Article ; Online: Liquid-like interactions in heterochromatin: Implications for mechanism and regulation.
Current opinion in cell biology
2020 Volume 64, Page(s) 90–96
Abstract: A large portion of the eukaryotic genome is packed into heterochromatin, a versatile platform that is essential to maintain genome stability. Often associated with a compact and transcriptionally repressed chromatin state, heterochromatin was earlier ... ...
| Abstract | A large portion of the eukaryotic genome is packed into heterochromatin, a versatile platform that is essential to maintain genome stability. Often associated with a compact and transcriptionally repressed chromatin state, heterochromatin was earlier considered a static and locked compartment. However, cumulative findings over the last 17 years have suggested that heterochromatin displays dynamics at different timescales and size scales. These dynamics are thought to be essential for the regulation of heterochromatin. This review illustrates how the key principles underlying heterochromatin structure and function have evolved along the years and summarizes the discoveries that have led to the continuous revision of these principles. Using heterochromatin protein 1-mediated heterochromatin as a context, we discuss a novel paradigm for heterochromatin organization based on two emerging concepts, phase separation and nucleosome structural plasticity. We also examine the broader implications of this paradigm for chromatin organization and regulation beyond heterochromatin. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Chromosomal Proteins, Non-Histone/metabolism ; Genomic Instability ; Heterochromatin/metabolism ; Humans ; Models, Biological ; Nucleosomes/metabolism | |||||
| Chemical Substances | Chromosomal Proteins, Non-Histone ; Heterochromatin ; Nucleosomes ; heterochromatin-specific nonhistone chromosomal protein HP-1 (107283-02-3) | |||||
| Language | English | |||||
| Publishing date | 2020-05-17 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1026381-0 | |||||
| ISSN | 1879-0410 ; 0955-0674 | |||||
| ISSN (online) | 1879-0410 | |||||
| ISSN | 0955-0674 | |||||
| DOI | 10.1016/j.ceb.2020.03.004 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2963: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.