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  1. Article ; Online: When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis.

    John, Teny M / Jacob, Ceena N / Kontoyiannis, Dimitrios P

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 4

    Abstract: Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published ... ...

    Abstract Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19.
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7040298
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  2. Article ; Online: Diagnosis of Clostridioides difficile infection by analysis of volatile organic compounds in breath, plasma, and stool: A cross-sectional proof-of-concept study.

    John, Teny M / Shrestha, Nabin K / Procop, Gary W / Grove, David / Leal, Sixto M / Jacob, Ceena N / Butler, Robert / Dweik, Raed

    PloS one

    2021  Volume 16, Issue 8, Page(s) e0256259

    Abstract: Clostridioides difficile infection (CDI) is an important infectious cause of antibiotic-associated diarrhea, with significant morbidity and mortality. Current diagnostic algorithms are based on identifying toxin by enzyme immunoassay (EIA) and toxin gene ...

    Abstract Clostridioides difficile infection (CDI) is an important infectious cause of antibiotic-associated diarrhea, with significant morbidity and mortality. Current diagnostic algorithms are based on identifying toxin by enzyme immunoassay (EIA) and toxin gene by real-time polymerase chain reaction (PCR) in patients with diarrhea. EIA's sensitivity is poor, and PCR, although highly sensitive and specific, cannot differentiate infection from colonization. An ideal test that incorporates microbial factors, host factors, and host-microbe interaction might characterize true infection, and assess prognosis and recurrence. The study of volatile organic compounds (VOCs) has the potential to be an ideal diagnostic test. The presence of VOCs accounts for the characteristic odor of stool in CDI but their presence in breath and plasma has not been studied yet. A cross-sectional proof-of-concept study analyzing VOCs using selected ion flow tube mass spectrometry (SIFT-MS) was done on breath, stool, and plasma of patients with clinical features and positive PCR for CDI (cases) and compared with patients with clinical features but a negative PCR (control). Our results showed that VOC patterns in breath, stool, and plasma, had good accuracy [area under the receiver operating characteristic curve (ROC) 93%, 86%, and 91%, respectively] for identifying patients with CDI.
    MeSH term(s) Adult ; Aged ; Area Under Curve ; Biomarkers/analysis ; Breath Tests/methods ; Clostridioides difficile/growth & development ; Clostridioides difficile/metabolism ; Clostridioides difficile/pathogenicity ; Clostridium Infections/diagnosis ; Clostridium Infections/metabolism ; Clostridium Infections/microbiology ; Cross-Sectional Studies ; Diarrhea/diagnosis ; Diarrhea/metabolism ; Diarrhea/microbiology ; Exhalation ; Feces/chemistry ; Feces/microbiology ; Female ; Humans ; Male ; Mass Spectrometry/instrumentation ; Mass Spectrometry/methods ; Middle Aged ; Proof of Concept Study ; ROC Curve ; Volatile Organic Compounds/analysis
    Chemical Substances Biomarkers ; Volatile Organic Compounds
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0256259
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  3. Article ; Online: Migratory Pulmonary Infiltrates in a Patient With COVID-19 Infection and the Role of Corticosteroids.

    John, Teny M / Malek, Alexandre E / Mulanovich, Victor E / Adachi, Javier A / Raad, Issam I / Hamilton, Alexis Ruth / Shpall, Elizabeth J / Rezvani, Katayoun / Aitken, Samuel L / Jain, Nitin / Klein, Kimberly / Martinez, Fernando / Jacob, Ceena N / Cherian, Sujith V / Manzano, Joanna-Grace M / Muthu, Mayoora / Wegner, Robert

    Mayo Clinic proceedings

    2020  Volume 95, Issue 9, Page(s) 2038–2040

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Female ; Humans ; Lung/diagnostic imaging ; Lung/physiopathology ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances Adrenal Cortex Hormones
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.06.023
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  4. Article: Migratory Pulmonary Infiltrates in a Patient With COVID-19 Infection and the Role of Corticosteroids

    John, Teny M / Malek, Alexandre E / Mulanovich, Victor E / Adachi, Javier A / Raad, Issam I / Hamilton, Alexis Ruth / Shpall, Elizabeth J / Rezvani, Katayoun / Aitken, Samuel L / Jain, Nitin / Klein, Kimberly / Martinez, Fernando / Jacob, Ceena N / Cherian, Sujith V / Manzano, Joanna-Grace M / Muthu, Mayoora / Wegner, Robert

    Mayo Clin Proc

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612812
    Database COVID19

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  5. Article ; Online: Migratory Pulmonary Infiltrates in a Patient With COVID-19 Infection and the Role of Corticosteroids

    John, Teny M. / Malek, Alexandre E. / Mulanovich, Victor E. / Adachi, Javier A. / Raad, Issam I. / Hamilton, Alexis Ruth / Shpall, Elizabeth J. / Rezvani, Katayoun / Aitken, Samuel L. / Jain, Nitin / Klein, Kimberly / Martinez, Fernando / Jacob, Ceena N. / Cherian, Sujith V. / Manzano, Joanna-Grace M. / Muthu, Mayoora / Wegner, Robert

    Mayo Clinic Proceedings

    2020  Volume 95, Issue 9, Page(s) 2038–2040

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.06.023
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Macrophage activation syndrome following Acinetobacter baumannii sepsis.

    John, Teny Mathew / Jacob, Ceena N / Ittycheria, Cherian C / George, Amrutha M / Jacob, Amith G / Subramaniyam, Saji / Puthiyaveettil, Jabbar / Jayaprakash, R

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2012  Volume 16, Issue 3, Page(s) e223–4

    Abstract: Macrophage activation syndrome (MAS) is a systemic disorder with a high mortality, commonly associated with rheumatological conditions, but which can also occur as a complication of several infections. Here we present a case of MAS following ... ...

    Abstract Macrophage activation syndrome (MAS) is a systemic disorder with a high mortality, commonly associated with rheumatological conditions, but which can also occur as a complication of several infections. Here we present a case of MAS following Acinetobacter baumannii sepsis. Early institution of therapy with prednisolone, cyclosporine, colistin, and polymyxin resulted in a prompt clinical recovery. There are very few reported cases of Acinetobacter-related MAS that have been successfully treated.
    MeSH term(s) Acinetobacter Infections/complications ; Acinetobacter Infections/drug therapy ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/pathogenicity ; Adult ; Anti-Bacterial Agents/therapeutic use ; Colistin/therapeutic use ; Cyclosporine/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Humans ; Macrophage Activation Syndrome/complications ; Macrophage Activation Syndrome/microbiology ; Male ; Polymyxins/therapeutic use ; Prednisolone/therapeutic use ; Sepsis/complications ; Sepsis/drug therapy ; Sepsis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Polymyxins ; Cyclosporine (83HN0GTJ6D) ; Prednisolone (9PHQ9Y1OLM) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2012-03
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2011.12.002
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    Zs.A 4516: Show issues Location:
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  7. Article: Macrophage activation syndrome following Acinetobacter baumannii sepsis

    John, Teny Mathew / Jacob, Ceena N / Ittycheria, Cherian C / George, Amrutha M / Jacob, Amith G / Subramaniyam, Saji / Puthiyaveettil, Jabbar / Jayaprakash, R

    International journal of infectious diseases. 2012 Mar., v. 16, no. 3

    2012  

    Abstract: Macrophage activation syndrome (MAS) is a systemic disorder with a high mortality, commonly associated with rheumatological conditions, but which can also occur as a complication of several infections. Here we present a case of MAS following ... ...

    Abstract Macrophage activation syndrome (MAS) is a systemic disorder with a high mortality, commonly associated with rheumatological conditions, but which can also occur as a complication of several infections. Here we present a case of MAS following Acinetobacter baumannii sepsis. Early institution of therapy with prednisolone, cyclosporine, colistin, and polymyxin resulted in a prompt clinical recovery. There are very few reported cases of Acinetobacter-related MAS that have been successfully treated.
    Keywords Acinetobacter baumannii ; colistin ; cyclosporine ; macrophage activation ; mortality ; prednisolone ; sepsis (infection) ; therapeutics
    Language English
    Dates of publication 2012-03
    Size p. e223-e224.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2011.12.002
    Database NAL-Catalogue (AGRICOLA)

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