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Article ; Online: Molecular basis for the increased activity of ZMS-2 serine protease in the presence of metal ions and hydrogen peroxide.

Khan, Zahoor / Tanoeyadi, Samuel / Jabeen, Nusrat / Shafique, Maryam / Naz, Sehar Afshan / Mahmud, Taifo

2024 Volume 256, Page(s) 112566

Abstract: Serine proteases are important enzymes widely used in commercial products and industry. Recently, we identified a new serine protease from the desert bacterium Bacillus subtilis ZMS-2 that showed enhanced activity in the presence of ... ...

Abstract	Serine proteases are important enzymes widely used in commercial products and industry. Recently, we identified a new serine protease from the desert bacterium Bacillus subtilis ZMS-2 that showed enhanced activity in the presence of Zn
MeSH term(s)	Hydrogen Peroxide/chemistry ; Bacillus subtilis/enzymology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Zinc/chemistry ; Zinc/metabolism ; Serine Proteases/metabolism ; Serine Proteases/chemistry ; Serine Proteases/genetics ; Silver/chemistry ; Amino Acid Sequence
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Bacterial Proteins ; Zinc (J41CSQ7QDS) ; Serine Proteases (EC 3.4.-) ; Silver (3M4G523W1G)
Language	English
Publishing date	2024-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2024.112566
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Article: In-vitro evaluation of virulence markers and antifungal resistance of clinical Candida albicans strains isolated from Karachi, Pakistan.

Jabeen, Gul / Naz, Sehar Afshan / Rangel, Drauzio E N / Jabeen, Nusrat / Shafique, Maryam / Yasmeen, Kousar

Fungal biology

2023 Volume 127, Issue 7-8, Page(s) 1241–1249

Abstract: Candidiasis is a significant fungal infection with high mortality and morbidity rates worldwide. Candida albicans is the most dominant species responsible for causing different manifestations of candidiasis. Certain virulence traits as well as its ... ...

Abstract	Candidiasis is a significant fungal infection with high mortality and morbidity rates worldwide. Candida albicans is the most dominant species responsible for causing different manifestations of candidiasis. Certain virulence traits as well as its resistance to antifungal drugs contribute to the pathogenesis of this yeast. This study was designed to determine the production of some virulence factors, such as biofilm formation and extracellular hydrolytic enzymes (esterase, coagulase, gelatinase, and catalase) by this fungus, as well as its antifungal resistance profile. A total of 304 clinical C. albicans isolates obtained from different clinical specimens were identified by a conventional diagnostic protocol. The antifungal susceptibility of C. albicans strains was determined by disk diffusion technique against commercially available antifungal disks, such as nystatin 50 μg, amphotericin B 100 unit, fluconazole 25 μg, itraconazole 10 μg, ketoconazole 10 μg, and voriconazole 1 μg. The assessment of biofilm formation was determined by the tube staining assay and spectrophotometry. Gelatinase, coagulase, catalase, and esterase enzyme production was also detected using standard techniques. A total of 66.1% (201/304) and 28.9% (88/304) of C. albicans strains were susceptible-dose dependent (SDD) to nystatin and itraconazole, respectively. Among the antifungal drugs, C. albicans strains showed high resistance to ketoconazole 24.7% (75/304); however, no statistically significant relationship between the clinical origin of C. albicans isolates and antifungal drug resistance pattern was detected. For virulence factors, the majority of the C. albicans strains actively produced biofilm and all hydrolytic enzymes. Biofilm formation was demonstrated by 88% (267/304) of the strains with a quantitative mean value 0.1762 (SD ± 0.08293). However, 100% (304/304) of isolates produced catalase enzyme, 69% (211/304) produced coagulase, 66% (197/304) produced gelatinase, and 52% (157/304) produced esterase enzyme. A significant relationship between the source of specimens and biofilm formation by C. albicans was observed; nevertheless, there was no significant relationship between different sources of C. albicans strains and the production of different enzymatic virulence factors. The study found that C. albicans strains have excellent potential to produce virulence markers and resistance to antifungals, which necessitates surveillance of these opportunistic pathogens to minimize the chances of severe invasive infections.
MeSH term(s)	Humans ; Antifungal Agents/pharmacology ; Candida albicans ; Itraconazole/pharmacology ; Catalase ; Nystatin/pharmacology ; Virulence ; Ketoconazole ; Pakistan ; Coagulase ; Candida ; Candidiasis/microbiology ; Esterases ; Virulence Factors ; Drug Resistance, Fungal ; Microbial Sensitivity Tests ; Gelatinases
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4) ; Catalase (EC 1.11.1.6) ; Nystatin (1400-61-9) ; Ketoconazole (R9400W927I) ; Coagulase ; Esterases (EC 3.1.-) ; Virulence Factors ; Gelatinases (EC 3.4.24.-)
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2532164-X
ISSN	1878-6162 ; 1878-6146
ISSN (online)	1878-6162
ISSN	1878-6146
DOI	10.1016/j.funbio.2023.04.003
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Article ; Online: In-vitro evaluation of virulence markers and antifungal resistance of clinical Candida albicans strains isolated from Karachi, Pakistan

Jabeen, Gul / Naz, Sehar Afshan / Rangel, Drauzio E.N. / Jabeen, Nusrat / Shafique, Maryam / Yasmeen, Kousar

Fungal Biology.

2023

Abstract: Candidiasis is a significant fungal infection with high mortality and morbidity rates worldwide. Candida albicans is the most dominant specie responsible for causing different manifestations of candidiasis. Certain virulence traits as well as its ... ...

Abstract	Candidiasis is a significant fungal infection with high mortality and morbidity rates worldwide. Candida albicans is the most dominant specie responsible for causing different manifestations of candidiasis. Certain virulence traits as well as its resistance to antifungal drugs contribute to the pathogenesis of this yeast fungus. This study was designed to determine the production of some virulence factors, such as biofilm formation and extracellular hydrolytic enzymes (esterase, coagulase, gelatinase, and catalase) by this fungus, as well as its antifungal resistance profile. A total of 304 clinical C. albicans isolates obtained from different clinical specimens were identified by a conventional diagnostic protocol. The antifungal susceptibility of C. albicans strains was determined by disk diffusion technique against commercially available antifungal disks, such as nystatin 50 μg, amphotericin B 100 unit, fluconazole 25 μg, itraconazole 10 μg, ketoconazole 10 μg, and voriconazole 1 μg. The assessment of biofilm formation was determined by the tube staining assay and spectrophotometry. Gelatinase, coagulase, catalase, and esterase enzyme production was also detected using standard techniques. A total of 66.1% (201/304) and 28.9% (88/304) of C. albicans strains were susceptible-dose dependent (SDD) to nystatin and itraconazole. Among the antifungal drugs, C. albicans strains showed high resistance to ketoconazole 24.7% (75/304); however, no statistically significant relationship between the clinical origin of C. albicans isolates and antifungal drug resistance pattern was detected. For virulence factors, the majority of the C. albicans strains actively produced biofilm and all hydrolytic enzymes. Biofilm formation was demonstrated by 88% (267/304) of the strains with a quantitative mean value 0.1762 (SD ± 0.08293). However, 100% (304/304) of isolates produced catalase enzyme, 69% (211/304) produced coagulase, 66% (197/304) produced gelatinase, and 52% (157/304) produced esterase enzyme. A significant relationship between the source of specimens and biofilm formation by C. albicans was observed; nevertheless, there was no significant relationship between different sources of C. albicans strains and the production of different enzymatic virulence factors. The study found that C. albicans strains have excellent potential to produce virulence markers and resistance to antifungals, which necessitates surveillance of these opportunistic pathogens to minimize the chances of severe invasive infections.
Keywords	Candida albicans ; amphotericin B ; biofilm ; candidiasis ; catalase ; drug resistance ; esterases ; fluconazole ; itraconazole ; ketoconazole ; monitoring ; morbidity ; mortality ; mycology ; nystatin ; pathogenesis ; spectroscopy ; virulence ; yeasts ; Pakistan ; Virulence factors ; Hydrolytic enzymes ; Antifungal resistance
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2532164-X
ISSN	1878-6162 ; 1878-6146
ISSN (online)	1878-6162
ISSN	1878-6146
DOI	10.1016/j.funbio.2023.04.003
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Article: Characterization of the genome and serine protease of a novel Bacillus subtilis isolate

Khan, Zahoor / Shafique, Maryam / Saleem, Faizan / Azim, M. Kamran / Jabeen, Nusrat / Naz, Sehar Afshan

Antonie van Leeuwenhoek. 2022 Feb., v. 115, no. 2

2022

Abstract: Current study was undertaken to carry out the genome-wide analysis of a multipotent isolate from desert soil which was previously identified as Bacillus tequilensis based on 16S rDNA analysis. This study also aims to characterize the serine protease and ... ...

Abstract	Current study was undertaken to carry out the genome-wide analysis of a multipotent isolate from desert soil which was previously identified as Bacillus tequilensis based on 16S rDNA analysis. This study also aims to characterize the serine protease and its biocatalytic potentials implying a combination of empirical and in-silico approaches. Next generation sequencing and short read de novo assembly generated the 4,235,084 bp draft genome of Bacillus sp. ZMS-2. Genome sequence analysis by digital DNA:DNA hybridization (dDDH) and average nucleotide identity classified the isolate as Bacillus subtilis ZMS-2 (Bioproject ID: PRJNA691551). Genome annotation revealed 10 antibiotic resistance genes, 8 antibiotic/antifungal gene clusters and 25 genes encoding proteases including subtilisin E, an extracellular alkaline protease. This extracellular protease (ZMS-2 protease) was produced using a statistically optimized medium, purified partially and characterized as alkaline serine protease. The partially purified ZMS-2 protease (780 U/mL) showed a 21 mm zone of casein hydrolysis and dehaired goat skin by pulling out hair with roots. These catalytic potentials of ZMS-2 protease were further confirmed using scanning electron microscopy of casein beads and dehaired skin. The study concludes B. subtilis ZMS-2 as a potent producer of a protease with promising potentials of commercial importance.
Keywords	Bacillus subtilis ; antibiotic resistance ; antibiotics ; casein ; computer simulation ; desert soils ; genome-wide association study ; goats ; hydrolysis ; nucleic acid hybridization ; nucleotide sequences ; subtilisin
Language	English
Dates of publication	2022-02
Size	p. 281-295.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	214861-4
ISSN	1572-9699 ; 0003-6072
ISSN (online)	1572-9699
ISSN	0003-6072
DOI	10.1007/s10482-021-01696-3
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Article ; Online: Characterization of the genome and serine protease of a novel Bacillus subtilis isolate.

Khan, Zahoor / Shafique, Maryam / Saleem, Faizan / Azim, M Kamran / Jabeen, Nusrat / Naz, Sehar Afshan

Antonie van Leeuwenhoek

2022 Volume 115, Issue 2, Page(s) 281–295

Abstract	Current study was undertaken to carry out the genome-wide analysis of a multipotent isolate from desert soil which was previously identified as Bacillus tequilensis based on 16S rDNA analysis. This study also aims to characterize the serine protease and its biocatalytic potentials implying a combination of empirical and in-silico approaches. Next generation sequencing and short read de novo assembly generated the 4,235,084 bp draft genome of Bacillus sp. ZMS-2. Genome sequence analysis by digital DNA:DNA hybridization (dDDH) and average nucleotide identity classified the isolate as Bacillus subtilis ZMS-2 (Bioproject ID: PRJNA691551). Genome annotation revealed 10 antibiotic resistance genes, 8 antibiotic/antifungal gene clusters and 25 genes encoding proteases including subtilisin E, an extracellular alkaline protease. This extracellular protease (ZMS-2 protease) was produced using a statistically optimized medium, purified partially and characterized as alkaline serine protease. The partially purified ZMS-2 protease (780 U/mL) showed a 21 mm zone of casein hydrolysis and dehaired goat skin by pulling out hair with roots. These catalytic potentials of ZMS-2 protease were further confirmed using scanning electron microscopy of casein beads and dehaired skin. The study concludes B. subtilis ZMS-2 as a potent producer of a protease with promising potentials of commercial importance.
MeSH term(s)	Bacillus subtilis/genetics ; Hydrogen-Ion Concentration ; Peptide Hydrolases ; Serine Endopeptidases/genetics ; Subtilisins
Chemical Substances	Peptide Hydrolases (EC 3.4.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
Language	English
Publishing date	2022-01-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	214861-4
ISSN	1572-9699 ; 0003-6072
ISSN (online)	1572-9699
ISSN	0003-6072
DOI	10.1007/s10482-021-01696-3
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Article ; Online: Characterization and Pilot-Scale Application of the ZMS-2 Serine Protease with Novel Properties for the Eco-friendly Leather Processing.

Khan, Zahoor / Shafique, Maryam / Tanoeyadi, Samuel / Solangi, Barkat Ali / Khan, Sumera Afzal / Jabeen, Nusrat / Nawaz, Hafiz Rub / Naz, Sehar Afshan / Mahmud, Taifo

Applied biochemistry and biotechnology

2023

Abstract: Microbial alkaline proteases are dominating the global enzyme market with a share of over 65% due to their multifarious catalytic potentials. Hence, production of proteases with novel properties of commercial significance is highly desirable to meet the ... ...

Abstract	Microbial alkaline proteases are dominating the global enzyme market with a share of over 65% due to their multifarious catalytic potentials. Hence, production of proteases with novel properties of commercial significance is highly desirable to meet the global enzyme demand. Here, we report the purification, characterization, and pilot-scale application of a serine protease from the desert soil bacterium Bacillus subtilis ZMS-2 with novel properties as dehairing agent in leather processing. The enzyme was purified 16.5-fold with a specific activity of 1543.5 U mg
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-023-04790-6
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Article: Growth response and nitrogen metabolism of sunflower (Helianthus annuus L.) to vermicompost and biogas slurry under salinity stress

Jabeen, Nusrat / Rafiq Ahmad

Journal of plant nutrition. 2017 Jan. 2, v. 40, no. 1

2017

Abstract: Sunflower was grown under saline media with or without vermicompost amendment and biogas slurry, the organic fertilizers. A randomized complete block design with five replications was used. Forty-five pots were divided in three sets comprising of 15 pots ...

Abstract	Sunflower was grown under saline media with or without vermicompost amendment and biogas slurry, the organic fertilizers. A randomized complete block design with five replications was used. Forty-five pots were divided in three sets comprising of 15 pots each. Out of 15 pots of each sets, five pots of each were subjected to different levels of saline water irrigation i.e. electrical conductivity (EC): 0.5, 4.8 8.6 dS/m). Amendments of vermicompost and biogas slurry have shown some reduction of sodium induced inhibitory effects. Analyses of fresh and dry weight of leaves, ions, amino acid, protein and nitrogen metabolism enzymes in leaves etc., have been undertaken with reference to above-mentioned treatments. Organic manure amendments improved growth yield, nitrate and protein content and decreased the amount of sodium (Na âº), chloride (Cl â»), ammonium and total amino acid under saline or non-saline condition. Activities of nitrogen (N)-assimilating enzymes i.e. nitrate reducatse (NR, EC 1.6.6.1), nitrite reductase (NiR, EC 1.6.6.4), glutamine synthetase (GS, EC 6.3.1.2) and glutamate synthase (NADH-GOGAT, EC 1.4.1.14) were enhanced to some extent irrespective to non saline or saline condition. Under salinity NADH-glutamate dehydrogenase (GDH, EC 1.4.1.2) activity was stimulated concomitantly with the increasing ammonium contents and proteolysis activity in the leaves and organic manure did not show a significant difference as compared to their respective control. With respect to salt stress, among the two above-mentioned organic manure, vermicompost showed better result in the entire studied parameter as compared to the biogas slurry.
Keywords	ammonium ; biogas ; chlorides ; electrical conductivity ; glutamate dehydrogenase ; glutamate synthase (NADH) ; glutamate-ammonia ligase ; glutamic acid ; Helianthus annuus ; leaves ; nitrates ; nitrite reductase ; nitrogen ; nitrogen metabolism ; protein content ; proteolysis ; saline water ; salinity ; salt stress ; slurries ; sodium ; vermicomposts
Language	English
Dates of publication	2017-0102
Size	p. 104-114.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	446190-3
ISSN	1532-4087 ; 0190-4167
ISSN (online)	1532-4087
ISSN	0190-4167
DOI	10.1080/01904167.2016.1201495
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Article: Growth response and nitrogen metabolism of sunflower (Helianthus annuus L) to vermicompost and biogas slurry under salinity stress

Jabeen, Nusrat / Ahmad, Rafiq

Journal of plant nutrition

2017 Volume 40, Issue 1/4, Page(s) 104

Document type	Article
ZDB-ID	446190-3
ISSN	0190-4167
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Prevalence and association of HBV and HCV infection with cardiovascular disease risk factors in a peri-urban population.

Jabeen, Sehrish / Rasheed, Asif / Jabeen, Nusrat / Naz, Sehar Afshan / Raza, Akhter

JPMA. The Journal of the Pakistan Medical Association

2020 Volume 70, Issue 1, Page(s) 58–63

Abstract: Objective: To investigate the possible associations of hepatitis B and C virus infection with cardiovascular disease risk factors inperi-urban population.: Methods: The cross-sectional study was conducted from February to December 2016 in the ... ...

Abstract	Objective: To investigate the possible associations of hepatitis B and C virus infection with cardiovascular disease risk factors inperi-urban population. Methods: The cross-sectional study was conducted from February to December 2016 in the periurban low-resource locality of Bin Qasim Town in Karachi. Serum samples were screened for hepatitis B surface antigen and hepatitis C virus antibodies. Anthropometric measurements were taken and markers related to cardiovascular disease were examined. Association of the two hepatitis virus infections with cardiovascular diseasewere investigated by anaylsing the data using SPSS 16. Results: There were 691 subjects. Serum triglyceride levels were significantly low in patients with hepatitis B virus (p<0.05). Those with hepatitis C virus had markedly low total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride levels (p<0.05 each), whereas random blood sugar and body mass index values were significantly high (p<0.05 each. Hepatitis C virus infection was positively associated with body mass index and random blood glucose, and inversely associated with total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol(p< 0.05 each). Conclusions: Hepatitis B virus infection showed a significant inverse association with triglyceride levels. However, hepatitis C virus infection was positively associated with body mass index and random blood sugar, and inversely associated with total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels.
MeSH term(s)	Adult ; Blood Glucose/analysis ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Cholesterol/blood ; Cross-Sectional Studies ; Female ; Hepatitis B/complications ; Hepatitis B/epidemiology ; Hepatitis C/complications ; Hepatitis C/epidemiology ; Humans ; Lipoproteins/blood ; Male ; Middle Aged ; Pakistan/epidemiology ; Prevalence ; Risk Factors ; Triglycerides/blood ; Urban Population/statistics & numerical data ; Young Adult
Chemical Substances	Blood Glucose ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2020-01-16
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.5455/JPMA.1542
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Article: Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome

Hussain, Mushtaq / Jabeen, Nusrat / Shabbir, Sanya / Udin, Nasir / Aziz, Basma / Amanullah, Anusha / Raza, Fozia / Baig, Ayesha Ashraf

Data in Brief. 2020 Oct., v. 32

2020

Abstract: Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of proteins found in ...

Abstract	Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of proteins found in Drosophila melanogaster that are orthologous to human proteins, reported as components of SARS-CoV-2/Human interactome. The dataset enlists sequence homology, query coverage, domain conservation, OrthoMCL and Ensembl Genome Browser support of 326 proteins in D.melanogaster that are potentially orthologous to 417 human proteins reported for their direct physical interactions with 28 proteins encoded by SARS-CoV-2 genome. Expression of these D.melanogaster orthologous genes in 26 anatomical positions are also plotted as heat maps in 27 sets, corresponding to the potential protein interactors for each viral protein. The data could be used to direct experiments and potentially predict their phenotypic and molecular outcome in order to dissect the biological roles and molecular functionality of SARS-CoV-2 proteins in a convenient animal model system like D.melanogaster.
Keywords	Drosophila melanogaster ; Severe acute respiratory syndrome coronavirus 2 ; animal models ; data collection ; heat ; humans ; phenotype ; sequence homology ; therapeutics
Language	English
Dates of publication	2020-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.106082
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