Article ; Online: Preparation and characterization of nanocochelate by using phosphatidylcholine as lipid carrier for enhancement of permeability and bioavailability of rosuvastatin.
Drug development and industrial pharmacy
2022 Volume 47, Issue 12, Page(s) 2004–2012
Abstract: Objective: Rosuvastatin (ROS) is a class of antihyperlipidemic agents belonging to the class of statins with poor permeability, which results in low oral bioavailability, i.e. 20%. The objective of the present study was to improve the permeability and ... ...
| Abstract | Objective: Rosuvastatin (ROS) is a class of antihyperlipidemic agents belonging to the class of statins with poor permeability, which results in low oral bioavailability, i.e. 20%. The objective of the present study was to improve the permeability and bioavailability of ROS by developing nanocochelates using naturally biocompatible phosphatidylcholine, a type of lipid which is used as Ca Significance: For the loaded ROS, the trapping method was used to build nanocochelates to boost the intestinal permeability of phosphatidylcholine and divalent choline is a calcium chloride cationic solution. Methods: Nine different formulations have been produced and with varying lipid and cationic solution concentrations. The formulation of nanocochelates characterized by scanning electron microscopy, particle size, and zeta potential. Permeability studies have been conducted to determine the permeability improvement property of nanocochelates. The pharmacokinetic study was performed in Wistar albino rats to determine the bioavailability enhancement potential of nanocochlelates. Results: The concentration of optimum lipid, calcium chloride was found to be 80 mg, 200 uL respectively which improve permeability by 3.44 times as compared to the marketed formulation. The Conclusion: The findings suggest that the use of natural lipid carrier by nanocochelates of Rosuvastatin was promising drug delivery approach. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Administration, Oral ; Animals ; Biological Availability ; Calcium Chloride ; Drug Carriers ; Excipients ; Lecithins ; Nanoparticles ; Particle Size ; Permeability ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; Rosuvastatin Calcium/pharmacokinetics | |||||
| Chemical Substances | Drug Carriers ; Excipients ; Lecithins ; Reactive Oxygen Species ; Rosuvastatin Calcium (83MVU38M7Q) ; Calcium Chloride (M4I0D6VV5M) | |||||
| Language | English | |||||
| Publishing date | 2022-06-15 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 751874-2 | |||||
| ISSN | 1520-5762 ; 0363-9045 | |||||
| ISSN (online) | 1520-5762 | |||||
| ISSN | 0363-9045 | |||||
| DOI | 10.1080/03639045.2022.2087081 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1335: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.