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Article ; Online: Potential of CD73 as a target for cancer immunotherapy.

Jadidi-Niaragh, Farhad

Immunotherapy

2019 Volume 11, Issue 16, Page(s) 1353–1355

MeSH term(s)	5'-Nucleotidase/antagonists & inhibitors ; 5'-Nucleotidase/metabolism ; Animals ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy/methods ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy
Chemical Substances	Antineoplastic Agents ; 5'-Nucleotidase (EC 3.1.3.5)
Language	English
Publishing date	2019-10-03
Publishing country	England
Document type	Editorial
ISSN	1750-7448
ISSN (online)	1750-7448
DOI	10.2217/imt-2019-0147
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Article ; Online: The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia.

Barshidi, Asal / Ardeshiri, Keivan / Ebrahimi, Farbod / Alian, Fatemeh / Shekarchi, Ali Akbar / Hojjat-Farsangi, Mohammad / Jadidi-Niaragh, Farhad

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 59

Abstract: The immune responses to cancer cells involve both innate and acquired immune cells. In the meantime, the most attention has been drawn to the adaptive immune cells, especially T cells, while, it is now well known that the innate immune cells, especially ... ...

Abstract	The immune responses to cancer cells involve both innate and acquired immune cells. In the meantime, the most attention has been drawn to the adaptive immune cells, especially T cells, while, it is now well known that the innate immune cells, especially natural killer (NK) cells, play a vital role in defending against malignancies. While the immune cells are trying to eliminate malignant cells, cancer cells try to prevent the function of these cells and suppress immune responses. The suppression of NK cells in various cancers can lead to the induction of an exhausted phenotype in NK cells, which will impair their function. Recent studies have shown that the occurrence of this phenotype in various types of leukemic malignancies can affect the prognosis of the disease, and targeting these cells may be considered a new immunotherapy method in the treatment of leukemia. Therefore, a detailed study of exhausted NK cells in leukemic diseases can help both to understand the mechanisms of leukemia progression and to design new treatment methods by creating a deeper understanding of these cells. Here, we will comprehensively review the immunobiology of exhausted NK cells and their role in various leukemic malignancies. Video Abstract.
MeSH term(s)	Humans ; Leukemia/therapy ; Immunotherapy ; Killer Cells, Natural ; Phenotype
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01428-2
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Article ; Online: The role of immune regulatory molecules in rheumatoid arthritis: Implication for etiopathogenesis and prospective for treatment.

Hemmatzadeh, Maryam / Ahangar Parvin, Elham / Mohammadi, Hamed / Azizi, Gholamreza / Shomali, Navid / Jadidi-Niaragh, Farhad

Journal of cellular physiology

2022 Volume 237, Issue 9, Page(s) 3541–3553

Abstract: Rheumatoid arthritis (RA) is considered an autoimmune chronic disorder and the most common inflammatory arthropathy. Disease progression in RA begins with asymptomatic autoimmune responses in cases with a genetic or environmental predisposition, that ... ...

Abstract	Rheumatoid arthritis (RA) is considered an autoimmune chronic disorder and the most common inflammatory arthropathy. Disease progression in RA begins with asymptomatic autoimmune responses in cases with a genetic or environmental predisposition, that alters to arthralgia phase as autoantibodies reach the joints and subjects begin demonstrating nonspecific musculoskeletal presentations lacking any clinical symptoms of synovial inflammation. After that, patients' symptoms develop to undifferentiated arthritis (UA)/idiopathic arthritis (IA) whenever the subjects progress to clinical synovitis systemic comorbidities affecting the vasculature, metabolism, and bone, and eventually with augmented immune cell infiltration, IA/UA patients progress to clinically classifiable RA. RA is mainly correlated with different immune cells and each of them contributes variously to the pathogenesis of the disease. The pathogenesis of RA is altered by the contribution of both T and B cells in an autoimmune irregularity. Modulation of the immune responses occurs through regulatory and inhibitory molecules that control activation of the adaptive system as well as immune hemostasis. To confine the exorbitant T cell-associated inflammatory reactions, the immune system provides a system of inhibitory feedbacks, collectively named immune checkpoints. In this review, we aimed to discuss about inhibitory members of immune checkpoint molecules, including programmed cell death 1 (PD-1)/PD-L1, cytotoxic-T-lymphocyte-antigen-4, lymphocyte activation gene-3, T cell immunoglobulin-3, V-domain Ig suppressor of T cell activation, B- and T-lymphocyte attenuator, and T cell immunoglobulin and ITIM domain and their role in RA.
MeSH term(s)	Arthritis, Rheumatoid ; Autoantibodies ; Humans ; Immune Checkpoint Proteins ; Prospective Studies ; Synovial Membrane/immunology ; Synovial Membrane/metabolism ; Synovitis/immunology ; Synovitis/pathology
Chemical Substances	Autoantibodies ; Immune Checkpoint Proteins
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30855
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Article ; Online: The Prognostic and therapeutic value and clinical implications of fibroblast activation protein-α as a novel biomarker in colorectal cancer.

Kalaei, Zahra / Manafi-Farid, Reyhaneh / Rashidi, Bentolhoda / Kiani, Fariba Karoon / Zarei, Asieh / Fathi, Mehrdad / Jadidi-Niaragh, Farhad

Cell communication and signaling : CCS

2023 Volume 21, Issue 1, Page(s) 139

Abstract: The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role in CRC progression. Fibroblast-Activation ... ...

Abstract	The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role in CRC progression. Fibroblast-Activation Protein-α (FAP) is a type II transmembrane cell surface proteinase expressed on the surface of cancer-associated fibroblasts in tumor stroma. As an enzyme, FAP has di- and endoprolylpeptidase, endoprotease, and gelatinase/collagenase activities in the Tumor Microenvironment (TME). According to recent reports, FAP overexpression in CRC contributes to adverse clinical outcomes such as increased lymph node metastasis, tumor recurrence, and angiogenesis, as well as decreased overall survival. In this review, studies about the expression level of FAP and its associations with CRC patients' prognosis are reviewed. High expression levels of FAP and its association with clinicopathological factors have made as a potential target. In many studies, FAP has been evaluated as a therapeutic target and diagnostic factor into which the current review tries to provide a comprehensive insight. Video Abstract.
MeSH term(s)	Humans ; Prognosis ; Biomarkers ; Endopeptidases ; Colorectal Neoplasms/diagnosis ; Tumor Microenvironment
Chemical Substances	fibroblast activation protein alpha (EC 3.4.21.-) ; Biomarkers ; Endopeptidases (EC 3.4.-)
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01151-y
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Article ; Online: PGE2-EP2/EP4 signaling elicits mesoCAR T cell immunosuppression in pancreatic cancer.

Akbari, Behnia / Soltantoyeh, Tahereh / Shahosseini, Zahra / Jadidi-Niaragh, Farhad / Hadjati, Jamshid / Brown, Christine E / Mirzaei, Hamid Reza

Frontiers in immunology

2023 Volume 14, Page(s) 1209572

Abstract: Introduction: For many years, surgery, adjuvant and combination chemotherapy have been the cornerstone of pancreatic cancer treatment. Although these approaches have improved patient survival, relapse remains a common occurrence, necessitating the ... ...

Abstract	Introduction: For many years, surgery, adjuvant and combination chemotherapy have been the cornerstone of pancreatic cancer treatment. Although these approaches have improved patient survival, relapse remains a common occurrence, necessitating the exploration of novel therapeutic strategies. CAR T cell therapies are now showing tremendous success in hematological cancers. However, the clinical efficacy of CAR T cells in solid tumors remained low, notably due to presence of an immunosuppressive tumor microenvironment (TME). Prostaglandin E2, a bioactive lipid metabolite found within the TME, plays a significant role in promoting cancer progression by increasing tumor proliferation, improving angiogenesis, and impairing immune cell's function. Despite the well-established impact of PGE2 signaling on cancer, its specific effects on CAR T cell therapy remain under investigation. Methods: To address this gap in knowledge the role of PGE2-related genes in cancer tissue and T cells of pancreatic cancer patients were evaluated Results: In-silico Discussion: In summary, our findings suggest that mitigating PGE2-EP2/EP4 signaling may be a viable strategy for enhancing CAR T cell activity within the challenging TME, thereby improving the efficacy of CAR T cell therapy in clinical settings.
MeSH term(s)	Humans ; Dinoprostone/metabolism ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Neoplasm Recurrence, Local ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Pancreatic Neoplasms/therapy ; Immunosuppression Therapy ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Receptors, Prostaglandin E, EP2 Subtype ; Receptors, Prostaglandin E, EP4 Subtype
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1209572
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Article ; Online: Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model.

Ahmadpour, Ehsan / Spotin, Adel / Moghimi, Ata / Shahrivar, Firooz / Jadidi-Niaragh, Farhad / Hajizadeh, Farnaz / Mehrani, Sirous / Mazhab-Jafari, Komeil

PloS one

2023 Volume 18, Issue 10, Page(s) e0292434

Abstract: Cystic echinococcosis (CE) is a life-threatening helminthic disease caused by the Echinococcus granulosus sensulato complex. Previous evidence indicates that the host's innate immune responses against CE can combat and regulate the growth rate and ... ...

Abstract	Cystic echinococcosis (CE) is a life-threatening helminthic disease caused by the Echinococcus granulosus sensulato complex. Previous evidence indicates that the host's innate immune responses against CE can combat and regulate the growth rate and mortality of hydatid cyst in the host's internal organs. However, the survival mechanisms of CE are not yet fully elucidated in the human body. In the present study, the apoptotic effects of fertile and infertile hydatid fluid (HF) were tested on murine peritoneal cells in vivo mice model. Mice were divided into five groups including; control group, fertile HF-treated peritoneal cells, infertile HF-treated peritoneal cells, protoscolices (PSCs)-treated peritoneal cells and HF+PSCs-treated peritoneal cells group. Mice groups were intraperitoneally inoculated with PBS, HF, and/or PSCs. Afterwards, peritoneal cells were isolated and mRNA expression of STAT3, caspase-3, p73 and Smac genes were evaluated by quantitative Real-time PCR. After 48 hours of exposure, the protein levels of Smac and STAT3 was determined by western blotting technique. After 6 hours of exposure, Caspase-3 activity was also measured by fluorometric assay. The intracellular reactive oxygen species (ROS) production was examined in all groups. The mRNA expression levels of p73, caspase-3 and also Caspase-3 activity in HF+PSCs-treated peritoneal cells were higher than in the test and control groups (Pv<0.05), while the mRNA expression level of anti-apoptotic STAT3 and Smac genes in HF+PSC-treated peritoneal cells were lower than in the other groups (Pv<0.05). As well, the level of intracellular ROS in the fertile HCF-treated peritoneal cells, infertile HCF-treated peritoneal cells, PSC-treated peritoneal cells and HF+PSC-treated peritoneal cells groups were significantly higher than in the control group (Pv<0.05).Current findings indicates that oxidative stress and p73 can trigger the apoptosis of murine peritoneal cells through modulator of HF-treated PSCs that is likely one of the hydatid cyst survival mechanisms in vivo mice model.
MeSH term(s)	Animals ; Mice ; Apoptosis ; Caspase 3/metabolism ; Echinococcosis ; Echinococcus granulosus ; Reactive Oxygen Species ; RNA, Messenger ; Tumor Protein p73/metabolism
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Reactive Oxygen Species ; RNA, Messenger ; Trp73 protein, mouse ; Tumor Protein p73
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292434
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Article ; Online: Enhancement of immunogenicity and neutralizing responses against SARS-CoV-2 spike protein using the Fc fusion fragment.

Ehteshaminia, Yahya / Jalali, Seyedeh Farzaneh / Jadidi-Niaragh, Farhad / Enderami, Seyed Ehsan / Pagheh, Abdol Sattar / Akbari, Esmaeil / Kenari, Saeid Abedian / Hassannia, Hadi

Life sciences

2023 Volume 320, Page(s) 121525

Abstract: Aims: Vaccination has played an important role in protecting against death and the severity of COVID-19. The recombinant protein vaccine platform has a long track record of safety and efficacy. Here, we fused the SARS-CoV-2 spike S1 subunit to the Fc ... ...

Abstract	Aims: Vaccination has played an important role in protecting against death and the severity of COVID-19. The recombinant protein vaccine platform has a long track record of safety and efficacy. Here, we fused the SARS-CoV-2 spike S1 subunit to the Fc region of IgG and investigated immunogenicity, reactivity to human vaccinated sera, and neutralizing activity as a candidate protein vaccine. Materials and method: We evaluated the immunogenicity of CHO-expressed S1-Fc fusion protein and tag-free S1 protein in rabbits via the production of S1-specific polyclonal antibodies. We subsequently compared the neutralizing activities of sera from immunized rabbits and human-vaccinated individuals using a surrogate Virus Neutralization Test (sVNT). Key findings: The results indicate that S1-specific polyclonal antibodies were induced in all groups; however, antibody levels were higher in rabbits immunized with S1-Fc fusion protein than tag-free S1 protein. Moreover, the reactivity of human vaccinated sera against S1-Fc fusion protein was significantly higher than tag-free S1 protein. Lastly, the results of the virus-neutralizing activity revealed that vaccination with S1-Fc fusion protein induced the highest level of neutralizing antibody response against SARS-CoV-2. Significance: Our results demonstrate that the S1 protein accompanied by the Fc fragment significantly enhances the immunogenicity and neutralizing responses against SARS-CoV-2. It is hoped that this platform can be used for human vaccination.
MeSH term(s)	Animals ; Humans ; Rabbits ; Spike Glycoprotein, Coronavirus ; COVID-19/prevention & control ; Immunoglobulin Fc Fragments/genetics ; Antibodies, Viral ; SARS-CoV-2 ; Antibodies, Neutralizing ; Vaccines ; Recombinant Proteins
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Immunoglobulin Fc Fragments ; Antibodies, Viral ; Antibodies, Neutralizing ; Vaccines ; Recombinant Proteins
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.121525
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Article ; Online: Enhancement of targeted therapy in combination with metformin on human breast cancer cell lines.

Mahmoudi, Ghazal / Ehteshaminia, Yahya / Kokhaei, Parviz / Jalali, Seyedeh Farzaneh / Jadidi-Niaragh, Farhad / Pagheh, Abdol Sattar / Enderami, Seyed Ehsan / Kenari, Saeid Abedian / Hassannia, Hadi

Cell communication and signaling : CCS

2024 Volume 22, Issue 1, Page(s) 10

Abstract: Background: Breast cancer remains a primary global health concern due to its limited treatment options, frequent disease recurrence, and high rates of morbidity and mortality. Thereby, there is a need for more effective treatment approaches. The ... ...

Abstract	Background: Breast cancer remains a primary global health concern due to its limited treatment options, frequent disease recurrence, and high rates of morbidity and mortality. Thereby, there is a need for more effective treatment approaches. The proposal suggests that the combination of targeted therapy with other antitumoral agents could potentially address drug resistance. In this study, we examined the antitumoral effect of combining metformin, an antidiabetic drug, with targeted therapies, including tamoxifen for estrogen receptor-positive (MCF-7), trastuzumab for HER2-positive (SKBR-3), and antibody against ROR1 receptor for triple-negative breast cancer (MDA-MB-231). Methods: Once the expression of relevant receptors on each cell line was confirmed and appropriate drug concentrations were selected through cytotoxicity assays, the antitumor effects of both monotherapy and combination therapy on colony formation, migration, invasion were assessed in in vitro as well as tumor area and metastatic potential in ex ovo Chick chorioallantoic membrane (CAM) models. Results: The results exhibited the enhanced effects of tamoxifen when combined with targeted therapy. This combination effectively inhibited cell growth, colony formation, migration, and invasion in vitro. Additionally, it significantly reduced tumor size and metastatic potential in an ex ovo CAM model. Conclusions: The findings indicate that a favorable strategy to enhance the efficacy of breast cancer treatment would be to combine metformin with targeted therapies.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Metformin/pharmacology ; Cell Line, Tumor ; Neoplasm Recurrence, Local ; Tamoxifen/pharmacology ; Triple Negative Breast Neoplasms/pathology ; Cell Proliferation
Chemical Substances	Metformin (9100L32L2N) ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01446-0
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Article ; Online: The role of exosomal non-coding RNAs in aging-related diseases.

Dolati, Sanam / Shakouri, Seyed Kazem / Dolatkhah, Neda / Yousefi, Mehdi / Jadidi-Niaragh, Farhad / Sanaie, Sarvin

BioFactors (Oxford, England)

2021 Volume 47, Issue 3, Page(s) 292–310

Abstract: Aging is a biological process caused by the accumulation of senescent cells with a permanent proliferative arrest. To the influence of aging on human life expectancy, there is essential for new biomarkers which possibly will assistance in recognizing age- ...

Abstract	Aging is a biological process caused by the accumulation of senescent cells with a permanent proliferative arrest. To the influence of aging on human life expectancy, there is essential for new biomarkers which possibly will assistance in recognizing age-associated pathologies. Exosomes, which are cell-secreted nanovesicles, make available a new biomarker detection and therapeutic approach for the transfer of different molecules with high capacity. Recently, non-coding RNAs (ncRNA) which are contained in exosomes have developed as important molecules regulating the complexity of aging and relevant human diseases. The discovery of ncRNA provided perceptions into an innovative regulatory platform that could interfere with cellular senescence. The non-coding transcriptome includes a different of RNA species, spanning from short ncRNAs (<200 nucleotides) to long ncRNAs, that are >200 bp long. Upgraded evidence displays that targeting ncRNAs possibly will influence senescence pathways. In this article, we will address ncRNAs that participated in age-related and cellular senescence diseases. Growing conception of ncRNAs in the aging process possibly will be responsible for new understandings into the improvement of age-related diseases and elongated life span.
MeSH term(s)	Aging/genetics ; Alzheimer Disease/genetics ; Animals ; Arthritis/genetics ; Exosomes/genetics ; Humans ; Mice ; Osteoporosis/genetics ; Parkinson Disease/genetics ; RNA, Untranslated/genetics
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2021-02-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.1715
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Article: Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer

Hemmat, Nima / Mokhtarzadeh, Ahad / Aghazadeh, Mohammad / Jadidi-Niaragh, Farhad / Baradaran, Behzad / Bannazadeh Baghi, Hossein

Molecular biology reports. 2020 June, v. 47, no. 6

2020

Abstract: Cervical cancer is one of the most common disorders in females all around the world. Similar to other types of cancer, several signaling pathways are demonstrated to be involved in the progression of this cancer including ERK/MAPK, PI3K/AKT, apoptotic ... ...

Abstract	Cervical cancer is one of the most common disorders in females all around the world. Similar to other types of cancer, several signaling pathways are demonstrated to be involved in the progression of this cancer including ERK/MAPK, PI3K/AKT, apoptotic signaling pathways, Wnt, and epidermal growth factor receptor (EGFR). Various microRNAs (miRNAs) and their target genes involved in cervical cancer have been extracted from the kinds of literature of Scopus, Pubmed and Google scholar databases. Regarding the targets, some of them were found to belong in EGFR signaling pathways. The regulation patterns of these miRNA are different in cervical cancer; however, their main aim is to trigger EGFR signaling to proceed with cancer. Moreover, several predicted miRNAs were found to have some interactions with the differentially expressed genes of cervical cancer which are the members of the EGFR signaling pathway by using miRWalk 3.0 (https://mirwalk.umm.uni-heidelberg.de/) and TargetScan 7.1 (https://www.targetscan.org/vert_71/). Also, the microarray data were obtained from the NCBI-Gene Expression Omnibus (GEO) datasets of cervical cancer. In the present review, we highlight the miRNAs involved in cervical cancer and the role of their targets in the EGFR signaling pathway. Furthermore, some predicted miRNAs were the candidate to target EGFR signaling pathway members differentially expressed in cervical cancer samples compared to normal samples.
Keywords	apoptosis ; data collection ; epidermal growth factor receptors ; gene expression regulation ; microRNA ; microarray technology ; molecular biology ; uterine cervical neoplasms
Language	English
Dates of publication	2020-06
Size	p. 4553-4568.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05494-4
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