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  1. Article ; Online: An endemic species flock of Cypridopsinae (Crustacea, Ostracoda) from the ancient Lake Malawi (Africa), with the description of a new genus and three new species.

    Jacobs, Bram / Martens, Koen

    Zootaxa

    2022  Volume 5100, Issue 3, Page(s) 301–348

    Abstract: We describe Malawidopsis gen. nov., a new genus of Cypridopsinae Kaufmann, 1900 from the African ancient Lake Malawi. The genus comprises at least 17 new species, which makes it a significant ostracod radiation in this lake, parallel to a similar (but ... ...

    Abstract We describe Malawidopsis gen. nov., a new genus of Cypridopsinae Kaufmann, 1900 from the African ancient Lake Malawi. The genus comprises at least 17 new species, which makes it a significant ostracod radiation in this lake, parallel to a similar (but independent) cypridopsine radiation in Lake Tanganyika. Three of these new species are here described: Malawidopsis stellae gen. et. sp. nov., the type species of the new genus; M. ruwaydae gen. et. sp. nov. and M. antoniae gen. et. sp. nov.. The other new species are briefly illustrated and described, but are left in open nomenclature (sp. A, B, C, etc.). Cypridopsis cunningtoni Sars, 1910 and Potamocypris fuelleborni Daday, 1910 are transferred to Malawidopsis gen. nov. and are identical to Malawidopsis spec. F and Malawidopsis spec. N, respectively. The new tribe Plesiocyprisopsini trib. nov. is erected, and comprises the cypridopsine genera previously in the Cypridopsini s.l. with the right valve overlapping the left valve, at least anteriorly. Potential drivers of speciation within this endemic clade in Lake Malawi are briefly discussed. Bathymetry might have been important, with most species being restricted to shallower depths and only four species also occurring at depths of 75 m or more, but very few specimens were retrieved from greater depths. Most species occurred on coarse sand, but this sediment category coincides with shallower stations. Overall, most species appear to have a wide geographical distribution in the lake, so no geographical parapatric speciation is apparent. The occurrence of all species in sexual populations and the significant differences in the male sexual organs and the valves suggest that sexual selection might have been the most important driver in the speciation process of this species flock, but this should be further explored. Following deep coring results in Lake Malawi, the present clade could be (at least) c one million years old.
    MeSH term(s) Animals ; Crustacea ; Lakes ; Malawi ; Male
    Language English
    Publishing date 2022-02-21
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5100.3.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Notes on establishing fear conditioning as causal in the postural orthostatic tachycardia syndrome.

    Lambrechts, Roald A / Jacobs, Bram

    Brain : a journal of neurology

    2022  Volume 145, Issue 11, Page(s) e107–e108

    MeSH term(s) Humans ; Postural Orthostatic Tachycardia Syndrome ; Causality ; Fear
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Accuracy of Labeling of Galantamine Generic Drugs and Dietary Supplements.

    Cohen, Pieter A / Jacobs, Bram / Van Hoorde, Koenraad / Vanhee, Céline

    JAMA

    2024  Volume 331, Issue 11, Page(s) 974–976

    MeSH term(s) Dietary Supplements ; Drug Contamination ; Drugs, Generic ; Galantamine ; Drug Labeling/standards
    Chemical Substances Drugs, Generic ; Galantamine (0D3Q044KCA)
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.0328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Highlights mild traumatic brain injury 2021.

    van der Naalt, Joukje / Jacobs, Bram

    Current opinion in anaesthesiology

    2022  Volume 35, Issue 5, Page(s) 577–582

    Abstract: Purpose: Mild traumatic brain injury (TBI) is one of the most common causes of morbidity worldwide. Patients at risk of unfavourable outcome may benefit from additional attention and help but identification of these patients necessitates the development ...

    Abstract Purpose: Mild traumatic brain injury (TBI) is one of the most common causes of morbidity worldwide. Patients at risk of unfavourable outcome may benefit from additional attention and help but identification of these patients necessitates the development of diagnostic methods to assess indices of brain injury at an early stage. The aim of this overview is to highlight studies that reflect the growing scientific attention to the early diagnosis and prognostication of mild TBI.
    Recent findings: The value of serum biomarkers for the diagnosis of TBI severity has been acknowledged in recent studies. The diagnostic and prognostic utility of several biomarkers of brain injury, such as glial fibrillary acidic protein, and of inflammation, such as interleukin (IL)-6 and IL-10, holds promise for application in daily clinical practice in a point-of-care platform. Besides head CT imaging, early advanced MRI brain imaging has been reported as a tool for assessment of injury severity and prognostication. The introduction of direct oral anticoagulants (DOACs) has raised new challenges for the treatment of intracranial traumatic haemorrhage at the Emergency Department.
    Summary: Promising findings of new diagnostic markers of brain injury severity highlight the potential prognostic value of serum biomarkers and early MRI imaging. The accurate assessment of patients at risk of incomplete recovery after mTBI will enhance more timely and individualized treatment.
    MeSH term(s) Biomarkers ; Brain ; Brain Concussion/diagnosis ; Brain Injuries ; Humans ; Magnetic Resonance Imaging/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Validation of a Targeted LC-MS/MS Method for Cereulide and Application in Food and Faeces.

    Masquelier, Julien / Segers, Céline / Jacobs, Bram / Van Nieuwenhuysen, Tom / Delbrassinne, Laurence / Van Hoeck, Els

    Toxins

    2023  Volume 16, Issue 1

    Abstract: Cereulide is an emetic toxin produced by some strains ... ...

    Abstract Cereulide is an emetic toxin produced by some strains of
    MeSH term(s) Humans ; Chromatography, Liquid ; Liquid Chromatography-Mass Spectrometry ; Reproducibility of Results ; Tandem Mass Spectrometry ; Feces ; Depsipeptides
    Chemical Substances cereulide ; Depsipeptides
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16010013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Long-Term Stability of Blood Serum Biomarkers in Traumatic Brain Injury: A Feasibility Study.

    van der Horn, Harm Jan / Visser, Koen / Bijzet, Johan / Vos, Pieter / van der Naalt, Joukje / Jacobs, Bram

    Frontiers in neurology

    2022  Volume 13, Page(s) 877050

    Abstract: Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In the current feasibility study we analyzed acute phase serum samples from patients with mild TBI as well ... ...

    Abstract Few studies on traumatic brain injury (TBI) have investigated the stability of blood serum biomarkers after long-term storage at low temperatures. In the current feasibility study we analyzed acute phase serum samples from patients with mild TBI as well as patients with moderate and severe TBI that were collected more than 10 years ago (
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.877050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incomplete recovery in patients with minor head injury directly discharged home from the emergency department: a prospective cohort follow-up study.

    Coffeng, Sophie Maria / Jacobs, Bram / Kim, Laura Jane / Ter Maaten, Jan Cornelis / van der Naalt, Joukje

    BMJ open

    2022  Volume 12, Issue 6, Page(s) e057308

    Abstract: Objectives: To determine the frequency of post-traumatic complaints and recovery rate of non-hospitalised patients with minor head injury (MHI) and their relationship with demographic and injury characteristics. We also evaluated the differences between ...

    Abstract Objectives: To determine the frequency of post-traumatic complaints and recovery rate of non-hospitalised patients with minor head injury (MHI) and their relationship with demographic and injury characteristics. We also evaluated the differences between patient groups in this least severe category of brain and head injury.
    Design: Prospective cohort follow-up study.
    Setting: Patients admitted to the emergency department (ED) of a tertiary hospital in the Netherlands.
    Participants: 242 patients with MHI (n=100 with head injury only and n=142 with mild traumatic brain injury (mTBI)) discharged home directly after evaluation at the ED.
    Outcome measures: The primary outcome measure was incomplete recovery at 3 months measured by the Glasgow Outcome Scale-Extended score <8. Secondary outcome measures were number of post-traumatic complaints assessed 2 weeks and 3 months postinjury by a standardised questionnaire. Also the number of patients that visited their general practitioner because of persistent complaints was determined.
    Results: Three months postinjury 48% of patients reported more than one post-traumatic complaint. Half (51%) of patients showed incomplete recovery. Incomplete recovery was associated with headache directly postinjury (OR 3.27, 95% CI 1.28 to 8.34), age (OR 1.02, 95% CI 1.00 to 1.05) and the number of post-traumatic complaints (OR 1.24, 95% CI 1.09 to 1.40) and depression (OR 6.31, 95% CI 1.24 to 32.00) 2 weeks postinjury. Incomplete recovery was comparable between the head injury only and mTBI group (55% vs 50%, 95% CI -12.5 to -23.0). In total 36 MHI patients (28%) visited their general practitioner because of complaints related to their head injury.
    Conclusion: Half of the non-hospitalised patients with MHI experienced incomplete recovery after 3 months without differences between head injury only and mTBI patients. Therefore, early identification of patients at risk for incomplete recovery must be started at the ED to provide appropriate aftercare to avoid long-term post-traumatic complaints.
    MeSH term(s) Brain Concussion/complications ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/epidemiology ; Emergency Service, Hospital ; Follow-Up Studies ; Humans ; Infant, Newborn ; Patient Discharge ; Prospective Studies
    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-057308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Slow Channel Syndrome Revisited: 40 Years Clinical Follow-Up and Genetic Characterization of Two Cases.

    Boon, Helena T M / Jacobs, Bram / Wouter, van Rheenen / Kamsteeg, Erik-Jan / Kuks, Jan B M / Vincent, Angela / Eymard, Bruno / Voermans, Nicol C

    Journal of neuromuscular diseases

    2022  Volume 9, Issue 4, Page(s) 525–532

    Abstract: Background: The slow channel syndrome is a rare hereditary disorder caused by a dominant gain-of-function variant in one of the subunits of the acetylcholine receptor at the neuromuscular junction. Patients typically experience axial, limb and ... ...

    Abstract Background: The slow channel syndrome is a rare hereditary disorder caused by a dominant gain-of-function variant in one of the subunits of the acetylcholine receptor at the neuromuscular junction. Patients typically experience axial, limb and particularly extensor finger muscle weakness.
    Objective: Age at diagnosis is variable and although the long-term prognosis is important for newly diagnosed patients, extensive follow-up studies are rare. We aim to provide answers and perspective for this patient group by presenting an elaborate description of the lifetime follow-up of two slow channel syndrome patients.
    Methods: We describe 40 years follow-up in two, genetically confirmed cases (CHRNA1; c.866G > T p.(Ser289Ile)(legacy Ser269Ile) and CHRNE; c.721C > T p.(Leu241Phe)(legacy Leu221Phe) variants).
    Results: We find that the disease course has a fluctuating pattern and is only mildly progressive. However, hormonal imbalances, (psychological) stress or excessive hot or cold environments are often aggravating factors. Quinidine and fluoxetine are helpful, but ephedrine and salbutamol may also improve symptoms.
    Conclusion: Slow channel syndrome is mildly progressive with a fluctuating pattern. The observations reported here provide a lifespan perspective and answers to the most pressing questions about prognosis and treatment options for newly diagnosed patients.
    MeSH term(s) Follow-Up Studies ; Humans ; Myasthenic Syndromes, Congenital/genetics ; Neuromuscular Junction ; Prognosis ; Receptors, Cholinergic
    Chemical Substances Receptors, Cholinergic
    Language English
    Publishing date 2022-04-25
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ISSN 2214-3602
    ISSN (online) 2214-3602
    DOI 10.3233/JND-220798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Spectrum of Long-Term Behavioral Disturbances and Provided Care After Traumatic Brain Injury.

    Timmer, Marlies L / Jacobs, Bram / Schonherr, Marleen C / Spikman, Jacoba M / van der Naalt, Joukje

    Frontiers in neurology

    2020  Volume 11, Page(s) 246

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2020-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.00246
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  10. Article: Evaluation of Clinical Characteristics and CT Decision Rules in Elderly Patients with Minor Head Injury: A Prospective Multicenter Cohort Study.

    Coffeng, Sophie M / Foks, Kelly A / van den Brand, Crispijn L / Jellema, Korné / Dippel, Diederik W J / Jacobs, Bram / van der Naalt, Joukje

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Age is variably described as a minor or major risk factor for traumatic intracranial lesions after head injury. However, at present, no specific CT decision rule is available for elderly patients with minor head injury (MHI). The aims of this prospective ...

    Abstract Age is variably described as a minor or major risk factor for traumatic intracranial lesions after head injury. However, at present, no specific CT decision rule is available for elderly patients with minor head injury (MHI). The aims of this prospective multicenter cohort study were to assess the performance of existing CT decision rules for elderly MHI patients and to compare the clinical and CT characteristics of elderly patients with the younger MHI population. Thirty-day mortality between two age groups (cutoff ≥ 60 years), along with clinical and CT characteristics, was evaluated with four CT decision rules: the National Institute for Health and Care Excellence (NICE) guideline, the Canadian CT Head Rule (CCHR), the New Orleans Criteria (NOC), and the CT Head Injury Patients (CHIP) rule. Of the 5517 MHI patients included, 2310 were aged ≥ 60 years. Elderly patients experienced loss of consciousness (17% vs. 32%) and posttraumatic amnesia (23% vs. 31%) less often, but intracranial lesions (13% vs. 10%), neurological deterioration (1.8% vs. 0.2%), and 30-day mortality (2.0% vs. 0.1%) were more frequent than in younger patients (all
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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