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  1. Article ; Online: Combinatorial Therapies: Embracing Our Multifaceted Future.

    Jabbour, Salma K / Yom, Sue S

    International journal of radiation oncology, biology, physics

    2024  Volume 118, Issue 5, Page(s) 1149–1151

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.01.199
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    Zs.A 1218: Show issues Location:
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  2. Article ; Online: Evolving paradigms in locally advanced rectal cancer: the means justify the ends.

    Jabbour, Salma K / Hochster, Howard S

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 12, Page(s) 1439–1441

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Rectal Neoplasms/therapy ; Receptors, Vascular Endothelial Growth Factor ; Recombinant Fusion Proteins
    Chemical Substances aflibercept (15C2VL427D) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; Recombinant Fusion Proteins
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad196
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  3. Article ; Online: The Oligometastatic State: Balancing Between Cure and Palliation.

    Jabbour, Salma K / Yom, Sue S

    International journal of radiation oncology, biology, physics

    2022  Volume 114, Issue 4, Page(s) 559–560

    MeSH term(s) Humans ; Neoplasm Metastasis ; Palliative Care ; Radiosurgery
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.07.1827
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    Zs.A 1218: Show issues Location:
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  4. Article ; Online: Sinoatrial Node Radiation Dose and Atrial Fibrillation in Patients With Lung Cancer.

    Yegya-Raman, Nikhil / Jabbour, Salma K / Feigenberg, Steven J

    JAMA oncology

    2023  Volume 9, Issue 4, Page(s) 572–573

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Sinoatrial Node ; Lung Neoplasms/complications ; Lung Neoplasms/radiotherapy ; Radiation Dosage
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.7872
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  5. Article ; Online: A narrative review of genetic biomarkers in non-small cell lung cancer: an update and future perspectives.

    Workman, Samuel / Jabbour, Salma K / Deek, Matthew P

    AME medical journal

    2023  Volume 8

    Abstract: Background and objective: Lung cancer has long been the leading cause of cancer deaths in the United States. Lung cancer has a poor prognosis, and our understanding of who will maximally benefit from different therapies is incomplete. This article ... ...

    Abstract Background and objective: Lung cancer has long been the leading cause of cancer deaths in the United States. Lung cancer has a poor prognosis, and our understanding of who will maximally benefit from different therapies is incomplete. This article discusses genetic biomarkers that may help in this regard.
    Methods: From origin until February 25, 2022, PubMed database was searched for terms "non-small cell lung cancer", "genomics" and "biomarker", with special attention paid to literature published within the past 10 years. Search was language restricted to English. Additional literature was identified through hand searches of the references of retrieved literature.
    Key content and findings: The most robustly described biomarkers for non-small cell lung cancer (NSCLC) are assessment of specific gene mutations. These are currently used in clinical practice for both prediction and prognostication. Abnormal mutation status of
    Conclusions: An improved understanding of tumor genetics in NSCLC has led to the development of targeted therapies and improved prognostication. As more work is done in this field, more and more genetic biomarkers will become candidates for clinical use. Much work will be required to validate these findings in the clinical setting.
    Language English
    Publishing date 2023-02-02
    Publishing country China
    Document type Journal Article
    ISSN 2520-0518
    ISSN (online) 2520-0518
    DOI 10.21037/amj-2022-01
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  6. Article ; Online: Metastasis-Directed Therapy: A Moving Target Advancing Progress Forward.

    Deek, Matthew P / Tran, Phuoc T / Jabbour, Salma K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 1, Page(s) 4–7

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01274
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  7. Article ; Online: Waiting for Big Changes in Limited-Stage Small-Cell Lung Cancer: For Now, More of the Same.

    Deek, Matthew P / Haigentz, Missak / Jabbour, Salma K

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 13, Page(s) 2326–2330

    Abstract: The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a ... ...

    Abstract The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in
    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Small Cell Lung Carcinoma ; Radiotherapy Dosage ; Dose Fractionation, Radiation ; Chemoradiotherapy/methods
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02316
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    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
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  8. Article ; Online: Adjuvant Radiation in Early Stage Vulvar Cancer: A Review of Indications and Optimal Dose.

    Khullar, Karishma / Patrich, Tomas / Jabbour, Salma K / Hathout, Lara

    Applied radiation oncology

    2022  Volume 11, Issue 1, Page(s) 14–20

    Abstract: Vulvar cancer is a relatively rare gynecologic malignancy for which surgery remains the cornerstone of treatment. A wide local excision is the goal for treatment with curative intent in patients with early stage vulvar cancer, given that there are ... ...

    Abstract Vulvar cancer is a relatively rare gynecologic malignancy for which surgery remains the cornerstone of treatment. A wide local excision is the goal for treatment with curative intent in patients with early stage vulvar cancer, given that there are adverse pathologic features shown to increase risk of local recurrence. Specifically, the presence of positive or close margins of < 8 mm or 2 or more positive nodes have been shown to significantly increase the risk of recurrence and have informed guidelines for risk-adapted adjuvant radiation, although the optimal dose for adjuvant radiation is yet to be established. Given the rarity of vulvar cancer, guidelines regarding the indications and dose for adjuvant radiation are based largely on retrospective studies. The purpose of this review is to summarize the evidence underlying the current indications for adjuvant radiation in early stage vulvar cancer as well as to determine the optimal dose for adjuvant radiation.
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2334-5446
    ISSN (online) 2334-5446
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  9. Article: Adaptive Lung Radiation Therapy in the Era of Immunotherapy: A Single-Center Retrospective Study.

    Portal, Daniella / Lu, Shou-En / Piperdi, Huzaifa / Jabbour, Salma K / Reyhan, Meral

    Advances in radiation oncology

    2023  Volume 9, Issue 1, Page(s) 101315

    Abstract: Purpose: Treatment for locally advanced non-small cell lung cancer consists of concurrent chemoradiation followed by immunotherapy. Though this combination has been shown to have a benefit in both progression-free survival and overall survival, ... ...

    Abstract Purpose: Treatment for locally advanced non-small cell lung cancer consists of concurrent chemoradiation followed by immunotherapy. Though this combination has been shown to have a benefit in both progression-free survival and overall survival, treatment is often limited by the development of pneumonitis. One way to mitigate toxicity is through adaptive radiation therapy, which does not currently have a standardized implementation in clinical practice.
    Methods and materials: A single-center retrospective review of patients with locally advanced stage III or oligometastatic stage IV non-small cell lung cancer who were treated with chemoradiation with concurrent or subsequent immunotherapy from 2015 to 2020 was performed. Patients were stratified based on having 1 or more offline adapted plan. The aim of this study was to evaluate the association between dose-volume histogram values and common toxicities experienced during this treatment, including pneumonitis and esophagitis.
    Results: Twenty-five patients were included in the final analysis: 10 with adapted plans (AP), and 15 with nonadapted plans (NAP). Mean age at onset was 74 years. The most common histology was adenocarcinoma (N = 13). Five patients experienced pneumonitis: 2 in AP and 3 in NAP. Mann-Whitney
    Conclusions: Despite similar toxicities in both groups, the gross tumor volume size in the AP was more than double compared with NAP, suggesting that adaptive techniques provide a method for patients with larger target volumes to be treated without an observed difference in pneumonitis rates. These results suggest adaptive radiation therapy may have a role in mitigating toxicity experience from chemoradiation and immunotherapy and warrants further investigation.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101315
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  10. Article ; Online: Analysis of Outcomes With Addition of Immunotherapy to Chemoradiation Therapy for Non-Small Cell Lung Cancer-Reply.

    Jabbour, Salma K / Keller, Steven M / Reck, Martin

    JAMA oncology

    2021  Volume 8, Issue 1, Page(s) 168–169

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Chemoradiotherapy ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy ; Lung Neoplasms/drug therapy ; Lung Neoplasms/radiotherapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.5611
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