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Article: A CURE Biochemistry Laboratory Module to Study Protein-Protein Interactions by NMR Spectroscopy.

Marsiglia, William M / Qamra, Rohini / Jackson, Kimberly M / Traaseth, Nathaniel J

2020 Volume 97, Issue 2, Page(s) 437–442

Abstract: Design of undergraduate laboratory courses that provide meaningful research-based experiences enhance undergraduate curricula and prepare future graduate students for research careers. In this article, a Course-based Undergraduate Research Experience ( ... ...

Abstract	Design of undergraduate laboratory courses that provide meaningful research-based experiences enhance undergraduate curricula and prepare future graduate students for research careers. In this article, a Course-based Undergraduate Research Experience (CURE) laboratory module was designed for upper-division undergraduate biochemistry and chemistry students. The laboratory module enabled students to build upon recently published data in the literature to decipher atomistic insight for an essential protein-protein interaction in human biology through the use of biomolecular NMR spectroscopy. Students compared their results with published data with the goal of identifying specific regions of the protein-protein interaction responsible for triggering an allosteric conformational change. The laboratory module introduced students to basic and advance laboratory techniques, including protein purification, NMR spectroscopy, and analysis of protein structure using molecular visualization software.
Language	English
Publishing date	2020-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	218164-2
ISSN	1938-1328 ; 0021-9584
ISSN (online)	1938-1328
ISSN	0021-9584
DOI	10.1021/acs.jchemed.9b00364
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Article: Realigning the Crooked Room: Spelman Claims a Space for African American Women in STEM.

Jackson, Kimberly M / Winfield, Leyte L

Peer review : emerging trends and key debates in undergraduate education

2014 Volume 16, Issue 2, Page(s) 9–12

Language	English
Publishing date	2014-12-15
Publishing country	United States
Document type	Journal Article
ISSN	1541-1389
ISSN	1541-1389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory.

Jackson, Kimberly M Palatini / Rathinasabapathy, Thirumurugan / Esposito, Debora / Komarnytsky, Slavko

Molecular nutrition & food research

2017 Volume 61, Issue 9

Abstract: Scope: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin ... ...

Abstract	Scope: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin biosynthesis in chicory, have been reported to improve glucose metabolism in humans, but the functional group in their structure responsible for this effect has not been yet characterized. Methods and results: Here, we showed that three di-O-caffeoylquinic acids suppressed hepatic glucose production in H4IIE rat hepatoma cells by reducing expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes that regulate hepatic gluconeogenesis. Direct comparisons between CQAs and their metabolites (3-caffeoylquinic, caffeic, and quinic acids) revealed the caffeic acid moiety alone was responsible for the observed effects. Further analysis suggested the activation of PI3K and MAPK pathways as a method of controlling gene expression was shared between caffeoylquinic and caffeic acids. These compounds promoted increased mitochondrial respiration and cellular metabolism, in part by inducing oxidative phosphorylation and proton leak. Conclusion: We concluded that the caffeic acid moiety was important for suppression of hepatic gluconeogenesis and hyperglycemia, ultimately strengthening the link between dietary interventions based on caffeic acid-containing plant foods and healthy glucose metabolism.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cichorium intybus/chemistry ; Gluconeogenesis/drug effects ; Hypoglycemic Agents/pharmacology ; MAP Kinase Signaling System ; Pharmacogenetics ; Phosphatidylinositol 3-Kinases/physiology ; Plant Roots/chemistry ; Quinic Acid/analogs & derivatives ; Quinic Acid/pharmacology ; Rats ; Structure-Activity Relationship
Chemical Substances	Hypoglycemic Agents ; caffeoylquinic acid ; Quinic Acid (058C04BGYI) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2017-04-27
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.201601118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Structural constraints and importance of caffeic acid moiety for antiâhyperglycemic effects of caffeoylquinic acids from chicory

Jackson, Kimberly M. Palatini / Thirumurugan Rathinasabapathy / Debora Esposito / Slavko Komarnytsky

Molecular nutrition & food research. 2017 Sept., v. 61, no. 9

2017

Abstract: SCOPE: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin biosynthesis ...

Abstract	SCOPE: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin biosynthesis in chicory, have been reported to improve glucose metabolism in humans, but the functional group in their structure responsible for this effect has not been yet characterized. METHODS AND RESULTS: Here, we showed that three diâOâcaffeoylquinic acids suppressed hepatic glucose production in H4IIE rat hepatoma cells by reducing expression of glucoseâ6âphosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes that regulate hepatic gluconeogenesis. Direct comparisons between CQAs and their metabolites (3âcaffeoylquinic, caffeic, and quinic acids) revealed the caffeic acid moiety alone was responsible for the observed effects. Further analysis suggested the activation of PI3K and MAPK pathways as a method of controlling gene expression was shared between caffeoylquinic and caffeic acids. These compounds promoted increased mitochondrial respiration and cellular metabolism, in part by inducing oxidative phosphorylation and proton leak. CONCLUSION: We concluded that the caffeic acid moiety was important for suppression of hepatic gluconeogenesis and hyperglycemia, ultimately strengthening the link between dietary interventions based on caffeic acidâcontaining plant foods and healthy glucose metabolism.
Keywords	Cichorium intybus ; biosynthesis ; caffeic acid ; chicory ; chlorogenic acid ; gene expression ; gluconeogenesis ; glucose ; glucose-6-phosphatase ; glycemic effect ; hepatoma ; humans ; hyperglycemia ; lignin ; metabolites ; mitochondria ; mitogen-activated protein kinase ; moieties ; nutritional intervention ; oxidative phosphorylation ; phosphatidylinositol 3-kinase ; quinic acid ; rats ; roots
Language	English
Dates of publication	2017-09
Size	p. .
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.201601118
Database	NAL-Catalogue (AGRICOLA)

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Article: Insights from the Inclusive Environments and Metrics in Biology Education and Research Network: Our Experience Organizing Inclusive Biology Education Research Events.

Campbell-Montalvo, Rebecca A / Caporale, Natalia / McDowell, Gary S / Idlebird, Candice / Wiens, Katie M / Jackson, Kimberly M / Marcette, Jana D / Moore, Michael E

Journal of microbiology & biology education

2020 Volume 21, Issue 1

Abstract: In contrast to efforts focusing on improving inclusion in STEM classrooms from kindergarten through undergraduate (K-16), efforts to improve inclusion in scientific meetings and conferences, important hubs of STEM culture, are more recent. Markers of ... ...

Abstract	In contrast to efforts focusing on improving inclusion in STEM classrooms from kindergarten through undergraduate (K-16), efforts to improve inclusion in scientific meetings and conferences, important hubs of STEM culture, are more recent. Markers of inclusion that are sometimes overlooked at these events can include the composition of panels, how workshops are run, the affordability of conferences, and various other mechanisms that maintain pre-existing hierarchies and norms that limit the participation of early-career researchers and individuals of minoritized cultural, linguistic, and economic backgrounds. The Inclusive Environments and Metrics in Biology Education and Research (iEMBER) network coordinates efforts of researchers from many fields interested in diversity and inclusion in biology education. Given the concerns regarding inclusion at professional meetings, iEMBER has developed and implemented several practices in planning and executing our meetings to make them more inclusive. In this report, we share our experiences developing inclusive meetings on biology education research and discuss the outcomes of such efforts. Specifically, we present our approach to planning and executing the iEMBER 2019 conference and the National Association of Biology Teachers iEMBER 2019 workshop. This report adds to the growing body of resources on inclusive meetings, provides readers with an account of how such an attempt at implementation might unfold, and complements existing theories and work relating to the importance and functioning of such meetings in terms of representation in STEM.
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.v21i1.2083
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Permeation of roxarsone and its metabolites increases caco-2 cell proliferation.

Bayse, Gladys S / Hammonds-Odie, Latanya P / Jackson, Kimberly M / Tucker, Deidre K / Kirlin, Ward G

Advances in biological chemistry

2015 Volume 3, Issue 4, Page(s) 389–396

Abstract: The benzenearsonate, Roxarsone, has been used since 1944 as an antimicrobial, growth-promoting poultry feed additive. USGS and EPA report that Roxarsone (4-hydroxy-3-nitrobenzenearsonate) and metabolites, including AHBA (3-amino-4-hydroxybenzenearsonate), ...

Abstract	The benzenearsonate, Roxarsone, has been used since 1944 as an antimicrobial, growth-promoting poultry feed additive. USGS and EPA report that Roxarsone (4-hydroxy-3-nitrobenzenearsonate) and metabolites, including AHBA (3-amino-4-hydroxybenzenearsonate), contaminate waterways at greater than 1100 tons annually. To assess human impact of these organic arsenic water contaminants, it was important to study their potential absorption. The human adenocarcinoma cell line, Caco-2, is a model for intestinal absorption. We found proliferative effects on Caco-2 cells at micromolar levels of these compounds, as monitored by [
Language	English
Publishing date	2015-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628817-5
ISSN	2162-2191 ; 2162-2183
ISSN (online)	2162-2191
ISSN	2162-2183
DOI	10.4236/abc.2013.34041
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Article: Qualitative identification of dibenzoylmethane in licorice root (Glycyrrhiza glabra) using gas chromatography-triple quadrupole mass spectrometry.

Mancia, Marisela D / Reid, Michelle E / DuBose, Evan S / Campbell, James A / Jackson, Kimberly M

Natural product communications

2014 Volume 9, Issue 1, Page(s) 91–94

Abstract: Licorice root (Glycyrrhiza glabra), an herbal Chinese medicine, has shown medicinal uses in therapeutics and cancer prevention. Dibenzoylmethane (DBM; 1, 3-diphenyl-1, 3-propadinedione), a small beta-diketone, has been reported to be a minor constituent ... ...

Abstract	Licorice root (Glycyrrhiza glabra), an herbal Chinese medicine, has shown medicinal uses in therapeutics and cancer prevention. Dibenzoylmethane (DBM; 1, 3-diphenyl-1, 3-propadinedione), a small beta-diketone, has been reported to be a minor constituent of licorice and a known deregulator of the human prostate cancer cell cycle. Characterization of the phytochemical profiles of licorice root forms including commercially available DBM will advance our search in identifying novel reagents for prostate cancer therapeutics. Gas chromatography- triple quadrupole-mass spectrometric analysis was used for detecting DBM in licorice root extracts. DBM and all licorice forms exhibited a component with a retention time of 14.5 minutes. The major fragment ions detected were at m/z 77, 105, 147, 223 and 224 at the identified retention time by selected reaction monitoring/SRM. These data confirm the presence of DBM from its natural source (G. glabra), and the GC-MS/SRM method helps in the identification of this minor component in a complex biological matrix.
MeSH term(s)	Chalcones/analysis ; Drugs, Chinese Herbal/chemistry ; Gas Chromatography-Mass Spectrometry ; Glycyrrhiza/chemistry ; Plant Roots/chemistry
Chemical Substances	Chalcones ; Drugs, Chinese Herbal ; dibenzoylmethane (ANS7ME8OKC)
Language	English
Publishing date	2014-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1934-578X
ISSN	1934-578X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Unleashing Our Chemistry Superpowers: Promoting Student Success and Well-Being at a Black Women's College during COVID-19

Johnson, Shanina Sanders / Gaines, Michelle K. / Van Vleet, Mary J. / Jackson, Kimberly M. / Barrett, Cachetne / Camp, Davita / Mancia, Marisela De Leon / Hibbard, Lisa / Rodriguez, Augusto

Journal of Chemical Education

Abstract: Spelman College, a small (2150 students) Black women's liberal arts college located in Atlanta, GA, USA, is dedicated to empowering women of African descent to become global leaders and change agents In the wake of the COVID-19 pandemic, and the ... ...

Abstract	Spelman College, a small (2150 students) Black women's liberal arts college located in Atlanta, GA, USA, is dedicated to empowering women of African descent to become global leaders and change agents In the wake of the COVID-19 pandemic, and the resulting abrupt and unforeseen campus closure, Spelman experienced pressure and urgency to maintain a high quality curriculum for its students, while balancing student and faculty well-being This communication is a reflection of the teaching practices that the faculty in Spelman's Department of Chemistry and Biochemistry implemented during the transition to emergency remote instruction (ERI) We first describe the initial week-long planning phase used to transition the Department to ERI, including detailed information on the faculty's efforts to redesign lecture and lab courses via the adoption of new learning platforms, teaching strategies, and student learning objectives Next, we use student survey data, collected by individual faculty, to reflect on the challenges, opportunities, and iterative course redesign that occurred throughout ERI Student well-being, engagement, and adaptation were of particular concern and challenge to the Department during ERI Nevertheless, by embracing a spirit of "productive disorder", the Department was able to channel its faculty "superpowers" toward pedagogical change and transformation More importantly, by allowing students to operate as independent and resilient learners in the time of COVID-19, we found that students rose to the challenge of creative expression and critique even in unconventional times
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #805099
Database	COVID19

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Article ; Online: Unleashing Our Chemistry Superpowers

Johnson, Shanina Sanders / Gaines, Michelle K. / Van Vleet, Mary J. / Jackson, Kimberly M. / Barrett, Cachetne / Camp, Davita / Mancia, Marisela De Leon / Hibbard, Lisa / Rodriguez, Augusto

Journal of Chemical Education

Promoting Student Success and Well-Being at a Black Women’s College during COVID-19

2020 Volume 97, Issue 9, Page(s) 3369–3373

Keywords	General Chemistry ; Education ; covid19
Language	English
Publisher	American Chemical Society (ACS)
Publishing country	us
Document type	Article ; Online
ZDB-ID	218164-2
ISSN	1938-1328 ; 0021-9584
ISSN (online)	1938-1328
ISSN	0021-9584
DOI	10.1021/acs.jchemed.0c00728
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: N-substituted phenylbenzamides of the niclosamide chemotype attenuate obesity related changes in high fat diet fed mice.

Bhagat, Hiral A / Compton, Sarah A / Musso, David L / Laudeman, Christopher P / Jackson, Kimberly M P / Yi, Na Young / Nierobisz, Lidia S / Forsberg, Lawrence / Brenman, Jay E / Sexton, Jonathan Z

PloS one

2018 Volume 13, Issue 10, Page(s) e0204605

Abstract: Obesity and insulin resistance are primary risk factors for Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD is generally exhibited by non-progressive simple steatosis. However, a significant subset of patient's progress to nonalcoholic steatohepatitis ( ... ...

Abstract	Obesity and insulin resistance are primary risk factors for Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD is generally exhibited by non-progressive simple steatosis. However, a significant subset of patient's progress to nonalcoholic steatohepatitis (NASH) that is defined by the presence of steatosis, inflammation and hepatocyte injury with fibrosis. Unfortunately, there are no approved therapies for NAFLD or NASH and therefore therapeutic approaches are urgently needed. Niclosamide is an U.S. Food and Drug Administration (FDA)-approved anthelmintic drug that mediates its effect by uncoupling oxidative phosphorylation. Niclosamide and its salt forms, Niclosamide Ethanolamine (NEN), and Niclosamide Piperazine (NPP) have shown efficacy in murine models of diet induced obesity characterized by attenuation of the prominent fatty liver disease phenotype and improved glucose metabolism. While the exact mechanism(s) underlying these changes remains unclear, the ability to uncouple oxidative phosphorylation leading to increased energy expenditure and lipid metabolism or attenuation of PKA mediated glucagon signaling in the liver have been proposed. Unfortunately, niclosamide has very poor water solubility, leading to low oral bioavailability. This, in addition to mitochondrial uncoupling activity and potential genotoxicity have reduced enthusiasm for its clinical use. More recently, salt forms of niclosamide, NEN and NPP, have demonstrated improved oral bioavailability while retaining activity. This suggests that development of safer more effective niclosamide derivatives for the treatment of NAFLD and Type 2 Diabetes may be possible. Herein we explored the ability of a series of N-substituted phenylbenzamide derivatives of the niclosamide salicylanilide chemotype to attenuate hepatic steatosis using a novel phenotypic in vitro model of fatty liver and the high fat diet-fed mouse model of diet induced obesity. These studies identified novel compounds with improved pre-clinical properties that attenuate hepatic steatosis in vitro and in vivo. These compounds with improved drug properties may be useful in alleviating symptoms and protection against disease progression in patients with metabolic syndrome and NAFLD.
MeSH term(s)	Animals ; Anti-Obesity Agents/chemistry ; Anti-Obesity Agents/pharmacokinetics ; Anti-Obesity Agents/pharmacology ; Benzamides/chemistry ; Benzamides/pharmacokinetics ; Benzamides/pharmacology ; Cell Respiration/drug effects ; Cells, Cultured ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Escherichia coli/drug effects ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; High-Throughput Screening Assays ; Humans ; Lipogenesis/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/drug therapy ; Obesity/metabolism ; Rats, Sprague-Dawley ; Salmonella typhimurium/drug effects
Chemical Substances	Anti-Obesity Agents ; Benzamides
Keywords	covid19
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0204605
Database	MEDical Literature Analysis and Retrieval System OnLINE

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