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Book ; Thesis: Auswirkungen der Qualität von Tumordokumentationsdaten auf die Ergebnisse des Follow-Up bei Krebspatienten

Merkel-Jens, Anja / Jöckel, Karl-Heinz

2022

Institution	Universität Duisburg-Essen
Author's details	vorgelegt von Anja Merkel-Jens. Gutachter/in: 1.-Herr Univ.-Prof. Dr. rer. nat. K.-H. Jöckel, 2. Frau Priv.-Doz. Dr. med. T. Trarbach
Language	German
Size	77 Blätter, Diagramme
Publishing place	Duisburg ; Essen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität Duisburg-Essen, 2022
HBZ-ID	HT021473113
Database	Catalogue ZB MED Medicine, Health

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2023 E 506	order for loan	Magazin

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Article ; Online: Age Categories Used Are Too Broad.

Kowall, Bernd / Jöckel, Karl-Heinz / Stang, Andreas

Deutsches Arzteblatt international

2023 Volume 120, Issue 3, Page(s) 40

Language	English
Publishing date	2023-03-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.m2022.0348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: On the gap between objective and perceived risks of COVID-19.

Kowall, Bernd / Jöckel, Karl-Heinz / Standl, Fabian / Stang, Andreas

Herz

2023 Volume 48, Issue 3, Page(s) 239–242

Abstract: A survey conducted by the German Socio-Economic Panel during the early phase of the SARS-CoV‑2 pandemic in spring 2020 showed that the perceived risks of SARS-CoV‑2 infection were a massive overestimation of the actual risks. A total of 5783 people (2.3% ...

Title translation	Zu den Unterschieden zwischen objektiven und wahrgenommenen Risiken von COVID-19.
Abstract	A survey conducted by the German Socio-Economic Panel during the early phase of the SARS-CoV‑2 pandemic in spring 2020 showed that the perceived risks of SARS-CoV‑2 infection were a massive overestimation of the actual risks. A total of 5783 people (2.3% missing data) stated how likely they thought it was that SARS-CoV‑2 would cause a life-threatening illness in them in the next 12 months. The average subjective probability was 26%. We consider how such an overestimation could have occurred and how a more realistic risk assessment could be achieved in the population in a future pandemic. We show that qualitative attributes of the pandemic, the reporting of the media, and psychological features may have contributed to the overestimation of SARS-CoV‑2 risks. In its early stages, the SARS-CoV‑2 pandemic had qualitative characteristics known to lead to an overestimation of risks: The risks associated with the pandemic were new, unfamiliar, perceived as poorly controllable, and were taken involuntarily. Phenomena known from cognitive psychology such as the availability and anchor heuristics can also explain the overestimation of pandemic risks. Characteristics of media coverage such as the focus on individual fates and the associated neglect of the denominator also contributed to the gap between perceived and objective risk. In a potential future pandemic, people need to be vigilant but not in a panic. Better risk communication-for example, with better prepared figures and graphically presented percentages while avoiding the denominator neglect-could help the population to perceive risks of future pandemics more realistically.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Risk Assessment ; Pandemics
Language	English
Publishing date	2023-04-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-023-05184-4
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Zs.A 1270: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 426: Show issues

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Book: Untersuchungen zu Lungenkrebs und Risiken am Arbeitsplatz

Jöckel, Karl-Heinz

(Schlußbericht) ; mit 110 Tabellen

(Schriftenreihe der Bundesanstalt für Arbeitsmedizin : Forschung)

1995

Author's details	[Hrsg.: Bundesanstalt für Arbeitsmedizin]. Karl-Heinz Jöckel
Series title	Schriftenreihe der Bundesanstalt für Arbeitsmedizin : Forschung
Keywords	Occupational Diseases / epidemiology ; Lung Neoplasms / chemically induced ; Smoke / adverse effects ; Vehicle Emissions / adverse effects ; Asbestos / adverse effects ; Lungenkrebs ; Arbeitsplatz ; Gefährlicher Arbeitsstoff ; Exposition
Subject	Arbeitsumgebung ; Lungenkarzinom ; Lunge
Language	German
Size	VI, 268 S. : graph. Darst.
Publisher	Wirtschaftsverl. NW, Verl. für Neue Wiss
Publishing place	Bremerhaven
Document type	Book
HBZ-ID	HT007117534
ISBN	3-89429-985-1 ; 978-3-89429-985-9
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Overestimated Numbers.

Kowall, Bernd / Jöckel, Karl-Heinz / Stang, Andreas

Deutsches Arzteblatt international

2021 Volume 118, Issue 27-28, Page(s) 488–489

Language	English
Publishing date	2021-09-07
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.m2021.0242
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Article ; Online: Health-related complications during follow-up and their impact on blood cancer survivors - results from the 'Aftercare in Blood Cancer Survivors' (ABC) study.

Baum, Julia / Lax, Hildegard / Lehmann, Nils / Merkel-Jens, Anja / Beelen, Dietrich W / Jöckel, Karl-Heinz / Dührsen, Ulrich

Acta haematologica

2024

Abstract: Introduction Blood cancer survivors are at increased risk for medical complications. Methods Our questionnaire-based study involved 1,551 blood cancer survivors with a ≥3-year interval since the last intense treatment. Its goal was to quantify health- ... ...

Abstract	Introduction Blood cancer survivors are at increased risk for medical complications. Methods Our questionnaire-based study involved 1,551 blood cancer survivors with a ≥3-year interval since the last intense treatment. Its goal was to quantify health-related complications during follow-up and assess their impact on the patients' lives. Results 20.4% of responding survivors reported a disease relapse, most often in indolent lymphomas. Second primary malignancies occurred in 14.1%, primarily in lymphoma and allogeneic transplantation survivors. The most frequent malignancy was basal cell carcinoma of the skin, but myeloid malignancies, melanoma, bladder, head-and-neck, and thyroid cancer also appeared disproportionately frequent. An increased infection rate was reported by 43.7%, most often after allogeneic transplantation. New cardiovascular diseases were reported by 30.2%, with a high rate of thromboembolic events in multiple myeloma and myeloproliferative diseases. Polyneuropathies were reported by 39.1%, most often by survivors with a history of multiple myeloma or aggressive lymphoma. Disease relapse was perceived as the highest burden, followed by second primary malignancy, increased infection frequency, and polyneuropathy. In each area investigated, the range of perceived severities was wide. Conclusions Health-related complications are frequent during blood cancer follow-up, with significant repercussions on the patients' lives.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000536155
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Ud II Zs.145: Show issues

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Article ; Online: Heterogeneity of national legislation and practice on clinical trials with vulnerable patients based on the EU Clinical Trials Directive by the example of adults permanently incapable of giving informed consent.

Schweim, Janna K / Nonnemacher, Michael / Jöckel, Karl-Heinz

German medical science : GMS e-journal

2021 Volume 19, Page(s) Doc03

Abstract: In principle, persons wishing to participate in a clinical trial must give informed consent in advance after comprehensive information has been provided. Under certain conditions, it is possible to deviate from this requirement in the European Union (EU) ...

Abstract	In principle, persons wishing to participate in a clinical trial must give informed consent in advance after comprehensive information has been provided. Under certain conditions, it is possible to deviate from this requirement in the European Union (EU) in order to enable the participation of so-called vulnerable persons who are incapable of giving their informed consent. Kuthning et al. [1] have already dealt with general and specific aspects of vulnerable patients and the principle of informed consent in clinical trials. One group of vulnerable persons, for example, are adults temporarily or permanently incapable of giving consent due to their state of health. For a long period of time, no systematic and uniform legal basis for clinical trials existed in the EU as a whole. The Clinical Trials Directive (CTD) [2], adopted in 2001, aimed to change this by harmonizing all legal regulations on clinical trials applicable in the EU, but nevertheless allowing national deviations in implementation into national laws through opening clauses and aspects that were left unregulated. In view of the Clinical Trials Regulation (CTR) [3] which, according to the current status, will with high probability be applied from 2022 on, and which in future will be the legal basis for clinical trials with medicinal products in humans, applied directly in all EU member states, the necessity to take stock of the effects of the CTD was evident. The national deviations with regard to the participation of patients incapable of giving informed consent were investigated qualitatively and quantitatively by means of a systematic analysis of legislation in 16 EU countries and a retrospective database analysis of a European clinical trial registry over a ten-year observation period. Although the analysis initially showed a predominantly homogeneous picture, the differences between the EU member states became apparent in a detailed examination. The database analysis yielded a clear result, since in some countries the majority of clinical trials are carried out. The clearest difference was found between the legal analysis and the results of the evaluated clinical trials concerning adults who are permanently incapable of giving informed consent. A presumed association between the "degree of liberality" of the national law and the frequency of clinical trials conducted in the respective country could not be confirmed. In the past, the selection of countries for conducting a clinical trial was based less on legal requirements and more on experience and financial considerations.
MeSH term(s)	Adult ; European Union ; Humans ; Informed Consent ; Retrospective Studies
Language	English
Publishing date	2021-03-02
Publishing country	Germany
Document type	Journal Article
ISSN	1612-3174
ISSN (online)	1612-3174
DOI	10.3205/000290
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Article: Differences in risk profile associated with varicose veins and chronic venous insufficiency - results from the Bonn Vein Study 1.

Kraus, Anna-Lena / Rabe, Eberhard / Kowall, Bernd / Schuldt, Katrin / Bock, Eva / Stang, Andreas / Jöckel, Karl-Heinz / Pannier, Felizitas

VASA. Zeitschrift fur Gefasskrankheiten

2024 Volume 53, Issue 2, Page(s) 145–154

MeSH term(s)	Male ; Pregnancy ; Humans ; Female ; Cross-Sectional Studies ; Quality of Life ; Varicose Veins/diagnostic imaging ; Varicose Veins/epidemiology ; Venous Insufficiency/diagnostic imaging ; Venous Insufficiency/epidemiology ; Chronic Disease ; Obesity/complications ; Hypertension ; Edema/complications
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	120977-2
ISSN	1664-2872 ; 0301-1526
ISSN (online)	1664-2872
ISSN	0301-1526
DOI	10.1024/0301-1526/a001115
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Zs.A 808: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Synergism between coexisting eye diseases and sex in increasing the prevalence of the dry eye syndrome.

Stang, Andreas / Schmidt, Börge / Schramm, Sara / Kowall, Bernd / Jöckel, Karl-Heinz / Erbel, Raimund / Kuss, Oliver / Geerling, Gerd

Scientific reports

2024 Volume 14, Issue 1, Page(s) 314

Abstract: The aim was to investigate prevalence of dry eye syndrome (DES) in a population-based sample in Germany. The association between coexisting eye diseases and DES was also of interest. We recontacted participants of the Heinz Nixdorf Recall study between ... ...

Abstract	The aim was to investigate prevalence of dry eye syndrome (DES) in a population-based sample in Germany. The association between coexisting eye diseases and DES was also of interest. We recontacted participants of the Heinz Nixdorf Recall study between 2018 and 2021 by postal questionnaire that included the Women's Health Study questionnaire on DES. We estimated prevalence of DES and examined DES-associated factors among 2095 participants aged 62-91 years. We performed interaction analyses between sex and coexisting eye diseases in relation to the DES prevalence and performed bias analyses to examine the robustness of the results. The DES prevalence was 31.5% (34-36% after correction for potential non-response bias, 24.1% after correction for outcome misclassification) and it was almost 2.1-times higher in women than in men (women 42.3%, men 20.4%). Among DES subjects, 70.3% had received treatment in the previous 12 months. There was synergism between female sex and coexisting eye diseases (cataract, glaucoma, macular degeneration) in terms of DES prevalence. The extrapolated numbers of patients aged 62-91 years with DES in Germany are 1.1-1.3 million men and 6.1-6.8 million women. The observed synergism may be explained by differences in ocular physiology, subjective perception and response behavior. Women with eye diseases (cataract, glaucoma, macula degeneration) appear to have a markedly higher susceptibility to suffer from DES than men, so that a diagnostic workup of DES symptoms is particularly justified in women with these eye diseases.
MeSH term(s)	Male ; Humans ; Female ; Prevalence ; Dry Eye Syndromes/epidemiology ; Dry Eye Syndromes/diagnosis ; Glaucoma ; Cataract ; Surveys and Questionnaires ; Macular Degeneration/epidemiology
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50871-1
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Article ; Online: Development and validation of TreatHSP-QoL: a patient-reported outcome measure for health-related quality of life in hereditary spastic paraplegia.

Malina, Jekaterina / Huessler, Eva-Maria / Jöckel, Karl-Heinz / Boog-Whiteside, Eva / Jeschonneck, Nicole / Schröder, Bernadette / Schüle, Rebecca / Kühl, Tobias / Klebe, Stephan

Orphanet journal of rare diseases

2024 Volume 19, Issue 1, Page(s) 2

Abstract: Background: Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disease that lacks specific and validated patient-centered outcome measures (PCOMs). We aimed to develop and validate a health-related quality of life (HRQoL) questionnaire ... ...

Abstract	Background: Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disease that lacks specific and validated patient-centered outcome measures (PCOMs). We aimed to develop and validate a health-related quality of life (HRQoL) questionnaire specific to HSP ("TreatHSP-QoL") that could be used as a PCOM. Results: The pilot-items of the TreatHSP-QoL (45 five-level Likert scale items, with values per item between 0 and 4) were developed based on a qualitative data analysis of 54 semi-structured interviews, conducted in person with 36 HSP patients and 18 caregivers. It was then reduced and modified through the validation process to 25 items. The main validation was performed using the online questionnaire in 242 HSP patients and 56 caregivers. The exploratory factor analysis defined five subdomains. Cronbach's alpha ranged from 0.57 to 0.85 for the subdomains and reached 0.85 for the total score. The test-retest Pearson correlation reached 0.86 (95% Confidence Interval (CI) [0.79, 0.91]). Pearson correlations with the EuroQol-5 Dimension (5 levels) (EQ-5D-5L) and Friedreich Ataxia Rating Scale-Activities of Daily Living (FARS-ADL) questionnaires varied strongly among the subdomains, with the total scores reaching 0.53 (95% CI [0.42, 0.61]) and -0.45 (95% CI [- 0.55, - 0.35]), respectively. The caregiver-patient response Pearson correlation ranged between 0.64 and 0.82 for subdomains and reached 0.65 (95% CI [0.38, 0.81]) for the total score. Conclusions: TreatHSP-QoL can be used in high-quality clinical trials and clinical practice as a disease-specific PCOM (i.e., HRQoL measure) and is also applicable as a proxy questionnaire. Score values between 0 and 100 can be reached, where higher value represents better HRQoL. The Pearson correlations to the EQ-5D-5L and FARS-ADL support the additional value and need of HSP-specific PCOM, while non-specific QoL-assessment and specific clinical self-assessment tools already exist. All in all, the results demonstrate good validity and reliability for this new patient-centered questionnaire for HSP.
MeSH term(s)	Humans ; Quality of Life ; Reproducibility of Results ; Activities of Daily Living ; Neurodegenerative Diseases ; Spastic Paraplegia, Hereditary ; Surveys and Questionnaires ; Patient Reported Outcome Measures ; Psychometrics
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-023-03012-w
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