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  1. AU="Jackson, Yvette A"
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  1. Article ; Online: Editorial (Thematic Issues: New Developments in the Medicinal Chemistry of Some Azoles).

    Downer-Riley, Nadale K / Jackson, Yvette A

    Current topics in medicinal chemistry

    2016  Volume 16, Issue 30, Page(s) 3567–3568

    MeSH term(s) Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Azoles/chemistry ; Azoles/pharmacology ; Chemistry, Pharmaceutical ; Humans
    Chemical Substances Antifungal Agents ; Azoles
    Language English
    Publishing date 2016-11-13
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802661630161021204249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Recent Advances in the Synthesis of 1,3-Azoles.

    Downer-Riley, Nadale K / Jackson, Yvette A

    Current topics in medicinal chemistry

    2016  Volume 16, Issue 30, Page(s) 3617–3626

    Abstract: The 1,3-azole motif is a common and integral feature of many clinical drugs. Due to their wide-ranging applications, the development of 1,3-azoles as therapeutic agents is an ongoing focus of medicinal chemists. This review highlights the recent ... ...

    Abstract The 1,3-azole motif is a common and integral feature of many clinical drugs. Due to their wide-ranging applications, the development of 1,3-azoles as therapeutic agents is an ongoing focus of medicinal chemists. This review highlights the recent approaches towards the assembly of 1,3-oxazole, 1,3-thiazole and 1,3-imidazole motifs.
    MeSH term(s) Azoles/chemical synthesis ; Azoles/chemistry ; Azoles/therapeutic use ; Cyclization ; Drug Design
    Chemical Substances Azoles
    Language English
    Publishing date 2016-04-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026616666160414122349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: [No title information]

    Morris, Andrew L. / Jackson, Yvette A.

    Synthesis

    2010  Volume 2011, Issue 02, Page(s) 229–234

    Abstract: The palladium-mediated intramolecular coupling reaction of 2-[(3-substituted-phenoxy)methyl]quinolines for preparing chromeno[3,4-B]quinolines was explored. The results of the cyclizations gave convincing evidence for an electrophilic aromatic ... ...

    Abstract The palladium-mediated intramolecular coupling reaction of 2-[(3-substituted-phenoxy)methyl]quinolines for preparing chromeno[3,4-B]quinolines was explored. The results of the cyclizations gave convincing evidence for an electrophilic aromatic substitution mechanism under standard Heck conditions.
    Keywords palladium catalysis ; Heck reaction ; chromenoquinoline
    Language English
    Publishing date 2010-11-26
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/s-0030-1258344
    Database Thieme publisher's database

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  4. Article: Synthesis of benzothiazoles via ipso substitution of ortho-methoxythiobenzamides.

    Downer, Nadale K / Jackson, Yvette A

    Organic & biomolecular chemistry

    2004  Volume 2, Issue 20, Page(s) 3039–3043

    Abstract: An efficient route to the synthesis of benzothiazoles from ortho-methoxythiobenzamides via the ipso substitution of an aromatic methoxy group is presented, and the mechanism of the Jacobson synthesis of benzothiazoles is further investigated. ...

    Abstract An efficient route to the synthesis of benzothiazoles from ortho-methoxythiobenzamides via the ipso substitution of an aromatic methoxy group is presented, and the mechanism of the Jacobson synthesis of benzothiazoles is further investigated.
    MeSH term(s) Benzamides/chemistry ; Benzothiazoles/chemical synthesis ; Models, Chemical ; Molecular Structure
    Chemical Substances Benzamides ; Benzothiazoles
    Language English
    Publishing date 2004-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/B410373D
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione, the B,C,D ring core of the shermilamine alkaloids.

    Townsend, Norman O / Jackson, Yvette A

    Organic & biomolecular chemistry

    2003  Volume 1, Issue 20, Page(s) 3557–3563

    Abstract: Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione (4), from N-(4-bromo-2,5-dimethoxyphenyl)acetamide (23) is described. Oxidative cyclisation of 2,2'-disulfanediylbis[N-(2,5-dimethoxyphenyl)acetamide] (19) to 5,8-dimethoxy-2H-1,4- ... ...

    Abstract Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione (4), from N-(4-bromo-2,5-dimethoxyphenyl)acetamide (23) is described. Oxidative cyclisation of 2,2'-disulfanediylbis[N-(2,5-dimethoxyphenyl)acetamide] (19) to 5,8-dimethoxy-2H-1,4-benzothiazin-3(4H)-one (7b) is also reported.
    Language English
    Publishing date 2003-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/b307124c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Thermally Induced Cyclization of Electron-Rich N-Arylthiobenzamides to Benzothiazoles

    Barrett, Oscene V. / Downer-Riley, Nadale K. / Jackson, Yvette A.

    Synthesis

    2012  Volume 44, Issue 16, Page(s) 2579–2586

    Abstract: Heating N -(2-methoxyphenyl)benzenecarbothioamides in refluxing nitrobenzene for 24 hours gives the corresponding benzothiazoles with intramolecular ipso substitution of the ortho -methoxy­ substituent. The thermal cyclization of various other N - ... ...

    Abstract Heating N -(2-methoxyphenyl)benzenecarbothioamides in refluxing nitrobenzene for 24 hours gives the corresponding benzothiazoles with intramolecular ipso substitution of the ortho -methoxy­ substituent. The thermal cyclization of various other N -arylthiobenzamides is also explored.
    Keywords cyclizations ; heterocycles ; thioamides
    Language English
    Publishing date 2012-07-23
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/s-0032-1316670
    Database Thieme publisher's database

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  7. Article ; Online: Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides.

    Grant, Julie-Ann A / Bonnick, Tamicka / Gossell-Williams, Maxine / Clayton, Terry / Cook, James M / Jackson, Yvette A

    Bioorganic & medicinal chemistry

    2010  Volume 18, Issue 2, Page(s) 909–921

    Abstract: Seven new 1,3-diazepinium chlorides exhibiting some structural similarities to the 1,4-benzodiazepines were synthesized. In a Hippocratic screen using mice, three of these salts, 3-methoxy-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin- ... ...

    Abstract Seven new 1,3-diazepinium chlorides exhibiting some structural similarities to the 1,4-benzodiazepines were synthesized. In a Hippocratic screen using mice, three of these salts, 3-methoxy-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8a), 3-methoxy-9-methyl-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8c) and 3-methoxy-11-methyl-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8e) were examined for their effect on the central nervous system, and their activities compared to that of diazepam. On their own, salts 8a, 8c and 8e solicited no sedative effects on the behaviour of the animals. However, they elicited significant effects in combination with diazepam on diazepam-induced activities such as decreased motor activity, ataxia and loss of righting reflex. Compounds 8a and 8c were fitted into the pharmacophore/receptor model developed by Cook et al. with interaction at the L(1), H(1) and A(2) sites indicating that they are potential inverse agonists of the Bz receptor. The compounds displayed some affinity for the alpha1 isoform of the GABA(A)/BzR (L(Di) interaction) but are non-selective for alpha5 (no L(2) interaction). Results of binding affinity studies showed that compound 8a is mildly selective for the alpha1 receptor although not very potent (K(i)=746.5nM). The significant potentiation of diazepam-induced ataxia and decreased motor activity by compounds 8a and 8c in the Hippocratic screen may be associated with alpha1 selectivity.
    MeSH term(s) Animals ; Ataxia/chemically induced ; Azepines/chemical synthesis ; Azepines/chemistry ; Azepines/pharmacology ; Central Nervous System/drug effects ; Diazepam/pharmacology ; Female ; Male ; Mice ; Models, Animal ; Models, Molecular ; Molecular Structure ; Motor Activity/drug effects ; Stereoisomerism
    Chemical Substances Azepines ; Diazepam (Q3JTX2Q7TU)
    Language English
    Publishing date 2010-01-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2009.11.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3815: Show issues Location:
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  8. Article ; Online: Nitrosoalkenes: Synthesis and Properties of Nitroso Derivatives of a Vinylogous Tetrathiafulvalene.

    Jackson, Yvette A. / Parakka, James P. / Lakshmikantham, M. V. / Cava, Michael P.

    The Journal of organic chemistry

    1997  Volume 62, Issue 8, Page(s) 2616–2618

    Language English
    Publishing date 1997-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo962209u
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  9. Article: Thiophene isosteres of 9,10-dithioanthraquinone.

    Jackson, Yvette A / Rajagopal, Desikan / Bendolph, Jackie / Guillory, Melanie / Lakshmikantham, M V / Yang, Jongtae / Cava, Michael P

    Organic letters

    2003  Volume 5, Issue 11, Page(s) 1883–1885

    Abstract: reaction: see text] The preparation of 1,3,5,7-tetramethyl-4,8-dihydrobenzo[1,2-c:4,5-c']dithiophene-4,8-dione and its conversion to the corresponding mono- and dithione are described. ...

    Abstract [reaction: see text] The preparation of 1,3,5,7-tetramethyl-4,8-dihydrobenzo[1,2-c:4,5-c']dithiophene-4,8-dione and its conversion to the corresponding mono- and dithione are described.
    Language English
    Publishing date 2003-05-29
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7060
    ISSN 1523-7060
    DOI 10.1021/ol034419g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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