Article ; Online: Meta-analysis of host response networks identifies a common core in tuberculosis
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-
2017 Volume 12
Abstract: Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts ... ...
| Abstract | Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts respond to the disease. A number of studies have profiled transcriptomes of human blood samples from TB patients, but a meta-analysis indicates that very few changes are consistently seen. The problem, to a large extent, lies with the way large data is analysed. We have used a genome-wide network approach to characterise the host response and have identified a common-core in the TB response networks of different patients, indicating the presence of unified host response mechanisms. This core network provides a comprehensive view into the most significant regulators of the infection-mediated biological processes across patients from different populations, and it shows partial reversals upon treatment. |
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| Keywords | Biology (General) ; QH301-705.5 |
| Language | English |
| Publishing date | 2017-02-01T00:00:00Z |
| Publisher | Nature Portfolio |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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