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  1. AU="Jadad, Alejandro R"
  2. AU="Lastres, Palma Rico" AU="Lastres, Palma Rico"
  3. AU="Manes, K"
  4. AU="Baugh, Matthew"
  5. AU="Qu, C"
  6. AU="Flett, Heather"
  7. AU="Shueh Lin Lim"
  8. AU="Schröder, Johann"
  9. AU=Butler Taylor
  10. AU="Yang, Fan"
  11. AU="Giacomo Frati"
  12. AU=Kokhaei P
  13. AU="Charikleia Triantopoulou"
  14. AU="Salil Bhargava"
  15. AU="Jong-Eun Lee"
  16. AU="Vargas C, Laura"

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Treffer 1 - 10 von insgesamt 117

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  1. Artikel ; Online: Could we survive a belief crisis?

    Jadad, Alejandro R

    Journal of public health policy

    2023  Band 44, Heft 1, Seite(n) 167–169

    Sprache Englisch
    Erscheinungsdatum 2023-01-08
    Erscheinungsland England
    Dokumenttyp News
    ZDB-ID 603208-4
    ISSN 1745-655X ; 0197-5897
    ISSN (online) 1745-655X
    ISSN 0197-5897
    DOI 10.1057/s41271-022-00381-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1767: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Artikel ; Online: Facing leadership that kills.

    Jadad, Alejandro R

    Journal of public health policy

    2021  Band 42, Heft 4, Seite(n) 651–657

    Mesh-Begriff(e) Humans ; Leadership
    Sprache Englisch
    Erscheinungsdatum 2021-11-22
    Erscheinungsland England
    Dokumenttyp News
    ZDB-ID 603208-4
    ISSN 1745-655X ; 0197-5897
    ISSN (online) 1745-655X
    ISSN 0197-5897
    DOI 10.1057/s41271-021-00315-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1767: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Buch: Randomized controlled trials

    Jadad, Alejandro R. / Enkin, Murray

    questions, answers, and musings

    2007  

    Verfasserangabe Alejandro R. Jadad ; Murray W. Enkin
    Schlagwörter Randomized controlled trials ; Quality Control
    Sprache Englisch
    Umfang XXIV, 136 S.
    Ausgabenhinweis 2. ed.
    Verlag Blackwell
    Erscheinungsort Malden, Mass. u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT014872029
    ISBN 978-1-4051-3266-4 ; 1-4051-3266-3
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2007 A 4666 bestellbar zur Ausleihe Magazin

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  4. Buch: Randomised controlled trials

    Jadad, Alejandro R.

    a user's guide

    1998  

    Verfasserangabe Alejandro R. Jadad
    Sprache Englisch
    Umfang XXIV, 123 S.
    Verlag BMJ Books
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    Anmerkung Includes index
    HBZ-ID HT010078138
    ISBN 0-7279-1208-9 ; 978-0-7279-1208-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    1999 A 1425 bestellbar zur Ausleihe Magazin

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  5. Artikel ; Online: Creating a pandemic of health: What is the role of digital technologies?

    Jadad, Alejandro R

    Journal of public health policy

    2016  Band 37, Heft Suppl 2, Seite(n) 260–268

    Abstract: Imagine a world in which every human being is healthy until the last breath. Thanks to the fast penetration of digital technologies in every region of the planet, this seemingly utopian scenario is not only feasible but also potentially viable. Now that ... ...

    Abstract Imagine a world in which every human being is healthy until the last breath. Thanks to the fast penetration of digital technologies in every region of the planet, this seemingly utopian scenario is not only feasible but also potentially viable. Now that digital technologies have provided almost full interconnectivity among all humans, they should be used to meet key challenges to ensure that health is created and that it spreads to reach every person on earth. The objective of this article is to describe and trigger a serious discussion of such challenges, which include: adopting a new concept of health; positioning self-rated health as the main outcome of the system; creating a health-oriented model to guide service provision; facilitating the identification, scaling up, and sustaining of innovations that can create and spread health; promoting a culture of health promotion; and encouraging the emergence of Precision Health. Once these challenges are met, and health becomes pandemic, public health would have fulfilled its vision, a healthy life for all, at last.
    Mesh-Begriff(e) Biomedical Technology ; Health Equity ; Health Promotion ; Health Services/standards ; Health Status ; Humans ; Medical Informatics ; Precision Medicine
    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 603208-4
    ISSN 1745-655X ; 0197-5897
    ISSN (online) 1745-655X
    ISSN 0197-5897
    DOI 10.1057/s41271-016-0016-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1767: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Artikel ; Online: What would it take to die well? A systematic review of systematic reviews on the conditions for a good death.

    Zaman, Mehreen / Espinal-Arango, Sara / Mohapatra, Ashita / Jadad, Alejandro R

    The lancet. Healthy longevity

    2022  Band 2, Heft 9, Seite(n) e593–e600

    Abstract: The medicalisation of life under the influence of health-care systems, focused on curing diseases, has made dying well challenging. This systematic review identifies common themes from published systematic reviews about the conditions for a good death as ...

    Abstract The medicalisation of life under the influence of health-care systems, focused on curing diseases, has made dying well challenging. This systematic review identifies common themes from published systematic reviews about the conditions for a good death as a means to guide decisions around this universal event. MEDLINE, Embase, APA PsycInfo, and AMED were searched for citations with "good death" or "dying well" in their titles on Sept 23, 2020, and complemented with backward reference and forward citation screening with Google Scholar. Articles published in peer-reviewed journals in any language were included. Articles that focused on the identification of conditions for a good death and described how primary studies were sought and selected were also included. Data on general characteristics, quality, and themes were extracted independently. 13 of 275 potentially eligible reviews were included. Common themes were dying at the preferred place, relief from pain and psychological distress, emotional support from loved ones, autonomous treatment decision making, avoidance of futile life-prolonging interventions and of being a burden to others, right to assisted suicide or euthanasia, effective communication with professionals, and performance of rituals. No reviews specified the meaning or timing of death, connected themes, or prioritised them. Vague jargon was often used to describe complex concepts. Most conditions for a good death could be offered to most dying people, without costly medical infrastructure or specialised knowledge. Efforts to describe these conditions clearly, to identify whether there are exceptions or missing items, and whether they apply in non-dominant settings (ie, outstide institutional, affluent, anglophone, and Christian settings) are needed.
    Mesh-Begriff(e) Humans ; Euthanasia ; Peer Review ; Suicide, Assisted ; Systematic Reviews as Topic
    Sprache Englisch
    Erscheinungsdatum 2022-09-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Systematic Review
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(21)00097-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Personalized Computerized Training for Cognitive Dysfunction after COVID-19: A Before-and-After Feasibility Pilot Study.

    Duñabeitia, Jon Andoni / Mera, Francisco / Baro, Óscar / Jadad-Garcia, Tamen / Jadad, Alejandro R

    International journal of environmental research and public health

    2023  Band 20, Heft 4

    Abstract: The current pilot study was set to evaluate the feasibility and potential benefit of a personalized computerized cognitive training (CCT) intervention to improve cognitive function among people living with post-acute sequelae of COVID-19 (PASC). Seventy ... ...

    Abstract The current pilot study was set to evaluate the feasibility and potential benefit of a personalized computerized cognitive training (CCT) intervention to improve cognitive function among people living with post-acute sequelae of COVID-19 (PASC). Seventy three adults who self-reported cognitive dysfunction more than 3 months after a diagnosis of COVID-19 took part in an 8-week training study. Participants' general cognitive function was assessed before they completed as many cognitive daily training sessions as they wished during an 8-week period, using a personalized CCT application at home. At the end of this period, participants repeated the general cognitive function assessment. The differences between the scores at 8 weeks and baseline in five cognitive domains (attention, memory, coordination, perception, reasoning), complemented with analyses of the changes based on the participants' age, training time, self-reported health level at baseline and time since the initial COVID-19 infection. Participants had significant cognitive dysfunction and self-reported negative health levels at baseline. Most of the participants obtained higher scores after CCT in each of the domains as compared with baseline. The magnitude of this score increase was high across domains. It is concluded that a self-administered CCT based on gamified cognitive tasks could be an effective way to ameliorate cognitive dysfunction in persons with PASC. The ClinicalTrials.gov identifier is NCT05571852.
    Mesh-Begriff(e) Adult ; Humans ; Pilot Projects ; Feasibility Studies ; COVID-19 ; Cognitive Dysfunction/psychology ; Cognition ; Post-Acute COVID-19 Syndrome
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043100
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: No Time to Waste: Real-World Repurposing of Generic Drugs as a Multifaceted Strategy Against COVID-19

    Rogosnitzky, Moshe Berkowitz Esther Jadad Alejandro R

    JMIRx Med

    Abstract: Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address urgent clinical needs—is an indispensable strategy gaining rapid traction in the current COVID-19 crisis Although off-label prescribing (ie, for a nonapproved ... ...

    Abstract Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address urgent clinical needs—is an indispensable strategy gaining rapid traction in the current COVID-19 crisis Although off-label prescribing (ie, for a nonapproved indication) is legal in most countries, it tends to shift the burden of liability and cost to physicians and patients, respectively Nevertheless, in urgent public health crises, it is often the only realistic source of a meaningful potential solution To be considered for real-world repurposing, drug candidates should ideally have a track record of safety, affordability, and wide accessibility Although thousands of such drugs are already available, the absence of a central repository of off-label uses presents a barrier to the immediate identification and selection of the safest, potentially useful interventions Using the current COVID-19 pandemic as an example, we provide a glimpse at the extensive literature that supports the rationale behind six generic drugs, in four classes, all of which are affordable, supported by decades of safety data, and pleiotropically target the underlying pathophysiology that makes COVID-19 so dangerous Having previously fast-tracked this paper to publication in summary form, we now expand on why cimetidine/famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate/bezafibrate (cholesterol/triglyceride-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19 based on their antiviral, anti-inflammatory, renoprotective, cardioprotective, and anticoagulation properties These examples also reveal the unlimited opportunity to future-proof public health by proactively mining, synthesizing, and cataloging the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #902246
    Datenquelle COVID19

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  9. Artikel ; Online: Delivering Benefits at Speed Through Real-World Repurposing of Off-Patent Drugs: The COVID-19 Pandemic as a Case in Point.

    Rogosnitzky, Moshe / Berkowitz, Esther / Jadad, Alejandro R

    JMIR public health and surveillance

    2020  Band 6, Heft 2, Seite(n) e19199

    Abstract: Real-world drug repurposing-the immediate "off-label" prescribing of drugs to address urgent clinical needs-is a widely overlooked opportunity. Off-label prescribing (ie, for a nonapproved indication) is legal in most countries and tends to shift the ... ...

    Abstract Real-world drug repurposing-the immediate "off-label" prescribing of drugs to address urgent clinical needs-is a widely overlooked opportunity. Off-label prescribing (ie, for a nonapproved indication) is legal in most countries and tends to shift the burden of liability and cost to physicians and patients, respectively. Nevertheless, health crises may mean that real-world repurposing is the only realistic source for solutions. Optimal real-world repurposing requires a track record of safety, affordability, and access for drug candidates. Although thousands of such drugs are already available, there is no central repository of off-label uses to facilitate immediate identification and selection of potentially useful interventions during public health crises. Using the current coronavirus disease (COVID-19) pandemic as an example, we provide a glimpse of the extensive literature that supports the rationale behind six generic drugs, in four classes, all of which are affordable, supported by decades of safety data, and targeted toward the underlying pathophysiology that makes COVID-19 so deadly. This paper briefly summarizes why cimetidine or famotidine, dipyridamole, fenofibrate or bezafibrate, and sildenafil citrate are worth considering for patients with COVID-19. Clinical trials to assess efficacy are already underway for famotidine, dipyridamole, and sildenafil, and further trials of all these agents will be important in due course. These examples also reveal the unlimited opportunity to future-proof our health care systems by proactively mining, synthesizing, cataloging, and evaluating the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs.
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus/drug effects ; Coronavirus/isolation & purification ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Drug Costs ; Drug Repositioning ; Drugs, Generic ; Humans ; Off-Label Use ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Public Health ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemische Substanzen Antiviral Agents ; Drugs, Generic
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-13
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/19199
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: No Time to Waste: Real-World Repurposing of Generic Drugs as a Multifaceted Strategy Against COVID-19.

    Rogosnitzky, Moshe / Berkowitz, Esther / Jadad, Alejandro R

    JMIRx med

    2020  Band 1, Heft 1, Seite(n) e19583

    Abstract: Real-world drug repurposing-the immediate "off-label" prescribing of drugs to address urgent clinical needs-is an indispensable strategy gaining rapid traction in the current COVID-19 crisis. Although off-label prescribing (ie, for a nonapproved ... ...

    Abstract Real-world drug repurposing-the immediate "off-label" prescribing of drugs to address urgent clinical needs-is an indispensable strategy gaining rapid traction in the current COVID-19 crisis. Although off-label prescribing (ie, for a nonapproved indication) is legal in most countries, it tends to shift the burden of liability and cost to physicians and patients, respectively. Nevertheless, in urgent public health crises, it is often the only realistic source of a meaningful potential solution. To be considered for real-world repurposing, drug candidates should ideally have a track record of safety, affordability, and wide accessibility. Although thousands of such drugs are already available, the absence of a central repository of off-label uses presents a barrier to the immediate identification and selection of the safest, potentially useful interventions. Using the current COVID-19 pandemic as an example, we provide a glimpse at the extensive literature that supports the rationale behind six generic drugs, in four classes, all of which are affordable, supported by decades of safety data, and pleiotropically target the underlying pathophysiology that makes COVID-19 so dangerous. Having previously fast-tracked this paper to publication in summary form, we now expand on why cimetidine/famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate/bezafibrate (cholesterol/triglyceride-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19 based on their antiviral, anti-inflammatory, renoprotective, cardioprotective, and anticoagulation properties. These examples also reveal the unlimited opportunity to future-proof public health by proactively mining, synthesizing, and cataloging the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs.
    Sprache Englisch
    Erscheinungsdatum 2020-09-30
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ISSN 2563-6316
    ISSN (online) 2563-6316
    DOI 10.2196/19583
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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