Article ; Online: Peripheral cortical bone density predicts vertebral bone mineral properties in spine fusion surgery patients.
2023 Volume 169, Page(s) 116678
Abstract: Spine fusion surgery is one of the most common orthopedic procedures, with over 400,000 performed annually to correct deformities and pain. However, complications occur in approximately one third of cases. While many of these complications may be related ...
| Abstract | Spine fusion surgery is one of the most common orthopedic procedures, with over 400,000 performed annually to correct deformities and pain. However, complications occur in approximately one third of cases. While many of these complications may be related to poor bone quality, it is difficult to detect bone abnormalities prior to surgery. Areal BMD (aBMD) assessed by DXA may be artifactually high in patients with spine pathology, leading to missed diagnosis of deficits. In this study, we related preoperative imaging characteristics of both central and peripheral sites to direct measurements of bone quality in vertebral biopsies. We hypothesized that pre-operative imaging outcomes would relate to vertebral bone mineralization and collagen properties. Pre-operative assessments included DXA measurements of aBMD of the spine, hip, and forearm, central quantitative computed tomography (QCT) of volumetric BMD (vBMD) at the lumbar spine, and high resolution peripheral quantitative computed tomography (HRpQCT; Xtreme CT2) measurements of vBMD and microarchitecture at the distal radius and tibia. Bone samples were collected intraoperatively from the lumbar vertebrae and analyzed using Fourier-transform Infrared (FTIR) spectroscopy. Bone samples were obtained from 23 postmenopausal women (mean age 67 ± 7 years, BMI 28 ± 8 kg/m |
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| MeSH term(s) | Humans ; Female ; Middle Aged ; Aged ; Absorptiometry, Photon/methods ; Bone Density ; Bone and Bones ; Cortical Bone ; Lumbar Vertebrae ; Radius | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2023-01-14 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 632515-4 | ||||||||||
| ISSN | 1873-2763 ; 8756-3282 | ||||||||||
| ISSN (online) | 1873-2763 | ||||||||||
| ISSN | 8756-3282 | ||||||||||
| DOI | 10.1016/j.bone.2023.116678 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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