Artikel: INFUSION OF CONVALESCENT PLASMA IS ASSOCIATED WITH CLINICAL IMPROVEMENT IN CRITICALLY ILL PATIENTS WITH COVID-19: A PILOT STUDY.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
2020 Band 72, Heft 3, Seite(n) 159–164
Abstract: Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed.: Objective: The objective of the study was to study the safety and outcomes of the administration ...
| Abstract | Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed. Objective: The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center. Methods: Ten patients were prospectively treated with plasma from COVID-19 convalescent donors. Results: Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO Conclusions: Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function. |
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| Mesh-Begriff(e) | Adult ; Aged ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; Biomarkers ; Body Temperature ; C-Reactive Protein/analysis ; COVID-19 ; Combined Modality Therapy ; Convalescence ; Coronavirus Infections/blood ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Coronavirus Infections/therapy ; Female ; Ferritins/blood ; Humans ; Immunization, Passive ; Kaplan-Meier Estimate ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pilot Projects ; Plasma ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/therapy ; Prospective Studies ; Respiration, Artificial ; SARS-CoV-2 ; Severity of Illness Index ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult |
| Chemische Substanzen | Antibodies, Viral ; Biomarkers ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) |
| Schlagwörter | covid19 |
| Sprache | Englisch |
| Erscheinungsdatum | 2020-06-25 |
| Erscheinungsland | Mexico |
| Dokumenttyp | Clinical Trial ; Journal Article |
| ZDB-ID | 138348-6 |
| ISSN | 0034-8376 |
| ISSN | 0034-8376 |
| DOI | 10.24875/RIC.20000237 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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