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  1. Article ; Online: Serbian dental institutions top cited research (1996-2018)

    Jaćimović Jelena

    Stomatološki glasnik Srbije, Vol 65, Iss 4, Pp 205-

    2018  Volume 216

    Abstract: Introduction Citation analysis, as one of the best-known bibliometric approaches, is widely used in the evaluation of research output and assessment of research performance and impact. The purpose of this study was to identify the top cited articles ... ...

    Abstract Introduction Citation analysis, as one of the best-known bibliometric approaches, is widely used in the evaluation of research output and assessment of research performance and impact. The purpose of this study was to identify the top cited articles published by researchers affiliated to Serbian dental institutions and to analyze their characteristics in order to describe cooperation at individual and institutional, as well as at national and international level. Material and Methods Articles that cited the most 2018 publication in the Web of Science were assessed. The analyzed aspects covered distribution of annual production, annual citations, journals, categories, countries, institutions, authors, research focuses and trends by author keywords and KeyWords Plus. Results the top cited papers were published in 60 journals from 1997 to 2016, with the mean number of 45.08 citations per article. These papers were co-authored by 449 authors, responsible for 726 authorships, affiliated to 149 institutions from 41 countries. Among the overall number of authors, 238 were from Serbia, while 211 were affiliated with international institutions. The most productive institutions were the University of Belgrade and Military Medical Academy from Serbia, whilst the international contributing institutions were primarily from the USA, England, and Italy. Conclusion the present study presented useful insight into the most influential Serbian dental institutions research, revealing the most productive actors and multidisciplinary nature of the research contribution.
    Keywords bibliometrics ; citation analysis ; serbia ; dentistry ; oral surgery and medicine ; RK1-715
    Subject code 001
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Serbian Medical Society - Dental Section, Belgrade
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effectiveness of vital pulp treatment in managing nontraumatic pulpitis associated with no or nonspontaneous pain: A systematic review.

    Jakovljevic, Aleksandar / Jaćimović, Jelena / Aminoshariae, Anita / Fransson, Helena

    International endodontic journal

    2022  Volume 56 Suppl 3, Page(s) 340–354

    Abstract: Background: The exposed pulp has been the topic of numerous studies, but well-designed and well-executed comparative trials on the outcome and treatment of these teeth have been limited.: Objectives: This study was conducted to answer the following ... ...

    Abstract Background: The exposed pulp has been the topic of numerous studies, but well-designed and well-executed comparative trials on the outcome and treatment of these teeth have been limited.
    Objectives: This study was conducted to answer the following questions: in patients with nontraumatic pulpitis associated with no or nonspontaneous pain in permanent teeth, (i) is direct pulp capping or pulpotomy (partial/full) as effective as selective or stepwise caries removal [Population/participants, Intervention(s), Comparator(s)/control, Outcome(s) (PICO) 1], (ii) is pulpotomy (partial/full) as effective as direct pulp capping (PICO 2) and (iii) is pulpotomy (partial/full) as effective as a pulpectomy (PICO 3), in terms of a combination of patient and clinical reported outcomes, with 'tooth survival' as the most critical outcome?
    Methods: A literature search was conducted using Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Central Register of Controlled Trials from inception to November 3rd 2021. Grey literature and contents of the major subject journals were examined. Eligibility criteria followed the PICO questions. Two independent reviewers performed study selection, data extraction and appraisal; disagreements were resolved by a third reviewer. The risk of bias was assessed by the revised Cochrane risk-of-bias tool for randomized trials.
    Results: Three randomized clinical trials (RCTs) were included in the review. No study fulfilled the criteria to answer PICO 1. There were no significant differences in the reported outcomes between investigated treatments in all included RCTs. None of the included studies reported the most critical outcome 'tooth survival'. A high loss of patients during the follow-up period was observed.
    Discussion: Although a few studies fulfilled strict eligible criteria, the results of this systematic review clearly highlight a paucity of available evidence. At the present time, clinical decisions cannot be substantiated by direct comparative trials.
    Conclusions: Based on limited evidence, this systematic review discovered no significant differences in effectiveness between compared vital pulp treatments in managing nontraumatic pulpitis associated with no or nonspontaneous pain. Further high-quality RCTs are necessary to investigate the effectiveness of direct pulp capping or pulpotomy (partial/full) compared to selective or stepwise caries removal.
    Registration: PROSPERO database (CRD42021259742).
    MeSH term(s) Humans ; Pulpitis/therapy ; Dental Caries/therapy ; Dental Pulp ; Pulpotomy/methods ; Root Canal Therapy ; Dental Pulp Capping/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Link Between Apical Periodontitis and Gastrointestinal Diseases-A Systematic Review.

    Jakovljevic, Aleksandar / Ideo, Francesca / Jacimovic, Jelena / Aminoshariae, Anita / Nagendrababu, Venkateshbabu / Azarpazhooh, Amir / Cotti, Elisabetta

    Journal of endodontics

    2023  

    Abstract: Introduction: This systematic review aimed to examine a potential link between apical periodontitis (AP) and gastrointestinal diseases (GIDs).: Methods: The protocol of the review has been registered in PROSPERO (CRD42022330771). The following ... ...

    Abstract Introduction: This systematic review aimed to examine a potential link between apical periodontitis (AP) and gastrointestinal diseases (GIDs).
    Methods: The protocol of the review has been registered in PROSPERO (CRD42022330771). The following engines were used with the aim of searching for relevant literature: PubMed, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and grey literature, from inception to May 2022. There were no language restrictions included. Study selection, data collection, and synthesis have been performed by 2 independent reviewers. For the purpose of estimating the quality of studies, the Newcastle-Ottawa Scale was used.
    Results: Four matched case control studies, as well as a single longitudinal cohort study were included in the final review. These were published between 2012 and 2017, and comprised 537 participants whose age range was 18 to 87 years. It was not possible to perform a meta-analysis due to different study designs and evaluated outcomes of included studies. Except for one study that was categorized as "Good," overall, for 4 out of 5 studies the quality was assessed as "Fair".
    Conclusions: This review highlighted sparse knowledge present in the literature concerned with the association between AP and GIDs. Available evidence reveals a potential link between impaired endodontic status, assessed by the number of root-filled teeth with periapical radiolucency, and GIDs. More research is needed to ascertain this association.
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 752412-2
    ISSN 1878-3554 ; 0099-2399
    ISSN (online) 1878-3554
    ISSN 0099-2399
    DOI 10.1016/j.joen.2023.07.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review.

    Andric, Miroslav / Jacimovic, Jelena / Jakovljevic, Aleksandar / Nikolic, Nadja / Milasin, Jelena

    Oral diseases

    2021  Volume 28, Issue 6, Page(s) 1421–1430

    Abstract: Objectives: The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these ... ...

    Abstract Objectives: The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these lesions.
    Materials and methods: A comprehensive search of Web of Science Scopus, PubMed, Cochrane Central Register of Controlled Trials and EMBASE was conducted using relevant key terms and supplemented by a gray literature search. Quality assessment of included studies was performed using criteria from the Strengthening the Reporting of Genetic Association (STREGA) statement.
    Results: Ten studies were included in the final review. Survivin -31G/C, interleukin IL-1α -889 C/T, p53 codon 72 G/C, tumor necrosis factor TNF-α (-308G>A) and its receptor TNF-R1 (36A>G), glioma-associated oncogene homolog 1 rs2228224 and matrix metalloproteinase 2 rs243865 gene polymorphisms were reported to be associated with OKC. For ameloblastomas, p53 codon 72 G/C, X-ray repair cross-complementing protein 1-codons 194 and 399 and matrix metalloproteinase 9 rs3918242 gene polymorphisms were identified as risk factors. It was not possible to establish a relationship between specific polymorphisms and clinical and histological features of investigated lesions.
    Conclusions: Several gene polymorphisms might be considered as a risk factor for the development of these lesions. Future studies should investigate whether these polymorphisms might be used to identify patients with increased risk of recurrence or aggressive disease.
    MeSH term(s) Ameloblastoma/pathology ; Humans ; Matrix Metalloproteinase 2/metabolism ; Odontogenic Cysts/genetics ; Odontogenic Cysts/pathology ; Odontogenic Tumors ; Polymorphism, Genetic ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Suppressor Protein p53
    Chemical Substances Tumor Necrosis Factor-alpha ; Tumor Suppressor Protein p53 ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2021-04-08
    Publishing country Denmark
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis.

    Nikolic, Nadja / Carkic, Jelena / Jacimovic, Jelena / Jakovljevic, Aleksandar / Anicic, Boban / Jezdic, Zoran / Milasin, Jelena

    Epigenetics

    2022  Volume 17, Issue 12, Page(s) 1661–1676

    Abstract: The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possible ... ...

    Abstract The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possible effect on clinical/histological characteristics. Review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (registration ID CRD42020218511). A comprehensive search of Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials was performed utilizing relevant key terms, supplemented by a search of grey literature. Newcastle-Ottawa Quality Assessment Scale (NOQAS) was used for the quality assessment of included studies. Sixteen cross-sectional and 12 case-control studies were included in the review, predominantly dealing with methylation in TSGs related to DNA repair, cell cycle, and cell growth regulation and differentiation. Quantitative synthesis could be performed on P16 (inhibitor of cyclin-dependent kinase 4a), RASSF1A (Ras association domain family 1 isoform A) and MGMT (O6-methylguanine DNA methyltransferase) genes only. It showed that P16 and RASSF1A genes were more frequently methylated in salivary gland tumours compared to controls (
    MeSH term(s) Humans ; Genes, Tumor Suppressor ; DNA Methylation ; Cross-Sectional Studies ; Salivary Gland Neoplasms/genetics ; Cyclin-Dependent Kinases ; DNA
    Chemical Substances Cyclin-Dependent Kinases (EC 2.7.11.22) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2022.2052426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Herpesviruses in Periodontitis: An Umbrella Review.

    Jakovljevic, Aleksandar / Andric, Miroslav / Jacimovic, Jelena / Milasin, Jelena / Botero, Javier Enrique

    Advances in experimental medicine and biology

    2022  Volume 1373, Page(s) 139–155

    Abstract: Background: Despite numerous studies indicating a high prevalence of herpesviruses in both apical and marginal periodontitis samples, their exact role in the pathogenesis of a periodontal disease is still unclear.: Objective: This umbrella review ... ...

    Abstract Background: Despite numerous studies indicating a high prevalence of herpesviruses in both apical and marginal periodontitis samples, their exact role in the pathogenesis of a periodontal disease is still unclear.
    Objective: This umbrella review aimed to summarize data on herpesviruses detection in marginal periodontitis (MP) and apical periodontitis of endodontic origin (APEO) samples.
    Methods: The study protocol has been drafted a priori and registered to the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42020215922). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to October 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between the occurrence of herpesviruses and different forms of periodontal diseases were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction, and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews).
    Results: Six systematic reviews were included in the current review. One was graded as high quality, another one was graded as moderate quality, whereas the other four were graded as critically low-quality reviews. The presence of herpesviruses in subgingival samples was associated with an increased risk of MP, supported by the corresponding meta-analyses. Although the association was strong (OR > 3.0), the confidence intervals were wide, heterogeneity was significant, and studies were of small sample size. In addition, publication bias was detected. Contrary, data from systematic reviews that assessed APEO and herpesviruses did not show any significant associations.
    Conclusions: Low-quality studies with high uncertainty suggest a strong association between herpesviruses and MP, but not with APEO.
    MeSH term(s) Databases, Factual ; Humans ; Periapical Periodontitis/epidemiology ; Periodontitis/epidemiology ; Simplexvirus ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-96881-6_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis.

    Sljivancanin Jakovljevic, Tamara / Martic, Jelena / Jacimovic, Jelena / Nikolic, Nadja / Milasin, Jelena / Mitrović, Tanja Lazić

    World journal of pediatrics : WJP

    2022  Volume 18, Issue 10, Page(s) 654–670

    Abstract: Background: The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis development.: Methods: A comprehensive literature ... ...

    Abstract Background: The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis development.
    Methods: A comprehensive literature search, reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines, was performed with no language restriction. Studies derived using the PICO (population, intervention, comparison and outcomes) strategy, with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without sepsis. Data were analyzed using Review Manager. The Cochran-Mantel-Haenszel test was used to calculate odds ratios with 95% confidence intervals. Heterogeneity was tested using the I
    Results: From a total of 9428 possibly relevant articles, 33 qualified for inclusion in this systematic review. According to the STrengthening the REporting of Genetic Association Studies, 23 studies were found to be of moderate quality, while 10 were of low quality. The results showed an association of the mannose-binding lectin (MBL) exon 1 genetic polymorphism with the risk of culture-proven sepsis. Toll-like receptor (TLR) 4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven sepsis. The certainty of evidence per GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) varied from very low to low. Publication bias was not detected.
    Conclusions: Out of the 11 investigated single-nucleotide polymorphisms, this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 polymorphisms. There is an evident need for larger well-designed, multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.
    MeSH term(s) Humans ; Infant, Newborn ; Genetic Predisposition to Disease ; Immunity, Innate/genetics ; Neonatal Sepsis/genetics ; Polymorphism, Single Nucleotide ; Sepsis/genetics ; Toll-Like Receptor 4/genetics
    Chemical Substances Toll-Like Receptor 4
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-022-00569-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effectiveness of pulpotomy compared with root canal treatment in managing non-traumatic pulpitis associated with spontaneous pain: A systematic review and meta-analysis.

    Tomson, Phillip L / Vilela Bastos, Juliana / Jacimovic, Jelena / Jakovljevic, Aleksandar / Pulikkotil, Shaju Jacob / Nagendrababu, Venkateshbabu

    International endodontic journal

    2022  Volume 56 Suppl 3, Page(s) 355–369

    Abstract: Background: Pulpitis characterized by spontaneous pain can result in debilitating pain. Dogma has existed to offer only have two treatment options, namely root canal treatment (RCT) or extraction, although pulpotomy has always remained a potential ... ...

    Abstract Background: Pulpitis characterized by spontaneous pain can result in debilitating pain. Dogma has existed to offer only have two treatment options, namely root canal treatment (RCT) or extraction, although pulpotomy has always remained a potential treatment modality.
    Objective: This review aimed to answer the following research question: 'Does pulpotomy (partial or full) (I) result in better patient and clinical reported outcomes (O), compared with RCT (C) in permanent teeth with pulpitis characterized by spontaneous pain (P) evaluated at various time intervals?' (T).
    Methods: Two authors independently performed study selection, data extraction and risk of bias assessment. The literature search was conducted in the following electronic databases: Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Central Register of Controlled Trials. English language clinical trials comparing the patient and clinical reported outcomes between RCT and pulpotomy were included. The meta-analysis was performed on a fixed-effect model and the quality of evidence assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
    Results: Two randomized clinical trials were included. Amongst two trials, one has published four reports at different time points involving the same cohorts. The meta-analysis revealed no difference in postoperative pain (Day 7) between RCT and pulpotomy (OR = 0.99, 95% CI 0.63-1.55, I
    Discussion: Pulpotomy is a definitive treatment modality that is as effective as RCT. This could have a significant impact on treatment of such patients affording the advantages of retaining a vital pulp and preventing the need for RCT.
    Conclusion: This review could only include two trials, hence there is insufficient evidence to draw robust conclusions. The clinical data accumulated so far suggests no difference in pain between RCT and pulpotomy at Day 7 postoperatively and a single randomized control trial suggests that the clinical success rate for both treatment modalities is similar long term. There is a need for more well-designed trials by different research groups to develop a stronger evidence base in this area.
    Registration: PROSPERO database (CRD42021259744).
    MeSH term(s) Humans ; Pulpotomy ; Pulpitis/complications ; Pulpitis/surgery ; Dental Pulp Cavity ; Root Canal Therapy ; Pain, Postoperative ; Treatment Outcome ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-10-29
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Critical analysis of the reporting quality of animal studies within Endodontics using the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 quality standard checklist.

    Tzanetakis, Giorgos / Jakovljevic, Aleksandar / Koletsi, Despina / Jacimovic, Jelena / Nagendrababu, Venkateshbabu / Duncan, Henry Fergus / Dummer, Paul Michael Howell

    International endodontic journal

    2023  Volume 56, Issue 9, Page(s) 1042–1062

    Abstract: Aim: To critically evaluate the reporting quality of a random sample of animal studies within the field of endodontics against the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 checklist and to investigate the association ... ...

    Abstract Aim: To critically evaluate the reporting quality of a random sample of animal studies within the field of endodontics against the Preferred Reporting Items for Animal Studies in Endodontics (PRIASE) 2021 checklist and to investigate the association between the quality of reporting and several characteristics of the selected studies.
    Methodology: Fifty animal studies related to endodontics were randomly selected from the PubMed database with publication dates from January 2017 to December 2021. For each study, a score of '1' was given when the item of the PRIASE 2021 checklist was fully reported, whereas a score of '0' was given when an item was not reported; when the item was inadequately or partially reported, a score of '0.5' was given. Based on the overall scores allocated to each manuscript, they were allocated into three categories of reporting quality: low, moderate and high. Associations between study characteristics and reporting quality scores were also analysed. Descriptive statistics and Fisher's exact tests were used to describe the data and determine associations. The probability value of .05 was selected as the level of statistical significance.
    Results: Based on the overall scores, four (8%) and 46 (92%) of the animal studies evaluated were categorized as 'High' and 'Moderate' reporting quality, respectively. A number of items were adequately reported in all studies related to background (Item 4a), relevance of methods/results (7a) and interpretation of images (11e), whereas only one item related to changes in protocol (6d) was not reported in any. No associations were confirmed between reporting quality scores and number of authors, origin of the corresponding author, journal of publication (endodontic specialty vs. non- specialty), impact factor or year of publication.
    Conclusions: Animal studies published in the specialty of endodontics were mostly of 'moderate' quality in terms of the quality of reporting. Adherence to the PRIASE 2021 guidelines will enhance the reporting of animal studies in the expectation that all future publications will be high quality.
    MeSH term(s) Animals ; Checklist ; Endodontics ; Research Design
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Lack of association between glutathione S-transferase M1 and T1 gene polymorphisms and susceptibility to preeclampsia: An updated systematic review and meta-analysis.

    Sljivancanin Jakovljevic, Tamara / Jacimovic, Jelena / Nikolic, Nadja / Milasin, Jelena

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2020  Volume 84, Issue 6, Page(s) e13303

    Abstract: Insufficient response to oxidative stress in placenta is proposed as a contributing factor for preeclampsia (PE) development. Glutathione S-transferases (GST) have significant role in detoxification processes. Conflicting results were published by ... ...

    Abstract Insufficient response to oxidative stress in placenta is proposed as a contributing factor for preeclampsia (PE) development. Glutathione S-transferases (GST) have significant role in detoxification processes. Conflicting results were published by several research groups regarding GST T1 and GST M1 deletion polymorphism as risk factors for PE. The aim of the present meta-analysis was to get a better understanding of the impact of these polymorphisms in preeclampsia development. To identify relevant case-control studies, the author team searched Clarivate Analytics Web of Science, Scopus, PubMed, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, major subject journals, and gray literature. Pooled odds ratios and 95% confidence intervals for GST M1 and GST T1 deletion polymorphism and preeclampsia were derived from random effects models. This meta-analysis included 10 eligible studies. The pooled analyses showed no association between GST M1/GST T1 deletion polymorphisms and susceptibility to PE. Even though high heterogeneity was founded among results for GST M1 and double null genotypes, Egger's and Begg's tests (0.17 and 0.18, respectively) revealed no statistical evidence of publication bias among included studies. The present updated systematic review and meta-analysis found no association between GST M1 and GST T1 deletion polymorphism and PE risk.
    MeSH term(s) Female ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase/genetics ; Humans ; Polymorphism, Genetic ; Pre-Eclampsia/genetics ; Pregnancy ; Risk ; Sequence Deletion/genetics
    Chemical Substances Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18) ; glutathione transferase T1-1, human (EC 2.5.1.18)
    Language English
    Publishing date 2020-08-01
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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