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  1. Article ; Online: A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer

    Haonan Lu / Mubarik Arshad / Andrew Thornton / Giacomo Avesani / Paula Cunnea / Ed Curry / Fahdi Kanavati / Jack Liang / Katherine Nixon / Sophie T. Williams / Mona Ali Hassan / David D. L. Bowtell / Hani Gabra / Christina Fotopoulou / Andrea Rockall / Eric O. Aboagye

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based ...

    Abstract Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based on CT scans acquired pre-operatively in 364 patients.
    Keywords Science ; Q
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer

    Haonan Lu / Mubarik Arshad / Andrew Thornton / Giacomo Avesani / Paula Cunnea / Ed Curry / Fahdi Kanavati / Jack Liang / Katherine Nixon / Sophie T. Williams / Mona Ali Hassan / David D. L. Bowtell / Hani Gabra / Christina Fotopoulou / Andrea Rockall / Eric O. Aboagye

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based ...

    Abstract Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient survival based on CT scans acquired pre-operatively in 364 patients.
    Keywords Science ; Q
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

    Bong, Yong Koy / Amritha Appaswami / Ben Mijts / David Entwistle / Derek Smith / Jack Liang / Jeff Colbeck / Jovana Nazor / Jun Zhu / Karthik Narayanaswamy / Magnus Widegren / Michael D. Clay / Michael Vogel / Rob Wilson / Ryan Fong / S. M. Palanivel / Sheela Muley / Shiwei Song / Steven J. Collier /
    Xiyun Zhang

    Journal of organic chemistry. 2018 June 22, v. 83, no. 14

    2018  

    Abstract: A wild-type Baeyer–Villiger monooxygenase was engineered to overcome numerous liabilities in order to mediate a commercial oxidation of pyrmetazole to esomeprazole, using air as the terminal oxidant in an almost exclusively aqueous reaction matrix. The ... ...

    Abstract A wild-type Baeyer–Villiger monooxygenase was engineered to overcome numerous liabilities in order to mediate a commercial oxidation of pyrmetazole to esomeprazole, using air as the terminal oxidant in an almost exclusively aqueous reaction matrix. The developed enzyme and process compares favorably to the incumbent Kagan inspired chemocatalytic oxidation, as esomeprazole was isolated in 87% yield, in >99% purity, with an enantiomeric excess of >99%.
    Keywords air ; chemical structure ; organic chemistry ; organic compounds ; oxidants ; oxidation
    Language English
    Dates of publication 2018-0622
    Size p. 7453-7458.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.8b00468
    Database NAL-Catalogue (AGRICOLA)

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