LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions

    Yannic C. Bartsch / Deniz Cizmeci / Jaewon Kang / Hailong Gao / Wei Shi / Abishek Chandrashekar / Ai-ris Y. Collier / Bing Chen / Dan H. Barouch / Galit Alter

    iScience, Vol 26, Iss 5, Pp 106582- (2023)

    2023  

    Abstract: Summary: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely ... ...

    Abstract Summary: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely linked to persistent recognition of BA.1 by T cells and non-neutralizing opsonophagocytic antibodies. Yet, the emergence of new sublineage BA.2, which is more transmissible than BA.1 despite relatively preserved neutralizing antibody responses, has raised the possibility that BA.2 may evade other vaccine-induced responses. Here, we comprehensively profiled the BNT162b2 vaccine-induced response to several VOCs, including omicron BA.1 and BA.2. While vaccine-induced immune responses were compromised against both omicron sublineages, vaccine-induced antibody isotype titers, and non-neutralizing Fc effector functions were attenuated to the omicron BA.2 spike compared to BA.1. Conversely, FcγR2a and FcγR2b binding was elevated to BA.2, albeit lower than BA.1 responses, potentially contributing to persistent protection against severity of disease.
    Keywords Immunology ; Virology ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Study on mechanism of retrogressive slope failure using artificial rainfall

    Regmi, Ram Krishna / Hajime Nakagawa / Jaewon Kang / Kwansue Jung

    Catena. 2014 Nov., v. 122

    2014  

    Abstract: Many slope failures have been observed in the mountainous environments of the world due to rainfall events. However, studies related to the correlation of rainfall intensity, sliding initiation time and the position of slip surface head are still lacking. ...

    Abstract Many slope failures have been observed in the mountainous environments of the world due to rainfall events. However, studies related to the correlation of rainfall intensity, sliding initiation time and the position of slip surface head are still lacking. Studies on the mechanisms of retrogressive slope failure that may occur in a series and the down-slope displacement of failure mass are also rare. In this study, slope failure experiments were performed using medium-grained silica sand S6 to prepare the model slope in a 5m long, 30cm wide and 50cm deep rectangular flume. The experiments consisted of detailed observations of failure process consisting series of failures successively, with particular emphasis on the time of failure; shape, size and position of the slip surface; and final shape of the model slope after down-slope displacement of the failure masses. Moisture profiles at different points within the model slope soil domain and the profile of surface-water forefront were also reported. The observations showed that the slope failure initiating once at the region near the toe results in successive sliding failures in a series, thereby propagating an unstable zone toward the up-slope. When the slope failure initiates at the region toward the head reach, the successive failures may propagate toward the down-slope first, and then again toward the up-slope. This study also noticed a strong correlation between rainfall intensity, sliding initiation time and the position of its slip surface head. The relationship might depend on the shape and size of the model slope and the type of material used in the formation of the model slope. However, the results indicate the possibility of finding a relationship among rainfall intensity, sliding initiation time, and the position of its slip surface head in a natural slope failure prone zone. A landslide model test and application in real field, based on the similarity theory, may reveal the relationship more realistic. Then it would have a significant impact on policy making to mitigate the probable catastrophe during extreme rainfall-induced landslide disaster.
    Keywords issues and policy ; landslides ; rain ; rain intensity ; sand ; silica ; soil ; surface water
    Language English
    Dates of publication 2014-11
    Size p. 27-41.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 519608-5
    ISSN 1872-6887 ; 0008-7769 ; 0341-8162
    ISSN (online) 1872-6887 ; 0008-7769
    ISSN 0341-8162
    DOI 10.1016/j.catena.2014.06.001
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3389: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Discrete SARS-CoV-2 antibody titers track with functional humoral stability

    Yannic C. Bartsch / Stephanie Fischinger / Sameed M. Siddiqui / Zhilin Chen / Jingyou Yu / Makda Gebre / Caroline Atyeo / Matthew J. Gorman / Alex Lee Zhu / Jaewon Kang / John S. Burke / Matthew Slein / Matthew J. Gluck / Samuel Beger / Yiyuan Hu / Justin Rhee / Eric Petersen / Benjamin Mormann / Michael de St Aubin /
    Mohammad A. Hasdianda / Guruprasad Jambaulikar / Edward W. Boyer / Pardis C. Sabeti / Dan H. Barouch / Boris D. Julg / Elon R. Musk / Anil S. Menon / Douglas A. Lauffenburger / Eric J. Nilles / Galit Alter

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to ...

    Abstract The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top