Article: Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions.
2018 Volume 9, Page(s) 1023
Abstract: The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and ... ...
| Abstract | The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophagosomes in effector CD4 T cells, further work has shown that not only autophagy levels are modulated in CD4 T cells in response to environmental signals but also that autophagy critically affects the biology of these cells. Mouse models of autophagy deletion in CD4 T cells have indeed shown that autophagy is essential for CD4 T cell survival and homeostasis in peripheral lymphoid organs. Furthermore, autophagy is required for CD4 T cell proliferation and cytokine production in response to T cell receptor activation. Recent developments have uncovered that autophagy controls CD4 T cell differentiation and functions. While autophagy is required for the maintenance of immunosuppressive functions of regulatory T cells, it restrains the differentiation of T |
|---|---|
| MeSH term(s) | Animals ; Autophagosomes ; Autophagy/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cell Proliferation ; Clinical Trials as Topic ; Cytokines/immunology ; Humans ; Immunity, Innate ; Inflammation/therapy ; Lymphocyte Activation/immunology ; Mice ; Neoplasms/therapy ; T-Lymphocytes, Regulatory/immunology |
| Chemical Substances | Cytokines |
| Language | English |
| Publishing date | 2018-05-09 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2018.01023 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.