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  1. Article ; Online: Healthcare-associated exposure to Borna disease virus 1 (BoDV-1)

    Judith Reinmiedl / Heiko Schulz / Viktoria C. Ruf / Moritz R. Hernandez Petzsche / Jürgen Rissland / Dennis Tappe

    Journal of Occupational Medicine and Toxicology, Vol 17, Iss 1, Pp 1-

    2022  Volume 6

    Abstract: Abstract The Borna disease virus 1 (BoDV-1) causes severe and often fatal encephalitis in humans. The virus is endemic in parts of Germany, Liechtenstein, Switzerland and Austria. As an increasing number of human BoDV-1 encephalitis cases is being ... ...

    Abstract Abstract The Borna disease virus 1 (BoDV-1) causes severe and often fatal encephalitis in humans. The virus is endemic in parts of Germany, Liechtenstein, Switzerland and Austria. As an increasing number of human BoDV-1 encephalitis cases is being diagnosed, the chance for healthcare professionals to come into contact with infected tissues and bodily fluids from patients with known acute bornavirus encephalitis is also increasing. Therefore, risk assessments are needed. Based on three different incidences of possible exposure to BoDV-1 including an autopsy knife injury, a needlestick injury, and a spill accident with cerebrospinal fluid from patients with acute BoDV-1 encephalitis, we perform risk assessments and review published data. BoDV-1 infection status of the index patient’s tissues and bodily fluids to which contact had occurred should be determined. There is only scarce evidence for possible postexposure prophylaxis, serology, and imaging in healthcare professionals who possibly came into contact with the virus. Despite decade-long laboratory work with BoDV-1, not a single clinically apparent laboratory infection has been published. Given the increasing number of severe or fatal BoDV-1 encephalitis cases, there is a growing need for efficacy-tested, potent antiviral therapeutics against BoDV-1 in humans, both in clinically ill patients and possibly as postexposure prophylaxis in healthcare professionals.
    Keywords Postexposure prophylaxis ; Bornavirus ; Serology ; Imaging ; Favipiravir ; Industrial medicine. Industrial hygiene ; RC963-969
    Subject code 616 ; 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Human bornavirus research

    Dennis Rubbenstroth / Kore Schlottau / Martin Schwemmle / Jürgen Rissland / Martin Beer

    PLoS Pathogens, Vol 15, Iss 8, p e

    Back on track!

    2019  Volume 1007873

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome

    Yuguang Fu / Marianne Wedde / Sigrun Smola / Djin-Ye Oh / Thorsten Pfuhl / Jürgen Rissland / Michael Zemlin / Fidelis A. Flockerzi / Rainer M. Bohle / Andrea Thürmer / Susanne Duwe / Barbara Biere / Janine Reiche / Brunhilde Schweiger / Christin Mache / Thorsten Wolff / Georg Herrler / Ralf Dürrwald

    International Journal of Medical Microbiology, Vol 314, Iss , Pp 151598- (2024)

    2024  

    Abstract: Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic ... ...

    Abstract Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined.Autopsy revealed hemorrhagic pneumonia as major pathological manifestation. Lung samples harbored a large population of A(H1N1)pdm09 viruses with the polymorphism H456H/Y in PB1 polymerase. The H456H/Y viruses replicated much faster to high viral titers than upper respiratory tract viruses in vitro. H456H/Y-infected air-liquid interface cultures of differentiated airway epithelial cells did reflect a more pronounced loss of ciliated cells. A different pattern of virus quasispecies was found in the upper airway samples where substitution S263S/F (HA1) was observed.The data support the notion that viral quasispecies had evolved locally in the lung to support high replicative fitness. This change may have initiated further pathogenic processes leading to rapid dissemination of inflammatory mediators followed by development of hemorrhagic lung lesions and fatal outcome.
    Keywords A(H1N1)pdm09 virus ; Fatal influenza ; S263S/F (HA1) and H456H/Y (PB1) mutations ; Microbiology ; QR1-502 ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance

    Stefan Lohse / Anna Sternjakob-Marthaler / Paul Lagemann / Jakob Schöpe / Jürgen Rissland / Nastasja Seiwert / Thorsten Pfuhl / Alana Müllendorff / Laurent S. Kiefer / Markus Vogelgesang / Luca Vella / Katharina Denk / Julia Vicari / Anabel Zwick / Isabelle Lang / Gero Weber / Jürgen Geisel / Jörg Rech / Bernd Schnabel /
    Gunter Hauptmann / Bernd Holleczek / Heinrich Scheiblauer / Stefan Wagenpfeil / Sigrun Smola

    Communications Medicine, Vol 2, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: Lohse, Sternjakob-Marthaler et al. assess anti-SARS-CoV-2 antibody responses of adults in the Saarland region of Germany after the first pandemic wave. They calculate infection and fatality rates, demonstrating that SARS-Cov-2 infections during this ... ...

    Abstract Lohse, Sternjakob-Marthaler et al. assess anti-SARS-CoV-2 antibody responses of adults in the Saarland region of Germany after the first pandemic wave. They calculate infection and fatality rates, demonstrating that SARS-Cov-2 infections during this period were underreported.
    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Human papillomavirus vaccination of girls in the German model region Saarland

    Anna Sternjakob-Marthaler / Barbara Berkó-Göttel / Jürgen Rissland / Jakob Schöpe / Emeline Taurian / Hanna Müller / Gero Weber / Stefan Lohse / Thomas Lamberty / Bernd Holleczek / Harry Stoffel / Gunter Hauptmann / Martin Giesen / Christiane Firk / Alexandra Schanzenbach / Florian Brandt / Heike Hohmann / Quirin Werthner / Dominik Selzer /
    Thorsten Lehr / Stefan Wagenpfeil / Sigrun Smola

    PLoS ONE, Vol 17, Iss 9, p e

    Insurance data-based analysis and identification of starting points for improving vaccination rates.

    2022  Volume 0273332

    Abstract: In Germany, the incidence of cervical cancer, a disease caused by human papillomaviruses (HPV), is higher than in neighboring European countries. HPV vaccination has been recommended for girls since 2007. However, it continues to be significantly less ... ...

    Abstract In Germany, the incidence of cervical cancer, a disease caused by human papillomaviruses (HPV), is higher than in neighboring European countries. HPV vaccination has been recommended for girls since 2007. However, it continues to be significantly less well received than other childhood vaccines, so its potential for cancer prevention is not fully realized. To find new starting points for improving vaccination rates, we analyzed pseudonymized routine billing data from statutory health insurers in the PRÄZIS study (prevention of cervical carcinoma and its precursors in women in Saarland) in the federal state Saarland serving as a model region. We show that lowering the HPV vaccination age to 9 years led to more completed HPV vaccinations already in 2015. Since then, HPV vaccination rates and the proportion of 9- to 11-year-old girls among HPV-vaccinated females have steadily increased. However, HPV vaccination rates among 15-year-old girls in Saarland remained well below 50% in 2019. Pediatricians vaccinated the most girls overall, with a particularly high proportion at the recommended vaccination age of 9-14 years, while gynecologists provided more HPV catch-up vaccinations among 15-17-year-old girls, and general practitioners compensated for HPV vaccination in Saarland communities with fewer pediatricians or gynecologists. We also provide evidence for a significant association between attendance at the children´s medical check-ups "U11" or "J1" and HPV vaccination. In particular, participation in HPV vaccination is high on the day of U11. However, obstacles are that U11 is currently not financed by all statutory health insurers and there is a lack of invitation procedures for both U11 and J1, resulting in significantly lower participation rates than for the earlier U8 or U9 screenings, which are conducted exclusively with invitations and reminders. Based on our data, we propose to restructure U11 and J1 screening in Germany, with mandatory funding for U11 and organized invitations for HPV vaccination at U11 or ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 070
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Simple Questionnaires to Improve Pooling Strategies for SARS-CoV-2 Laboratory Testing

    Sophie Schneitler / Philipp Jung / Florian Bub / Farah Alhussein / Sophia Benthien / Fabian K. Berger / Barbara Berkó-Göttel / Janina Eisenbeis / Daphne Hahn / Alexander Halfmann / Katharina Last / Maximilian Linxweiler / Stefan Lohse / Cihan Papan / Thorsten Pfuhl / Jürgen Rissland / Sophie Roth / Uwe Schlotthauer / Jürg Utzinger /
    Sigrun Smola / Barbara C. Gärtner / Sören L. Becker

    Annals of Global Health, Vol 86, Iss

    2020  Volume 1

    Abstract: Background: Liberal PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to contain the coronavirus disease 2019 (COVID-19) pandemic. Combined multi-sample testing in pools instead of single tests might enhance laboratory ... ...

    Abstract Background: Liberal PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to contain the coronavirus disease 2019 (COVID-19) pandemic. Combined multi-sample testing in pools instead of single tests might enhance laboratory capacity and reduce costs, especially in low- and middle-income countries. Objective: The purpose of our study was to assess the value of a simple questionnaire to guide and further improve pooling strategies for SARS-CoV-2 laboratory testing. Methods: Pharyngeal swabs for SARS-CoV-2 testing were obtained from healthcare and police staff, hospital inpatients, and nursing home residents in the southwestern part of Germany. We designed a simple questionnaire, which included questions pertaining to a suggestive clinical symptomatology, recent travel history, and contact with confirmed cases to stratify an individual’s pre-test probability of having contracted COVID-19. The questionnaire was adapted repeatedly in face of the unfolding pandemic in response to the evolving epidemiology and observed clinical symptomatology. Based on the response patterns, samples were either tested individually or in multi-sample pools. We compared the pool positivity rate and the number of total PCR tests required to obtain individual results between this questionnaire-based pooling strategy and randomly assembled pools. Findings: Between March 11 and July 5, 2020, we processed 25,978 samples using random pooling (n = 6,012; 23.1%) or questionnaire-based pooling (n = 19,966; 76.9%). The overall prevalence of SARS-CoV-2 was 0.9% (n = 238). Pool positivity (14.6% vs. 1.2%) and individual SARS-CoV-2 prevalence (3.4% vs. 0.1%) were higher in the random pooling group than in the questionnaire group. The average number of PCR tests needed to obtain the individual result for one participant was 0.27 tests in the random pooling group, as compared to 0.09 in the questionnaire-based pooling group, leading to a laboratory capacity increase of 73% and 91%, respectively, as compared to single PCR ...
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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