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  1. AU="Jacquemet, Elise"
  2. AU="Cappelleri, Joseph C"
  3. AU="Frank, Samuel A"
  4. AU="Srensen, Henrik Toft"
  5. AU="Matteo Tosato"

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  1. Article ; Online: Longitudinal Study of Viral Diversity Associated with Mosquito Species Circulating in Cambodia.

    Mohamed Ali, Souand / Rakotonirina, Antsa / Heng, Kimly / Jacquemet, Elise / Volant, Stevenn / Temmam, Sarah / Boyer, Sebastien / Eloit, Marc

    Viruses

    2023  Volume 15, Issue 9

    Abstract: Arthropod-borne viruses (arboviruses) pose a significant global health threat and are primarily transmitted by mosquitoes. In Cambodia, there are currently 290 recorded mosquito species, with at least 17 of them considered potential vectors of ... ...

    Abstract Arthropod-borne viruses (arboviruses) pose a significant global health threat and are primarily transmitted by mosquitoes. In Cambodia, there are currently 290 recorded mosquito species, with at least 17 of them considered potential vectors of arboviruses to humans. Effective surveillance of virome profiles in mosquitoes from Cambodia is vital, as it could help prevent and control arbovirus diseases in a country where epidemics occur frequently. The objective of this study was to identify and characterize the viral diversity in mosquitoes collected during a one-year longitudinal study conducted in various habitats across Cambodia. For this purpose, we used a metatranscriptomics approach and detected the presence of chikungunya virus in the collected mosquitoes. Additionally, we identified viruses categorized into 26 taxa, including those known to harbor arboviruses such as
    MeSH term(s) Humans ; Animals ; Cambodia/epidemiology ; Longitudinal Studies ; Mosquito Vectors ; Birnaviridae ; Culicidae
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation.

    Darrau, Estelle / Jacquemet, Elise / Pons, Stéphanie / Schlick, Laurène / Zouridakis, Marios / Wu, Ching-Lien / Richard, Jean-Romain / Barau, Caroline / Le Corvoisier, Philippe / Yolken, Robert / Tamouza, Ryad / Leboyer, Marion / Maskos, Uwe

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 146

    Abstract: There is growing evidence that autoantibodies (AAbs) against proteins expressed in the brain are playing an important role in neurological and psychiatric disorders. Here, we explore the presence and the role of peripheral AAbs to the α7-nicotinic ... ...

    Abstract There is growing evidence that autoantibodies (AAbs) against proteins expressed in the brain are playing an important role in neurological and psychiatric disorders. Here, we explore the presence and the role of peripheral AAbs to the α7-nicotinic acetylcholine receptor (nAChR) in inflammatory subgroups of psychiatric patients with bipolar disorder (BD) or schizophrenia (SCZ) and healthy controls. We have identified a continuum of AAb levels in serum when employing a novel ELISA technique, with a significant elevation in patients compared to controls. Using unsupervised two-step clustering to stratify all the subjects according to their immuno-inflammatory background, we delineate one subgroup consisting solely of psychiatric patients with severe symptoms, high inflammatory profile, and significantly increased levels of anti-nAChR AAbs. In this context, we have used monoclonal mouse anti-human α7-nAChR antibodies (α7-nAChR-mAbs) and shown that TNF-α release was enhanced upon LPS stimulation in macrophages pre-incubated with α7-nAChR-mAbs compared to the use of an isotype control. These findings provide a basis for further study of circulating nicotinic AAbs, and the inflammatory profile observed in patients with major mood and psychotic disorders.
    MeSH term(s) Humans ; Mice ; Animals ; Bipolar Disorder ; Schizophrenia ; alpha7 Nicotinic Acetylcholine Receptor ; Inflammation/metabolism ; Receptors, Nicotinic ; Autoantibodies
    Chemical Substances alpha7 Nicotinic Acetylcholine Receptor ; Receptors, Nicotinic ; Autoantibodies
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02853-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Comprehensive Characterization of Viral Diversity of Female Mosquitoes in Madagascar.

    Bennouna, Amal / Tantely, Michael Luciano / Raharinosy, Vololoniaina / Andriamandimby, Soa Fy / Bigot, Thomas / Chrétien, Delphine / Jacquemet, Elise / Volant, Stevenn / Temmam, Sarah / Dussart, Philippe / Lacoste, Vincent / Girod, Romain / Eloit, Marc

    Viruses

    2023  Volume 15, Issue 9

    Abstract: The diversity and circulation of arboviruses are not much studied in Madagascar. The fact is that arboviral emergences are rarely detected. The existing surveillance system primarily relies on serological detection and records only a few human infections ...

    Abstract The diversity and circulation of arboviruses are not much studied in Madagascar. The fact is that arboviral emergences are rarely detected. The existing surveillance system primarily relies on serological detection and records only a few human infections annually. The city of Mahajanga, however, experienced a confirmed dengue fever epidemic in 2020 and 2021. This study aimed to characterize and analyze the virome of mosquitoes collected in Mahajanga, near patients with dengue-like syndromes to detect known and unknown viruses as well as investigate the factors contributing to the relative low circulation of arboviruses in the area. A total of 4280 mosquitoes representing at least 12 species from the
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091852
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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