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  1. Article ; Online: Erythrodermic dermatomyositis with anti-TIF1-γ antibodies.

    Tang, Ke-Yun / Jin, Hong-Zhong

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17164
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  2. Article ; Online: Extracellular vesicles from keratinocytes and other skin-related cells in psoriasis: A review.

    Qi, Fei / Jin, Hongzhong

    Experimental dermatology

    2024  Volume 33, Issue 1, Page(s) e15001

    Abstract: Psoriasis is a highly prevalent chronic inflammatory skin condition involving abnormal proliferation and differentiation of keratinocytes, together with substantial infiltration of immune cells. Extracellular vesicles (EVs), which are released ... ...

    Abstract Psoriasis is a highly prevalent chronic inflammatory skin condition involving abnormal proliferation and differentiation of keratinocytes, together with substantial infiltration of immune cells. Extracellular vesicles (EVs), which are released spontaneously into the extracellular space by virtually all cell types, play a crucial role in cell-to-cell communication by delivering bioactive cargos such as mRNA nucleic acids and proteins to recipient cells. Numerous studies have highlighted the significant contributions of EVs to both the pathogenesis and treatment of psoriasis. This review provides a concise overview of skin-derived EVs and their involvement in the pathogenesis of psoriasis.
    MeSH term(s) Humans ; Skin/metabolism ; Keratinocytes/metabolism ; Psoriasis/metabolism ; Extracellular Vesicles/metabolism ; Cell Differentiation
    Language English
    Publishing date 2024-01-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15001
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  3. Article ; Online: The potential role of tumor necrosis factor-α in thrombosis in livedoid vasculopathy.

    Qi, Fei / Jin, HongZhong

    Archives of dermatological research

    2024  Volume 316, Issue 5, Page(s) 124

    MeSH term(s) Humans ; Tumor Necrosis Factor-alpha ; Livedo Reticularis/pathology ; Thrombosis ; Livedoid Vasculopathy
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Letter
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-024-02857-w
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  4. Article ; Online: Work Progress and Outlook of Rare Skin Diseases Team

    WU Chao / JIN Hongzhong

    罕见病研究, Vol 2, Iss 2, Pp 153-

    2023  Volume 156

    Abstract: There are many kinds of rare skin diseases, but the research into the diagnosis and treatment of rare skin diseases is relatively scarce. In recent years, the rare skin diseases team has made a series of accomplishments, including establishing the ... ...

    Abstract There are many kinds of rare skin diseases, but the research into the diagnosis and treatment of rare skin diseases is relatively scarce. In recent years, the rare skin diseases team has made a series of accomplishments, including establishing the professional committee of Rare Skin Disease Committee of China Alliance for Rare Diseases, establishing China's first Medical Care Alliance for Rare Skin Diseases, launching two national collaborative projects, promoting the project of improving the diagnosis and treatment of rare diseases supported by the Central Special Lottery public welfare Fund, exploring the multidisciplinary diagnosis and treatment model of skin rare diseases, holding academic conferences, and compiling professional books on rare skin diseases. In the future, we will further improve the remote consultation model of rare skin diseases, develop artificial intelligence assisted diagnosis system of rare skin diseases, carry out high-quality clinical research, and improve the overall diagnosis and treatment level of rare skin diseases in China, for the sake of benefiting more patients.
    Keywords rare skin diseases ; rare skin disease committee of china alliance for rare diseases ; medical care alliance for rare skin diseases ; Medicine ; R
    Subject code 610
    Language Chinese
    Publishing date 2023-04-01T00:00:00Z
    Publisher Editorial Office of Journal of Rare Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Progress in the Diagnosis and Treatment and the Establishment of Care System for Rare Skin Diseases

    LIU Xiaohan / JIN Hongzhong

    罕见病研究, Vol 2, Iss 2, Pp 147-

    2023  Volume 152

    Abstract: Rare skin diseases are various in kinds facing many challenges and difficulties in diagnosis and treatment. Recently, the diagnosis of rare skin diseases has improved continuously. Molecular diagnostic tool, a representation of the next generation ... ...

    Abstract Rare skin diseases are various in kinds facing many challenges and difficulties in diagnosis and treatment. Recently, the diagnosis of rare skin diseases has improved continuously. Molecular diagnostic tool, a representation of the next generation sequencing technology, can effectively assist the accuracy of clinical diagnosis for rare diseases. The research and development of orphan drugs and gene therapy have made continuous breakthroughs and progress, bringing hope to patients with rare skin diseases. It is crucial to establish scientific disease management system of the disease, layered referral networks, and the standardized clinical pathways to improve the diagnosis and treatment level of rare skin diseases.This article provides a brief overview of the progress in the diagnosis and treatment of rare skin diseases and explore the future possibilities.
    Keywords dermatosis ; rare diseases ; diagnosis ; treatment ; management ; Medicine ; R
    Subject code 610
    Language Chinese
    Publishing date 2023-04-01T00:00:00Z
    Publisher Editorial Office of Journal of Rare Diseases
    Document type Article ; Online
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  6. Article ; Online: A Case Report of Annular Elastolytic Giant Cell Granuloma

    QIAO Zusha / JIN Hongzhong

    罕见病研究, Vol 2, Iss 2, Pp 285-

    2023  Volume 289

    Abstract: Annular elastolytic giant cell granuloma(AEGCG) is a rare granulomatous skin condition. We present a case of a 67-year-old man with annular plaques on the face, neck, shoulder, back and upper limbs, and mildly pruritis exceeding one year. ... ...

    Abstract Annular elastolytic giant cell granuloma(AEGCG) is a rare granulomatous skin condition. We present a case of a 67-year-old man with annular plaques on the face, neck, shoulder, back and upper limbs, and mildly pruritis exceeding one year. Histopathological examination demonstrated granulomatous inflammatory infiltration of lymphocytes, histiocytes and multinuclear giant cells in the middle and the upper dermis, with more local eosinophils. Elastic fiber staining showed that elastic fibers were absent in granuloma area and were engulfed by multinucleated giant cells. Based on the clinical and histopathological findings, a diagnosis of AEGCG was made. The etiology and pathogenesis of this condition are unclear, and atypical manifestations of non-exposed areas can also occur.It is usually related to systemic diseases lacks specific treatment at present.
    Keywords annular plaque ; plaque granuloma ; multinuclear giant cell ; elastosis ; Medicine ; R
    Language Chinese
    Publishing date 2023-04-01T00:00:00Z
    Publisher Editorial Office of Journal of Rare Diseases
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: [Advances in the Role of Low-Dose Interleukin-2 in Immune-Mediated Dermatosis].

    Qiao, Zu-Sha / Jin, Hong-Zhong

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2023  Volume 45, Issue 4, Page(s) 683–688

    Abstract: Immune-mediated dermatoses are the skin diseases caused by the breakdown of immune tolerance,including lupus erythematosus and dermatomyositis.The imbalance between regulatory T cells (Tregs) and effector T cells (Teffs) plays a key role in the ... ...

    Abstract Immune-mediated dermatoses are the skin diseases caused by the breakdown of immune tolerance,including lupus erythematosus and dermatomyositis.The imbalance between regulatory T cells (Tregs) and effector T cells (Teffs) plays a key role in the pathogenesis of these diseases.Low-dose interleukin-2 can preferentially activate Tregs and reverse the imbalance between Tregs and Teffs to recover the immune tolerance,which has attracted attention in the treatment of immune-mediated dermatoses.This review summarizes the research progress in the immunomodulatory mechanism and clinical application of low-dose interleukin-2 in immune-mediated dermatoses,providing a new idea for the clinical treatment of these diseases.
    MeSH term(s) Humans ; Interleukin-2 ; Lupus Erythematosus, Systemic ; T-Lymphocytes, Regulatory ; Skin Diseases/drug therapy
    Chemical Substances Interleukin-2
    Language Chinese
    Publishing date 2023-09-01
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15198
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  8. Article ; Online: Research progress of metabolomics in psoriasis.

    Guo, Lan / Jin, Hongzhong

    Chinese medical journal

    2023  Volume 136, Issue 15, Page(s) 1805–1816

    Abstract: Abstract: Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burdens. The interplay between the innate and adaptive immune systems is thought to contribute to the pathogenesis; however, the details of the ... ...

    Abstract Abstract: Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burdens. The interplay between the innate and adaptive immune systems is thought to contribute to the pathogenesis; however, the details of the pathogenesis remain unclear. In addition, reliable biomarkers for diagnosis, assessment of disease activity, and monitoring of therapeutic response are limited. Metabolomics is an emerging science that can be used to identify and analyze low molecular weight molecules in biological systems. During the past decade, metabolomics has been widely used in psoriasis research, and substantial progress has been made. This review summarizes and discusses studies that applied metabolomics to psoriatic disease. These studies have identified dysregulation of amino acids, carnitines, fatty acids, lipids, and carbohydrates in psoriasis. The results from these studies have advanced our understanding of: (1) the molecular mechanisms of psoriasis pathogenesis; (2) diagnosis of psoriasis and assessment of disease activity; (3) the mechanism of treatment and how to monitor treatment response; and (4) the link between psoriasis and comorbid diseases. We discuss common research strategies and progress in the application of metabolomics to psoriasis, as well as emerging trends and future directions.
    MeSH term(s) Humans ; Psoriasis/drug therapy ; Skin/metabolism ; Biomarkers/metabolism ; Metabolomics/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-08-05
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002504
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  9. Article ; Online: Biologics in pediatric psoriasis.

    Wang, Wen-Ming / Jin, Hong-Zhong

    The Journal of dermatology

    2023  Volume 50, Issue 4, Page(s) 415–421

    Abstract: Psoriasis is a chronic inflammatory skin disorder with a chronic relapsing course. Biologics have revolutionized the treatment of adult psoriasis with higher efficacy and favorable safety profile. Recently, more studies have focused on the use of ... ...

    Abstract Psoriasis is a chronic inflammatory skin disorder with a chronic relapsing course. Biologics have revolutionized the treatment of adult psoriasis with higher efficacy and favorable safety profile. Recently, more studies have focused on the use of biologics in pediatric psoriasis, and several biologics have been approved for use therein. This review is divided into two sections: the first part focuses on real-world studies on the use of biologics in pediatric psoriasis and the second part summarizes the findings of other clinical trials related to biologics in pediatric psoriasis. Case reports have been excluded from this review. Several biologics were used for treating pediatric psoriasis and the efficacy is encouraging. According to the studies included in this review, anti-IL-12/23 and anti-IL-17A for treating pediatric psoriasis might have a better efficacy than anti-TNF-α, but more data are needed.
    MeSH term(s) Adult ; Humans ; Child ; Biological Products/therapeutic use ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Psoriasis/drug therapy ; Interleukin-12 ; Tumor Necrosis Factor-alpha ; Chronic Disease
    Chemical Substances Biological Products ; Tumor Necrosis Factor Inhibitors ; Interleukin-12 (187348-17-0) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16702
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  10. Article ; Online: A Review of CRISPR-Based Advances in Dermatological Diseases.

    Lu, Xinyi / Jin, Hongzhong

    Molecular diagnosis & therapy

    2023  Volume 27, Issue 4, Page(s) 445–456

    Abstract: Clustered regularly interspaced short palindromic repeat (CRISPR) has revolutionized biomedical research by offering novel approaches to genetic and epigenetic manipulation. In dermatology, it has significantly promoted our understanding of complex ... ...

    Abstract Clustered regularly interspaced short palindromic repeat (CRISPR) has revolutionized biomedical research by offering novel approaches to genetic and epigenetic manipulation. In dermatology, it has significantly promoted our understanding of complex diseases, and shown great potential in therapeutic applications. In this review, we introduce the adoption of CRISPR technology as a tool to study different types of skin disorders, including monogenic genodermatoses, inflammatory disorders, and cutaneous infections. We highlight the promising preclinical results of CRISPR-mediated treatment and important mechanic discoveries in investigative studies. Future opportunities and remaining challenges are also discussed. We predict that CRISPR will be more extensively used for dermatological research and even be accessible to patients in the future.
    MeSH term(s) Humans ; Gene Editing/methods ; CRISPR-Cas Systems
    Language English
    Publishing date 2023-04-11
    Publishing country New Zealand
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2232796-4
    ISSN 1179-2000 ; 1177-1062
    ISSN (online) 1179-2000
    ISSN 1177-1062
    DOI 10.1007/s40291-023-00642-5
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