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  1. AU="Júnior, José Dias Correa"
  2. AU="Hsiao, Ta-Chih"
  3. AU=Barton Michael C
  4. AU=Yang Li-Qin
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  13. AU="Reed, K R"
  14. AU="Gnanapragasam, Vincent J"
  15. AU="Vutova, M"
  16. AU="Conley, Matthew"
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  1. Article: The effects of salinity on growth, gill tissue and muscle cellularity in Lophiosilurus alexandri juvenile, a Neotropical freshwater catfish

    Takata, Rodrigo / Mattioli, Cristiano Campos / Bazzoli, Nilo / Júnior, José Dias Corrêa / Luz, Ronald Kennedy

    Aquaculture research. 2021 Sept., v. 52, no. 9

    2021  

    Abstract: The present study investigated the effects of salinity on growth, mortality, gill morphology and muscle cellularity in Lophiosilurus alexandri. Fish were submitted to the following salinity for 28 days: 0 (S0), 2.5 (S2.5), 5.0 (S5), 7.5 (S7.7) and 10 ( ... ...

    Abstract The present study investigated the effects of salinity on growth, mortality, gill morphology and muscle cellularity in Lophiosilurus alexandri. Fish were submitted to the following salinity for 28 days: 0 (S0), 2.5 (S2.5), 5.0 (S5), 7.5 (S7.7) and 10 (S10) ppt. Growth and protein efficiency ratio (PER) decreased with the increase of salinity. All fish from S10 died between the 16th and 21st day of the experiment. Mortality in S7.5 was 78% at the end of 28 days of salinity exposure. Increased salinity was accompanied by increased vascular congestion, hyperplasia of gill filament epithelium, lamellar fusion and loss of structural integrity of pillar cells. Fish at S2.5 and S5 had higher mucosal cell hyperplasia. Chloride cell quantity was higher in fish in the S2.5 to S7.5. In general, L. alexandri juvenile exposed to treatments of freshwater and S2.5 had similar patterns of muscle cellularity, with high averages for the most of the variables of muscle cellularity evaluated. The large fibre size classes tended to decrease with increasing salinity. L. alexandri juveniles may be cultivated up to 2.5 g of salt/L, and superior concentrations change growth, induce damage to gills and modify muscle cellularity.
    Keywords Lophiosilurus alexandri ; Neotropics ; aquaculture ; catfish ; chlorides ; epithelium ; freshwater ; hyperplasia ; juveniles ; mortality ; muscles ; protein efficiency ratio ; research ; salinity
    Language English
    Dates of publication 2021-09
    Size p. 4064-4075.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1227359-4
    ISSN 1355-557X
    ISSN 1355-557X
    DOI 10.1111/are.15244
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4230: Show issues

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  2. Article: Novel nanostructure obtained from pacaman, Lophiosilurus alexandri, skin mucus presents potential as a bioactive career in fish

    Charlie-Silva, Ives / Conceição, Katia / de Andrade Belo, Marco Antonio / de Melo, Nathalie Ferreira Silva / Fraceto, Leonardo Fernandes / Gomes, Juliana M.M / Junior, Jose Dias Corrêa / Luz, Ronald Kennedy

    Aquaculture. 2019 July 08,

    2019  

    Abstract: Nanoparticles to delivery drugs and immunomodulatory substances in fish have been widely studied by several research groups. In general, these nanoparticles are polymers, ceramic, fullerenes and metal derivates which can be toxic to fish and other ... ...

    Abstract Nanoparticles to delivery drugs and immunomodulatory substances in fish have been widely studied by several research groups. In general, these nanoparticles are polymers, ceramic, fullerenes and metal derivates which can be toxic to fish and other aquatic organisms. We reported for the first time a nanostructured system composed of proteins obtained from pacaman fish (Lophiosilurus alexandri) mucus. We identified and characterized the formation of nanoparticles with 210.8 nm and zeta potential of −13.4 (mV). These characteristics suggest a possible application of this material as a biocompatible coating. These nanoparticles are biodegradable, metabolizable and can be easily manipulated; as well as they can easily undergo surface modification to transport biomolecules, thus exhibiting greater versatility. Our study suggests that these nanoparticles from fish mucus could be used to delivery drugs and to modulate the immune system, since they demonstrated to be biocompatible coating.
    Keywords biodegradability ; ceramics ; coatings ; drugs ; fish ; fullerene ; immune system ; Lophiosilurus alexandri ; mucus ; polymers ; proteins ; skin (animal) ; toxicity ; zeta potential
    Language English
    Dates of publication 2019-0708
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 185380-6
    ISSN 0044-8486 ; 0044-8516
    ISSN 0044-8486 ; 0044-8516
    DOI 10.1016/j.aquaculture.2019.734294
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  3. Article ; Online: Effects of nanocapsules of poly-ε-caprolactone containing artemisinin on zebrafish early-life stages and adults.

    Charlie-Silva, Ives / Feitosa, Natália Martins / Fukushima, Hirla Costa Silva / Borra, Ricardo Carneiro / Foglio, Mary Ann / Xavier, Rogéria Maura Pazini / de Melo Hoyos, Daniela Chemin / de Oliveira Sousa, Ilza Maria / de Souza, Giovane Galdino / Bailone, Ricardo Lacava / de Andrade Belo, Marco Antonio / Correia, Sostenes Apolo Marcelino / Junior, José Dias Corrêa / Pierezan, Felipe / Malafaia, Guilherme

    The Science of the total environment

    2020  Volume 756, Page(s) 143851

    Abstract: Artemisinin extracted from Artemisia annua L. plants has a range of properties that qualifies it to treat several diseases, such as malaria and cancer. However, it has short half-life, which requires making continuous use of it, which has motivated the ... ...

    Abstract Artemisinin extracted from Artemisia annua L. plants has a range of properties that qualifies it to treat several diseases, such as malaria and cancer. However, it has short half-life, which requires making continuous use of it, which has motivated the association of artemisinin (ART) with polymeric nanoparticles to increase its therapeutic efficiency. However, the ecotoxicological safety of this association has been questioned, given the scarcity of studies in this area. Thus, in this work the toxicity of Poly (ε-Caprolactone) nanocapsules added with ART (ART-NANO) in zebrafish (Danio rerio), embryos and adults was studied. Different endpoints were analyzed in organisms exposed to ART-NANO, including those predictive of embryotoxicity and histopatoxicity. Embryotoxicity was analyzed based on Organization for Economic Co-operation and Development (OECD) test guideline (236) for fish embryo acute toxicity applied to zebrafish (Danio rerio) at 96 hpf under five nominal logarithmic concentrations (0.125 to 2.0 mg/ L). Our results demonstrate, mainly, that fertilized eggs presented increased coagulation, lack of heart rate, vitelline sac displacement and lack of somite formation. On the other hand, adult individuals (exposed to the same concentrations and evaluated after 24 and 96 h of exposure) have shown increased pericarditis. Therefore, the treatment based on ART, poly (ε-caprolactone) nanocapsules and on their combination at different concentrations have shown toxic effects on zebrafish embryos and adult individuals.
    MeSH term(s) Adult ; Animals ; Artemisinins/toxicity ; Caproates ; Embryo, Nonmammalian ; Humans ; Lactones ; Nanocapsules ; Water Pollutants, Chemical/toxicity ; Zebrafish
    Chemical Substances Artemisinins ; Caproates ; Lactones ; Nanocapsules ; Water Pollutants, Chemical ; caprolactone (56RE988L1R)
    Language English
    Publishing date 2020-11-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.143851
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  4. Article: Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

    Ventura Fernandes, Bianca H. / Feitosa, Natália Martins / Barbosa, Ana Paula / Bomfim, Camila Gasque / Garnique, Anali M.B. / Rosa, Ivana F. / Rodrigues, Maira S. / Doretto, Lucas B. / Costa, Daniel F. / Camargo-dos-Santos, Bruno / Franco, Gabrielli A. / Neto, João Favero / Lunardi, Juliana Sartori / Bellot, Marina Sanson / Alves, Nina Pacheco Capelini / Costa, Camila C. / Aracati, Mayumi F. / Rodrigues, Letícia F. / Cirilo, Rafaela Hemily /
    Colagrande, Raul Marcelino / Gomes, Francisco I.F. / Nakajima, Rafael T. / Belo, Marco A.A. / Giaquinto, Percília Cardoso / de Oliveira, Susana Luporini / Eto, Silas Fernandes / Fernandes, Dayanne Carla / Manrique, Wilson G. / Conde, Gabriel / Rosales, Roberta R.C. / Todeschini, Iris / Rivero, Ilo / Llontop, Edgar / Sgro, Germán G. / Oka, Gabriel Umaji / Bueno, Natalia Fernanda / Ferraris, Fausto K. / de Magalhães, Mariana T.Q. / Medeiros, Renata J. / Mendonça-Gomes, Juliana M. / Junqueira, Mara Souza / Conceição, Kátia / Pontes, Leticia Gomes de / Condino-Neto, Antonio / Perez, Andrea C. / Barcellos, Leonardo J.G. / Júnior, José Dias Correa / Dorlass, Erick Gustavo / Camara, Niels O.S. / Durigon, Edison Luiz / Cunha, Fernando Q. / Nóbrega, Rafael H. / Machado-Santelli, Glaucia M. / Farah, Chuck S. / Veras, Flavio P. / Galindo-Villegas, Jorge / Costa-Lotufo, Letícia V. / Cunha, Thiago M. / Chammas, Roger / Carvalho, Luciani R. / Guzzo, Cristiane R. / Malafaia, Guilherme / Charlie-Silva, Ives

    Science of the total environment. 2022 Mar. 20, v. 813

    2022  

    Abstract: Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this ... ...

    Abstract Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this study evaluated the deleterious effects caused by SARS-CoV-2 Spike protein on the health of Danio rerio, zebrafish. We demonstrated, for the first time, that zebrafish injected with fragment 16 to 165 (rSpike), which corresponds to the N-terminal portion of the protein, presented mortalities and adverse effects on liver, kidney, ovary and brain tissues. The conserved genetic homology between zebrafish and humans might be one of the reasons for the intense toxic effects followed inflammatory reaction from the immune system of zebrafish to rSpike which provoked damage to organs in a similar pattern as happen in severe cases of COVID-19 in humans, and, resulted in 78,6% of survival rate in female adults during the first seven days. The application of spike protein in zebrafish was highly toxic that is suitable for future studies to gather valuable information about ecotoxicological impacts, as well as vaccine responses and therapeutic approaches in human medicine. Therefore, besides representing an important tool to assess the harmful effects of SARS-CoV-2 in the aquatic environment, we present the zebrafish as an animal model for translational COVID-19 research.
    Keywords COVID-19 infection ; Danio rerio ; Severe acute respiratory syndrome coronavirus 2 ; animal models ; aquatic environment ; brain ; ecotoxicology ; females ; freshwater ; hospitals ; human health ; immune system ; kidneys ; liver ; medicine ; survival rate ; therapeutics ; toxicity ; vaccines ; viruses ; wastewater
    Language English
    Dates of publication 2022-0320
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.152345
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

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  5. Article ; Online: Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

    Ventura Fernandes, Bianca H / Feitosa, Natália Martins / Barbosa, Ana Paula / Bomfim, Camila Gasque / Garnique, Anali M B / Rosa, Ivana F / Rodrigues, Maira S / Doretto, Lucas B / Costa, Daniel F / Camargo-Dos-Santos, Bruno / Franco, Gabrielli A / Neto, João Favero / Lunardi, Juliana Sartori / Bellot, Marina Sanson / Alves, Nina Pacheco Capelini / Costa, Camila C / Aracati, Mayumi F / Rodrigues, Letícia F / Cirilo, Rafaela Hemily /
    Colagrande, Raul Marcelino / Gomes, Francisco I F / Nakajima, Rafael T / Belo, Marco A A / Giaquinto, Percília Cardoso / de Oliveira, Susana Luporini / Eto, Silas Fernandes / Fernandes, Dayanne Carla / Manrique, Wilson G / Conde, Gabriel / Rosales, Roberta R C / Todeschini, Iris / Rivero, Ilo / Llontop, Edgar / Sgro, Germán G / Oka, Gabriel Umaji / Bueno, Natalia Fernanda / Ferraris, Fausto K / de Magalhães, Mariana T Q / Medeiros, Renata J / Mendonça-Gomes, Juliana M / Junqueira, Mara Souza / Conceição, Kátia / Pontes, Leticia Gomes de / Condino-Neto, Antonio / Perez, Andrea C / Barcellos, Leonardo J G / Júnior, José Dias Correa / Dorlass, Erick Gustavo / Camara, Niels O S / Durigon, Edison Luiz / Cunha, Fernando Q / Nóbrega, Rafael H / Machado-Santelli, Glaucia M / Farah, Chuck S / Veras, Flavio P / Galindo-Villegas, Jorge / Costa-Lotufo, Letícia V / Cunha, Thiago M / Chammas, Roger / Carvalho, Luciani R / Guzzo, Cristiane R / Malafaia, Guilherme / Charlie-Silva, Ives

    The Science of the total environment

    2021  Volume 813, Page(s) 152345

    Abstract: Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this ... ...

    Abstract Despite the significant increase in the generation of SARS-CoV-2 contaminated domestic and hospital wastewater, little is known about the ecotoxicological effects of the virus or its structural components in freshwater vertebrates. In this context, this study evaluated the deleterious effects caused by SARS-CoV-2 Spike protein on the health of Danio rerio, zebrafish. We demonstrated, for the first time, that zebrafish injected with fragment 16 to 165 (rSpike), which corresponds to the N-terminal portion of the protein, presented mortalities and adverse effects on liver, kidney, ovary and brain tissues. The conserved genetic homology between zebrafish and humans might be one of the reasons for the intense toxic effects followed inflammatory reaction from the immune system of zebrafish to rSpike which provoked damage to organs in a similar pattern as happen in severe cases of COVID-19 in humans, and, resulted in 78,6% of survival rate in female adults during the first seven days. The application of spike protein in zebrafish was highly toxic that is suitable for future studies to gather valuable information about ecotoxicological impacts, as well as vaccine responses and therapeutic approaches in human medicine. Therefore, besides representing an important tool to assess the harmful effects of SARS-CoV-2 in the aquatic environment, we present the zebrafish as an animal model for translational COVID-19 research.
    MeSH term(s) Animals ; COVID-19 ; Female ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Zebrafish
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-12-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.152345
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

    Fernandes, Bianca H Ventura / Feitosa, Natalia Martins / Barbosa, Ana Paula / Bomfim, Camila Gasque / Garnique, Anali MB / Gomes, Francisco IF / Nakajima, Rafael T / Belo, Marco AA / Eto, Silas Fernandes / Fernandes, Dayanne Carla / Malafaia, Guilherme / Manrique, Wilson G / Conde, Gabriel / Rosales, Roberta RC / Todeschini, Iris / Rivero, Ilo / Llontop, Edgar / Sgro, German G / Oka, Gabriel Umaji /
    Bueno, Natalia Fernanda / Ferraris, Fausto K / de Magalhaes, Mariana TQ / Medeiros, Renata J / Gomes, Juliana MM / Junqueira, Mara Souza / Conceicao, Katia / Pontes, Leticia G. / Neto, Antonio Condino / Perez, Andrea C / Barcellos, Leonardo G / Junior, Jose Dias Correa / Dorlass, Erick Gustavo / Camara, Niels OS / Durigon, Edison Luiz / Cunha, Fernando Q / Nobrega, Rafael H / Machado-Santelli, Glaucia M / Farah, Chuck S / Veras, Flavio P / Galindo-Villegas, Jorge / Costa-Lotufo, Leticia / Cunha, Thiago M / Chammas, Roger / Carvalho, Luciani R. / Guzzo, Cristiane R. / Charlie-Silva, Ives

    bioRxiv

    Abstract: Establishing new experimental animal models to assess the safety and immune response to the antigen used in the development of COVID-19 vaccine is an imperative issue. Based on the advantages of using zebrafish as a model in research, herein we suggest ... ...

    Abstract Establishing new experimental animal models to assess the safety and immune response to the antigen used in the development of COVID-19 vaccine is an imperative issue. Based on the advantages of using zebrafish as a model in research, herein we suggest doing this to test the safety of the putative vaccine candidates and to study immune response against the virus. We produced a recombinant N-terminal fraction of the Spike SARS-CoV-2 protein and injected it into adult female zebrafish. The specimens generated humoral immunity and passed the antibodies to the eggs. However, they presented adverse reactions and inflammatory responses similar to severe cases of human COVID-19. The analysis of the structure and function of zebrafish and human Angiotensin-converting enzyme 2, the main human receptor for virus infection, presented remarkable sequence similarities. Moreover, bioinformatic analysis predicted protein-protein interaction of the Spike SARS-CoV-2 fragment and the Toll-like receptor pathway. It might help in the choice of future therapeutic pharmaceutical drugs to be studied. Based on the in vivo and in silico results presented here, we propose the zebrafish as a model for translational research into the safety of the vaccine and the immune response of the vertebrate organism to the SARS-CoV-2 virus.
    Keywords covid19
    Language English
    Publishing date 2020-10-20
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.10.20.346262
    Database COVID19

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