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Article ; Online: The Effect of Hydro-Alcoholic Extraction of Valerian on Number and Morphology of Raphe Magnus Nucleus in Astrocytes in Rat Model

Hatamijoni Sajad / Rozbehi Amrolla / Seyed Forootan Farzad / Jafari Barmak Mehrzad

Journal of Clinical and Diagnostic Research, Vol 12, Iss 2, Pp AC10-AC

2018 Volume 13

Abstract: Introduction: The valerian root extract has been used to treat sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocyte cells are involved in neural support, nutrition and protection. They regulate the transmission of ... ...

Abstract	Introduction: The valerian root extract has been used to treat sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocyte cells are involved in neural support, nutrition and protection. They regulate the transmission of electrical impulses within the brain. Aim: The aim of the present study was to evaluate the effect(s) of valerian extract on the number and size of the astrocyte cells in raphe magnus nucleus of rats. Materials and Methods: In the present experimental study, 40 male Wistar rats weighing 170-250 gm were randomly divided into four groups as follows: one control and three experimental groups. The control group received distilled water while animals in Group 2, 3 and 4 were gavaged by 300, 400 and 600 mg valerian root extract daily, respectively for two weeks. Astrocyte cells were stained with phosphotungstic acid. The size and number of astrocyte cells were calculated using the LS starter software. The collected data were analysed using SPSS statistical analysis with ANOVA and LSD tests. Results: The mean number of astrocytes in experimental Groups 3 and 4 showed a significant increase in comparison with the control and experimental Group 2 (p-value <0.05). The mean diameter of astrocytes in all groups compared with the control group showed a significant decrease. Moreover, in Group 2, compared with Groups 3 and 4, the difference was statistically significant (p-value <0.05). Conclusion: Aqueous extracts of valerian taken orally will increase the number of astrocytes in the raphe magnus. In addition, administration of this extract reduced the diameter of astrocytes in nucleus raphe magnus, which is indicative of cell proliferation in the nucleus raphe magnus.
Keywords	animal model ; astrocyte cells ; valeriana root extact ; Medicine ; R
Subject code	630
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article: Evaluation of the Biodistribution of Arginine, glycine, aspartic acid peptide-modified Nanoliposomes Containing Curcumin in Rats.

Salehi Najafabadi, Parisa / Delaviz, Hamdollah / Asfaram, Arash / Jafari Barmak, Mehrzad / Ghanbari, Amir / Alipour, Mohsen / Rad, Parastou / Bardania, Hassan

Iranian journal of biotechnology

2022 Volume 20, Issue 2, Page(s) e2990

Abstract: Background: Liposomes, as a biological membrane, is successfully used for drug delivery, reduces toxicity in normal cells and improves bio-accessibility of the drug to the target cells. Curcumin, as a bioactive substance with pleiotropic biological ... ...

Abstract	Background: Liposomes, as a biological membrane, is successfully used for drug delivery, reduces toxicity in normal cells and improves bio-accessibility of the drug to the target cells. Curcumin, as a bioactive substance with pleiotropic biological activities, is an anti-inflammatory compound and has several anticancer effects in different cancers such as pancreatic and breast cancer. Objectives: This study was conducted to determine the bio-distribution of arginine-glycine-aspartic acid (RGD)-modified nanoliposomes containing curcumin in different tissues of rats. Materials and methods: The amount of curcumin in each tissue was examined by HPLC analysis. The distribution of liposomal Hoechst in the rats was evaluated by using fluorescence spectrophotometry, live animal imaging analyses and histological methods. Results: HPLC analysis showed the mean of curcumin in the blood significantly increased in the liposomal curcumin modified with RGD compared to free curcumin. These results were confirmed by fluorescence measurement for RGD modified liposome containing Hoechst dye. There was negligible fluorescent intensity in the blood rats, which received Hoechst alone. Live animal imaging analysis showed the presence of fluorescent color in heart tissue for all groups. It was also detected in kidney tissue for liposomal Hoechst modified with RGD group. Conclusions: The present study demonstrated that RGD-modified nano-liposomes can significantly improve drug retention time in the blood of rats.
Language	English
Publishing date	2022-04-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2223669-7
ISSN	2322-2921 ; 1728-3043
ISSN (online)	2322-2921
ISSN	1728-3043
DOI	10.30498/ijb.2021.272168.2990
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Article ; Online: Evaluation of the effect of the internal layer of oak fruit (jaft) extract on the prevention of gastric ulcers caused by stress in male rats.

Jafari Barmak, Mehrzad / Dehghan Menshadi, Alireza / Mahmoudi, Reza / Bardania, Hassan

Journal of medicine and life

2018 Volume 11, Issue 3, Page(s) 225–230

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Animals ; Anti-Ulcer Agents/pharmacology ; Anti-Ulcer Agents/therapeutic use ; Fruit/chemistry ; Hydrogen-Ion Concentration ; Male ; Malondialdehyde/metabolism ; Nitric Oxide/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Quercus/chemistry ; Rats, Wistar ; Stomach Ulcer/drug therapy ; Stomach Ulcer/etiology ; Stomach Ulcer/prevention & control ; Stress, Psychological/complications
Chemical Substances	Anti-Ulcer Agents ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; Malondialdehyde (4Y8F71G49Q)
Language	English
Publishing date	2018-10-11
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3109 ; 1844-122X
ISSN (online)	1844-3117 ; 1844-3109
ISSN	1844-122X
DOI	10.25122/jml-2017-0025
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Article ; Online: Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle.

Mahmoudi, Reza / Azizi, Arsalan / Abedini, Soheila / Hemayatkhah Jahromi, Vahid / Abidi, Hassan / Jafari Barmak, Mehrzad

Journal of medicine and life

2019 Volume 11, Issue 4, Page(s) 371–380

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Animals ; Cadmium Chloride/toxicity ; Male ; Malondialdehyde/metabolism ; Plant Extracts/pharmacology ; Rats, Wistar ; Sperm Motility/drug effects ; Spermatogenesis/drug effects ; Spermatozoa/drug effects ; Spermatozoa/pathology ; Tea/chemistry ; Testis/drug effects ; Testis/pathology
Chemical Substances	Plant Extracts ; Tea ; Malondialdehyde (4Y8F71G49Q) ; Cadmium Chloride (J6K4F9V3BA)
Language	English
Publishing date	2019-03-20
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3109 ; 1844-122X
ISSN (online)	1844-3117 ; 1844-3109
ISSN	1844-122X
DOI	10.25122/jml-2018-0005
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Article ; Online: RGD peptide-mediated liposomal curcumin targeted delivery to breast cancer cells.

Mahmoudi, Reza / Ashraf Mirahmadi-Babaheidri, Seyedeh / Delaviz, Hamdollah / Fouani, Mohamad Hassan / Alipour, Mohsen / Jafari Barmak, Mehrzad / Christiansen, Gunna / Bardania, Hassan

Journal of biomaterials applications

2020 Volume 35, Issue 7, Page(s) 743–753

Abstract: In this study, turmeric's active ingredient (Curcumin) was encapsulated into RGD modified Liposomes (RGD-Lip-Cur) its cytotoxic effect on the breast cancer cell line (MCF-7) was evaluated by MTT, flow cytometry and Caspase assay. Liposomes were ... ...

Abstract	In this study, turmeric's active ingredient (Curcumin) was encapsulated into RGD modified Liposomes (RGD-Lip-Cur) its cytotoxic effect on the breast cancer cell line (MCF-7) was evaluated by MTT, flow cytometry and Caspase assay. Liposomes were characterized using transmission electron microscopy (TEM). Results demonstrated that the liposomes were spherical in shape, ranging from 70 to 100 nm. MTT assay revealed that RGD-Lip-Cur had a significant cytotoxic effect on MCF-7 cells at concentrations of 32, 16 and 4 μg/ml compared to Lip-Cur (P < 0.05) and curcumin (P < 0.01). The apoptosis assay demonstrated that RGD-Lip-Cur induces the apoptosis in MCF-7 cells (39.6% vs 40.2% for initial and secondary apoptosis) significantly more than Lip-Cur (67.7% vs 9.16% for initial and secondary apoptosis) and free curcumin (7.84% vs 38.8% for initial and secondary apoptosis). Moreover, caspase assay showed that RGD-Lip-Cur activates caspase 3/7 compared to Lip-Cur (P < 0.05) and free curcumin (P < 0.01). The RGD-Lip-Cur was similar to the control group and had no significant cytotoxicity effect. It is concluded that RGD-Lip-Cur as a novel carrier have high cytotoxicity effect on breast cancer cell line (MCF-7).
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis ; Breast Neoplasms/drug therapy ; Cell Survival ; Curcumin/chemistry ; Drug Delivery Systems ; Female ; Humans ; Liposomes/chemistry ; MCF-7 Cells ; Microscopy, Electron, Transmission ; Oligopeptides/pharmacology ; Particle Size
Chemical Substances	Antineoplastic Agents ; Liposomes ; Oligopeptides ; arginyl-glycyl-aspartic acid (78VO7F77PN) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2020-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/0885328220949367
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Article: Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite.

Mahmoudi, Reza / Honarmand, Zahra / Karbalay-Doust, Saied / Jafari-Barmak, Mehrzad / Nikseresht, Mohsen / Noorafshan, Ali

EXCLI journal

2017 Volume 16, Page(s) 583–592

Abstract: Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on ... ...

Abstract	Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respectively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue volume increased (15-20 %) in both groups (P<0.01). Besides, 19-36 % and 41-57 % of the cells (spermatogonia types A and B, spermatids, Sertoli and Leydig) were lost in the rats that received intermediate and high doses of Na-MBS respectively in comparison to the control groups. Nonetheless, all the above-mentioned alterations ameliorated drastically in the rats that received Na-MBS plus CUR compared to those exposed to Na-MBS without CUR therapy (P<0.01). The acceptable daily intake of Na-MBS for 7 weeks did not affect on testicular parameters. CUR (100 mg/kg/day) could prevent structural impairments of testicles in the rats induced by Na-MBS (7 and 70 mg/kg/day).
Language	English
Publishing date	2017-04-24
Publishing country	Germany
Document type	Journal Article
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2017-143
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Article ; Online: Pramipexole reduces inflammation in the experimental animal models of inflammation.

Sadeghi, Heibatollah / Parishani, Mohammad / Akbartabar Touri, Mehdi / Ghavamzadeh, Mehdi / Jafari Barmak, Mehrzad / Zarezade, Vahid / Delaviz, Hamdollah / Sadeghi, Hossein

Immunopharmacology and immunotoxicology

2017 Volume 39, Issue 2, Page(s) 80–86

Abstract: Pramipexole is a dopamine (DA) agonist (D2 subfamily receptors) that widely use in the treatment of Parkinson's diseases. Some epidemiological and genetic studies propose a role of inflammation in the pathophysiology of Parkinson's disease. To our ... ...

Abstract	Pramipexole is a dopamine (DA) agonist (D2 subfamily receptors) that widely use in the treatment of Parkinson's diseases. Some epidemiological and genetic studies propose a role of inflammation in the pathophysiology of Parkinson's disease. To our knowledge, there is no study regarding the anti-inflammatory activity of pramipexol. Therefore, the aim of the study was to investigate anti-inflammatory effect of pramipexol. Anti-inflammatory effects of pramipexole were studied in three well-characterized animal models of inflammation, including carrageenan- or formalin-induced paw inflammation in rats, and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. The animals received pramipexol (0.25, 0.5 and 1 mg/kg, I.P.) 30 min before subplantar injection of carrageenan or formalin. Pramipexol (0.5 and 1 mg/kg) was also injected 30 min before topical application of TPA on the ear mice. Serum malondialdehyde (MDA) levels were evaluated in the carrageenan test. Finally, pathological examination of the inflamed tissues was carried out. Pramipexole significantly inhibited paw inflammation 1, 2, 3 and 4 h after carrageenan challenge compared with the control group (p < .001). Pramipexol also showed considerable anti-inflammatory activity against formalin-evoked paw edema over a period of 24 h (p < .001). TPA-induced ear edema was markedly decreased by pramipexol (p < .001). The pathological evaluation of the paws and ears revealed that pramipexole reduced tissue injury, neutrophil infiltration, and subcutaneous edema. Pramipexole did not alter the increased serum levels of MDA due to carrageenan injection. These data clearly indicate that pramipexol possesses significant anti-inflammatory activity. It seems that its antioxidants do not play an important role in these effects.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Benzothiazoles/pharmacology ; Carrageenan/toxicity ; Disease Models, Animal ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/pathology ; Male ; Mice ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/drug therapy ; Parkinson Disease, Secondary/immunology ; Parkinson Disease, Secondary/pathology ; Rats ; Rats, Wistar ; Tetradecanoylphorbol Acetate/toxicity
Chemical Substances	Anti-Inflammatory Agents ; Benzothiazoles ; pramipexole (83619PEU5T) ; Carrageenan (9000-07-1) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2017.1284230
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Article: The Effects of L-arginine on the Hippocampus of Male Rat Fetuses under Maternal Stress.

Mahmoudi, Reza / Enant, Elham / Delaviz, Hamdollah / Rad, Parastou / Roozbehi, Amrollah / Jafari Barmak, Mehrzad / Azizi, Arsalan

Basic and clinical neuroscience

2016 Volume 7, Issue 1, Page(s) 5–11

Abstract: Introduction: Prenatal stress has deleterious effects on the development of the brain and is associated with behavioral and psychosocial problems in childhood and adulthood. This study aimed to determine the protective effect of L-arginine on fetal ... ...

Abstract	Introduction: Prenatal stress has deleterious effects on the development of the brain and is associated with behavioral and psychosocial problems in childhood and adulthood. This study aimed to determine the protective effect of L-arginine on fetal brain under maternal stress. Methods: Twenty pregnant Wistar rats (weighting 200-230 g) were randomly divided into 4 groups (n=5 for each group). The first nonstress and stress groups received 2 mL of normal saline and the other nonstress and stress two groups received L-arginine (200 mg/kg, IP) from their 5(th) to 20(th) days of pregnancy. The pregnant rats were killed on 20(th) day and the brain fetuses removed and prefrontal cortical thickness, total neurons in the prefrontal cortex and in the areas of CA1, CA2, and CA3 of the hippocampus were measured and counted. Nitrite levels in the brain were measured as an indicator for nitric oxide (NO) level. Results: There was a significant decrease of mean number of pyramidal cells in the CA1 in prenatal stress group compared to nonstress and nonstress plus arginine groups. The NO level in brain tissue increased significantly in the stress plus arginine (3.8±0.4 nmol/mg) and in nonstress rats (2.9±0.3 nmol/mg) compared to the stress group (1.8±0.1 nmol/mg). Prefrontal cortical thickness decreased significantly in stress rats (1.2±0.09 mm) compared to the nonstress plus arginine (1.7±0.15 mm) and nonstress (1.6±0.13 mm) groups. Discussion: Results indicated that prenatal stress could lead to neurodegeneration of hippocampus and prefrontal cortex of rat fetuses. L-arginine as a precursor of NO synthesis had neuroprotective effect during prenatal stress and could be used an effective treatment for stress.
Language	English
Publishing date	2016-05-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
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Article: Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat.

Sadeghi, Heibatollah / Hosseinzadeh, Saleh / Akbartabar Touri, Mehdi / Ghavamzadeh, Mehdi / Jafari Barmak, Mehrzad / Sayahi, Moslem / Sadeghi, Hossein

Avicenna journal of phytomedicine

2016 Volume 6, Issue 2, Page(s) 181–188

Abstract: Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.: Materials and methods: Male ... ...

Abstract	Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Materials and methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina 750 mg/kg alone. R. canina (p.o., daily) and CCl4 (1 ml/kg twice a week, 50% v/v in olive oil, i.p.) were administered to animals for six weeks. Serum analysis was performed to assay the levels of aspartate aminotransferase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), albumin (ALB), total protein (TP) and malondialdehyde (MDA). Biochemical observations were also supplemented with histopathological examination (haematoxylin and eosin staining) of liver section. Results: Hepatotoxicity was evidenced by considerable increase in serum levels of AST, ALT, ALP, and lipid peroxidation (MDA) and decrease in levels of ALB and TP. Injection of CCL4 also induced congestion in central vein, and lymphocyte inﬁltration. Treatment with hydro-alcoholic fruit extract of R. canina at doses of 500 and 750 mg/kg significantly reduced CCl4-elevated levels of ALT, AST, ALP and MDA (p<0.01). The extract also increased the serum levels of ALB and TP compared to CCl4 group (p<0.01) at the indicated dose Histopathological studies supported the biochemical finding. Conclusion: Our finding indicated hepatoprotective effects of the hydro-alcoholic fruit extract of R. canina on CCl4-induced hepatic damage in rats and suggested that these effects may be produced through reducing oxidative stress.
Language	English
Publishing date	2016-04-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2658672-1
ISSN	2228-7949 ; 2228-7930
ISSN (online)	2228-7949
ISSN	2228-7930
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Article: Anti-inﬂammatory Activity of Stachys Pilifera Benth.

Sadeghi, Heibatollah / Zarezade, Vahid / Sadeghi, Hossein / Akbartabar Toori, Mehdi / Jafari Barmak, Mehrzad / Azizi, Arsalan / Ghavamizadeh, Mehdi / Mostafazadeh, Mostafa

Iranian Red Crescent medical journal

2014 Volume 16, Issue 9, Page(s) e19259

Abstract: Background: Stachys pilifera Benth has long been used to treat infectious diseases as well as respiratory and rheumatoid disorders in Iranian folk medicine. Antioxidants, antitumor, and antimicrobial properties of the plant have been reported.: ... ...

Abstract	Background: Stachys pilifera Benth has long been used to treat infectious diseases as well as respiratory and rheumatoid disorders in Iranian folk medicine. Antioxidants, antitumor, and antimicrobial properties of the plant have been reported. Objectives: This experimental study was designed to evaluate systemic and topical anti-inflammatory effects of the hydro-alcoholic extract from aerial parts of Stachys pilifera (HESP). Materials and methods: Anti-inflammatory effects of HESP was studied in four well-known animal models of inflammation, including carrageenan- or formalin-induced paw edema in rat (thirteen groups, 6 rats per each group), and 12-O-tetradecanoylphorbol-13-acetate (TPA)- or xylene-induced ear edema in mouse (ten groups, 6 mice per each group). The rats received HESP (50-400 mg/ kg) orally 45 minutes before the subplantar injection of carrageenan or formalin. In TPA or xylene tests, HESP (1, 2.5, and 5 mg/ear) was applied topically simultaneous with these phlogistic agents on the ear mice. Finally, pathological examination of the inflamed tissues (paw and ear) was carried out. Results: Acute toxicity study of the extract showed that no rats were killed at 5000 mg/kg (LD50 > 5000 mg/kg). The extract (100 and 200 mg/ kg) significantly suppressed carrageenan-induced paw edema 1, 2, 3, and 4 hours after carrageenan challenge in comparison with the control group (P < 0.001). The HESP (100 and 200 mg/kg) also produced a considerable antiedematogenic effect in the formalin test over a period of 24 hours (P < 0.01). Furthermore, topical administration of the HESP (1, 2.5, and 5 mg/ear) inhibited TPA- and xylene-induced ear edema in comparison with the control group (P < 0.001). The pathological analysis of the paws and ears revealed that HESP was capable of reducing tissue destruction, cellular inﬁltration, and subcutaneous edema induced by the indicated phlogistic agents. Conclusions: The present data confirmed systemic and topical anti-inflammatory effects of Stachys pilifera which is comparable to indomethacin.
Language	English
Publishing date	2014-09-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2415781-8
ISSN	2074-1812 ; 1561-4395 ; 2074-1804
ISSN (online)	2074-1812 ; 1561-4395
ISSN	2074-1804
DOI	10.5812/ircmj.19259
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