Article: Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases
Journal of functional foods. 2016 Dec., v. 27
2016
Abstract: β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its ... ...
| Abstract | β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its protective effects when administered in a casein matrix. We also evaluated whether a casein matrix enriched in β-casofensin protects against intestinal enteritis induced by indomethacin. β-Casofensin abolished NMS-induced jejunal hyperpermeability and prevented the depletion of goblet and Paneth cells induced by NMS. In addition, β-casofensin maintained its effectiveness against NMS-induced intestinal barrier alterations when administered in a casein matrix. A casein matrix containing β-casofensin also reduced intestinal damages induced by indomethacin. A functional food containing β-casofensin may prevent both the deleterious effects of neonatal stress on the intestinal barrier and indomethacin-induced enteritis. These results suggest a promising application of β-casofensin as a gut barrier protector in the context of bioactive foods and clinical nutrition. |
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| Keywords | absorption barrier ; casein ; clinical nutrition ; enteritis ; functional foods ; goblet cells ; indomethacin ; jejunum ; models ; oral administration ; protective effect | |||||
| Language | English | |||||
| Dates of publication | 2016-12 | |||||
| Size | p. 223-235. | |||||
| Publishing place | Elsevier Ltd | |||||
| Document type | Article | |||||
| ZDB-ID | 2511964-3 | |||||
| ISSN | 1756-4646 | |||||
| ISSN | 1756-4646 | |||||
| DOI | 10.1016/j.jff.2016.09.007 | |||||
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| Database | NAL-Catalogue (AGRICOLA) |
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