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  1. Article ; Online: Living with COVID-19 in 2022: the impact of the pandemic on Australian general practice.

    Jackson, Claire L

    The Medical journal of Australia

    2022  Volume 216, Issue 9, Page(s) 442–444

    MeSH term(s) Australia/epidemiology ; COVID-19/epidemiology ; General Practice ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-05-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51512
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  2. Article ; Online: Methods for the assessment of human airway ciliary function.

    Jackson, Claire L / Bottier, Mathieu

    The European respiratory journal

    2022  Volume 60, Issue 1

    MeSH term(s) Cilia ; Humans ; Trachea
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02300-2021
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  3. Article ; Online: Reforming our health care system: time to rip off the band-aid?

    Jackson, Claire L / O'Halloran, Diana

    The Medical journal of Australia

    2021  Volume 215, Issue 7, Page(s) 301–303.e1

    MeSH term(s) Australia/epidemiology ; Benchmarking/statistics & numerical data ; Delivery of Health Care/legislation & jurisprudence ; Health Care Reform/methods ; Humans ; Leadership
    Language English
    Publishing date 2021-09-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51261
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  4. Article ; Online: Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia.

    Dabrowski, Maciej / Bukowy-Bieryllo, Zuzanna / Jackson, Claire L / Zietkiewicz, Ewa

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: Primary ciliary dyskinesia (PCD) is a rare disease with autosomal recessive inheritance, caused mostly by bi-allelic gene mutations that impair motile cilia structure and function. Currently, there are no causal treatments for PCD. In many disease models, ...

    Abstract Primary ciliary dyskinesia (PCD) is a rare disease with autosomal recessive inheritance, caused mostly by bi-allelic gene mutations that impair motile cilia structure and function. Currently, there are no causal treatments for PCD. In many disease models, translational readthrough of premature termination codons (PTC-readthrough) induced by aminoglycosides has been proposed as an effective way of restoring functional protein expression and reducing disease symptoms. However, variable outcomes of pre-clinical trials and toxicity associated with long-term use of aminoglycosides prompt the search for other compounds that might overcome these problems. Because a high proportion of PCD-causing variants are nonsense mutations, readthrough therapies are an attractive option. We tested a group of chemical compounds with known PTC-readthrough potential (ataluren, azithromycin, tylosin, amlexanox, and the experimental compound TC007), collectively referred to as non-aminoglycosides (NAGs). We investigated their PTC-readthrough efficiency in six PTC mutations found in Polish PCD patients, in the context of cell and cilia health, and in comparison to the previously tested aminoglycosides. The NAGs did not compromise the viability of the primary nasal respiratory epithelial cells, and the ciliary beat frequency was retained, similar to what was observed for gentamicin. In HEK293 cells transfected with six PTC-containing inserts, the tested compounds stimulated PTC-readthrough but with lower efficiency than aminoglycosides. The study allowed us to select compounds with minimal negative impact on cell viability and function but still the potential to induce PTC-readthrough.
    MeSH term(s) Aminoglycosides/pharmacology ; Cell Death/drug effects ; Cells, Cultured ; Cilia/drug effects ; Cilia/metabolism ; Ciliary Motility Disorders/genetics ; Codon, Nonsense/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; HEK293 Cells ; Humans ; Mutation/genetics ; Nose/pathology ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/genetics
    Chemical Substances Aminoglycosides ; Codon, Nonsense
    Language English
    Publishing date 2021-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094923
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  5. Article ; Online: Our first National Primary Health Care Strategy: 3 years on, what change for general practice?

    Jackson, Claire L

    The Medical journal of Australia

    2013  Volume 198, Issue 11, Page(s) 581–582

    MeSH term(s) Australia ; Delivery of Health Care, Integrated/organization & administration ; Forecasting ; General Practice/organization & administration ; Health Care Reform/organization & administration ; Health Care Reform/trends ; Health Planning/organization & administration ; Humans ; Telemedicine ; Workforce
    Language English
    Publishing date 2013-05-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja13.10298
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  6. Article ; Online: Australian general practice: primed for the "patient-centred medical home"?

    Jackson, Claire L

    The Medical journal of Australia

    2011  Volume 197, Issue 7, Page(s) 365–366

    MeSH term(s) Australia ; General Practice/standards ; Humans ; Patient-Centered Care
    Language English
    Publishing date 2011-03-28
    Publishing country Australia
    Document type Editorial
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja12.11373
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  7. Article ; Online: Improving quality in general practice using the Primary Care Practice Improvement Tool (PC-PIT) with Primary Health Network support.

    Borg, Samantha J / Donald, Maria / Totsidis, Koula / Quinn, Narelle / Jackson, Claire L

    Australian journal of primary health

    2021  Volume 26, Issue 6, Page(s) 484–491

    Abstract: Optimal primary care sector performance is vital for ensuring the delivery of quality health services and effective clinical management of populations. The Primary Care Practice Improvement Tool (PC-PIT) incorporates subjective staff input and objective ... ...

    Abstract Optimal primary care sector performance is vital for ensuring the delivery of quality health services and effective clinical management of populations. The Primary Care Practice Improvement Tool (PC-PIT) incorporates subjective staff input and objective indicators to measure 13 elements of organisational performance. This study aimed to measure change in organisational performance for general practices using the PC-PIT with Primary Health Network (PHN) support. A pre-post design was used for changes in PC-PIT subjective and objective scores. Practices used results with PHN support to complete two Plan Do Study Act initiatives and were reassessed 9-months later. PC-PIT scales were dichotomised into lower and higher scores, with odds ratios used to determine effect size. Staff survey response rates were 55.4% at baseline and 50.1% at follow up. There were modest increases in the likelihood of staff rating several elements higher at follow up. When implemented with PHN support staff, the PC-PIT has the potential for effective, focussed and sustained quality improvement, with capacity to support Health Care Home model transition and implementation.
    MeSH term(s) Efficiency, Organizational ; General Practice/standards ; Humans ; Primary Health Care ; Quality Improvement ; Quality Indicators, Health Care ; Queensland
    Language English
    Publishing date 2021-01-28
    Publishing country Australia
    Document type Comparative Study ; Journal Article
    ZDB-ID 2566332-X
    ISSN 1836-7399 ; 1448-7527
    ISSN (online) 1836-7399
    ISSN 1448-7527
    DOI 10.1071/PY20192
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  8. Article ; Online: Community-based integrated care versus hospital outpatient care for managing patients with complex type 2 diabetes: costing analysis.

    Donald, Maria / Jackson, Claire L / Byrnes, Joshua / Vaikuntam, Bharat Phani / Russell, Anthony W / Hollingworth, Samantha A

    Australian health review : a publication of the Australian Hospital Association

    2021  Volume 45, Issue 1, Page(s) 42–50

    Abstract: Objective This study compared the cost of an integrated primary-secondary care general practitioner (GP)-based Beacon model with usual care at hospital outpatient departments (OPDs) for patients with complex type 2 diabetes. Methods A costing analysis ... ...

    Abstract Objective This study compared the cost of an integrated primary-secondary care general practitioner (GP)-based Beacon model with usual care at hospital outpatient departments (OPDs) for patients with complex type 2 diabetes. Methods A costing analysis was completed alongside a non-inferiority randomised control trial. Costs were calculated using information from accounting data and interviews with clinic managers. Two OPDs and three GP-based Beacon practices participated. In the Beacon practices, GPs with a special interest in advanced diabetes care worked with an endocrinologist and diabetes nurse educator to care for referred patients. The main outcome was incremental cost saving per patient course of treatment from a health system perspective. Uncertainty was characterised with probabilistic sensitivity analysis using Monte Carlo simulation. Results The Beacon model is cost saving: the incremental cost saving per patient was A$365 (95% confidence interval -A$901, A$55) and was cost saving in 93.7% of simulations. The key contributors to the variance in the cost saving per patient course of treatment were the mean number of patients seen per site and the number of additional presentations per course of treatment associated with the Beacon model. Conclusions Beacon clinics were less costly per patient course of treatment than usual care in hospital OPDs for equivalent clinical outcomes. Local contractual arrangements and potential variation in the operational cost structure are of significant consideration in determining the cost-efficiency of Beacon models. What is known about this topic? Despite the growing importance of achieving care quality within constrained budgets, there are few costing studies comparing clinically-equivalent hospital and community-based care models. What does this paper add? Costing analyses comparing hospital-based to GP-based health services require considerable effort and are complex. We show that GP-based Beacon clinics for patients with complex chronic disease can be less costly per patient course of treatment than usual care offered in hospital OPDs. What are the implications for practitioners? In addition to improving access and convenience for patients, transferring care from hospital to the community can reduce health system costs.
    MeSH term(s) Ambulatory Care ; Cost-Benefit Analysis ; Delivery of Health Care, Integrated ; Diabetes Mellitus, Type 2/therapy ; Hospitals ; Humans ; Outpatients
    Language English
    Publishing date 2021-02-09
    Publishing country Australia
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639155-2
    ISSN 1449-8944 ; 0159-5709 ; 0156-5788
    ISSN (online) 1449-8944
    ISSN 0159-5709 ; 0156-5788
    DOI 10.1071/AH19226
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  9. Article ; Online: Co-creation: a new approach to optimising research impact?

    Jackson, Claire L / Greenhalgh, Trisha

    The Medical journal of Australia

    2015  Volume 203, Issue 7, Page(s) 283–284

    MeSH term(s) Evidence-Based Nursing/organization & administration ; Health Services Research/organization & administration ; Humans ; Journal Impact Factor ; Nursing Evaluation Research/organization & administration ; Nursing Research/organization & administration
    Language English
    Publishing date 2015-08-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja15.00219
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  10. Article: Misdiagnosis of acute eye diseases by primary health care providers: incidence and implications.

    Jackson, Claire L

    The Medical journal of Australia

    2008  Volume 190, Issue 6, Page(s) 343–344

    MeSH term(s) Australia ; Clinical Competence ; Diagnostic Errors ; Eye Diseases/diagnosis ; Humans ; Primary Health Care/standards ; Referral and Consultation
    Language English
    Publishing date 2008-08-05
    Publishing country Australia
    Document type Comment ; Letter
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/j.1326-5377.2009.tb02439.x
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