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  1. Article ; Online: Malunion of the Tibia

    Ishan Patel / Jacob Young / Austen Washington / Rahul Vaidya

    Medicina, Vol 58, Iss 389, p

    A Systematic Review

    2022  Volume 389

    Abstract: Background and Objectives : Tibial malunions are defined as tibial fractures that have healed in a clinically unacceptable position, resulting in deformity such as shortening, lengthening, abnormal rotation, or angulation. These deformities can have ... ...

    Abstract Background and Objectives : Tibial malunions are defined as tibial fractures that have healed in a clinically unacceptable position, resulting in deformity such as shortening, lengthening, abnormal rotation, or angulation. These deformities can have adverse effects on patients, such as pain and gait disturbance, as well as long term development of post-traumatic arthritis. This paper seeks to highlight some of the options for surgical management of malunions and detail the strategies and approaches used to manage these complicated cases. Materials and Methods: An exhaustive search was conducted on PubMed using the key search terms “Tibial” OR “Tibia” AND “Malunion” to be included in the title. Exclusions to the search included any article with patients aged < 18 years, any nonhuman subjects, and any article not published or translated into English. Results : A systematic review of the literature revealed 26 articles encompassing 242 patients who had undergone surgical correction for tibia malunion. A total of 19 patients suffered from complications. Methods of treatment included osteotomies, with plate and screws, external fixator, angled blade plate, intramedullary nails, Ilizarov fixator, Taylor Spatial Frame, Precise nail, and total knee arthroplasty. Restoring alignment and the articular surface led to overwhelmingly positive patient outcomes. Conclusions : Tibial malunions take many forms, and as such, there are many approaches to correcting deformities. The literature supports the following radiological parameters to diagnose tibial malunion: 5–10 degrees angulation, 1–2 cm shortening, 10–15 degrees internal rotation, and 10–20 degrees external rotation. Surgical plans should be customized to each individual patient, as there are many approaches to tibial malunion that have been shown to be successful in delivering excellent clinical outcomes.
    Keywords tibia ; tibial ; malunion ; approach ; outcomes ; plateau ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Concussion Is Associated With Increased Odds of Acute Lower-Extremity Musculoskeletal Injury Among National Basketball Association Players

    Toufic R. Jildeh, M.D. / Fabien Meta, M.D. / Jacob Young, B.S. / Brendan Page, B.S. / Benedict Nwachukwu, M.D., M.B.A. / Robert W. Westermann, M.D. / Kelechi R. Okoroha, M.D.

    Arthroscopy, Sports Medicine, and Rehabilitation, Vol 3, Iss 1, Pp e219-e

    2021  Volume 225

    Abstract: Purpose: To determine the odds of sustaining an acute lower-extremity (LE) musculoskeletal injury during the 90-day period after return-to-play (RTP) from concussion in National Basketball Association (NBA) athletes. Methods: Concussion data for NBA ... ...

    Abstract Purpose: To determine the odds of sustaining an acute lower-extremity (LE) musculoskeletal injury during the 90-day period after return-to-play (RTP) from concussion in National Basketball Association (NBA) athletes. Methods: Concussion data for NBA players were collected from the 1999-2000 to 2017-2018 seasons, from publicly available sources. Age, position, injury, time to RTP, and demographic factors were collected. The 90-day period after each case of concussion was reviewed for acute noncontact LE musculoskeletal injury. Control athletes without a documented history of concussion were matched to concussed athletes by age, body mass index, position, and experience. Conditional logistic regression with a calculated odds ratio and a 95% confidence interval were used to assess the association between concussion and subsequent risk of LE injury. Results: In total, 189 concussions were documented in 153 athletes. Of these, 140 cases were the first recorded instance of concussion in players with publicly available data. Thirty-six (25.7%) athletes sustained a LE injury within 90 days of concussion; 26 (20.2%) were non–season-ending and included in RTP analysis. The odds of sustaining an acute LE musculoskeletal injury within the 90-day period after concussion was 4.69 times greater in concussed players compared with controls (95% confidence interval 1.96-11.23, P < .001). There was no significant difference in games (4.2 ± 5.0 vs 4.7 ± 4.7 games, P = .566) or days (18.5 ± 39.1 days vs 10.9 ± 10.6 days, P = .912) missed between concussed players with LE injury and nonconcussed controls. The most common LE injuries in concussed athletes were ligament sprains/tears (65%). Conclusions: Concussed NBA athletes have increased odds for sustaining an acute LE musculoskeletal injury within 90 days of RTP compared with nonconcussed controls. The most common injuries were ligament strains or tears. Changes in neuromotor control and proprioception following a concussion should be evaluated in high-level basketball players ...
    Keywords Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology

    Melike Pekmezci / Ramin A. Morshed / Pranathi Chunduru / Balaji Pandian / Jacob Young / Javier E. Villanueva-Meyer / Tarik Tihan / Emily A. Sloan / Manish K. Aghi / Annette M. Molinaro / Mitchel S. Berger / Shawn L. Hervey-Jumper

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract In the management of diffuse gliomas, the identification and removal of tumor at the infiltrative margin remains a central challenge. Prior work has demonstrated that fluorescence labeling tools and radiographic imaging are useful surgical ... ...

    Abstract Abstract In the management of diffuse gliomas, the identification and removal of tumor at the infiltrative margin remains a central challenge. Prior work has demonstrated that fluorescence labeling tools and radiographic imaging are useful surgical adjuvants with macroscopic resolution. However, they lose sensitivity at the tumor margin and have limited clinical utility for lower grade histologies. Fiber-laser based stimulated Raman histology (SRH) is an optical imaging technique that provides microscopic tissue characterization of unprocessed tissues. It remains unknown whether SRH of tissues taken from the infiltrative glioma margin will identify microscopic residual disease. Here we acquired glioma margin specimens for SRH, histology, and tumor specific tissue characterization. Generalized linear mixed models were used to evaluate agreement. We find that SRH identified residual tumor in 82 of 167 margin specimens (49%), compared to IHC confirming residual tumor in 72 of 128 samples (56%), and H&E confirming residual tumor in 82 of 169 samples (49%). Intraobserver agreements between all 3 modalities were confirmed. These data demonstrate that SRH detects residual microscopic tumor at the infiltrative glioma margin and may be a promising tool to enhance extent of resection.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction

    Mats I Nilsson / Jacqueline M Bourgeois / Joshua P Nederveen / Marlon R Leite / Bart P Hettinga / Adam L Bujak / Linda May / Ethan Lin / Michael Crozier / Daniel R Rusiecki / Chris Moffatt / Paul Azzopardi / Jacob Young / Yifan Yang / Jenny Nguyen / Ethan Adler / Lucy Lan / Mark A Tarnopolsky

    PLoS ONE, Vol 15, Iss 5, p e

    Lifelong aerobic exercise protects against inflammaging and cancer.

    2020  Volume 0233401

    Abstract: This corrects the article DOI:10.1371/journal.pone.0210863.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0210863.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Lifelong aerobic exercise protects against inflammaging and cancer.

    Mats I Nilsson / Jacqueline M Bourgeois / Joshua P Nederveen / Marlon R Leite / Bart P Hettinga / Adam L Bujak / Linda May / Ethan Lin / Michael Crozier / Daniel R Rusiecki / Chris Moffatt / Paul Azzopardi / Jacob Young / Yifan Yang / Jenny Nguyen / Ethan Adler / Lucy Lan / Mark A Tarnopolsky

    PLoS ONE, Vol 14, Iss 1, p e

    2019  Volume 0210863

    Abstract: Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic ... ...

    Abstract Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, and enhances both health and lifespan. In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model (C57BL/J6). Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines (P < 0.05 O-SED vs. 2-month-old Y-CON), was potently mitigated by lifelong AET (P < 0.05 O-AET vs. O-SED), including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). In addition, circulating SPARC, previously known to be upregulated in metabolic disease, was elevated in old, sedentary mice, but was normalized to young control levels in lifelong runners. Remarkably, malignant tumours were also completely absent in the O-AET group, whereas they were present in the brain (pituitary), liver, spleen, and intestines of sedentary mice. Collectively, our results indicate that early-onset, lifelong running dampens inflammaging, protects against multiple cancer types, and extends healthspan of naturally-aged mice.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: External validation and recalibration of an incidental meningioma prognostic model – IMPACT

    Julie Woodfield / Boris Krischek / Giles Critchley / Damian Holliman / Angelos Kolias / Thomas Santarius / Ola Rominiyi / Michael McDermott / Michael D Jenkinson / Jörg-Christian Tonn / Mohsen Javadpour / Andrea Saladino / Tiit Illimar Mathiesen / Rory Piper / Michael Vogelbaum / Chaya Brodie / Sara Venturini / Daniel M Fountain / Roland Goldbrunner /
    Elliot Tilling / Felix Sahm / Priscilla Brastianos / Rory J Piper / Antonio Santoro / Sylvia Kurz / Pierfrancesco Lapolla / Andrea Mingoli / Jennifer Brown / Debraj Mukherjee / Simon Walling / Andrew Morokoff / Patrick Wen / Ghazaleh Tabatabai / Jill Barnholtz-Sloan / Ryan K Mathew / Alexander Smedley / Helen Shih / William Taylor / Minh Nguyen / Bryony Ford / Samantha J Mills / Tamara Ali / Ruwanthi Kolamunnage-Dona / Josephine Jung / Muhammed Elhadi / Erminia Albanese / Aswin Chari / David Rowland / Melissa Gough / Michael Cearns / Simon Lammy / Yasir Chowdhury / Christian Mawrin / Mahmoud Saleh / Jens Schittenhelm / Farshad Nassiri / Raymond Huang / Pietro Familiari / Manfred Westphal / Warren Selman / Daniel Brown / Nathan McSorley / Oliver Hanemann / Richard Pullicino / Francesco Gaillard / Mirjam Renovanz / Chris Barrett / Christine Jungk / Aaron Cohen-Gadol / Javier Martín-Alonso / Gelareh Zadeh / Hytham Hamid / Abdurrahman I Islim / Christopher P Millward / Shaveta Mehta / Usama Ali / Shelli Diane Koszdin / Theo Georgious / Andrew R Brodbelt / Mohamed Abdelsadg / Suhaib Abualsaud / Amro Abuleil / Kevin Agyemang / Hanan Akbari / Likhith Alakandy / Clarissa Alfonso / Arousa Ali / Michael Amoo / Mohamed A. R. Arbab / Mutiu Asha / Kareem Austin / Khaled Badran / Jarnail Bal / Parameswaran Bhattathiri / Paul M. Brennan / Andrew R. Brodbelt / Ferran Brugada-Bellsolà / Placido Bruzzaniti / Annabel Butcher / Rory S. Cairns / Michael Canty / Sachiv Chakravarti / Rebecca Chave-Cox / Anna Craig-McQuade / Peter Crossley / Elizabeth Culpin / Alessia D'Amico / Bassam Dabbous / Pedro David Delgado-López / Mohamed Draz / Katharine J. Drummond / Rusiru T. Ekanayaka / Ibrahim Elmaadawi / Omar Elmandouh / Mazin Elsharif / Daisy Evans / Andreas Fahlström / Fleur L. Fisher / Daniel M. Fountain / Keiko Fox / Chloé Gelder / Shamayitri Ghosh / Aimee Goel / Athanasios Grivas / Andrew Gvozdanovic / Allan Hall / Liv Hartrick / Samih Hassan / Jack Henry / Abdurrahman I. Islim / Asgeir S. Jakola / Michael D. Jenkinson / Sanjeeva Jeyaretna / Adrian Jimenez / Andranik Kahramanian / Neeraj Kalra / David O. Kamson / Oliver Kennion / Adham M. Khalafallah / Sarah Kingdon / Howra Ktayen / Aditaya Kumar / Jun Yi Lau / Jing Xian Lee / Ryan Leyden / Patricia Littlechild / Sophie Liu / Darmanin Lora-Kay / Vivia Lung / Stephen T. Magill / Hani J. Marcus / Fawaz E. Marhoom / Ryan K. Mathew / Calan Mathieson / Tobias Mederer / Torstien R. Meling / Samantha J. Mills / Christopher P. Millward / Mujtaba Mohammad / Amir H. Zamanipoor Najafabadi / Olivia Näslund / Imran Noorani / Gildas Patet / Omar N. Pathmanaban / Andrea Perera / Amit Persad / See Yung Phang / Rory J. Piper / Jonathan Pollock / Benjamin Price / Martin Proescholdt / James Robins / Bobby Sachdev / Fozia Saeed / Ieva Sataite / Antony Kevin Scafa / Verena Schadewaldt / Syed Wajahat Shah / Mustafa El Sheikh / Zenab Sher / Bente Sandvei Skeie / Agbolahan Sofela / Jerome St George / Torbjørn Strømsnes / Nigel Suttner / Philip Theodosopoulos / Manjul Tripathi / Ismail Ughratdar / James Ulrich / Adithya Varma / Anil Varma / Maria Velicu / Esther Wu / Jacob Young / Giuseppa Zancana / Catherine Zhang / Karolyn Au / Felix Behling / Linda Bi / Nicholas Butowski / Ana Castro / Marta Couce / Francesco Dimeco / Katherine J. Drummond / Ian Dunn / Craig Erker / Michelle Felicella / Eva Galanis / Norbert Galldiks / Caterina Giannini / Christel Herold-Mende / Luke Hnenny / Craig Horbinski / Gerhard Jungwirth / Timothy Kaufmann / Daniel Lachance / Christian Lafougere / Katrin Lamszus / Serge Makarenko / Tathiana Malta / Jennifer Moliterno-Gunel / HK Ng / Houtan Noushmehr / Arie Perry / Laila Poisson / Bianco Pollo / Aditya Ragunathan / David Raleigh / Franz Ricklefs / Antonio Santacroce / Christian Schichor / Nils Schimdt / Andrew Sloan / Matija Snuderl / Jim Snyder / Erik Sulman / Suganth Suppiah / Marcos Tatagiba / Marco Timmer / Andreas Von Deimling / Tobias Walbert / Justin Z. Wang / Stephen Yip / Gabriel Zada / Viktor Zherebitskiy / Michael T.C. Poon

    BMJ Open, Vol 12, Iss

    protocol for an international multicentre retrospective cohort study

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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