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  1. Book: Antimicrobial resistance: challenges and solutions

    Jacobs, Michael R.

    (Clinics in laboratory medicine ; 24,2)

    2004  

    Author's details guest ed. Michael R. Jacobs
    Series title Clinics in laboratory medicine ; 24,2
    Collection
    Language English
    Size XIV S., S. 329 - 558 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014090292
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1695 -24,2- not available for loan Zeitschriften-Lesesaal

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  2. Article: Bacterial Contamination of Platelet Products.

    Jacobs, Michael R / Zhou, Bowen / Tayal, Aditi / Maitta, Robert W

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, ... ...

    Abstract Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, diversion of the first part of donations, use of apheresis platelet units rather than whole-blood derived pools, primary and secondary testing by culture or rapid test, and use of pathogen reduction. Primary culture has been in use the US since 2004, using culture 24 h after collection of volumes of 4-8 mL from apheresis collections and whole-blood derived pools inoculated into aerobic culture bottles, with limited use of secondary testing by culture or rapid test to extend shelf-life from 5 to 7 days. Primary culture was introduced in the UK in 2011 using a "large-volume, delayed sampling" (LVDS) protocol requiring culture 36-48 h after collection of volumes of 16 mL from split apheresis units and whole-blood derived pools, inoculated into aerobic and anaerobic culture bottles (8 mL each), with a shelf-life of 7 days. Pathogen reduction using amotosalen has been in use in Europe since 2002, and was approved for use in the US in 2014. In the US, recent FDA guidance, effective October 2021, recommended several strategies to limit bacterial contamination of platelet products, including pathogen reduction, variants of the UK LVDS method and several two-step strategies, with shelf-life ranging from 3 to 7 days. The issues associated with bacterial contamination and these strategies are discussed in this review.
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Accuracy of Direct Antimicrobial Susceptibility Testing of Gram-Negative Bacteria from Positive Blood Cultures Using MicroScan System and Value of Using Expert Rules for β-Lactam Agents.

    Jacobs, Michael R / Good, Caryn E / Abdelhamed, Ayman M / Bonomo, Robert A

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 3, Page(s) e0214821

    Abstract: Direct antimicrobial susceptibility testing (AST) of positive blood cultures with Gram-negative bacteria produces results within 24 h, compared to 48 to 96 h with conventional methods. Positive clinical blood cultures were studied, supplemented with ... ...

    Abstract Direct antimicrobial susceptibility testing (AST) of positive blood cultures with Gram-negative bacteria produces results within 24 h, compared to 48 to 96 h with conventional methods. Positive clinical blood cultures were studied, supplemented with contrived blood cultures inoculated with a spectrum of resistant isolates. Bacterial inocula used for direct AST were quantitated. Direct AST was performed using MicroScan NM43 trays inoculated directly from positive blood cultures (100 μL in 25 mL water) and incubated using a WalkAway instrument, with trays read after 16 h. Reference AST was performed the following day from growth on solid medium using the same trays. Agreement of AST results between direct and reference methods, with and without the use of three expert rules for β-lactams, was evaluated using FDA categorical agreement criteria. Of 86 specimens tested (41 clinical specimens and 45 contrived specimens), the mean bacterial load in positive blood cultures was 8.98 log
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Blood Culture ; Gram-Negative Bacteria ; Microbial Sensitivity Tests ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.02148-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genomes of

    Singh, Vaidhvi / West, Gail / Fiocchi, Claudio / Cominelli, Fabio / Good, Caryn E / Jacobs, Michael R / Rodriguez-Palacios, Alexander

    Microbiology resource announcements

    2024  Volume 13, Issue 4, Page(s) e0115223

    Abstract: Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six ... ...

    Abstract Surgically removed bowels from Crohn's disease patients exhibit a novel form of micropathologies known as cavernous fistulous tract microlesions (CavFT), resembling fissures. We announce the genomes/plasmids and antimicrobial resistance genes of six CavFT bacterial isolates representing the
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.01152-23
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  5. Article ; Online: Recent advances in rapid antimicrobial susceptibility testing systems.

    Jacobs, Michael R / Colson, Jordan D / Rhoads, Daniel D

    Expert review of molecular diagnostics

    2021  Volume 21, Issue 6, Page(s) 563–578

    Abstract: Introduction: Until recently antimicrobial susceptibility testing (AST) methods based on the demonstration of phenotypic susceptibility in 16-24 h remained largely unchanged.: Areas covered: Advances in rapid phenotypic and molecular-based AST ... ...

    Abstract Introduction: Until recently antimicrobial susceptibility testing (AST) methods based on the demonstration of phenotypic susceptibility in 16-24 h remained largely unchanged.
    Areas covered: Advances in rapid phenotypic and molecular-based AST systems.
    Expert opinion: AST has changed over the past decade, with many rapid phenotypic and molecular methods developed to demonstrate phenotypic or genotypic resistance, or biochemical markers of resistance such as β-lactamases associated with carbapenem resistance. Most methods still require isolation of bacteria from specimens before both legacy and newer methods can be used. Bacterial identification by MALDI-TOF mass spectroscopy is now widely used and is often key to the interpretation of rapid AST results. Several PCR arrays are available to detect the most frequent pathogens associated with bloodstream infections and their major antimicrobial resistance genes. Many advances in whole-genome sequencing of bacteria and fungi isolated by culture as well as directly from clinical specimens have been made but are not yet widely available. High cost and limited throughput are the major obstacles to uptake of rapid methods, but targeted use, continued development and decreasing costs are expected to result in more extensive use of these increasingly useful methods.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Bacteria/genetics ; Humans ; Microbial Sensitivity Tests ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2021.1924679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6073: Show issues Location:
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  6. Book: Beratung Alkoholabhängiger

    Jacobs, Michael R.

    therapeut. Möglichkeiten im ambulanten Bereich

    1988  

    Title translation Problems presented by alcoholic clients
    Keywords Alcoholism / therapy ; Counseling ; Alkoholismus ; Ambulante Behandlung
    Subject Ambulante ärztliche Versorgung ; Ambulante Krankenversorgung ; Ambulante Therapie ; Alkoholabhängigkeit ; Trunksucht ; Alkoholbedingte Krankheit ; Alkoholkrankheit ; Alkoholsucht ; Alkohol
    Language German
    Size 115 S.
    Publisher Hippokrates-Verl
    Publishing place Stuttgart
    Document type Book
    Note Aus d. Engl. übers.
    HBZ-ID HT003157906
    ISBN 3-7773-0855-2 ; 978-3-7773-0855-5
    Database Catalogue ZB MED Medicine, Health

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    1988 A 4686 order for loan Magazin

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  7. Article ; Online: The negative secondary test for bacterial contamination: reducing the risk of septic transfusion reactions from platelets.

    Tomasulo, Peter A / Jacobs, Michael R

    Transfusion

    2017  Volume 57, Issue 8, Page(s) 2054–2055

    MeSH term(s) Bacterial Infections/prevention & control ; Bacterial Infections/transmission ; Bacteriological Techniques ; Blood Platelets/microbiology ; Blood Safety/methods ; Blood Safety/standards ; Disease Transmission, Infectious/prevention & control ; False Negative Reactions ; Guidelines as Topic ; Humans ; Multicenter Studies as Topic ; Platelet Transfusion/adverse effects ; Sensitivity and Specificity ; Transfusion Reaction/prevention & control ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2017-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.14221
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    Zs.A 284: Show issues Location:
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  8. Article: The Mechanisms of Benefit of High-Flow Nasal Therapy in Stable COPD.

    Zantah, Massa / Pandya, Aloknath / Jacobs, Michael R / Criner, Gerard J

    Journal of clinical medicine

    2020  Volume 9, Issue 12

    Abstract: High-flow nasal therapy (HFNT) is a unique system that delivers humidified, heated oxygen-enriched air via nasal cannula at high flow rates. It is a promising therapy for chronic obstructive pulmonary disease (COPD) patients. Several studies have ... ...

    Abstract High-flow nasal therapy (HFNT) is a unique system that delivers humidified, heated oxygen-enriched air via nasal cannula at high flow rates. It is a promising therapy for chronic obstructive pulmonary disease (COPD) patients. Several studies have examined the physiologic effects of this therapy in the patient population and have revealed that it improves mucociliary clearance, reduces nasopharyngeal dead space, and subsequently increases CO
    Language English
    Publishing date 2020-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9123832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Evolving Role of the Clinical Microbiology Laboratory in Identifying Resistance in Gram-Negative Bacteria: An Update.

    Endimiani, Andrea / Ramette, Alban / Rhoads, Daniel D / Jacobs, Michael R

    Infectious disease clinics of North America

    2020  Volume 34, Issue 4, Page(s) 659–676

    Abstract: The evolution of resistance to antimicrobial agents in gram-negatives has challenged the role of the clinical microbiology laboratory to implement new methods for their timely detection. Recent development has enabled the use of novel methods for more ... ...

    Abstract The evolution of resistance to antimicrobial agents in gram-negatives has challenged the role of the clinical microbiology laboratory to implement new methods for their timely detection. Recent development has enabled the use of novel methods for more rapid pathogen identification, antimicrobial susceptibility testing, and detection of resistance markers. Commonly used methods improve the rapidity of resistance detection from both cultured bacteria and specimens. This review focuses on the commercially available systems available together with their technical performance and possible clinical impact.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Typing Techniques ; Drug Resistance, Bacterial ; Gram-Negative Bacteria/classification ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Humans ; Laboratories ; Microbial Sensitivity Tests ; Microbiological Techniques/methods ; Nucleic Acid Amplification Techniques ; Whole Genome Sequencing
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2020.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Changing Role of the Clinical Microbiology Laboratory in Defining Resistance in Gram-negatives.

    Endimiani, Andrea / Jacobs, Michael R

    Infectious disease clinics of North America

    2016  Volume 30, Issue 2, Page(s) 323–345

    Abstract: The evolution of resistance in Gram-negatives has challenged the clinical microbiology laboratory to implement new methods for their detection. Multidrug-resistant strains present major challenges to conventional and new detection methods. More rapid ... ...

    Abstract The evolution of resistance in Gram-negatives has challenged the clinical microbiology laboratory to implement new methods for their detection. Multidrug-resistant strains present major challenges to conventional and new detection methods. More rapid pathogen identification and antimicrobial susceptibility testing have been developed for use directly on specimens, including fluorescence in situ hybridization tests, automated polymerase chain reaction systems, microarrays, mass spectroscopy, next-generation sequencing, and microfluidics. Review of these methods shows the advances that have been made in rapid detection of resistance in cultures, but limited progress in direct detection from specimens.
    MeSH term(s) Drug Resistance, Bacterial/genetics ; Gram-Negative Bacteria/classification ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/genetics ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/microbiology ; Humans ; In Situ Hybridization, Fluorescence ; Molecular Typing ; Polymerase Chain Reaction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2016.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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