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  1. Article ; Online: Heat Shock Proteins Support Refolding and Shredding of Misfolded Proteins.

    Izumi, Masanori

    Plant physiology

    2019  Volume 180, Issue 4, Page(s) 1777–1778

    MeSH term(s) HSP70 Heat-Shock Proteins ; Heat-Shock Proteins ; Proteasome Endopeptidase Complex ; Protein Aggregates
    Chemical Substances HSP70 Heat-Shock Proteins ; Heat-Shock Proteins ; Protein Aggregates ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2019-07-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.19.00711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mitochondrial Dynamics for Pollen Development.

    Izumi, Masanori

    Plant physiology

    2019  Volume 180, Issue 2, Page(s) 686–687

    MeSH term(s) Imaging, Three-Dimensional ; Mitochondria ; Mitochondrial Dynamics ; Pollen
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.19.00335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How To Identify Autophagy Modulators.

    Izumi, Masanori

    Plant physiology

    2019  Volume 181, Issue 3, Page(s) 853–854

    MeSH term(s) Autophagy
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.19.01146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Roles of the Clock in Controlling Starch Metabolism.

    Izumi, Masanori

    Plant physiology

    2019  Volume 179, Issue 4, Page(s) 1441–1443

    MeSH term(s) Arabidopsis ; Carbohydrate Metabolism ; Carbon Dioxide ; Circadian Clocks ; Starch
    Chemical Substances Carbon Dioxide (142M471B3J) ; Starch (9005-25-8)
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.19.00166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Discovery of Mitochondrial Endonucleases.

    Izumi, Masanori

    Plant physiology

    2018  Volume 178, Issue 4, Page(s) 1428–1429

    MeSH term(s) DNA, Mitochondrial ; Down-Regulation ; Endonucleases/genetics ; Mitochondria/genetics ; Pollen
    Chemical Substances DNA, Mitochondrial ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.18.01197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification.

    Soma, Kaori / Watanabe, Kengo / Izumi, Masanori

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19852

    Abstract: Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tissue-nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous ... ...

    Abstract Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tissue-nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate (PPi). This study evaluated the anticalcification effects of DS-1211, an orally administered, potent, and highly selective small molecule TNAP inhibitor, in mouse models of PXE. Calcium content in vibrissae was measured in KK/HlJ and ABCC6
    MeSH term(s) Mice ; Animals ; Pseudoxanthoma Elasticum/drug therapy ; Pseudoxanthoma Elasticum/genetics ; Alkaline Phosphatase/metabolism ; Disease Models, Animal ; Phenotype ; Calcinosis/drug therapy ; Calcinosis/metabolism ; Multidrug Resistance-Associated Proteins/genetics
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1) ; Abcc6 protein, mouse ; Multidrug Resistance-Associated Proteins
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23892-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants.

    Kusano, Shuhei / Nakamura, Sakuya / Izumi, Masanori / Hagihara, Shinya

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 11, Page(s) 1685–1688

    Abstract: Here, we report the installation of 1,8-naphthalimide dyes in live cell imaging of plants. We developed a series of 1,8-naphthalimide-based probes that illuminate different subcellular compartments by altering their spectral characteristics. Simple ... ...

    Abstract Here, we report the installation of 1,8-naphthalimide dyes in live cell imaging of plants. We developed a series of 1,8-naphthalimide-based probes that illuminate different subcellular compartments by altering their spectral characteristics. Simple infiltration of the probes into leaves rapidly visualized the structure of chloroplasts or the vacuole. We further demonstrated that these probes are applicable to monitor the organelle behaviors in an autophagy pathway.
    MeSH term(s) Naphthalimides
    Chemical Substances Naphthalimides
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc05798g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants

    Kusano, Shuhei / Nakamura, Sakuya / Izumi, Masanori / Hagihara, Shinya

    Chemical communications. 2022 Feb. 3, v. 58, no. 11

    2022  

    Abstract: Here, we report the installation of 1,8-naphthalimide dyes in live cell imaging of plants. We developed a series of 1,8-naphthalimide-based probes that illuminate different subcellular compartments by altering their spectral characteristics. Simple ... ...

    Abstract Here, we report the installation of 1,8-naphthalimide dyes in live cell imaging of plants. We developed a series of 1,8-naphthalimide-based probes that illuminate different subcellular compartments by altering their spectral characteristics. Simple infiltration of the probes into leaves rapidly visualized the structure of chloroplasts or the vacuole. We further demonstrated that these probes are applicable to monitor the organelle behaviors in an autophagy pathway.
    Keywords autophagy ; chloroplasts ; vacuoles
    Language English
    Dates of publication 2022-0203
    Size p. 1685-1688.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc05798g
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Chlorophagy does not require PLANT U-BOX4-mediated ubiquitination.

    Nakamura, Sakuya / Izumi, Masanori

    Plant signaling & behavior

    2020  Volume 16, Issue 3, Page(s) 1861769

    Abstract: Chloroplasts and mitochondria serve as intracellular energy production sites that are powered by the electron transport chain in their membranes. These organelles constantly accumulate damage, as their energetic reactions generate reactive oxygen species. ...

    Abstract Chloroplasts and mitochondria serve as intracellular energy production sites that are powered by the electron transport chain in their membranes. These organelles constantly accumulate damage, as their energetic reactions generate reactive oxygen species. To prevent the accumulation of damaged organelles and perturbation of cellular homeostasis, eukaryotic cells must remove damaged mitochondria and chloroplasts. Autophagy is the main route by which organelles are degraded. A type of mitochondrion-targeted autophagy known as mitophagy removes damaged mitochondria in mammalian cells; dysfunctional mitochondria that lose their membrane potential are marked by protein ubiquitination, becoming targets of selective mitophagy. Studies of the quality control system for chloroplasts in plants revealed the involvement of both autophagy and ubiquitination in the degradation of damaged chloroplasts. We recently assessed the relationship between chloroplast-associated ubiquitination mediated by PLANT U-BOX4 (PUB4) and chloroplast-targeted autophagy (chlorophagy) in the turnover of oxidatively damaged chloroplasts. Multiple assays using an
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Autophagosomes/metabolism ; Chloroplasts/metabolism ; Microautophagy ; Models, Biological ; Mutation/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
    Chemical Substances Arabidopsis Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; PUB4 protein, Arabidopsis (EC 6.3.2.-)
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-2324
    ISSN (online) 1559-2324
    DOI 10.1080/15592324.2020.1861769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557).

    Arai, Yoshikazu / Kiyotsuka, Yohei / Nagamochi, Masatoshi / Oyama, Kazunori / Izumi, Masanori

    Bioorganic & medicinal chemistry

    2022  Volume 64, Page(s) 116763

    Abstract: We report the discovery of a series of novel zwitterionic hPTHR1 antagonists. Optimization of lead compound 2 led to 4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxo-pyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoro-azetidin-3-yl]methylamino] ... ...

    Abstract We report the discovery of a series of novel zwitterionic hPTHR1 antagonists. Optimization of lead compound 2 led to 4-[[1-[4-(2,9-dichloro-5,5-dimethyl-6-oxo-pyrido[2,3-d][1]benzazepin-7-yl)phenyl]-3-fluoro-azetidin-3-yl]methylamino]cyclohexanecarboxylic acid (19e, DS69910557), a compound with excellent potency and selectivity over activity at the human ether-a-go-go-related-gene (hERG) channel. Compound 19e demonstrated in vivo potency to decrease the plasma calcium concentration in rats upon oral administration. 2022 Elsevier Ltd. All rights reserved.
    MeSH term(s) Administration, Oral ; Animals ; Benzazepines/pharmacology ; Humans ; Rats ; Receptor, Parathyroid Hormone, Type 1 ; Structure-Activity Relationship
    Chemical Substances Benzazepines ; Receptor, Parathyroid Hormone, Type 1
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2022.116763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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