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  1. Article ; Online: Youngsters' perceptions of the experience of pain and utilisation of over-the-counter pain medication as needed in community: A qualitative study.

    Ndengeyingoma, Assumpta / Lebel, Valérie / Bigras, Magali / Jacob, Maria H / Lacelle, Marika

    Journal for specialists in pediatric nursing : JSPN

    2021  Volume 26, Issue 2, Page(s) e12323

    Abstract: Purpose: Pain is common in youngsters. No matter its nature, youngsters' consideration of pain is complex since its communications vary as a function of several components. The aim of this study is to explore the youngsters' perception linked to their ... ...

    Abstract Purpose: Pain is common in youngsters. No matter its nature, youngsters' consideration of pain is complex since its communications vary as a function of several components. The aim of this study is to explore the youngsters' perception linked to their experience of physiological pain at the home/family setting, as well as their experience with the utilisation of over-the-counter pain medication as needed.
    Design and methods: A qualitative exploratory study was undertaken with 22 youngsters aged 5-17 years old. Semidirected interviews led to the understanding of these components by means of the pain experiences. Thematic analysis allowed the detection of the themes and subthemes emerging from the verbatim collected with the participants.
    Results: The way pain is described is influenced by the child's development, previous experiences, and the projection of having pain. The pain communication is influenced by the severity perceived, the beliefs of the youngster experiencing pain, the comparison of the pain communication with his brothers and sisters, as well as the anticipated consequences of expressing his pain. The choice of behaviour towards pain is influenced by self-management through nonpharmacological management, with medicines if needed, and by family modelization.
    Practice implications: This study confirms that previous pain experiences, beliefs related to pain tolerance and intended reactions of parents exert influence not only on the communication of pain, but also on youngsters' behaviour towards pain. It is important to consider these elements whenever youngsters' pain is evaluated.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Communication ; Humans ; Male ; Pain/diagnosis ; Pain/drug therapy ; Parents ; Perception ; Qualitative Research
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2082595-X
    ISSN 1744-6155 ; 1539-0136 ; 1088-145X
    ISSN (online) 1744-6155
    ISSN 1539-0136 ; 1088-145X
    DOI 10.1111/jspn.12323
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    Zs.A 4755: Show issues Location:
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  2. Article ; Online: DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats.

    Jacob, Maria H V M / Fernandes, Rafael O / Bonetto, Jéssica H P / Mendes, Roberta H / da R Araujo, Alex Sander / Belló-Klein, Adriane / Ribeiro, Maria F M

    Current aging science

    2018  Volume 11, Issue 2, Page(s) 126–132

    Abstract: Background: Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern.: Objective: We investigated whether chronic DHEA administration impacts on redox ... ...

    Abstract Background: Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern.
    Objective: We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 months-old rats).
    Methods: Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Gastrocnemius muscle was removed to evaluate glutathione system, hydrogen peroxide, antioxidant enzymes, and expression of Akt kinase protein.
    Results: In the 3-months-old rats DHEA induced an increase in hydrogen peroxide when compared both to its control (276%) and the 24-months-old DHEA group (485%). Moreover, in the 24- months-old rats DHEA caused an increase in GSSG (41 and 28%), a decrease in reduced-GSH (55 and 51%), and a more oxidized redox status (reduction in GSH/GSSG ratio, 47 and 65 %) when compared to 3-month-old DHEA and to 24-months-old control groups, respectively. Both older groups had increased G6PDH (2.7 fold) and GST (1.7 fold) activities when compared to younger groups, independently of any DHEA treatment. However, there was no modulation of Akt protein (phosphorylated/total isoform).
    Conclusion: The results show that chronic DHEA administration to 3 and 24-months-old rats may not present positive effects regarding the redox environment in skeletal muscle without modulation of pro-survival Akt kinase. Due to the large-scale self-administration of DHEA as an "anti-aging" dietary supplement, it is crucial to investigate its molecular mechanisms over oxidative stressinduced related diseases.
    MeSH term(s) Age Factors ; Aging/metabolism ; Animals ; Biomarkers/metabolism ; Dehydroepiandrosterone/pharmacology ; Enzyme Activation ; Glucosephosphate Dehydrogenase/metabolism ; Glutathione Disulfide/metabolism ; Hydrogen Peroxide/metabolism ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Wistar ; Time Factors
    Chemical Substances Biomarkers ; Dehydroepiandrosterone (459AG36T1B) ; Hydrogen Peroxide (BBX060AN9V) ; Glucosephosphate Dehydrogenase (EC 1.1.1.49) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glutathione Disulfide (ULW86O013H)
    Language English
    Publishing date 2018-08-02
    Publishing country United Arab Emirates
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/1874609811666180803125723
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  3. Article ; Online: Dehydroepiandrosterone effects on Akt signaling modulation in central nervous system of young and aged healthy rats.

    Janner, Daiane da Rocha / Jacob, Maria H V M / Jahn, Matheus P / Kucharski, Luiz Carlos R / Ribeiro, Maria Flávia Marques

    The Journal of steroid biochemistry and molecular biology

    2010  Volume 122, Issue 4, Page(s) 142–148

    Abstract: Dehydroepiandrosterone (DHEA) is a steroid synthesized in adrenal cortex as well as in the nervous system. DHEA effects on central nervous system (CNS) have been associated with several brain functions such as marked neurotrophic and neuroprotective ... ...

    Abstract Dehydroepiandrosterone (DHEA) is a steroid synthesized in adrenal cortex as well as in the nervous system. DHEA effects on central nervous system (CNS) have been associated with several brain functions such as marked neurotrophic and neuroprotective activity. DHEA plasma concentration decreases steadily with aging and studies have reported an inverse correlation between levels of DHEA and neurological diseases age-associated. Nonetheless, its mechanisms of action are not yet fully understood. Akt signaling pathway is one protein kinase which has been related to be DHEA modulated. The goal of this study was to investigate whether short-term (6 or 24h) or chronic (5 weeks) DHEA treatment modulates Akt in CNS of adult (3 months) and aged (18 and 24 months) healthy rats. Hypothalamus and hippocampus homogenates were prepared to quantify total-Akt and phosphorylated Akt at Ser(473) (pAkt). The results here presented have shown that acute (50mg/kg) and chronic (10mg/kg) DHEA injections modulate total and pAkt levels. This effect was dose and time-dependent as well as age and tissue-dependent. In addition, the age variable also intervenes on total and pAkt levels expression independently of DHEA treatment.
    MeSH term(s) Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/pharmacology ; Aging/drug effects ; Animals ; Dehydroepiandrosterone/administration & dosage ; Dehydroepiandrosterone/pharmacology ; Hippocampus/drug effects ; Hypothalamus/drug effects ; Male ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects
    Chemical Substances Adjuvants, Immunologic ; Dehydroepiandrosterone (459AG36T1B) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2010.07.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
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  4. Article: Dehydroepiandrosterone modulates antioxidant enzymes and Akt signaling in healthy Wistar rat hearts.

    Jacob, Maria H V M / Janner, Daiane da R / Belló-Klein, Adriane / Llesuy, Susana F / Ribeiro, Maria F M

    The Journal of steroid biochemistry and molecular biology

    2008  Volume 112, Issue 1-3, Page(s) 138–144

    Abstract: Dehydroepiandrosterone (DHEA) is an endogenous steroid synthesized mainly in the adrenal cortex. It is known that DHEA is a precursor of sex steroids and that part of its effects depends on its conversion to estrogens and androgens. Sex steroids exert ... ...

    Abstract Dehydroepiandrosterone (DHEA) is an endogenous steroid synthesized mainly in the adrenal cortex. It is known that DHEA is a precursor of sex steroids and that part of its effects depends on its conversion to estrogens and androgens. Sex steroids exert profound and controversial effects on cardiovascular function. Exogenous DHEA can exert a dual effect, antioxidant or prooxidant, depending on the dose and on the tissue specificity [1,2] (F. Celebi, I. Yilmaz, H. Aksoy, M. Gümüs, S. Taysi, D. Oren, Dehydroepiandrosterone prevents oxidative injury in obstructive jaundice in rats, J. Int. Med. Res. 32 (4) (2004) 400-405; S.K. Kim, R.F. Novak, The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression, Pharmacol. Ther. 113 (1) (2007) 88-120). Akt signaling pathway is one of the anti-proliferative mechanisms of DHEA (Y. Jiang, T. Miyazaki, A. Honda, T. Hirayama, S. Yoshida, N. Tanaka, Y. Matsuzaki, Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone, J. Gastroenterol. 40 (5) (2005) 490-497). Heart homogenates were prepared to quantify lipid peroxidation (LPO), concentration of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), 4-hydroxy-2-nonenal (HNE) and p-Akt/Akt ratio, and the activities of those antioxidant enzymes. When administrated to male Wistar rats in short-term (6 or 24h) intraperitoneally, DHEA produced significant differences in some parameters of oxidative stress in rat hearts among the distinct doses (1, 10, and 50mg/kg) used. The results here presented, regarding 6 and 24h oxidative stress status, have shown that DHEA injections promoted a prooxidant answer in healthy Wistar rat hearts.
    MeSH term(s) Animals ; Catalase/metabolism ; Dehydroepiandrosterone Sulfate/metabolism ; Dehydroepiandrosterone Sulfate/pharmacology ; Enzyme Activation ; Lipid Peroxidation ; Male ; Myocardium/metabolism ; Oxidative Stress ; Proto-Oncogene Proteins c-akt/physiology ; Rats ; Rats, Wistar ; Signal Transduction ; Superoxide Dismutase/metabolism
    Chemical Substances Dehydroepiandrosterone Sulfate (57B09Q7FJR) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2008-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2008.09.008
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  5. Article ; Online: Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH.

    Courboulin, Audrey / Barrier, Marjorie / Perreault, Tanya / Bonnet, Pierre / Tremblay, Veronique L / Paulin, Roxane / Tremblay, Eve / Lambert, Caroline / Jacob, Maria H / Bonnet, Sandra N / Provencher, Steeve / Bonnet, Sébastien

    The European respiratory journal

    2012  Volume 40, Issue 3, Page(s) 618–629

    Abstract: Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) proliferation is enhanced and apoptosis suppressed. The sustainability of this ... ...

    Abstract Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) proliferation is enhanced and apoptosis suppressed. The sustainability of this phenotype requires the activation of pro-survival transcription factors, such as signal transducer and activator of transcription (STAT)3 and nuclear factor of activated T-cells (NFAT). There are no drugs currently available that are able to efficiently and safely inhibit this axis. We hypothesised that plumbagin (PLB), a natural organic compound known to block STAT3 in cancer cells, would reverse experimental pulmonary hypertension. Using human PAH-PASMC, we demonstrated in vitro that PLB inhibits the activation of the STAT3/NFAT axis, increasing the voltage-gated K(+) current bone morphogenetic protein receptor type II (BMPR2), and decreasing intracellular Ca(2+) concentration ([Ca(2+)](i)), rho-associated coiled-coil containing protein kinase (ROCK)1 and interleukin (IL)-6, contributing to the inhibition of PAH-PASMC proliferation and resistance to apoptosis (proliferating cell nuclear antigen (PCNA), TUNEL, Ki67 and anexine V). In vivo, PLB oral administration decreases distal pulmonary artery remodelling, mean pulmonary artery pressure and right ventricular hypertrophy without affecting systemic circulation in both monocrotaline- and suden/chronic hypoxia-induced PAH in rats. This study demonstrates that the STAT3/NFAT axis can be therapeutically targeted by PLB in human PAH-PASMC and experimental PAH rat models. Thus, PLB could be considered a specific and attractive future therapeutic strategy for PAH.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Bone Morphogenetic Protein Receptors, Type II/biosynthesis ; Calcium/metabolism ; Cardiotonic Agents/therapeutic use ; Cell Proliferation/drug effects ; Cells, Cultured ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary/drug therapy ; In Situ Nick-End Labeling ; Interleukin-6/metabolism ; Male ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; NFATC Transcription Factors/biosynthesis ; Naphthoquinones/therapeutic use ; Potassium Channels, Voltage-Gated/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Rats ; rho-Associated Kinases/metabolism
    Chemical Substances Cardiotonic Agents ; IL6 protein, human ; Interleukin-6 ; NFATC Transcription Factors ; Naphthoquinones ; Potassium Channels, Voltage-Gated ; Proliferating Cell Nuclear Antigen ; ROCK1 protein, human (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30) ; Calcium (SY7Q814VUP) ; plumbagin (YAS4TBQ4OQ)
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00084211
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    Zs.A 2322: Show issues Location:
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  6. Article: Aortic-banding induces myocardial oxidative stress and changes in concentration and activity of antioxidants in male Wistar rats.

    Jacob, Maria H V M / Pontes, Mauro R N / Araújo, Alex S R / Barp, Jaqueline / Irigoyen, Maria C / Llesuy, Susana F / Ribeiro, Maria F M / Belló-Klein, Adriane

    Life sciences

    2006  Volume 79, Issue 23, Page(s) 2187–2193

    Abstract: Myocardial activity and gene expression of antioxidant defenses and oxidative damage were examined in an experimental model of pressure overload hypertrophy. Male Wistar rats were divided into abdominal aortic-banded or sham-operated groups. After 30 ... ...

    Abstract Myocardial activity and gene expression of antioxidant defenses and oxidative damage were examined in an experimental model of pressure overload hypertrophy. Male Wistar rats were divided into abdominal aortic-banded or sham-operated groups. After 30 days, arterial pressure and heart rate were measured. Heart, lung, and liver were extracted and weighted to evaluate cardiac hypertrophy and pulmonary and hepatic congestion. Heart homogenates were prepared to quantify lipid peroxidation (LPO); the activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GR); and Cu-Zn SOD and GST concentrations. Total glutathione (GSH) myocardial content was also measured. Arterial pressure (142 +/- 17 mmHg) and cardiac hypertrophy index (3.4 +/- 0.45 mg/g) were significantly increased (by 38% and 22%, respectively, p<0.0001) in the aortic-banded group. LPO was enhanced by 55% in the aortic-banded group (11891 +/- 766 cps/mg protein, p<0.001) compared with that in the controls. SOD activity and concentration were higher (40% and 38%, 15.15 +/- 1.03 U/mg protein, 49.187 pixels, respectively, p<0.05) in the aortic-banded group than in the controls. Aortic-banding induced a decrease by 28% in GST (48 +/- 10 pmol/min/mg protein, p<0.005), by 36% in GPx (38.2 +/- 9.5 nmol/min/mg protein, p<0.005), by 31% in GR activities (1.55 +/- 0.23 nmol/mg protein, p<0.0005), and by 43% in GSH content (0.13 +/- 0.02 nmol/mg protein, p<0.005). In conclusion, in this model it was observed that myocardial oxidative stress induces alterations in antioxidant enzyme activities and protein expression. The follow up of these parameters could afford an early therapeutical window to avoid heart failure progression.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Aorta/pathology ; Aorta/surgery ; Cardiomegaly/enzymology ; Cardiomegaly/pathology ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic ; Heart Failure/enzymology ; Heart Failure/pathology ; Heart Failure/prevention & control ; Lipid Peroxidation ; Liver/enzymology ; Liver/pathology ; Lung/enzymology ; Lung/pathology ; Male ; Oxidative Stress ; Rats ; Rats, Wistar
    Chemical Substances Antioxidants
    Language English
    Publishing date 2006-11-02
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2006.07.015
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