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  1. Article: [No title information]

    Jacquérioz Bausch, Frédérique

    Revue medicale suisse

    2020  Volume 16, Issue 719, Page(s) 2458

    Title translation Atteintes neurologiques chez les patients Covid-19.
    MeSH term(s) Brain ; Brain Diseases ; COVID-19 ; Humans ; Morbidity ; SARS-CoV-2
    Language French
    Publishing date 2020-08-17
    Publishing country Switzerland
    Document type News ; Comment
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systematic screening for SARS-CoV-2 in pregnant women admitted for delivery: not as easy as it sounds.

    Haller, Guy / Jacquerioz Bausch, Frédérique / Gayet-Ageron, Angèle

    Journal of perinatal medicine

    2020  Volume 49, Issue 4, Page(s) 526–527

    MeSH term(s) Asymptomatic Infections ; COVID-19 ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; Pregnant Women ; SARS-CoV-2
    Language English
    Publishing date 2020-12-23
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2020-0574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel outpatient management of mild to moderate COVID-19 spares hospital capacity and safeguards patient outcome: The Geneva PneumoCoV-Ambu study.

    Chevallier Lugon, Chloé / Smit, Mikaela / Salamun, Julien / Abderrahmane, Meriem / Braillard, Olivia / Nehme, Mayssam / Jacquerioz Bausch, Frédérique / Guessous, Idris / Spechbach, Hervé

    PloS one

    2021  Volume 16, Issue 3, Page(s) e0247774

    Abstract: Background: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is creating an unprecedented burden on health care systems across the world due to its high rate of pneumonia-related ... ...

    Abstract Background: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes coronavirus disease (COVID-19), is creating an unprecedented burden on health care systems across the world due to its high rate of pneumonia-related hospitalizations. This study presents recommendations for the outpatient management of moderate SARS-CoV-2 pneumonia implemented at the Geneva University Hospital, Switzerland, from April 4 to June 30, 2020 and evaluated the impact of these recommendations on patient safety, patient satisfaction, and overall hospital capacity.
    Methods: Recommendations for the outpatient management of moderate pneumonia implemented in the Geneva University Hospital (PneumoCoV-Ambu) between April 4 and June 30, 2020, were evaluated prospectively. The primary endpoint was hospitalization. Secondary endpoints were: severity of COVID-19 disease based on a 7-points ordinal scale assessed at 1 and 2 months following SARS-CoV-2 infection; patient satisfaction using a satisfaction survey and the analysis of number of beds and costs potentially averted.
    Results: A total of 36 patients with COVID-19-related pneumonia were followed between April 4 and May 5, 2020. Five patients (14%) were hospitalized and none died over a median of 30 days follow-up. The majority of patients (n = 31; 86%) were satisfied with the ambulatory care they received. These novel recommendations for outpatient management resulted in sparing an estimated potential 124 hospital bed-nights and CHF 6'826 per capita averted hospitalization costs over the three months period.
    Conclusions: Recommendations developed for the outpatient management of COVID-19-related pneumonia were able to spare hospital capacity without increasing adverse patient outcomes. Widely implementing such recommendations is crucial in preserving hospital capacity during this pandemic.
    MeSH term(s) Adult ; Aged ; Ambulatory Care/methods ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; Disease Management ; Female ; Hospitalization ; Hospitals, University ; Humans ; Male ; Middle Aged ; Outpatients ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Switzerland/epidemiology
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0247774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Report of the WHO independent high-level commission on NCDs: where is the focus on addressing inequalities?

    Aebischer Perone, Sigiriya / Jacquerioz Bausch, Frédérique / Boulle, Philippa / Chappuis, François / Miranda, J Jaime / Beran, David

    BMJ global health

    2020  Volume 5, Issue 6

    MeSH term(s) Health Policy ; Humans ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2020-002820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load Kinetics in Symptomatic Children, Adolescents, and Adults.

    Bellon, Mathilde / Baggio, Stephanie / Jacquerioz Bausch, Frederique / Spechbach, Hervé / Salamun, Julien / Genecand, Camille / Tardin, Aglae / Kaiser, Laurent / L'Huillier, Arnaud G / Eckerle, Isabella

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 6, Page(s) e1384–e1386

    Abstract: SARS-CoV-2 viral load (VL) can serve as a correlate for infectious virus presence and transmission. Viral shedding kinetics over the first week of illness for symptomatic children (n = 279), adolescents (n = 639), and adults (n = 7109) show VLs ... ...

    Abstract SARS-CoV-2 viral load (VL) can serve as a correlate for infectious virus presence and transmission. Viral shedding kinetics over the first week of illness for symptomatic children (n = 279), adolescents (n = 639), and adults (n = 7109) show VLs compatible with infectious virus presence, with slightly lower VL in children than adults.
    MeSH term(s) Adolescent ; Adult ; COVID-19 ; Child ; Humans ; Kinetics ; SARS-CoV-2 ; Viral Load ; Virus Shedding
    Language English
    Publishing date 2021-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Infectious viral load in unvaccinated and vaccinated patients infected with SARS-CoV-2 WT, Delta and Omicron

    Puhach, Olha / Adea, Kenneth / Hulo, Nicolas / Sattonnet-Roche, Pascale / Genecand, Camille / Iten, Anne / Jacquerioz Bausch, Frederique / Kaiser, Laurent / Vetter, Pauline / Eckerle, Isabella / Meyer, Benjamin

    medRxiv

    Abstract: Abstract Background Viral load (VL) is one determinant of secondary transmission of SARS-CoV-2. Emergence of variants of concerns (VOC) Alpha and Delta was ascribed, at least partly, to higher VL. Furthermore, with parts of the population vaccinated, ... ...

    Abstract Abstract Background Viral load (VL) is one determinant of secondary transmission of SARS-CoV-2. Emergence of variants of concerns (VOC) Alpha and Delta was ascribed, at least partly, to higher VL. Furthermore, with parts of the population vaccinated, knowledge on VL in vaccine breakthrough infections is crucial. As RNA VL is only a weak proxy for infectiousness, studies on infectious virus presence by cell culture isolation are of importance. Methods We assessed nasopharyngeal swabs of COVID-19 patients for quantitative infectious viral titres (IVT) by focus-forming assay and compared to overall virus isolation success and RNA genome copies. We assessed infectious viral titres during the first 5 symptomatic days in a total of 384 patients: unvaccinated individuals infected with pre-VOC SARS-CoV-2 (n= 118) or Delta (n= 127) and vaccine breakthrough infections with Delta (n= 121) or Omicron (n=18). Findings Correlation between RNA copy number and IVT was low for all groups. No correlation between IVTs and age or sex was seen. We observed higher RNA genome copies in pre-VOC SARS-CoV-2 compared to Delta, but significantly higher IVTs in Delta infected individuals. In vaccinated vs. unvaccinated Delta infected individuals, RNA genome copies were comparable but vaccinated individuals have significantly lower IVTs, and cleared virus faster. Vaccinated individuals with Omicron infection had comparable IVTs to Delta breakthrough infections. Interpretation Quantitative IVTs can give detailed insights into virus shedding kinetics. Vaccination was associated with lower infectious titres and faster clearance for Delta, showing that vaccination would also lower transmission risk. Omicron vaccine breakthrough infections did not show elevated IVTs compared to Delta, suggesting that other mechanisms than increase VL contribute to the high infectiousness of Omicron. Funding This work was supported by the Swiss National Science Foundation 196644, 196383, NRP (National Research Program) 78 Covid-19 Grant 198412, the Fondation Ancrage Bienfaisance du Groupe Pictet and the Fondation Privée des Hôpitaux Universitaires de Genève.
    Keywords covid19
    Language English
    Publishing date 2022-01-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.01.10.22269010
    Database COVID19

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  7. Article ; Online: Beyond the virus: Ensuring continuity of care for people with diabetes during COVID-19.

    Beran, David / Aebischer Perone, Sigiriya / Castellsague Perolini, Montserrat / Chappuis, François / Chopard, Pierre / Haller, Dagmar M / Jacquerioz Bausch, Frédérique / Maisonneuve, Hubert / Perone, Nicolas / Gastaldi, Giacomo

    Primary care diabetes

    2020  Volume 15, Issue 1, Page(s) 16–17

    Abstract: The current COVID-19 pandemic is a major concern for the diabetes community. A meta-analysis in China found that the proportions of people with COVID-19 and diabetes was 9.7% and that having diabetes resulted in a two-fold increased risk of having a ... ...

    Abstract The current COVID-19 pandemic is a major concern for the diabetes community. A meta-analysis in China found that the proportions of people with COVID-19 and diabetes was 9.7% and that having diabetes resulted in a two-fold increased risk of having a severe case. Global guidance on confinement measures for the prevention of COVID-19 have a particular emphasis on vulnerable populations which include people with diabetes. These recommendations are coherent to avoid the spread of SARSCoV-2 infection, but are in contradiction with comprehensive diabetes care, which requires regular patient-provider interactions for patient education, prescriptions and possible management of complications or mental health. Moreover, confinement drives risk for unhealthy diets, decreased physical activity, mental health related concerns, in parallel to delayed care-seeking due to fear of contracting COVID-19. Another weakness in the current COVID-19 response is the focus on hospital care which overlooks the importance of Primary Care in guaranteeing continuity of care. Ensuring the availability of insulin, other medicines, self-monitoring and diagnostic tools is another challenge. These are all global concerns for the diabetes community, as well as for those suffering from other chronic conditions. Undoubtedly, the global priority is to contain the spread and impact of COVID-19. However, health systems still need to meet the needs of the entire population, including individuals with diabetes. Clear guidance for preparedness, crisis and post-crisis management of diabetes and chronic diseases during mass disruptions to health systems are lacking. Therefore, in parallel to the epidemic response efforts to ensure existing healthcare services keep running should be supported to avoid health consequences that might be worse than the epidemic itself. This includes targeted messaging for people with diabetes and vulnerable populations with regards to possible risk of infection as well as their disease-related management; continued support via telephone, video conferencing or even home visits; ensuring access to insulin and other medicines and supplies both nationally and individually; and most importantly, preparing for the future.
    MeSH term(s) COVID-19/epidemiology ; Comorbidity ; Continuity of Patient Care/organization & administration ; Diabetes Mellitus/epidemiology ; Humans ; Mental Health ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2020.05.014
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  8. Article ; Online: Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2.

    Ngo Nsoga, Marie Thérèse / Kronig, Ilona / Perez Rodriguez, Francisco Javier / Sattonnet-Roche, Pascale / Da Silva, Diogo / Helbling, Javan / Sacks, Jilian A / de Vos, Margaretha / Boehm, Erik / Gayet-Ageron, Angèle / Berger, Alice / Jacquerioz-Bausch, Frédérique / Chappuis, François / Kaiser, Laurent / Schibler, Manuel / Renzoni, Adriana / Eckerle, Isabella

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0253321

    Abstract: Background: Antigen-detecting rapid diagnostic tests (Ag-RDTs) for the detection of SARS-CoV-2 offer new opportunities for testing in the context of the COVID-19 pandemic. Nasopharyngeal swabs (NPS) are the reference sample type, but oropharyngeal swabs ...

    Abstract Background: Antigen-detecting rapid diagnostic tests (Ag-RDTs) for the detection of SARS-CoV-2 offer new opportunities for testing in the context of the COVID-19 pandemic. Nasopharyngeal swabs (NPS) are the reference sample type, but oropharyngeal swabs (OPS) may be a more acceptable sample type in some patients.
    Methods: We conducted a prospective study in a single screening center to assess the diagnostic performance of the Panbio™ COVID-19 Ag Rapid Test (Abbott) on OPS compared with reverse-transcription quantitative PCR (RT-qPCR) using NPS during the second pandemic wave in Switzerland.
    Results: 402 outpatients were enrolled in a COVID-19 screening center, of whom 168 (41.8%) had a positive RT-qPCR test. The oropharyngeal Ag-RDT clinical sensitivity compared to nasopharyngeal RT-qPCR was 81% (95%CI: 74.2-86.6). Two false positives were noted out of the 234 RT-qPCR negative individuals, which resulted in a clinical specificity of 99.1% (95%CI: 96.9-99.9) for the Ag-RDT. For cycle threshold values ≤ 26.7 (≥ 1E6 SARS-CoV-2 genomes copies/mL, a presumed cut-off for infectious virus), 96.3% sensitivity (95%CI: 90.7-99.0%) was obtained with the Ag-RDT using OPS.
    Interpretation: Based on our findings, the diagnostic performance of the Panbio™ Covid-19 RDT with OPS samples, if taken by a trained person and high requirements regarding quality of the specimen, meet the criteria required by the WHO for Ag-RDTs (sensitivity ≥80% and specificity ≥97%) in a high incidence setting in symptomatic individuals.
    MeSH term(s) Antigens, Viral/genetics ; Antigens, Viral/immunology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19 Nucleic Acid Testing ; COVID-19 Serological Testing ; Humans ; Nasopharynx/immunology ; Nasopharynx/virology ; Prospective Studies ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Switzerland/epidemiology
    Chemical Substances Antigens, Viral
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0253321
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  9. Article ; Online: Building Local Capacity in Hand-Rub Solution Production during the 2014-2016 Ebola Outbreak Disaster: The Case of Liberia and Guinea.

    Jacquerioz Bausch, Frederique A / Heller, Olivia / Bengaly, Loséni / Matthey-Khouity, Béatrice / Bonnabry, Pascal / Touré, Yakaria / Kervillain, Garrison J / Bah, Elhadj Ibrahima / Chappuis, François / Hagon, Olivier

    Prehospital and disaster medicine

    2018  Volume 33, Issue 6, Page(s) 660–667

    Abstract: Background: During the 2014-2015 Ebola outbreak in West Africa, the lack of infection prevention and control (IPC) measures in health care facilities amplified human-to-human transmission and contributed to the magnitude of this humanitarian disaster ... ...

    Abstract Background: During the 2014-2015 Ebola outbreak in West Africa, the lack of infection prevention and control (IPC) measures in health care facilities amplified human-to-human transmission and contributed to the magnitude of this humanitarian disaster.Case ReportIn the summer of 2014, the Geneva University Hospitals (HUG; Geneva, Switzerland) conducted an IPC assessment and developed a project based on the local needs and their expertise with the support of the Swiss Agency for Development and Cooperation and the Humanitarian Aid Unit (SDC/HA; Bern, Switzerland). The project consisted of building local capacity in the production of alcohol-based hand-rub solution (ABHRS) based on the World Health Organization (WHO; Geneva, Switzerland) formula in non-Ebola health facilities at the peak of the outbreak in Liberia (Fall 2014) and during recovery in Guinea (September 2015) to promote safer care. Twenty-one pharmacists in Liberia and 22 in Guinea were trained and one years' worth of laboratory equipment, chemical products, containers for personal use, and bioethanol were delivered to 10 hospitals per country with more than 8,000 100 ml bottles of solution produced at the end of the project.DiscussionHand hygiene using hand-rub solution is a critical component of safer care, especially in health care settings lacking runnable water. Throughout the Ebola outbreak, it was a timely moment to promote hand-rub solution and to reinforce IPC measures in non-Ebola health facilities. During the project implementation, a substantial challenge was the unavailability of bioethanol in Liberia and Guinea. In the long run, sustainability of the production can become an issue as it depends heavily on the local government's financial and political commitment, the capacity to create an on-going demand for hand-rub solution in health facilities, the local purchase and replacement of the materials and chemical products, as well as the availability of continuous local partners' support.
    Conclusion: The project demonstrated that it was feasible to build local capacity in ABHRS production during an emergency and in limited-resource settings when materials and training are provided. Future programs in similar contexts should identify and address the factors of sustainability during the implementation phase and provide regular, long-term technical support. Jacquerioz BauschFA, HellerO, BengalyL, Matthey-KhouityB, BonnabryP, TouréY, KervillainGJ, BahEI, ChappuisF, HagonO. Building local capacity in hand-rub solution production during the 2014-2016 Ebola outbreak disaster: the case of Liberia and Guinea.. Prehosp Disaster Med. 2018;33(6):660-667.
    MeSH term(s) Disease Outbreaks/prevention & control ; Guinea/epidemiology ; Hand Disinfection ; Hand Sanitizers/administration & dosage ; Hand Sanitizers/supply & distribution ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Infection Control ; Liberia/epidemiology
    Chemical Substances Hand Sanitizers
    Language English
    Publishing date 2018-11-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1025975-2
    ISSN 1945-1938 ; 1049-023X
    ISSN (online) 1945-1938
    ISSN 1049-023X
    DOI 10.1017/S1049023X18000985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Beyond the virus: Ensuring continuity of care for people with diabetes during COVID-19

    Beran, David / Aebischer Perone, Sigiriya / Castellsague Perolini, Montserrat / Chappuis, François / Chopard, Pierre / Haller, Dagmar M / Jacquerioz Bausch, Frédérique / Maisonneuve, Hubert / Perone, Nicolas / Gastaldi, Giacomo

    Abstract: The current COVID-19 pandemic is a major concern for the diabetes community. A meta-analysis in China found that the proportions of people with COVID-19 and diabetes was 9.7% and that having diabetes resulted in a two-fold increased risk of having a ... ...

    Abstract The current COVID-19 pandemic is a major concern for the diabetes community. A meta-analysis in China found that the proportions of people with COVID-19 and diabetes was 9.7% and that having diabetes resulted in a two-fold increased risk of having a severe case. Global guidance on confinement measures for the prevention of COVID-19 have a particular emphasis on vulnerable populations which include people with diabetes. These recommendations are coherent to avoid the spread of SARSCoV-2 infection, but are in contradiction with comprehensive diabetes care, which requires regular patient-provider interactions for patient education, prescriptions and possible management of complications or mental health. Moreover, confinement drives risk for unhealthy diets, decreased physical activity, mental health related concerns, in parallel to delayed care-seeking due to fear of contracting COVID-19. Another weakness in the current COVID-19 response is the focus on hospital care which overlooks the importance of Primary Care in guaranteeing continuity of care. Ensuring the availability of insulin, other medicines, self-monitoring and diagnostic tools is another challenge. These are all global concerns for the diabetes community, as well as for those suffering from other chronic conditions. Undoubtedly, the global priority is to contain the spread and impact of COVID-19. However, health systems still need to meet the needs of the entire population, including individuals with diabetes. Clear guidance for preparedness, crisis and post-crisis management of diabetes and chronic diseases during mass disruptions to health systems are lacking. Therefore, in parallel to the epidemic response efforts to ensure existing healthcare services keep running should be supported to avoid health consequences that might be worse than the epidemic itself. This includes targeted messaging for people with diabetes and vulnerable populations with regards to possible risk of infection as well as their disease-related management; continued support via telephone, video conferencing or even home visits; ensuring access to insulin and other medicines and supplies both nationally and individually; and most importantly, preparing for the future.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #437367
    Database COVID19

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