcerative colitis-related postoperative enteritis treated with granulocyte and monocyte apheresis.

Adachi, Kazunori / Sugiyama, Tomoya / Yamaguchi, Yoshiharu / Tamura, Yasuhiro / Izawa, Shinya / Ebi, Masahide / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Kasugai, Kunio

Clinical journal of gastroenterology

2022 Volume 16, Issue 1, Page(s) 43–47

Abstract: A 46-year-old man, receiving continuous steroid therapy for refractory ulcerative colitis with an insufficient response to anti-tumor necrosis factor-α therapy, presented with left buttock pain. He was diagnosed with steroidal left femoral head necrosis, ...

Abstract	A 46-year-old man, receiving continuous steroid therapy for refractory ulcerative colitis with an insufficient response to anti-tumor necrosis factor-α therapy, presented with left buttock pain. He was diagnosed with steroidal left femoral head necrosis, and total proctocolectomy with permanent ileostomy was performed. At 6 months postoperatively, the patient developed general fatigue, abdominal pain, and severe ileostomy diarrhea. Computed tomography revealed continuous intestinal edema from the descending duodenal leg to the upper jejunum. Gastrointestinal endoscopy revealed deep ulcers, coarse mucosa, and duodenal erosion. Based on clinical progress, findings, and pathology, the patient was diagnosed with ulcerative colitis-related postoperative enteritis. Although 5-aminosalicylic acid treatment was initiated, his symptoms persisted, bloody diarrhea from colostomy was observed. Subsequently, granulocyte and monocyte apheresis treatment was added. Symptoms and endoscopic findings improved with granulocyte and monocyte apheresis. Azathioprine was introduced as maintenance therapy, and no sign of recurrence was observed. Although ulcerative colitis-related postoperative enteritis has no definitive treatment, granulocyte and monocyte apheresis may be considered for initial treatment.
MeSH term(s)	Male ; Humans ; Middle Aged ; Colitis, Ulcerative/diagnosis ; Monocytes/pathology ; Leukapheresis/methods ; Treatment Outcome ; Blood Component Removal ; Enteritis ; Steroids ; Granulocytes/pathology
Chemical Substances	Steroids
Language	English
Publishing date	2022-10-10
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-022-01716-3
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Article ; Online: A Vonoprazan, Clarithromycin, and Metronidazole Regimen as Helicobacter pylori Eradication Therapy for Patients with Penicillin Allergy in Light of Clarithromycin Resistance.

Adachi, Kazunori / Kato, Shunsuke / Koshino, Akira / Nagao, Kazuhiro / Sugiyama, Tomoya / Yoshimine, Takashi / Yamaguchi, Yoshiharu / Izawa, Shinya / Ohashi, Wataru / Ebi, Masahide / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Kasugai, Kunio

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 16, Page(s) 2301–2306

Abstract: Objective Vonoprazan (VPZ), clarithromycin (CAM), metronidazole (MNZ) and VPZ, MNZ, and sitafloxacin (STFX) regimen are all established Helicobacter pylori eradication therapies for patients with penicillin allergy in Japan. However, no study has ... ...

Abstract	Objective Vonoprazan (VPZ), clarithromycin (CAM), metronidazole (MNZ) and VPZ, MNZ, and sitafloxacin (STFX) regimen are all established Helicobacter pylori eradication therapies for patients with penicillin allergy in Japan. However, no study has assessed the efficacy of a VPZ, CAM, and MNZ (VCM) regimen in patients with clarithromycin resistance (CAM-R). We therefore assessed the efficacy of a VCM regimen for treating H. pylori infection in patients with CAM-R and penicillin allergy. Methods Fifty-three patients with penicillin allergy who received H. pylori eradication therapy were retrospectively analyzed. Eight patients received a 7-day proton-pump inhibitor, CAM, and MNZ (PCM) regimen; 35 patients [11 CAM-R, and 10 with clarithromycin sensitivity (CAM-S)] received 7-day VCM regimens; and 10 patients received 7-day VPZ, MNZ, and STFX (VMS) regimens. A
MeSH term(s)	Humans ; Clarithromycin/therapeutic use ; Metronidazole/therapeutic use ; Helicobacter pylori ; Anti-Bacterial Agents/adverse effects ; Retrospective Studies ; Drug Therapy, Combination ; Helicobacter Infections/drug therapy ; Penicillins/therapeutic use ; Proton Pump Inhibitors/adverse effects ; Hypersensitivity/drug therapy ; Amoxicillin/therapeutic use ; Treatment Outcome
Chemical Substances	Clarithromycin (H1250JIK0A) ; Metronidazole (140QMO216E) ; Anti-Bacterial Agents ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Penicillins ; Proton Pump Inhibitors ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2023-01-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0789-22
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Article: Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japan.

Ogasawara, Naotaka / Kasugai, Kunio / Funaki, Yasushi / Ebi, Masahide / Izawa, Shinya / Tamura, Yasuhiro / Kato, Aya / Yamaguchi, Yoshiharu / Adachi, Kazunori / Sugiyama, Tomoya / Sasaki, Makoto

Journal of clinical biochemistry and nutrition

2023 Volume 73, Issue 1, Page(s) 84–90

Abstract: Detailed evaluations of body mass index (BMI) and stool form based on the Bristol Stool Form Scale (BSFS) in individuals with constipation, gastroesophageal reflux disease (GERD), and concomitant constipation and GERD have not been performed in Japan. ... ...

Abstract	Detailed evaluations of body mass index (BMI) and stool form based on the Bristol Stool Form Scale (BSFS) in individuals with constipation, gastroesophageal reflux disease (GERD), and concomitant constipation and GERD have not been performed in Japan. This study was an internet survey conducted to examine the relationships between BMI and constipation, GERD, stool forms based on the BSFS, and education level. This internet-based survey recruited participants from general public survey panels. 10,000 individuals meeting the eligibility criteria were enrolled. Questions included demographics, medical data, and assessments based on validated measures for constipation and GERD. BMI was significantly lower in males with versus without constipation. BMI was significantly higher with GERD both males and females. Mean BMI increased from the BSFS-1/2 group through the BSFS-3/4/5 to the BSFS-6/7 groups in both sexes. BMI was highest in individuals with a maximum education level of junior high school and second highest in individuals completing high school. This is the first real-world survey that closely examines the relationship between BMI and stool forms of individuals in Japan. When the BMI increased, stool forms varied from hard to watery in Japanese people. BMI was related with education level in Japan. (Trial registration: UMIN000039688).
Language	English
Publishing date	2023-05-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.22-143
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Article ; Online: Urgent colonoscopy is not necessary in case of colonic diverticular bleeding without extravasation on contrast-enhanced computed tomography.

Sugiyama, Tomoya / Kojima, Yuki / Hirata, Yoshikazu / Ebi, Masahide / Yoshimine, Takashi / Adachi, Kazunori / Yamaguchi, Yoshiharu / Izawa, Shinya / Hijikata, Yasutaka / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Ohashi, Wataru / Sobue, Satoshi / Kasugai, Kunio

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2023 Volume 25, Issue 1, Page(s) 22–27

Abstract: Background and aims: Acute lower gastrointestinal bleeding (ALGIB) increase with age and the administration of antiplatelet drugs. Colonic diverticular bleeding (CDB) is the most common cause of ALGIB, and endoscopic hemostasis is an effective treatment ...

Abstract	Background and aims: Acute lower gastrointestinal bleeding (ALGIB) increase with age and the administration of antiplatelet drugs. Colonic diverticular bleeding (CDB) is the most common cause of ALGIB, and endoscopic hemostasis is an effective treatment for massive CDB. But in patients without extravasation on contrast-enhanced computed tomography (CECT), the efficacy of urgent colonoscopy (UCS) is controversial from the point of the clinical course, including rebleeding rate. We aimed to establish a potential strategy including UCS for CDB patients without extravasation on CECT. Patients and methods: Patients from two centers treated for CDB without extravasation on CECT between July 2014 and July 2019 were retrospectively identified (n = 282). Seventy-four underwent UCS, and 208 received conservative management. We conducted two analyses. The first analysis investigates the risk factors of rebleeding rate within 5 days after administration (very early rebleeding), and no UCS (NUCS) was not the independent factor of the very early rebleeding. The second analysis is whether UCS positively influenced the clinical course after hospitalization. Results: The prevalence of very early rebleeding and early rebleeding (6-30 days from admission), patients requiring blood transfusion within 0-5 days and 6-30 days post-admission, and duration of hospitalization were examined as clinical course factors between UCS and NUCS group. There was no significant difference between the UCS and non-UCS groups in the clinical course factors. UCS for the CDB patients without extravasation was not improved rebleeding rate and clinical course. Conclusions: UCS is not necessary in case ofCDB patient without extravasation on CECT.
MeSH term(s)	Humans ; Retrospective Studies ; Colonoscopy/methods ; Tomography, X-Ray Computed/methods ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Diverticular Diseases/complications ; Disease Progression ; Diverticulum, Colon/complications ; Diverticulum, Colon/diagnostic imaging
Language	English
Publishing date	2023-11-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2023.11.003
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Article: Gastric Plexiform Fibromyxoma Resected Using Nonexposed Endoscopic Wall-Inversion Surgery: A Case Report.

Ebi, Masahide / Nagao, Kazuhiro / Sugiyama, Tomoya / Yamamoto, Kazuhiro / Saito, Takuya / Kurahashi, Shintaro / Yamaguchi, Yoshiharu / Adachi, Kazunori / Tamura, Yasuhiro / Izawa, Shinya / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Tsuzuki, Toyonori / Kasugai, Kunio

Case reports in gastroenterology

2022 Volume 16, Issue 1, Page(s) 159–164

Abstract: Gastric plexiform fibromyxoma is extremely rare. In our case, upper gastrointestinal endoscopy of a 41-year-old woman patient revealed a 1-cm submucosal tumor (SMT) in the greater curvature of the lower body of the stomach. On contrast-enhanced computed ... ...

Abstract	Gastric plexiform fibromyxoma is extremely rare. In our case, upper gastrointestinal endoscopy of a 41-year-old woman patient revealed a 1-cm submucosal tumor (SMT) in the greater curvature of the lower body of the stomach. On contrast-enhanced computed tomography, the tumor was hypervascular in the arterial phase with continuous enhancement in the post-venous phase. On endoscopic ultrasonography, it had a low echo pattern. The preoperative diagnosis was a gastric SMT with a rich vasculature; however because the biosy specimen did not contain tumor tissue, a malignant tumor could not be excluded. The patient underwent nonexposed endoscopic wall-inversion surgery (NEWS), and the tumor was completely resected. Immunohistochemical examination revealed that the tumor was positive for D2-40 and α-smooth muscle actin, but negative for c-kit, discovered on gastrointestinal stromal tumor-1, desmin, S100, Melan-A, signal transducer and activator of transcription 6, insulinoma-associated protein 1, CXCL13, ETS transcription factor, follicular dendritic cell, anaplastic lymphoma kinase, human melanoma black, h-caldesmon, and CD1a, 10, 21, 23, 31, 34, 68, and 163. Approximately, 1-2% of the tumor cell nuclei were Ki-67-positive. Finally, we diagnosed the tumor as a plexiform fibromyxoma. In conclusion, NEWS is an effective method for the treatment of SMTs with a diameter of <3 cm.
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000522411
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Article ; Online: A case report of olmesartan-associated sprue-like enteropathy: Diagnosis and healing confirmed by capsule endoscopy.

Yamaguchi, Yoshiharu / Miwa, Takahiro / Murakami, Ryo / Sugimura, Akane / Yamamoto, Kazuhiro / Sugiyama, Tomoya / Tamura, Yasuhiro / Izawa, Shinya / Ebi, Masahide / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Kasugai, Kunio

DEN open

2022 Volume 3, Issue 1, Page(s) e142

Abstract: Herein, we describe a case of olmesartan-related sprue-like enteropathy in which improvement in villous atrophy was confirmed by small-bowel capsule endoscopy (CE). We successfully treated a 66-year-old man with a chief complaint of loose diarrhea. The ... ...

Abstract	Herein, we describe a case of olmesartan-related sprue-like enteropathy in which improvement in villous atrophy was confirmed by small-bowel capsule endoscopy (CE). We successfully treated a 66-year-old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea 10 times a day and experienced a weight loss of 9 kg in 3 months. An abdominal computed tomography scan showed fluid retention in the small intestine. Blood test results revealed no inflammatory reaction. Esophagogastroduodenoscopy detected villous atrophy in the stomach and duodenum. Moreover, small-bowel CE showed villous atrophy in about two-thirds of the small intestine. Based on other examinations, hyperthyroidism, intestinal tuberculosis, intestinal amyloidosis, and intestinal malignant lymphoma were ruled out. Therefore, the patient was suspected of having an olmesartan-related sprue-like disease. Early after discontinuation of medication, diarrhea symptoms improved, and a repeat CE indicated improvements in small intestinal villous atrophy. Since the patient had been administered olmesartan for a long time and CE showed villous atrophy throughout the small bowel, we suspected him of having the olmesartan-associated sprue-like disease. The findings of gastric mucosa atrophy on esophagogastroduodenoscopy may lead to an early diagnosis of this disease. Olmesartan-related sprue-like enteropathy should be considered as a differential diagnosis in patients with chronic severe watery diarrhea.
Language	English
Publishing date	2022-06-18
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.142
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Article: Background factors involved in the epidemiology of functional constipation in the Japanese population: a cross-sectional study.

Yamamoto, Sayuri / Ohashi, Wataru / Yamaguchi, Yoshiharu / Inamoto, Shunsuke / Koshino, Akira / Sugiyama, Tomoya / Nagao, Kazuhiro / Tamura, Yasuhiro / Izawa, Shinya / Ebi, Masahide / Usami, Jun / Hamano, Koichi / Izumi, Junko / Wakita, Yoshinori / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Maekawa, Masato / Kasugai, Kunio

BioPsychoSocial medicine

2022 Volume 16, Issue 1, Page(s) 8

Abstract: Background: Functional constipation (FC), a functional bowel disorder with symptoms of constipation, has considerable impact on quality of life. As data regarding its prevalence and epidemiology are lacking, this study aimed to evaluate the prevalence, ... ...

Abstract	Background: Functional constipation (FC), a functional bowel disorder with symptoms of constipation, has considerable impact on quality of life. As data regarding its prevalence and epidemiology are lacking, this study aimed to evaluate the prevalence, population composition, lifestyle, quality of life, and clinical characteristics of these individuals by comparing people with and without FC. These parameters were also compared among individuals with strong and weak awareness of constipation. Methods: An internet survey was conducted among 10,000 individuals aged 20-69 years from the general Japanese population; they were registered with an internet survey company. The following data were obtained: age, sex, educational history, occupation, residence, history of other diseases, lifestyle (including smoking/drinking habits using the Japanese Health Practice Index, medication use, symptoms of constipation according to the Rome III criteria, stool types according to the Bristol stool scale, and use of laxatives, including the place of purchase and cost per month or acceptable cost per month. The 8-item Short Form Health Survey Questionnaire was also used; FC was diagnosed based on Rome III criteria. All respondents were classified according to their awareness of constipation (i.e. strong or weak), and their characteristic features were compared. Results: The data of 3000 respondents were evaluated; 262 (8.7%) had FC, which was common among older adults, women, and homemakers. FC was associated with changes in the frequency of bowel movement, sensation of incomplete or scanty evacuation, and the use of manual maneuvers; these are consequential clinical symptoms of FC. These individuals frequently skipped breakfast, had insufficient sleep, had more severe constipation, and had purchased laxatives in pharmacies or online more often than those without FC. A strong awareness of constipation was significantly more prevalent among women and homemakers. A history of anemia and cardiovascular disease was significantly more frequent in the strong awareness group, whereas a history of hypertension was more frequent in the weak awareness group. Conclusions: Appropriate and comprehensive management should be provided for FC, based on the understanding of its characteristic features and considering the symptoms and lifestyle.
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2265705-8
ISSN	1751-0759
ISSN	1751-0759
DOI	10.1186/s13030-022-00237-2
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Article ; Online: Vonoprazan-Based Triple-Therapy Could Improve Efficacy of the Tailored Therapy of Helicobacter pylori Infection.

Shinmura, Tetsuya / Adachi, Kazunori / Yamaguchi, Yoshiharu / Izawa, Shinya / Hijikata, Yasutaka / Ebi, Masahide / Funaki, Yasushi / Ogasawara, Naotaka / Sasaki, Makoto / Kasugai, Kunio

Journal of gastrointestinal and liver diseases : JGLD

2019 Volume 28, Issue 4, Page(s) 389–395

Abstract: Background and aims: The prevalence of clarithromycin resistant bacteria is increasing, and the effectiveness of Helicobacter pylori (H. pylori) triple therapy is gradually decreasing in Japan. Vonoprazan, a potassiumcompetitive acid blocker, has been ... ...

Abstract	Background and aims: The prevalence of clarithromycin resistant bacteria is increasing, and the effectiveness of Helicobacter pylori (H. pylori) triple therapy is gradually decreasing in Japan. Vonoprazan, a potassiumcompetitive acid blocker, has been reported for its effectiveness in eradicating H. pylori. We aimed to evaluate the efficacy of tailored vonoprazan-based triple therapy in patients with H. pylori. This study is the first to compare the efficacy of vonoprazan-based tailored triple therapy to that of vonoprazan-based conventional therapy. Method: This retrospective cohort study evaluated the treatment efficacy in 920 patients. Of these, 541 received conventional and 379 received tailored therapy. Successful eradication was confirmed by a negative 13C-urea breath test 6-8 weeks following completion of H. pylori eradication therapy, and the data were evaluated using the Chi-square test, or Fisher's exact test, as appropriate. Results: The eradication rate of tailored therapy was 90% and 96.3% by intent-to-treat analysis and per protocol analysis, respectively, which was significantly higher than the 85% and 90.2% found for conventional therapy (p < 0.05 and p < 0.001, respectively). Amoxicillin- or clarithromycin-resistant bacteria did not affect treatment outcomes. By univariate and multivariate analysis, both amoxicillin- and clarithromycin-resistant bacteria and conventional therapy were detected as risk factors for eradication failure (odds ratio = 6.267, 95% CI [1.056-119.924], p < 0.05, and odd ratio =3.113, 95% confidence interval [1.688-6.160], p < 0.001, by multivariate analysis). Conclusion: Vonoprazan-based triple therapy could be a more effective treatment for H. pylori infection than conventional therapy when combined with a therapy regimen tailored according to bacterial antibiotic susceptibility.
MeSH term(s)	Aged ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Breath Tests/methods ; Clarithromycin/therapeutic use ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Female ; Helicobacter Infections/drug therapy ; Helicobacter pylori/drug effects ; Humans ; Male ; Microbial Sensitivity Tests/methods ; Middle Aged ; Proton Pump Inhibitors/therapeutic use ; Pyrroles/therapeutic use ; Retrospective Studies ; Sulfonamides/therapeutic use ; Treatment Outcome
Chemical Substances	1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Anti-Bacterial Agents ; Proton Pump Inhibitors ; Pyrroles ; Sulfonamides ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2019-12-09
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2427021-0
ISSN	1842-1121 ; 1841-8724
ISSN (online)	1842-1121
ISSN	1841-8724
DOI	10.15403/jgld-222
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