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  1. Article ; Online: Th17 Cells in Viral Infections—Friend or Foe?

    Iury Amancio Paiva / Jéssica Badolato-Corrêa / Débora Familiar-Macedo / Luzia Maria de-Oliveira-Pinto

    Cells, Vol 10, Iss 1159, p

    2021  Volume 1159

    Abstract: Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 cells also play a central role in the induction of autoimmune ... ...

    Abstract Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 cells also play a central role in the induction of autoimmune diseases. Recent advances have evaluated Th17 effector functions during viral infections, including their critical role in the production and induction of pro-inflammatory cytokines and in the recruitment and activation of other immune cells. Thus, Th17 is involved in the induction both of pathogenicity and immunoprotective mechanisms seen in the host’s immune response against viruses. However, certain Th17 cells can also modulate immune responses, since they can secrete immunosuppressive factors, such as IL-10; these cells are called non-pathogenic Th17 cells. Here, we present a brief review of Th17 cells and highlight their involvement in some virus infections. We cover these notions by highlighting the role of Th17 cells in regulating the protective and pathogenic immune response in the context of viral infections. In addition, we will be describing myocarditis and multiple sclerosis as examples of immune diseases triggered by viral infections, in which we will discuss further the roles of Th17 cells in the induction of tissue damage.
    Keywords Il-17 ; Th17 cells ; viruses ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Subsets of Cytokines and Chemokines from DENV-4-Infected Patients Could Regulate the Endothelial Integrity of Cultured Microvascular Endothelial Cells

    Marcio da Costa Cipitelli / Iury Amancio Paiva / Jéssica Badolato-Corrêa / Cíntia Ferreira Marinho / Victor Edgar Fiestas Solórzano / Nieli Rodrigues da Costa Faria / Elzinandes Leal de Azeredo / Luiz José de Souza / Rivaldo Venâncio da Cunha / Luzia Maria de-Oliveira-Pinto

    Pathogens, Vol 11, Iss 509, p

    2022  Volume 509

    Abstract: Introduction: It is a consensus that inflammatory mediators produced by immune cells contribute to changes in endothelial permeability in dengue. We propose to relate inflammatory mediators seen in dengue patients with the in vitro alteration of ... ...

    Abstract Introduction: It is a consensus that inflammatory mediators produced by immune cells contribute to changes in endothelial permeability in dengue. We propose to relate inflammatory mediators seen in dengue patients with the in vitro alteration of endothelial cells (ECs) cultured with serum from these patients. Methods: Patients with mild (DF) to moderate and severe dengue (DFWS/Sev) were selected. ELISA quantified inflammatory mediators. Expression of adhesion molecules and CD147 were evaluated in the ECs cultured with the patient’s serum by flow cytometry. We assessed endothelial permeability by measuring transendothelial electrical resistance in cocultures of ECs with patient serum. Results: Dengue infection led to an increase in inflammatory mediators—the IL-10 distinguished DF from DFWS/Sev. There were no changes in CD31, CD54, and CD106 but decreased CD147 expression in ECs. DFWS/Sev sera induced a greater difference in endothelial permeability than DF sera. Correlation statistical test indicated that low IL-10 and IFN-γ and high CCL5 maintain the integrity of ECs in DF patients. In contrast, increased TNF, IFN-γ, CXCL8, and CCL2 maintain EC integrity in DFWS/Sev patients. Conclusions: Our preliminary data suggest that a subset of inflammatory mediators may be related to the maintenance or loss of endothelial integrity, reflecting the clinical prognosis.
    Keywords dengue ; cytokines ; chemokines ; endothelial cells ; permeability ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The inability of a dengue NS1 ELISA to detect Zika infections

    Monique da Rocha Queiroz Lima / Thais Chouin-Carneiro / Elzinandes Azeredo / Luciana Santos Barbosa / Thiara Manuele Alves Souza / Jéssica Badolato Corrêa da Silva / Priscila Conrado Guerra Nunes / Márcia Dal Fabbro / Izilyanne H. Romanholi Facco / Rivaldo Venâncio-da-Cunha / Flavia Barreto dos Santos

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 7

    Abstract: Abstract The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological ... ...

    Abstract Abstract The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological assays may show a high rate of cross-reactivity. Here, we evaluated a Dengue NS1 capture assay for early and differential diagnosis of dengue during the Zika epidemic occurred in Brazil in 2016. Samples (n = 227) from 218 patients included sera, plasma and urine from previously confirmed acute cases of Zika, dengue and Zika/dengue co-infections. Nine of those patients presented two specimens. The Dengue NS1 test was very specific for dengue diagnosis (99.32%), even in the co-circulation with ZIKV, and exhibited a high accuracy in not detecting acute Zika infections (92.43%). Our findings showed that the dengue NS1 capture test analyzed here was not able to recognize the ZIKV NS1 and its potential for cross-reaction.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The inability of a dengue NS1 ELISA to detect Zika infections.

    Lima, Monique da Rocha Queiroz / Chouin-Carneiro, Thais / Azeredo, Elzinandes / Barbosa, Luciana Santos / Souza, Thiara Manuele Alves / Silva, Jéssica Badolato Corrêa da / Nunes, Priscila Conrado Guerra / Dal Fabbro, Márcia / Facco, Izilyanne H Romanholi / Venâncio-da-Cunha, Rivaldo / Dos Santos, Flavia Barreto

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 18596

    Abstract: The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological assays ... ...

    Abstract The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological assays may show a high rate of cross-reactivity. Here, we evaluated a Dengue NS1 capture assay for early and differential diagnosis of dengue during the Zika epidemic occurred in Brazil in 2016. Samples (n = 227) from 218 patients included sera, plasma and urine from previously confirmed acute cases of Zika, dengue and Zika/dengue co-infections. Nine of those patients presented two specimens. The Dengue NS1 test was very specific for dengue diagnosis (99.32%), even in the co-circulation with ZIKV, and exhibited a high accuracy in not detecting acute Zika infections (92.43%). Our findings showed that the dengue NS1 capture test analyzed here was not able to recognize the ZIKV NS1 and its potential for cross-reaction.
    MeSH term(s) Antibodies, Viral/immunology ; Brazil/epidemiology ; Cross Reactions ; Cross-Sectional Studies ; Dengue/diagnosis ; Dengue/immunology ; Dengue Virus ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Reproducibility of Results ; Sensitivity and Specificity ; Serotyping ; Viral Nonstructural Proteins/analysis ; Viral Nonstructural Proteins/immunology ; Zika Virus ; Zika Virus Infection/diagnosis ; Zika Virus Infection/immunology
    Chemical Substances Antibodies, Viral ; NS1 protein, dengue-1 virus ; Viral Nonstructural Proteins
    Language English
    Publishing date 2019-12-09
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-55160-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV.

    Torrentes-Carvalho, Amanda / Hottz, Eugênio Damaceno / Marinho, Cintia Ferreira / da Silva, Jéssica Badolato-Corrêa / Pinto, Luzia Maria de Oliveira / Fialho, Luciana Gomes / Bozza, Fernando Augusto / Cunha, Rivaldo Venâncio / Damasco, Paulo Vieira / Kubelka, Claire Fernandes / de Azeredo, Elzinandes Leal

    Clinical immunology (Orlando, Fla.)

    2016  Volume 164, Page(s) 95–105

    Abstract: The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients ... ...

    Abstract The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV.
    MeSH term(s) Adult ; Aged ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes/immunology ; Coinfection/blood ; Coinfection/immunology ; Cytokines/blood ; Dengue/blood ; Dengue/immunology ; Female ; HIV Infections/blood ; HIV Infections/immunology ; Humans ; Male ; Middle Aged ; Young Adult
    Chemical Substances Cytokines
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2016.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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