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  1. Article: Consent Rights of Gender Diverse Children in Australia and the United Kingdom: Will the Court's Involvement End?

    Jacko, Georgina

    Journal of law and medicine

    2022  Volume 29, Issue 4, Page(s) 1269–1287

    Abstract: Gender diversity allows individuals to express their innate sense of self and has been increasingly recognised over time. Consequently, paediatric gender services have seen exponential increases in referrals internationally. This has resulted in novel ... ...

    Abstract Gender diversity allows individuals to express their innate sense of self and has been increasingly recognised over time. Consequently, paediatric gender services have seen exponential increases in referrals internationally. This has resulted in novel issues for courts, such as a child's "best interests" when accessing puberty-suppressing and gender-affirming medical care. Most recently, in the United Kingdom, the adequacy of information provided to transgender children and their families was also debated. Progression of the common law in Australia has resulted in transgender children consenting to medical treatment once Gillick competent. Yet, Bell v Tavistock [2020] EWHC 3274 temporarily halted the care of the United Kingdom's transgender children, who were previously afforded consenting rights. On appeal it was determined to be inappropriate for the divisional court to have provided generalised guidance on children's capacity to consent to medical therapy. Through comparative analysis of case law, the adequacy of these regulations will be assessed.
    MeSH term(s) Humans ; Child ; United Kingdom ; Gender Identity ; Australia ; Informed Consent
    Language English
    Publishing date 2022-11-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1236328-5
    ISSN 1320-159X
    ISSN 1320-159X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Equity in blood transfusion precision services.

    Jacko, Georgina / Thorpe, Rachel / Daly, James

    International journal for equity in health

    2024  Volume 23, Issue 1, Page(s) 77

    Abstract: Background: Blood collection agencies are integrating precision medicine techniques to improve and individualise blood donor and recipient outcomes. These organisations have a role to play in ensuring equitable application of precision medicine ... ...

    Abstract Background: Blood collection agencies are integrating precision medicine techniques to improve and individualise blood donor and recipient outcomes. These organisations have a role to play in ensuring equitable application of precision medicine technologies for both donors and transfusion recipients. BODY: Precision medicine techniques, including molecular genetic testing and next generation sequencing, have been integrated in transfusion services to improve blood typing and matching with the aim to reduce a variety of known transfusion complications. Internationally, priorities in transfusion research have aimed to optimise services through the use of precision medicine technologies and consider alternative uses of genomic information to personalise transfusion experiences for both recipients and donors. This has included focusing on the use of genomics when matching blood products for transfusion recipients, to personalise a blood donor's donation type or frequency, and longitudinal donor research utilising blood donor biobanks.
    Conclusion: Equity in precision services and research must be of highest importance for blood collection agencies to maintain public trust, especially when these organisations rely on volunteer donors to provide transfusion services. The investment in implementing equitable precision medicine services, including development of blood donor biobanks, has the potential to optimise and personalise services for both blood donors and transfusion recipients.
    MeSH term(s) Humans ; Blood Transfusion ; Blood Donors
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Letter
    ZDB-ID 2092056-8
    ISSN 1475-9276 ; 1475-9276
    ISSN (online) 1475-9276
    ISSN 1475-9276
    DOI 10.1186/s12939-024-02170-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Frequency of red blood cell phenotypes from genotyped Australian blood donors.

    Jacko, Georgina / Powley, Tanya / Daly, James

    Transfusion medicine (Oxford, England)

    2024  

    Abstract: Background: Australian Red Cross Lifeblood (Lifeblood) performs human erythrocyte antigen (HEA) genotyping for a subset of repeat whole-blood donors through preferential selection which aims to maximise variation of results and possibility of ... ...

    Abstract Background: Australian Red Cross Lifeblood (Lifeblood) performs human erythrocyte antigen (HEA) genotyping for a subset of repeat whole-blood donors through preferential selection which aims to maximise variation of results and possibility of identifying donors lacking high frequency red cell antigens.
    Materials and methods: The HEA Molecular Bead chip™ assay is used by Lifeblood for donor genotyping. A review of all donor HEA genotype data from March 2019 to May 2022 (3 years) was conducted.
    Results: HEA genotyping was performed for 20,185donors. Due to selective genotyping of donors, a higher frequency of R1R1 predicted phenotype was identified. However, frequencies of other red cell phenotypes were relatively similar to previous reported in the Australian population. A small number of donors with rare red cell phenotypes was identified.
    Conclusion: Genotyping of blood donors provides an available pool of extended matched red blood cell products for matching to recipients. Additionally genotyping can improve the identification of donors with rare phenotypes. Whilst limitations exist, genotyping may reduce the need for labour intensive serotyping, improve blood inventory management, and may be useful in donor recruitment and retention.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.13044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3177: Show issues Location:
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  4. Article ; Online: Red cell antibodies: frequency in the Western Australian Antibody Register and Australian blood donor populations.

    Jacko, Georgina / Powley, Tanya / Cawthorne, Tanya / Tan, Zhi / Daly, James

    Pathology

    2024  

    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Evaluation of two temperature storage conditions for full blood count samples from Lifeblood's donors.

    Jacko, Georgina / Green, Anna / Lycett, Leo / Ismay, Sue / Peberdy, James / Daly, James

    Transfusion medicine (Oxford, England)

    2023  Volume 33, Issue 3, Page(s) 221–226

    Abstract: Background and objectives: Lifeblood completes full blood count samples for selected donors to assess their suitability for future donations. Removing the current practice for refrigerated (2-8°C) storage and aligning with room temperature (20-24°C) ... ...

    Abstract Background and objectives: Lifeblood completes full blood count samples for selected donors to assess their suitability for future donations. Removing the current practice for refrigerated (2-8°C) storage and aligning with room temperature (20-24°C) storage of other donor blood samples would produce significant efficiencies in blood donor centres. This study aimed to compare full blood count results under two temperature conditions.
    Materials and methods: Paired full blood count samples were collected from 250 whole blood or plasma donors. These were stored either refrigerated or room temperature for testing on arrival at the processing centre and the following day. The primary outcomes of interest included differences between mean cell volume, haematocrit, platelet count, white cell and differential counts, and the need to produce blood films, based on existing Lifeblood criteria.
    Results: A statistically significant (p < 0.05) difference for most full blood count parameters results was found between the two temperature conditions. The number of blood films required was similar under each temperature condition.
    Conclusion: The clinical significance of the small numerical differences in results is considered minimal. Furthermore, the number of blood films required remained similar under either temperature condition. Given the significant reductions in time, processing and costs associated with room temperature over refrigerated processing, we recommend a further pilot study to monitor the broader impacts, with the intent to implement national storage of full blood count samples at room temperature within Lifeblood.
    MeSH term(s) Humans ; Temperature ; Pilot Projects ; Blood Cell Count/methods ; Hematocrit ; Platelet Count
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Next generation sequencing to identify iron status and individualise blood donors' experience.

    Jacko, Georgina / Sivakaanthan, Aarany / Obeysekera, Maheshi / Welvaert, Marijke / Viennet, Elvina / Hyland, Catherine / Tung, John-Paul / Perros, Alexis J / Flower, Robert L / Roulis, Eileen

    Blood transfusion = Trasfusione del sangue

    2023  Volume 21, Issue 6, Page(s) 463–471

    Abstract: Background: Young adults form the majority of first-time blood donors to Australian Red Cross Lifeblood. However, these donors pose unique challenges for donor safety. Young blood donors, who are still undergoing neurological and physical development, ... ...

    Abstract Background: Young adults form the majority of first-time blood donors to Australian Red Cross Lifeblood. However, these donors pose unique challenges for donor safety. Young blood donors, who are still undergoing neurological and physical development, have been found to have lower iron stores, and have higher risks of iron deficiency anaemia when compared to older adults and non-donors. Identifying young donors with higher iron stores may improve donor health and experience, increase donor retention, and reduce the burden on product donation. In addition, these measures could be used to individualise donation frequency.
    Materials and methods: Stored DNA samples from young male donors (18-25 years; No.=47) were sequenced using a custom panel of genes identified in the literature to be associated with iron homeostasis. The custom sequencing panel used in this study identified and reported variants to human genome version 19 (Hg19).
    Results: 82 gene variants were analysed. Only one of which, rs8177181, was found to have a statistically significant (p<0.05) association with plasma ferritin level. Heterozygous alleles of this Transferrin gene variant, rs8177181T>A, significantly predicted a positive effect on ferritin levels (p=0.03).
    Discussion: This study identified gene variants involved in iron homeostasis using a custom sequencing panel and analysed their association with ferritin levels in a young male blood donor population. Additional studies of factors associated with iron deficiency in blood donors are required if a goal of personalised blood donation protocols is to be achieved.
    MeSH term(s) Young Adult ; Male ; Humans ; Aged ; Iron ; Blood Donors ; Ferritins ; High-Throughput Nucleotide Sequencing ; Australia ; Hemoglobins
    Chemical Substances Iron (E1UOL152H7) ; Ferritins (9007-73-2) ; Hemoglobins
    Language English
    Publishing date 2023-04-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 798: Show issues Location:
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