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Article ; Online: It's a gas! Pneumatic release of VMT.

Jackson, T L / Steel, D H

2017 Volume 31, Issue 3, Page(s) 347–348

Language	English
Publishing date	2017-03
Publishing country	England
Document type	Editorial
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2016.229
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Book ; Online: Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors

Kara, Erdi / Jackson, T. L. / Jones, Chartese / McGee II, Reginald L. / Sison, Rockford

Antigen Heterogeneity and Bystander Effects

2023

Abstract: As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique ... ...

Abstract	As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells. One such barrier is antigen heterogeneity - variability in the expression of the antigen on tumor cells. Success of CAR T-cell therapy in solid tumors is unlikely unless almost all the tumor cells express the specific antigen that CAR T-cells target. A critical question for solving the heterogeneity problem is whether CAR T therapy induces bystander effects, such as antigen spreading. Antigen spreading occurs when CAR T-cells activate other endogenous antitumor CD8 T cells against antigens that were not originally targeted. In this work, we develop a mathematical model of CAR T-cell therapy for solid tumors that takes into consideration both antigen heterogeneity and bystander effects. Our model is based on in vivo treatment data that includes a mixture of target antigen-positive and target antigen-negative tumor cells. We use our model to simulate large cohorts of virtual patients to gain a better understanding of the relationship between bystander killing. We also investigate several strategies for enhancing the bystander effect and thus increasing the overall efficacy of CAR T-cell therapy for solid tumor.
Keywords	Quantitative Biology - Tissues and Organs
Subject code	610 ; 570
Publishing date	2023-07-10
Publishing country	us
Document type	Book ; Online
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Article: Indocyanine green accused.

Jackson, T L

The British journal of ophthalmology

2005 Volume 89, Issue 4, Page(s) 395–396

MeSH term(s)	Coloring Agents/adverse effects ; Epiretinal Membrane/surgery ; Humans ; Indocyanine Green/adverse effects ; Intraoperative Care/methods ; Macula Lutea/surgery
Chemical Substances	Coloring Agents ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2005-04
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjo.2004.055558
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Article: Third-order thermo-mechanical properties for packs of Platonic solids using statistical micromechanics.

Gillman, A / Amadio, G / Matouš, K / Jackson, T L

Proceedings. Mathematical, physical, and engineering sciences

2016 Volume 471, Issue 2177, Page(s) 20150060

Abstract: Obtaining an accurate higher order statistical description of heterogeneous materials and using this information to predict effective material behaviour with high fidelity has remained an outstanding problem for many years. In a recent letter, Gillman & ... ...

Abstract	Obtaining an accurate higher order statistical description of heterogeneous materials and using this information to predict effective material behaviour with high fidelity has remained an outstanding problem for many years. In a recent letter, Gillman & Matouš (2014
Language	English
Publishing date	2016-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	209241-4
ISSN	1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
ISSN (online)	1471-2946
ISSN	1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
DOI	10.1098/rspa.2015.0060
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Article ; Online: An integrative model of prostate cancer interaction with the bone microenvironment.

Farhat, A / Jiang, D / Cui, D / Keller, E T / Jackson, T L

Mathematical biosciences

2017 Volume 294, Page(s) 1–14

Abstract: Despite advanced efforts in early diagnosis, aggressive surgical treatment, and use of targeted chemotherapies, the prognosis for many cancers is still dismal. This emphasizes the necessity to develop new strategies for understanding tumor growth and ... ...

Abstract	Despite advanced efforts in early diagnosis, aggressive surgical treatment, and use of targeted chemotherapies, the prognosis for many cancers is still dismal. This emphasizes the necessity to develop new strategies for understanding tumor growth and metastasis. Here we use a systems approach that combines mathematical modeling and numerical simulation to develop a predictive computational model for prostate cancer and its subversion of the bone microenvironment. This model simulates metastatic prostate cancer evolution, progressing from normal bone and hormone levels to quantifiable diseased states. The simulations clearly demonstrate phenomena similar to those found clinically in prostate cancer patients. In addition, the major prediction of this model is the existence of low and high osteogenic states that are markedly different from one another. The existence and potential realization of these steady states appear to be mediated by the Wnt signaling pathway and by the effects of PSA on TGF-β, which encourages the bone microenvironment to evolve. The model is used to explore several potential therapeutic strategies, with some potential drug targets showing more promise than others: in particular, completely blocking Wnt and greatly increasing DKK-1 had significant positive effects, while blocking RANKL did not improve the outcome.
MeSH term(s)	Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Computer Simulation ; Humans ; Male ; Models, Theoretical ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology
Language	English
Publishing date	2017-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1126-5
ISSN	1879-3134 ; 0025-5564
ISSN (online)	1879-3134
ISSN	0025-5564
DOI	10.1016/j.mbs.2017.09.005
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Article: Vitrectomy with fibrovascular membrane delamination for proliferative diabetic retinopathy with or without preoperative Avastin.

Papavasileiou, E / Vasalaki, M / Garnavou-Xirou, C / Velissaris, S / Zygoura, V / McHugh, D / Jackson, T L

Hellenic journal of nuclear medicine

2018 Volume 20 Suppl, Page(s) 161

Abstract: Objective: To describe and compare 1. The changes in intraretinal microstructure using serial spectral domain optical coherence tomography (SD-OCT) preceding and following pars plana vitrectomy and delamination of fibrovascular membranes and 2. ... ...

Abstract	Objective: To describe and compare 1. The changes in intraretinal microstructure using serial spectral domain optical coherence tomography (SD-OCT) preceding and following pars plana vitrectomy and delamination of fibrovascular membranes and 2. Intraoperative and postoperative complications in patients with proliferative diabetic retinopathy (PDR) who had preoperative Avastin (group A) or not (group B). Subjects and method: This retrospective, interventional case series includes 113 eyes. Outcome measures included LogMAR distance best-corrected visual acuity (BCVA), SD-OCT integrity of photoreceptor inner and outer segments junction (IS/OS), and integrity of external limiting membrane (ELM), intraoperative and postoperative complications. Results: Pre-operative central macular thickness (CMT) was significantly correlated with the final post-operative LogMAR BCVA in group A. Both groups were also categorised into three sub-groups based on post-operative IS/OS integrity (group 0: IS/OS intact; group 1: IS/OS irregular but not completely disrupted; group 2: IS/OS completely disrupted). Mean BCVA improved significantly and IS/OS integrity and ELM integrity postoperatively, were significantly and positively correlated with final BCVA in group A. Intraoperative complications such as iatrogenic tears and haemorrhage and postoperative such as vitreous haemorrhage and neovascular glaucoma were significantly less in group A compared to group B. Conclusion: Pre-operative Avastin reduces the risk of intraoperative and postoperative complications and results in better postoperative anatomic and functional outcomes in fibrovascular delamination surgery for patients with PDR.
MeSH term(s)	Adult ; Bevacizumab/pharmacology ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/pathology ; Diabetic Retinopathy/surgery ; Female ; Humans ; Male ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Preoperative Period ; Retina/diagnostic imaging ; Retina/drug effects ; Retina/pathology ; Retina/surgery ; Retrospective Studies ; Tomography, Optical Coherence ; Vitrectomy/adverse effects ; Vitrectomy/methods
Chemical Substances	Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2018-01-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
DOI	10.1111/j.1755-3768.2017.02313
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Article ; Online: Cost analysis comparing adjuvant epimacular brachytherapy with anti-VEGF monotherapy for the management of neovascular age-related macular degeneration.

Jackson, T L / Kirkpatrick, L / Tang, G / Prasad, S

Eye (London, England)

2012 Volume 26, Issue 4, Page(s) 557–563

Abstract: Aims: To consider the cost implication of adopting epimacular brachytherapy (EMB) for the treatment of neovascular (wet) age-related macular degeneration (wAMD), compared with ranibizumab or bevacizumab monotherapy.: Methods: This analysis compared ... ...

Abstract	Aims: To consider the cost implication of adopting epimacular brachytherapy (EMB) for the treatment of neovascular (wet) age-related macular degeneration (wAMD), compared with ranibizumab or bevacizumab monotherapy. Methods: This analysis compared the cumulative 3-year costs of anti-VEGF (vascular endothelial growth factor) monotherapy to EMB combined with anti-VEGF therapy. Two patient groups were considered: newly diagnosed (treatment-naïve) patients; and patients already receiving chronic anti-VEGF therapy. Results: In the treatment-naïve patients, the highest cumulative treatment costs were associated with ranibizumab monotherapy (£25,658), followed by bevacizumab monotherapy (£16,177), EMB with ranibizumab (£14,002), then EMB with bevacizumab (£10,289). In previously treated patients, the highest treatment costs were ranibizumab monotherapy (£18,355), followed by EMB with ranibizumab (£17,428), bevacizumab monotherapy (£16,177), then EMB with bevacizumab (£12,129). Conclusion: EMB combined with anti-VEGF treatment has the potential to yield considerable cost savings, compared with anti-VEGF monotherapy. If the ongoing large studies of EMB confirm the published feasibility data, then adjuvant EMB may represent a cost-effective alternative to anti-VEGF monotherapy.
MeSH term(s)	Angiogenesis Inhibitors/economics ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized/economics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Bevacizumab ; Brachytherapy/economics ; Brachytherapy/methods ; Combined Modality Therapy/economics ; Cost-Benefit Analysis ; Humans ; Macular Degeneration/economics ; Macular Degeneration/therapy ; Radiotherapy, Adjuvant ; Ranibizumab ; State Medicine/economics ; Vascular Endothelial Growth Factors/antagonists & inhibitors
Chemical Substances	Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Vascular Endothelial Growth Factors ; Bevacizumab (2S9ZZM9Q9V) ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2012-01-20
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2011.351
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Article ; Online: Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety.

Stanescu-Segall, D / Jackson, T L

Eye (London, England)

2009 Volume 23, Issue 3, Page(s) 504–518

Abstract: Indocyanine green (ICG) is extremely effective when used as a vital stain during macular hole surgery. By staining the internal limiting membrane, ICG facilitates removal of this delicate and sometimes hard to visualize structure. There is, however, ... ...

Abstract	Indocyanine green (ICG) is extremely effective when used as a vital stain during macular hole surgery. By staining the internal limiting membrane, ICG facilitates removal of this delicate and sometimes hard to visualize structure. There is, however, considerable debate regarding its safety. This review considers the clinical and experimental studies of ICG and a related agent, infracyanine green. Some clinical papers show visual field defects, reduced visual acuity, and persistence of ICG at the macula and optic nerve. Other clinical studies fail to demonstrate toxicity. The experimental studies are also conflicting, but there are emerging trends. These suggest that surgeons who continue to use ICG should use concentrations not greater than 0.05 mg/ml, in fluid-filled eyes, with short exposure times, iso-osmolar solutions, and avoid proximal or prolonged endoillumination of stained tissue. A smaller number of studies suggest that infracyanine green produces similar staining to ICG, and may possibly be safer, but there are too few well-designed studies to reach a conclusion. Although the use of ICG continues, on the balance of evidence, this review suggests that it is has the potential to produce subtle visual damage.
MeSH term(s)	Animals ; Coloring Agents/administration & dosage ; Coloring Agents/adverse effects ; Disease Models, Animal ; Epiretinal Membrane/surgery ; Evidence-Based Medicine/methods ; Humans ; Indocyanine Green/administration & dosage ; Indocyanine Green/adverse effects ; Indocyanine Green/analogs & derivatives ; Intraoperative Care/adverse effects ; Staining and Labeling/methods ; Vision Disorders/chemically induced ; Visual Fields/drug effects
Chemical Substances	Coloring Agents ; Infracyanine green ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2009-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2008.249
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Article ; Online: United Kingdom National Ophthalmology Database Study of Vitreoretinal Surgery: report 1; case mix, complications, and cataract.

Jackson, T L / Donachie, P H J / Sparrow, J M / Johnston, R L

Eye (London, England)

2013 Volume 27, Issue 5, Page(s) 644–651

Abstract: Aim: To report the vitreoretinal (VR) surgical case mix in the United Kingdom, the intraoperative complication rate of pars plana vitrectomy (PPV), and the incidence of post-vitrectomy cataract extraction.: Methods: Participating hospitals ... ...

Abstract	Aim: To report the vitreoretinal (VR) surgical case mix in the United Kingdom, the intraoperative complication rate of pars plana vitrectomy (PPV), and the incidence of post-vitrectomy cataract extraction. Methods: Participating hospitals prospectively collected ophthalmic data using a single electronic medical record system, with automatic extraction of anonymised data to a national database. This study included the subset of 11618 VR operations undertaken on 9619 eyes, of 8741 patients, over 8 years, from 27 sites. Surgical data included the indication for surgery, all procedure elements, and whether or not an intraoperative complication occurred. Post-vitrectomy cataract data were also analysed. The main outcome measures were a description of the indications for surgery, intraoperative PPV complication rate, and percentage of eyes undergoing post-vitrectomy cataract surgery (PVCS). Results: The most common indications for VR intervention were retinal breaks and rhegmatogenous retinal detachment (48.5%), macular hole (9.8%), epiretinal membrane (9.6%), and diabetic eye disease (7.3%). Overall, 7.8% of PPVs had at least one intraoperative complication-the most common were iatrogenic retinal breaks (3.2%), and lens touch (1.2-1.6% of phakic eyes). PVCS occurred in 50.2, 68.7, and 74.0% of eyes at 1, 2, and 3 years, respectively. Conclusion: VR surgery is undertaken for a wide range of conditions, but a small number of diagnoses encompass the majority of cases. Intraoperative PPV complications are not uncommon, and post-vitrectomy cataract is to be expected in most phakic eyes.
MeSH term(s)	Aged ; Cataract Extraction/statistics & numerical data ; Female ; Humans ; Incidence ; Intraoperative Complications/epidemiology ; Intraoperative Complications/etiology ; Male ; Middle Aged ; Postoperative Complications ; Prospective Studies ; United Kingdom/epidemiology ; Vitrectomy/adverse effects ; Vitrectomy/methods
Language	English
Publishing date	2013-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2013.12
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Article: Characteristics, socioeconomic status and ethnic variations of primary idiopathic macular hole repair in vitreoretinal centers in the United Kingdom.

Papavasileiou, E / Vasalaki, M / Velissaris, S / Garnavou-Xirou, C / Zygoura, V / Theodorou, O / Zakir, R / Duguid, G / Sandinha, T / Steel, D / Jackson, T L

Hellenic journal of nuclear medicine

2018 Volume 20 Suppl, Page(s) 160

Abstract: Objective: The purpose of this multicentre retrospective study was to investigate the characteristics and role of ethnicity and socioeconomic status amongst patients with idiopathic macular holes (IMH) and the surgical outcome.: Subjects and method: ... ...

Abstract	Objective: The purpose of this multicentre retrospective study was to investigate the characteristics and role of ethnicity and socioeconomic status amongst patients with idiopathic macular holes (IMH) and the surgical outcome. Subjects and method: Consecutive patients undergoing primary IMH surgery at three vitreoretinal units in the UK (King's College Hospital, London, UK, Western Eye Hospital, London, UK, Sunderland Eye Infirmary, Sunderland, UK) between January 2007 and May 2017 were included. The main outcome measure was anatomical closure of IMH. Results: Two hundred and thirty three primary IMH surgeries were included. All patients underwent pars plana vitrectomy, internal limiting membrane peeling, and gas tamponade. 69.10% of patients were European Caucasian, 6.44% were Asian, and 24.46% were Afro-Caribbean. The mean base macular hole diameter (BD) was 475.5mcm. Mean BD was 432.2mcm in European Caucasian patients, 481.3mcm in Asians (P=0.005), and 505.61mcm in Afro-Caribbeans (P=0.006). Regression analysis demonstrated that BD and Afro-Caribbean ethnicity were independent significant risk factors for surgical failure. Those who have longer duration of symptoms (Afro-Caribbeans) and leave in more deprived places (Afro-Caribbeans) in England where found to have lower success rate on macular hole closure. Conclusion: Asian and Afro-Caribbean patients present with larger IMH than European Caucasians. In addition to IMH base diameter, black origin and lower socioeconomic status are independent risk factors for surgical failure. This study presents a large population-based data analysis on ethnic variation in macular holes and may assist in the management and predicting the surgical outcome.
MeSH term(s)	Adult ; Ethnic Groups/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Retinal Perforations/surgery ; Retrospective Studies ; Risk Factors ; Social Class ; Treatment Outcome ; United Kingdom ; Vitrectomy
Language	English
Publishing date	2018-01-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
DOI	10.1111/j.1755-3768.2017.02684
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