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  1. Article ; Online: Monoclonal IgM and neuropathy: not always anti-MAG.

    Jaccard, Arnaud

    Blood

    2020  Volume 136, Issue 21, Page(s) 2366–2367

    MeSH term(s) Autoantibodies ; B-Lymphocytes ; Humans ; Immunoglobulin M ; Myelin-Associated Glycoprotein ; Paraproteinemias
    Chemical Substances Autoantibodies ; Immunoglobulin M ; Myelin-Associated Glycoprotein
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008540
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  2. Article ; Online: POEMS Syndrome: Therapeutic Options.

    Jaccard, Arnaud

    Hematology/oncology clinics of North America

    2018  Volume 32, Issue 1, Page(s) 141–151

    Abstract: Treatment of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome should be directed at the underlying plasma cell clone with risk-adapted therapy based on the extent of the plasma cell disorder. ... ...

    Abstract Treatment of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome should be directed at the underlying plasma cell clone with risk-adapted therapy based on the extent of the plasma cell disorder. Radiation therapy is effective for patients with a localized presentation, without bone marrow involvement, and 1 to 3 bone lesions. Patients with disseminated disease should receive, preferably, high-dose chemotherapy with peripheral blood transplantation. Low-dose melphalan and dexamethasone or new agents used in myeloma are also effective. The most promising agent is lenalidomide, which could be given before high-dose therapy or radiation to get rapid neurologic responses.
    Language English
    Publishing date 2018-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2017.09.011
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  3. Article ; Online: Treatment of AL amyloidosis

    Jaccard, Arnaud / Bridoux, Frank

    Nephrologie & therapeutique

    2019  Volume 15 Suppl 1, Page(s) S115–S121

    Abstract: AL amyloidosis is caused by the conversion of monoclonal immunoglobulin light chains into amyloid fibrillar aggregates that deposit in tissue and lead to organ dysfunction. Diagnosis is histological and relies primarily on non-invasive biopsies, showing ... ...

    Title translation Traitement de l’amylose AL.
    Abstract AL amyloidosis is caused by the conversion of monoclonal immunoglobulin light chains into amyloid fibrillar aggregates that deposit in tissue and lead to organ dysfunction. Diagnosis is histological and relies primarily on non-invasive biopsies, showing Congo red-positive amorphous deposits containing immunoglobulin light chains, most commonly of lambda isotype. The clinical presentation is extremely polymorphous, due to the large number of organs that can be affected by the disease. The kidneys and the heart are most frequently involved organs, in about two thirds of patients each, responsible for nephrotic syndrome and restrictive cardiomyopathy. Treatment is based on chemotherapy aimed at eliminating the medullary clone producing the pathogenic monoclonal light chains. It is guided by risk assessment, based on the serum levels of cardiac biomarkers. Its effectiveness must be regularly assessed by the serum free light chain assay. Current reference regimens combine an alkylating agent, with high doses of dexamethasone and most often a proteasome inhibitor. They are effective in the majority of patients. The overall prognosis depends on the importance of the initial severity of organ involvement, particularly the heart, and is strongly influenced by the haematological response. The treatment must be rapidly modified in non-responders, especially in those with severe cardiac disease, with the introduction of immunomodulatory drugs and antibodies targeting plasma cells. However, effective therapies for patients with the more severe amyloid cardiopathy are an unmet need. Strategies directly accelerating the removal of amyloid deposits, despite disappointing preliminary results, could further improve the prognosis of this disease.
    Language French
    Publishing date 2019-04-10
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2019.03.002
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  4. Article ; Online: Amylose AL, du diagnostic au traitement.

    Villesuzanne, Camille / Jaccard, Arnaud / Nicol, Martin

    La Revue du praticien

    2021  Volume 70, Issue 10, Page(s) 1137–1141

    Abstract: Al amyloidosis, from diagnosis to treatment. AL amyloidosis is a rare hemopathy characterized by immunoglobulin light chains deposits in almost all organs causing organ failure. The main issue is the early diagnosis, which must be made in front of an ... ...

    Title translation AL amyloidosis, from diagnosis to treatment.
    Abstract Al amyloidosis, from diagnosis to treatment. AL amyloidosis is a rare hemopathy characterized by immunoglobulin light chains deposits in almost all organs causing organ failure. The main issue is the early diagnosis, which must be made in front of an unexplained non-specific symptomatology, especially cardiac or renal, in frequently elderly patients with monoclonal gammopathy. Non-invasive biopsies should be made for histological confirmation revealing positive congo red and birefringent yellow-green deposits in polarized light specific for amyloidosis. Severity is assessed by biological markers of cardiac involvement. The treatment consists in eliminating the plasma or lympho-plasma cell dyscrasia secreting the amyloidogenic light chain, and in proposing supportive care specific to this pathology.
    MeSH term(s) Aged ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Humans ; Immunoglobulin Light Chains ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/therapy ; Kidney ; Paraproteinemias/diagnosis ; Paraproteinemias/therapy
    Chemical Substances Immunoglobulin Light Chains
    Language French
    Publishing date 2021-03-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  5. Article ; Online: A major turning point in NK/T-cell lymphoma?

    Jaccard, Arnaud / Hermine, Olivier

    Blood

    2017  Volume 129, Issue 17, Page(s) 2342–2343

    MeSH term(s) Humans ; Killer Cells, Natural ; Lymphoma, T-Cell ; Lymphoma, T-Cell, Peripheral ; Nose Neoplasms
    Language English
    Publishing date 2017-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-03-769075
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  6. Article ; Online: Electrochemical skin conductance values suggest frequent subclinical autonomic involvement in patients with AL amyloidosis.

    Montcuquet, Alexis / Duchesne, Mathilde / Roussellet, Olivier / Jaccard, Arnaud / Magy, Laurent

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    2020  Volume 27, Issue 3, Page(s) 215–216

    MeSH term(s) Aged ; Female ; Humans ; Immunoglobulin Light-chain Amyloidosis/complications ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/physiopathology ; Male ; Middle Aged ; Neural Conduction/physiology ; Peripheral Nervous System Diseases/complications ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/physiopathology ; Primary Dysautonomias/complications ; Primary Dysautonomias/diagnosis ; Primary Dysautonomias/physiopathology
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Letter
    ZDB-ID 1205246-2
    ISSN 1744-2818 ; 1350-6129
    ISSN (online) 1744-2818
    ISSN 1350-6129
    DOI 10.1080/13506129.2020.1757423
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  7. Article ; Online: Thalidomide and POEMS syndrome: a cautious step forward.

    Jaccard, Arnaud / Magy, Laurent

    The Lancet. Neurology

    2016  Volume 15, Issue 11, Page(s) 1104–1105

    MeSH term(s) Dexamethasone ; Humans ; POEMS Syndrome ; Thalidomide ; Vascular Endothelial Growth Factor A
    Chemical Substances Vascular Endothelial Growth Factor A ; Thalidomide (4Z8R6ORS6L) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(16)30176-4
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  8. Article: Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL).

    Bahri, Racha / Boyer, François / Halabi, Mohamad Adnan / Chaunavel, Alain / Feuillard, Jean / Jaccard, Arnaud / Ranger-Rogez, Sylvie

    Cancers

    2022  Volume 14, Issue 12

    Abstract: The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced ... ...

    Abstract The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the entire EBV genome in biopsies from 18 patients with AITL, 16 patients with another EBV-associated lymphoma, and 2 controls. We chose an EBV target capture method, given the high specificity of this technique, followed by a second capture to increase sensitivity. We identified two main viral strains in AITL, one of them associated with the mutations
    Language English
    Publishing date 2022-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14122899
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  9. Article: Amylose.

    Jaccard, Arnaud / Bridoux, Frank

    La Revue du praticien

    2014  Volume 64, Issue 4, Page(s) 575–581

    Title translation Amyloidosis.
    MeSH term(s) Amyloidosis/diagnosis ; Amyloidosis/epidemiology ; Amyloidosis/therapy ; Diagnostic Imaging ; Humans
    Language French
    Publishing date 2014-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  10. Article ; Online: Créer une communauté de chefs de service pour répondre aux défis du système hospitalier : première expérience en hématologie.

    Houot, Roch / Bay, Jacques-Olivier / Chevallier, Patrice / Choquet, Sylvain / Fornecker, Luc-Matthieu / Ianotto, Jean-Christophe / Jaccard, Arnaud / Jardin, Fabrice / Legros, Laurence / Lemonnier, François / Park, Sophie / Pascal, Laurent / Soussain, Carole / Gyan, Emmanuel

    Bulletin du cancer

    2023  Volume 110, Issue 9, Page(s) 950–954

    Abstract: The French hospital system crises are constantly forcing the heads of departments to adapt and find solutions for maintaining optimal patient care in a context of staff shortage. Facing these challenges, we had the desire to create a community of ... ...

    Title translation Creating a community of heads of department to meet hospital system challenges: First experience in haematology.
    Abstract The French hospital system crises are constantly forcing the heads of departments to adapt and find solutions for maintaining optimal patient care in a context of staff shortage. Facing these challenges, we had the desire to create a community of department heads capable of helping each other, sharing their experiences, relying on collective intelligence and, ultimately, contributing to rebuilding their hospitals from the bottom up. In this respect, we arranged a two-day seminar, which brought together fourteen heads of hematology departments who share the same desire to challenge their organizations with a collaborative approach and make them evolve. The seminar was animated by an external speaker and included many fruitful sessions, both formal and informal. Following this seminar, participants are now interested in sharing this experience with other department heads throughout the organization of "collaborative seminars of heads of department." Such seminars would serve to create a real community of department heads capable of supporting each other to improve our organizations and to generate new ideas to participate in the reconstruction of our health system from the bottom. This approach is in line with the current strategy of public services to restore a prominent role to hospital departments. We hope that our initiative will also inspire heads of departments in other specialties.
    MeSH term(s) Humans ; Hospitals ; Hematology
    Language French
    Publishing date 2023-07-26
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2023.06.003
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