Article ; Online: Therapy understanding and health related quality of life in stage III/IV melanoma patients treated with novel adjuvant therapies.
2021 Volume 19, Issue 2, Page(s) 215–221
Abstract: Objective: Our aims were to investigate the motivation for therapy, the understanding and valuation of potential treatment toxicities in melanoma patients offered adjuvant therapies.: Methods: Between September 2018 and September 2019 49 adjuvant ... ...
| Abstract | Objective: Our aims were to investigate the motivation for therapy, the understanding and valuation of potential treatment toxicities in melanoma patients offered adjuvant therapies. Methods: Between September 2018 and September 2019 49 adjuvant patients with stage III and IV melanoma received a self-created, pre-treatment questionnaire. Furthermore, the patients were handed out the REPERES-G, EQ-5D-3L and EORTC QLQ C-30 questionnaires. Results: Eight patients (18.3 %) decided against adjuvant therapy (mean age 71.6 years). Four of these had stage IIIA melanoma. The majority of patients (73.4 %) decided for adjuvant treatment with PD1-inhibitors despite their potential high grade, persistent, irreversible or even fatal toxicities. About a third of patients with BRAF V600 mutated melanoma who decided for therapy chose targeted therapy (31.3 %). These patients were younger (mean age 49 years), still working and had families with children. The REPERES-G questionnaire showed that our patients were generally satisfied with medical care. The average scores in the EQ-5D-3L and EORTC QLQ C-30 questionnaires indicated good subjective general health. Conclusions: Despite the associated toxicities as well as the required time and effort for a one-year treatment the majority of patients decided for adjuvant treatments. |
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| MeSH term(s) | Aged ; Antineoplastic Combined Chemotherapy Protocols ; Child ; Humans ; Melanoma/drug therapy ; Middle Aged ; Quality of Life ; Skin Neoplasms/drug therapy ; Surveys and Questionnaires |
| Language | English |
| Publishing date | 2021-01-25 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2093479-8 |
| ISSN | 1610-0387 ; 1610-0379 |
| ISSN (online) | 1610-0387 |
| ISSN | 1610-0379 |
| DOI | 10.1111/ddg.14317 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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