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  1. Article ; Online: An overview of JAK/STAT pathways and JAK inhibition in alopecia areata.

    Lensing, Maddison / Jabbari, Ali

    Frontiers in immunology

    2022  Volume 13, Page(s) 955035

    Abstract: Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair loss ranging from patches on the scalp to complete hair loss involving the entire body. Disease onset is hypothesized to follow the collapse of immune privilege of the ...

    Abstract Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair loss ranging from patches on the scalp to complete hair loss involving the entire body. Disease onset is hypothesized to follow the collapse of immune privilege of the hair follicle, which results in an increase in self-peptide/MHC expression along the follicular epithelium. Hair loss is associated with infiltration of the hair follicle with putatively self-reactive T cells. This process is thought to skew the hair follicle microenvironment away from a typically homeostatic immune state towards one of active inflammation. This imbalance is mediated in part by the dominating presence of specific cytokines. While interferon-γ (IFNγ) has been identified as the key player in AA pathogenesis, many other cytokines have also been shown to play pivotal roles. Mechanistic studies in animal models have highlighted the contribution of common gamma chain (γ
    MeSH term(s) Alopecia Areata/drug therapy ; Animals ; Interferon-gamma/metabolism ; Interleukin Receptor Common gamma Subunit/metabolism ; Interleukin-15/metabolism ; Interleukin-2/metabolism ; Interleukin-7/metabolism ; Janus Kinase Inhibitors/pharmacology ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinases/metabolism ; STAT Transcription Factors/metabolism ; Signal Transduction
    Chemical Substances Interleukin Receptor Common gamma Subunit ; Interleukin-15 ; Interleukin-2 ; Interleukin-7 ; Janus Kinase Inhibitors ; STAT Transcription Factors ; Interferon-gamma (82115-62-6) ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.955035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The current state of knowledge of the immune ecosystem in alopecia areata.

    Connell, Samuel J / Jabbari, Ali

    Autoimmunity reviews

    2022  Volume 21, Issue 5, Page(s) 103061

    Abstract: Alopecia areata (AA) is an autoimmune disease that affects approximately 2% of the general population. Patients with AA most commonly present with one or more patches of hair loss on the scalp in defined circular areas. A fraction of patients progress to ...

    Abstract Alopecia areata (AA) is an autoimmune disease that affects approximately 2% of the general population. Patients with AA most commonly present with one or more patches of hair loss on the scalp in defined circular areas. A fraction of patients progress to more severe forms of the disease, in some cases with involvement of all body surfaces. The healthy anagen stage hair follicle is considered an immune privileged site, described as an environment that suppresses inflammatory immune responses. However, in AA, this immune privileged state collapses and marks the hair follicle as a target for the immune system, resulting in peri- and intrafollicular infiltration by lymphocytes. The complexity of the inflammatory ecosystem of the immune response to the hair follicle, and the relationships between the cellular and soluble participants, in AA remains incompletely understood. Many studies have demonstrated the presence of various immune cells around diseased hair follicles; however, often little is known about their respective contributions to AA pathogenesis. Furthering our understanding of the mechanisms of disease in AA is essential for the novel identification of targeted therapeutics that are efficacious and have few unintended effects.
    MeSH term(s) Alopecia Areata ; Autoimmune Diseases/pathology ; Ecosystem ; Hair Follicle/pathology ; Humans
    Language English
    Publishing date 2022-02-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2022.103061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV-Vis and Smartphone Triple Mode.

    Dadkhah, Sahar / Mehdinia, Ali / Jabbari, Ali / Manbohi, Ahmad

    Journal of fluorescence

    2022  Volume 32, Issue 2, Page(s) 681–689

    Abstract: Development of an efficient, portable and simple nanosensor-based systems with reliable analytical performance for on-site monitoring of vitamin B12 (VB12) are still major problems and a challenging work for quality control of manufacturers. Herein, a ... ...

    Abstract Development of an efficient, portable and simple nanosensor-based systems with reliable analytical performance for on-site monitoring of vitamin B12 (VB12) are still major problems and a challenging work for quality control of manufacturers. Herein, a new fluorescence, UV-Vis and smartphone triple mode nanosensors were designed for the simultaneous detection of VB12 with high sensitivity and accuracy. A novel nanosensor was synthesized through nicotinamide-functionalizing of carbon quantum dot (NA-CQDs) by an one-step microwave-assisted method with green approach. The NA-CQDs sensor showed excellent fluorescence properties and wide linear ranges from 0.1-60 µM with the detection limits of 31.7 nM. Moreover, color changes of NA-CQDs induced by the VB12 could also be detected by UV-Vis spectrophotometer and inhouse-developed application installed on smartphone as a signal reader, simultanusly. The Red, Green and Blue (RGB) intensities of the colorimetric images of NA-CQDs/VB12 system which taken by smartphone's camera converted into quantitative values by the application. A smartphone-integrated with NA-CQDs as colorimetric sensing platform displays good linear ranges (4.16 to 66.6 μM) for on-site determination of VB12 with detection limit of 1.40 μM. The method was successfully applied in the determination of VB12 in complex pharmaceutical supplement formulations without any sample pre-treatment and matrix interfering effects. The recovery results (96.52% to 105.10%) which were in agreement with the reference methods, demonstrating the capability of the smartphone-assisted colorimetric sensing platform in many on-site practical applications of quality controls.
    MeSH term(s) Biosensing Techniques/methods ; Carbon ; Colorimetry ; Limit of Detection ; Mobile Applications ; Niacinamide ; Photoelectron Spectroscopy/methods ; Point-of-Care Testing ; Quantum Dots ; Smartphone ; Spectrometry, Fluorescence/methods ; Vitamin B 12/analysis
    Chemical Substances Niacinamide (25X51I8RD4) ; Carbon (7440-44-0) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-021-02863-5
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  4. Article: Flipped Presentation of Authentic Audio-Visual Materials: Impacts on Intercultural Sensitivity and Intercultural Effectiveness in an EFL Context.

    Khabir, Masoud / Jabbari, Ali Akbar / Razmi, Mohammad Hasan

    Frontiers in psychology

    2022  Volume 13, Page(s) 832862

    Abstract: Utilizing a pre-experimental pre-test post-test design, this study investigated the effect of an authentic audio-visual American sitcom ( ...

    Abstract Utilizing a pre-experimental pre-test post-test design, this study investigated the effect of an authentic audio-visual American sitcom (
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.832862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Catalytic nanozyme Zn/Cl-doped carbon quantum dots as ratiometric fluorescent probe for sequential on-off-on detection of riboflavin, Cu

    Dadkhah, Sahar / Mehdinia, Ali / Jabbari, Ali / Manbohi, Ahmad

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18276

    Abstract: A novel metal-doped Zn/Cl carbon quantum dots (Zn/Cl-CQDs) was developed successfully as ratiometric fluorescent probes for the sequential on-off-on detection of riboflavin, ... ...

    Abstract A novel metal-doped Zn/Cl carbon quantum dots (Zn/Cl-CQDs) was developed successfully as ratiometric fluorescent probes for the sequential on-off-on detection of riboflavin, Cu
    MeSH term(s) Quantum Dots/chemistry ; Carbon/chemistry ; Fluorescent Dyes/chemistry ; Riboflavin/chemistry ; Thiamine ; Halogens ; Zinc
    Chemical Substances Carbon (7440-44-0) ; Fluorescent Dyes ; Riboflavin (TLM2976OFR) ; Thiamine (X66NSO3N35) ; Halogens ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23055-6
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  6. Article: Contemplation about dexamethasone usage in neuroaxial analgesia for labor pain.

    Jabbari, Ali / Alijanpour, Ebrahim / Nooralishahi, Behrang / Banihashem, Nadia

    Journal of anaesthesiology, clinical pharmacology

    2022  Volume 37, Issue 4, Page(s) 672–673

    Language English
    Publishing date 2022-01-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 1401760-x
    ISSN 0970-9185
    ISSN 0970-9185
    DOI 10.4103/joacp.JOACP_156_19
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4830: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Examining the Association of Grit Profiles With Big Five Personality and Achievement Among Iranian Foreign Language Learners.

    Khodaverdian Dehkordi, Maryam / Jabbari, Ali Akbar / Mazdayasna, Golnar

    Frontiers in psychology

    2021  Volume 12, Page(s) 801844

    Abstract: Grit-trait-level perseverance and prolonged passion for primary goals-is related to several indicators of educational success such as academic achievement, engagement, and motivation. Although there is new evidence showing the beneficial effects of grit, ...

    Abstract Grit-trait-level perseverance and prolonged passion for primary goals-is related to several indicators of educational success such as academic achievement, engagement, and motivation. Although there is new evidence showing the beneficial effects of grit, most research has taken a variable-focused approach and consequently has failed to indicate how individuals with different grit profiles might have different academic results. The present study aimed to build on the existing literature on grit by investigating the relationship between grit, big five personality and L2 achievement. The participants of this study were 384 English as a Foreign Language (EFL) students from different academic majors studying at Yazd University. They had enrolled in General English (GE) courses. The results of the cluster analyses showed that there were three natural grit profiles (Cluster 1 = High Perseverance and High Consistency; Cluster 2 = High Perseverance and Low Consistency; Cluster = Low Perseverance and High Consistency) in the current study. The results of the multivariate analysis of variance (ANOVA) showed that students belonging to cluster 1 had the highest scores on big five personality traits and L2 achievement. The results also showed that when taking academic exams, high perseverance of effort and low consistency of interest were related to higher level of neuroticism and lower level of consciousness. Our study has some theoretical and practical implications. Regarding the theory, this study is related to the existing grit literature by elaborating the relationship between grit profiles, big five personality traits, and L2A. Regarding the practice, our findings affirm the significance of developing and implementing the big five personality traits interventions in grit prediction.
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.801844
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  8. Article ; Online: Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.

    Lefebvre, Mitchell N / Borcherding, Nicholas / Reis, Ryan J / Mou, Eric / Liu, Vincent / Jabbari, Ali

    Frontiers in immunology

    2023  Volume 14, Page(s) 1228563

    Abstract: Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective ... ...

    Abstract Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective and standardized diagnostic and prognostic clinical tools. Currently, diagnosis of CTCL practically relies on clinical presentation, histopathology, and immunohistochemistry. These methods are collectively fraught with limitations in sensitivity and specificity. Fortunately, recent advances in flow cytometry, polymerase chain reaction, high throughput sequencing, and other molecular techniques have shown promise in improving diagnosis and treatment of CTCL. Examples of these advances include T cell receptor clonotyping via sequencing to detect CTCL earlier in the disease course and single-cell RNA sequencing to identify gene expression patterns that commonly drive CTCL pathogenesis. Experience with these techniques has afforded novel insights which may translate into enhanced diagnostic and therapeutic approaches for CTCL.
    MeSH term(s) Humans ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoma, T-Cell, Cutaneous/genetics ; Lymphoma, T-Cell, Cutaneous/therapy ; Skin ; Lymphoma, Non-Hodgkin ; Disease Progression ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/therapy
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1228563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preparation of a magnetic polystyrene nanocomposite for dispersive solid-phase extraction of copper ions in environmental samples.

    Mehdinia, Ali / Salamat, Maede / Jabbari, Ali

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 3279

    Abstract: The core shell nanostructure of magnetic polystyrene (PS@ ... ...

    Abstract The core shell nanostructure of magnetic polystyrene (PS@Fe
    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-60232-x
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  10. Article ; Online: Rapid and sensitive fluorescence and smartphone dual-mode detection of dopamine based on nitrogen-boron co-doped carbon quantum dots.

    Dadkhah, Sahar / Mehdinia, Ali / Jabbari, Ali / Manbohi, Ahmad

    Mikrochimica acta

    2020  Volume 187, Issue 10, Page(s) 569

    Abstract: A dual-mode fluorescence and colorimetric biosensor based on nitrogen-boron co-doped carbon quantum dot (N-B CQDs) for rapid and sensitive detection of dopamine (DA) was developed. The quantum dot luminescent materials, N-B CQDs, were prepared by a one- ... ...

    Abstract A dual-mode fluorescence and colorimetric biosensor based on nitrogen-boron co-doped carbon quantum dot (N-B CQDs) for rapid and sensitive detection of dopamine (DA) was developed. The quantum dot luminescent materials, N-B CQDs, were prepared by a one-step microwave-assisted method. The N-B CQDs were characterized using SEM, HR-TEM, XRD, FT-IR, Raman, fluorescence, and UV-Vis techniques. The dual-mode assays of fluorescence and colorimetric methods were used for detection of DA. The high fluorescent N-B CQDs mediated turn-off assay for the facile room temperature detection of dopamine via inner filter effect (IFE) and Forster resonance energy transfer (FRET) processes at basic pH. The colorimetric detection of DA was also developed via in-house android application using a smartphone and N-B CQD solution-based nanosensor. The smartphone-based colorimetric biosensors generated more reliable information for quantitative analysis of color changes than the naked eye. Furthermore, a smartphone application with N-B CQD solution-based nanosensor was integrated to monitor the color changes through the DA addition. Wide linear ranges were achieved for DA in the ranges 0.25-50 μM and 5-500 μM with fluorescence and smartphone-based method, respectively. The satisfactory results of the dual-mode detection of DA, not only in aqueous solution, but also in human urine and serum biological sample demonstrated its potential application in biosensing, as a point of care diagnostic tool. Graphical abstract.
    Language English
    Publishing date 2020-09-15
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-020-04543-w
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
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